白藜芦醇对MERS-冠状病毒感染的有效抑制作用
BMC传染病 15， 文章编号：144 （2017）
Results
Resveratrol significantly inhibited MERS-CoV infection and prolonged cellular survival after virus infection. We also found that the expression of nucleocapsid (N) protein essential for MERS-CoV replication was decreased after resveratrol treatment. Furthermore, resveratrol down-regulated the apoptosis induced by MERS-CoV in vitro. By consecutive administration of resveratrol, we were able to reduce the concentration of resveratrol while achieving inhibitory effectiveness against MERS-CoV.
结果：白藜芦醇可显著抑制病毒感染后的MERS-CoV感染并延长细胞存活时间。我们还发现，白藜芦醇治疗后，MERS-CoV复制所必需的核衣壳（N）蛋白的表达降低。此外，白藜芦醇在体外下调了MERS-CoV诱导的细胞凋亡。通过连续施用白藜芦醇，我们能够降低白藜芦醇的浓度，同时达到针对MERS-CoV的抑制效果。
Conclusion
In this study, we first demonstrated that resveratrol is a potent anti-MERS agent in vitro. We perceive that resveratrol can be a potential antiviral agent against MERS-CoV infection in the near future.
结论: 白藜芦醇是一种有效的抗 MERS药物，我们认为白藜芦醇可能是一种潜在的抗病毒药物，在不久的将来。
白藜芦醇 对人和动病毒的抗病毒活性研究
病毒学进展， 文章ID 184241(3) ,2015/11/
Conclusion
Resveratrol has shown a high antiviral potential that can be explored in both human and animal viral infections. Its main antiviral mechanisms were seen to be elicited through inhibition of viral protein synthesis, inhibition of various transcription and signaling pathways, and inhibition of viral related gene expressions. Even though there are still limitations on its bioavailability following intake, which is being widely studied, more studies should be focused on its direct use in the amelioration of viral infections in humans and companion animals.
结论：
白藜芦醇显示出很高的抗病毒潜力，可在人和动物病毒感染中进行探索。它的主要抗病毒机制被认为是通过抑制病毒蛋白质的合成，抑制各种转录和信号传导途径以及抑制病毒相关基因的表达引起的。尽管摄入后其生物利用度仍然存在局限性，这已被广泛研究，但更多的研究应集中在直接用于改善人类和伴侣动物的病毒感染上。
白藜芦醇强烈抑制流感病毒的复制，是一种特别有价值的抗流感病毒药物，具有显著的剂量抑制，甚至完全阻断病毒的复制。
白藜芦醇对甲型流感病毒复制和抑制作用
《传染病杂志》 第191卷 ，第10期，2005.5.15
- RV对MDCK细胞中PR8复制的抑制作用
- 白藜芦醇（RV）抑制MDCK细胞中流感病毒A / Puerto Rico / 8/34 H1N1（PR8）复制
- RV治疗后晚期病毒蛋白的表达和vRNP流量
- 白藜芦醇（RV）治疗期间晚期病毒蛋白的表达和核糖核蛋白运输
- RV干扰了晚期病毒蛋白合成和vRNPs的核输出。 然后，我们研究了造成这种作用的分子机制
- RV和细胞内氧化还原状态
