David Sinclair, director of Paul F. Glenn biological aging center at Harvard University and professor of medical school, is famous for his first discovery of the anti-aging effect of β – nicotinamide mononucleotide (NMN). Not long ago, David Sinclair was interviewed by Boston Magazine, the mainstream media of the United States. Sinclair firmly believed that “aging is a disease that […]
Interview with NMN discoverer Sinclair: aging can be cured and you will live to 150
Aging Hallmarks – 2: Telomere Attrition
Telomeres are repetitive nucleotide sequences that protect the ends of chromosomes and maintain genomic stability (Fig. 5). Telomere dysfunction and genomic instability appear to be of critical importance for ageing at a cellular level. Age-related diseases and premature ageing syndromes are frequently associated with telomere shortening. Figure 5 Open in figure viewerPowerPoint Telomere attrition, telomere length and telomerase. Chromosomes have repeated […]
Aging Hallmark 1： Genomic Instability
Genomic instability Human DNA is exposed constantly to all kinds of possible mutagens. These can be exogenous such as radiation and chemicals, or endogenous such as free radicals, the by-products of energy production from the electron transport chain. Powerful cellular DNA repair machinery can fix the majority of the damage; however, some will inevitably escape repair, so mutations and damage […]
Longevity In A Bottle
With an understanding of the fundamental biological processes that drive aging, researchers are now searching for drugs that could prolong life. AsianScientist (Aug. 15, 2018) ‘Tick, tock,’ goes the clock, and with each passing second, vitality silently slips away. The slow trace of wrinkles over smooth and supple skin, the nefarious creep of aches and pains in the muscles and […]