NMN’s restoration of youthful kidney protein levels in aged mice may translate therapeutically to humans. The world’s population of older adults continues to expand at an unprecedented pace. So, there is a need for a better understanding of aging processes to mitigate age-related diseases and disorders. But not all organs age at the same pace, so it’s important for scientists […]
Study Indicates NMN Has Anti-Aging Potential for Kidneys
NMN May Improve the Brain-Associated Blood Vessel Cell Response to Stress
NMN treatment improves brain associated blood vessel cell survival and protects against harmful stress in metabolic disorders like diabetes. Diabetes cases continue to rise sharply worldwide. These patients are more prone to stroke with a 50% greater risk of hemorrhagic stroke—blood vessels rupturing in the brain. This is thought to be caused by the dysfunction of brain-associated blood vessel cells—endothelial […]
NMN Stifles Mouse Inflammation Response Like NSAIDs
Similar to anti-inflammatory drugs, treating immune cells called macrophages with NMN inhibits chronic inflammation that can cause cancer and insulin resistance. Highlights · NMN treatment alleviates the inflammatory response of immune cells called macrophages. · Supplementing with the molecule also inhibits the buildup of inflammation-associated proteins, including COX-2. · By dampening COX-2 accumulation, NMN targets inflammation like non-steroidal anti-inflammatory drugs […]
Study Shows NMN Enhances Cancer-Preventing Immune Cell Activation
Taking NMN by under-the-skin injections or oral consumption improves immune cells that attack cancer and virally infected cells in mice. Highlights · NMN increases natural killer cell capabilities to destroy cancer cells (cytotoxicity) without increasing immune cell numbers. · The study supports that taking NMN may be a way to rejuvenate natural killer immune cell activation to preserve tissue health […]
NMN Makes Ears Resistant to Chemotherapy Poisoning in Mice
New research reveals that nicotinamide mononucleotide protects cells critical for hearing and balance from damage caused by the chemotherapeutic cisplatin. Highlights · Cisplatin causes ototoxicity — ear poisoning — and reductions in the cell essential molecule nicotinamide adenine dinucleotide (NAD+). · The NAD+ precursor nicotinamide mononucleotide (NMN) protects cochlear cells from cisplatin-induced ototoxicity in mice, preserving […]
Study Finds Protecting Skin Cells from UV Damage Depends on NMN Synthesis
Research indicates that preserving NAD+ levels is critical to skin cell survival responses to damage from UV rays. Highlights · UV radiation triggers the enzymes NAMPT and PARP — which produce and consume NAD+, respectively — in a tug of war between cell survival and dysfunction. · Inhibiting NAMPT allows PARP to exhaust the NAD+ supply, which hinders […]
Aged Lung Cells Protected from Functional Decline with NMN
Lung cells entering an aged, non-proliferating state (senescence) can trigger disease, which researchers can prevent with nicotinamide mononucleotide (NMN) in mice. Highlights · Supplementing aged mice with NMN protects lung cells from entering a stress and age-induced state called senescence that can facilitate lung disease. · NMN treatment reduces lung structural damage following exposure to a […]
NMN attenuates brain injury after intracerebral hemorrhage by activating Nrf2/HO-1 signaling pathway
Replenishment of NAD+ has been shown to protect against brain disorders such as amyotrophic lateral sclerosis and ischemic stroke. However, whether this intervention has therapeutic effects in intracerebral hemorrhage (ICH) is unknown. In this study, we sought to determine the potential therapeutic value of replenishment of NAD+ in ICH. In a collagenase-induced ICH (cICH) mouse model, nicotinamide mononucleotide (NMN), a key intermediate […]
NMN Administration Promotes Mitochondrial Health and Prevents Heart Failure
Scientists found NMN administration preserved mitochondrial health and prevented heart failure in mice deficient in a molecule that makes them susceptible to heart disease. In 2017, scientists from Case Western Reserve University, who published a study in the Journal of Molecular and Cellular Cardiology, found nicotinamide mononucleotide (NMN) supplementation promotes the health of the cell’s powerhouse, the mitochondria, and prevents […]
NMN Supplementation Promotes Brain Blood Vessel Rejuvenation
Scientists provide genetic evidence indicating NMN supplementation promotes rejuvenation of blood vessels providing nutrients to the brain. This April, a team of scientists from the University of Oklahoma published a study in GeroScience where they found that nicotinamide mononucleotide (NMN) supplementation reversed the effects of aging on the neurovascular units and restored cellular pathways, according to the genetic expression profiles of mouse brains. NMN supplementation may […]