NMN, Metformin, and Rapamycin Mitigate Age-Related Cognitive Impairment
This study by the University of North Texas had the following findings:
• Treatment with (1) NMN, (2) metformin, or (3) rapamycin improves learning and memory in rats modeling vascular cognitive impairment (VCI), the second leading cause of dementia after Alzheimer’s disease.
• The compounds reduce brain lesions caused by the lack of blood flow that characterize VCI.
• The degradation of the fatty tissue that makes our neurons fire faster, called myelin, is prevented by treatment with NMN, metformin, or rapamycin.
https://www.nmn.com/news/nmn-metformin-and-rapamycin-mitigate-age-related-cognitive-impairment
Despite its prevalence, like Alzheimer’s, no therapy currently exists to delay or prevent VCI.
From the above study, each of the 3 compounds is found to be able to protect cognition even under the situation of reduced blood flow. Each of them can also reduce areas of damages in the brain and prevent myelin degradation.
What is myelin?
Myelin is like the isolation that’s used to protect an electrical wire.
Myelin is a lipid-rich material that surrounds nerve cell axons (the nervous system’s “wires”) to insulate them and increase the rate at which electrical impulses (called action potentials) are passed along the axon
Multiple sclerosis (MS) is the most common disease associated with myelin damage. In this disease, myelin damage is caused by the attack by the body’s own immune cells. Repeated attacks lead to nerve signals to slow down or stop and eventually also axons degeneration and death of nerve cells.
Other than dysfunctioning of the immune system, damage to myelin can be caused by:
• Stroke
• Infections
• Inflammation
• Metabolic disorders
• Certain medications
• Excessive alcohol use
• Carbon monoxide poisoning
• Vitamin B12 deficiency
In this article, you can also find other diseases due to myelin damage.
https://www.verywellhealth.com/myelin-sheath-4129059
Aging is also one of the common causes of myelin degradation.
Myelin Loss Is a Major Factor in Age-Related Brain Deterioration
In the conclusion of the University of North Texas study (first article shared here today), it says “Compared to rapamycin and metformin, NMN exerts a broader range of benefits by stimulating sirtuin proteins to combat harmful cell oxidative stress, while also activating the AMPK protein to promote mitochondrial function and suppress mTOR.”
In the same paper, there is also an indication that none of the three compounds provide more benefit than the others in regard to cognition protection under reduced blood flow. A cost comparison found that metformin is the cheapest while rapamycin is the most expensive. NMN lies in the middle.
However, regarding side effects, it only mentions that NMN provides a broader range of other benefits. It’s not sure about the side effects of the 2 other compounds.
🔖 Really hope that everyone of you can consider taking NMN to improve brain functions and other health issues.
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