David Sinclair, director of Paul F. Glenn biological aging center at Harvard University and professor of medical school, is famous for his first discovery of the anti-aging effect of β – nicotinamide mononucleotide (NMN). Not long ago, David Sinclair was interviewed by Boston Magazine, the mainstream media of the United States. Sinclair firmly believed that “aging is a disease that […]
Interview with NMN discoverer Sinclair: aging can be cured and you will live to 150
Reversing ACE cell senescence: NMN can protect and relieve lung cells from functional decline
Recently, the team of Tingting Fang and Jingyun Yang of West China Hospital of Sichuan University in China published a research paper titled Nicotinamide mononucleotide ameliorates senescence in alveolar epithelial cells in MedComm[1]. Nicotinamide mononucleotide ameliorates senescence in alveolar epithelial cells Abstract Alveolar epithelial cells (ACEs) gradually senescent as aging, which is one of the main causes of respiratory defense […]
Cell Reports: Increasing NAD+ levels can reduce muscle amyloid aggregation and improve muscle mitochondrial homeostasis.
Recently, the team of Prof. Johan Auwerx from the Federal Institute of Technology Lausanne, Switzerland published a paper in Cell Reports (a sub-Journal of Cell) entitled “NAD+ boosting reduces age-associated amyloidosis and restores mitochondrial homeostasis in muscle”. Multi-factor biological processes are characterized by the decline of many cell functions, including mitochondrial dysfunction and protein balance disorders, which ultimately affect body […]
Study Demonstrates NMN Can Improve Newborn Health
Treating obese female mice with nicotinamide mononucleotide (NMN) reduces DNA damage and improves structural protein composition within egg cells (oocytes) while restoring low offspring birth weight. (Jilin University | vipyidian.com_ By Brett J. Weiss Published: 2:31 p.m. PST Jul 19, 2022 | Updated: 2:19 p.m. PST Jul 26, 2022 Highlights Obese females treated with NMN have oocytes with less DNA damage. NMN administration […]
David Sinclair and Anti-Aging Supplements – 2022
Dr. David Sinclair has revolutionized the way that people view aging. As a scientist and pioneer in genetics and longevity research, he’s been listed by TIME as one of the “100 Most Influential People in the World,” has received more than 35 awards and honors, and is currently working as a professor in the Department of Genetics and co-director of […]
If aging is a disease, the best solution is …
r David Sinclair is a Professor in the Department of Genetics and co-Director of the Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School. He is best known for his work on understanding why we age and how to slow its effects. His new book “Life Span – Why we aging ,why we don’t have to […]
NAD+ Boosting Molecule Protects Mice from Hearing Loss
Scientists find injecting mice with NAD+ booster protects against hearing loss through the activation of SIRT3, a protein that prevents damage to nerve connections between the ear and the brain.
TELOMERE SHORTENING AND TELOMERASE
Telomere Shortening and Telomerase. Content What are telomeres? Telomeres shorten with each cell division as we age Shorter telomeres. So what? Rates of telomere shortening vary from person to person: genetic and lifestyle factors. Controversial data Telomerase. A solution to the telomere shortening? Maintaining or improving telomere length. Practical Recommendations Summary References and literature What are Telomeres? Telomeres are sequences […]
What is a Telomere?
Telomere (tel-uh-meer) from the Greek telos (end) and meros (part). Telomeres are an essential part of human cells that affect how our cells age. Telomeres are the caps at the end of each strand of DNA that protect our chromosomes, like the plastic tips at the end of shoelaces. Without the coating, shoelaces become frayed until they can no longer […]
Aging Hallmarks – 2: Telomere Attrition
Telomeres are repetitive nucleotide sequences that protect the ends of chromosomes and maintain genomic stability (Fig. 5). Telomere dysfunction and genomic instability appear to be of critical importance for ageing at a cellular level. Age-related diseases and premature ageing syndromes are frequently associated with telomere shortening. Figure 5 Open in figure viewerPowerPoint Telomere attrition, telomere length and telomerase. Chromosomes have repeated […]