After Professor David Sinclair published the NMN paper that shocked the world in 2013, the world’s top institutions and scientists all invested resources to accelerate research, and also published hundreds of related papers in authoritative journals. NMN related research also won the 2017 Nobel Prize. Award, the research effects of NMN related papers are as follows:
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(1) NMN can promote stem cell function to prolong healthy life Reference: ( ncbi.nlm.nih.gov/pmc )
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NMN improves the function of mitochondria and stem cells , restores youthful vitality to various functions of the body, and prolongs the lifespan of mice. References cell.com/
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NMN regulates mesenchymal stromal cells in aged bone marrow, thereby promoting osteogenesis and reducing adipogenesis . Reduce osteoporosis and obesity . Reference: nature.com/
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NMN increases hematopoietic stem cell activity to accelerate blood production Reference (cell.com/cell-stem)
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NMN delays senescence of rat bone marrow mesenchymal stem cells
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NMN rejuvenates aging intestinal adult stem cells
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(2) NMN reverses muscle aging and prevents radiation . Since this function of NMN can be used to improve the muscle atrophy of astronauts (astronauts lack of exercise due to weightlessness) and resist radiation. NASA also awarded the discovery team the David Sinclair iTech Award. Reference: (https://doi.org/)
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(3) NMN regenerates blood vessels : Studies have found that after using NMN in old mice, the number and density of capillaries are almost the same as in young mice, and muscle endurance can reach 80%. Further reading: Vascular aging is the root cause of all diseases!
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(4) NMN reverses vascular aging , NMN reversed the level of microRNA (miRNA) in aging blood vessels in mice, thereby rejuvenating blood vessels and resisting atherosclerosis, preventing and improving cardiovascular and renal diseases . Referenceslink
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(5) NMN has a significant cerebrovascular protective effect , and NMN can treat/prevent neurovascular dysfunction and cognitive impairment ( senile dementia, etc. ) in elderly patients. Further reading: Terrifying Alzheimer’s is saved!
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(6) NMN prevents various senile diseases : On February 19, 2019, Shinkowa, Japan released a clinical trial report on the benefits of 24-week oral NMN on the human body. The expression of longevity protein increased after oral administration of NMN , and the expression of various types of hormones also increased , No side effects. It is speculated that various diseases of the elderly (such as: common diseases of the elderly, cancer and Alzheimer’s…) can be improved or fully recovered by treatment.
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(7) NMN improves basal metabolism : Studies have shown that NMN can increase the level of NAD+, improve cell vitality, like exercise, improve body metabolism, and effectively prevent hypertension, hyperlipidemia and hyperglycemia .
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(8) NMN stabilizes telomeres , maintains telomere length and improves the symptoms of telomere disorders, and can significantly improve physical activity, metabolism, brain function and lifespan. Further reading: Scientists find hard evidence that NMN lengthens telomeres
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(9) NMN helps pregnancy: an enzyme NMNAT2 that can mediate NAD+ synthesis, and NAD+ synthesis mediated by it has a protective effect on senescent oocytes. Referencesncbi.nlm.nih.gov
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(10) NMN enhances gene repair : Scientists published in a scientific journal, NAD+ activates the DNA repair enzyme PARP to repair DNA in cells and cells, and fundamentally solves the problem of disease, confirming that NMN directly affects the self-repair and regeneration of cells .
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(11) NMN relieves hangover and protects the liver. NMN can increase liver NAD+ levels, prevent ethanol-induced ALT and AST elevations through Atf3 and Erk1/2 signaling, and change the expression of 25% of genes regulated by ethanol metabolism. The treatment of alcoholic fatty liver is effective. Referenceslink.springer.com
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(12) NMN improves depressive behavior . NMN can improve the condition of mice with cortisol (CORT)-induced depression, enhance the activity of NAD+ synthesis rate-limiting enzyme NAMPT, and improve sleep!
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(13) Improve sex hormone NMN to improve sexual function , improve kidney function, restore energy and increase physical strength .
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(14) NMN enhances immunity, fights viruses and cancer : published in Biomedical Research on September 27, 2021, NMN can effectively enhance the activity of immune cells NK cells, and increase the natural killing of cancer cells without increasing the number of NK immune cells. Ability, enhance immunity, achieve the effect of fighting and preventing virus infection and cancer. Links to Reference Papers
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(15) NMN improves diabetes : April 22, 2021 Washington University School of Medicine, in the journal Science, published a human clinical trial conclusion that NMN improves:
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1. Metabolism in middle-aged and elderly women with prediabetes. 2. Promote muscle function and growth. 3. Prevention of various age-related diseases
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(16) NMN prevents skin photoaging: On June 12, 2021, the laboratory of DHC Corporation in Japan published a research conclusion in the Journal of Photochemistry and Photobiology that NMN can protect skin cells from UV damage and prevent skin photoaging.
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(17) NMN enhances muscle function and mobility : The University of Tokyo published a paper in Research Square on 2021/06/09, showing that daily oral administration of 250 mg of NMN significantly increased their NAD+ levels and improved their Muscle performance and athletic ability.
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(18) NMN prevents and improves the Covid-19 virus : 1. NMN increases NAD+ levels can enhance the immune response to COVID-19 infection. 2. COVID-19 (new coronavirus) patients improved by NMN cocktail therapy.