Compound found in red wine opens door for new treatments for depression, anxiety Resveratrol, found in grape skin, shuts down depression-causing enzyme in brain Date:July 29, 2019Source:University at BuffaloSummary:A new study has revealed that the plant compound resveratrol, which is found in red wine, displays anti-stress effects by blocking the expression of an enzyme related to the control of stress […]
Compound found in red wine opens door for new treatments for depression, anxiety
The antidepressant- and anxiolytic-like effects of resveratrol: Involvement of phosphodiesterase-4D inhibition
Highlights • The neuroprotective effects of resveratrol in vitro or in vivo were investigated. • The increases of PDE4D in the hippocampus led to depression- and anxiety-like behavior. • PDE4D-mediated cAMP signaling may play an important role in resveratrol’s protective effects in stressed mice. Abstract Resveratrol is a natural non-flavonoid polyphenol found in red wine, which has numerous pharmacological properties including anti-stress and antidepressant-like abilities. […]
Resveratrol shows promise for anxiety and depression
A new study has shown that the compound resveratrol found in red wine demonstrates stress relieving effects in anxiety and depression. This could be due to resveratrol’s ability to control an enzyme in the brain that is liked to stress say the researchers from the University at Buffalo in collaboration with Xuzhou Medical University in China. Image Credit: Ievgenii Meyer / Shutterstock […]
Study Indicates NMN Has Anti-Aging Potential for Kidneys
NMN’s restoration of youthful kidney protein levels in aged mice may translate therapeutically to humans. The world’s population of older adults continues to expand at an unprecedented pace. So, there is a need for a better understanding of aging processes to mitigate age-related diseases and disorders. But not all organs age at the same pace, so it’s important for scientists […]
NMN May Improve the Brain-Associated Blood Vessel Cell Response to Stress
NMN treatment improves brain associated blood vessel cell survival and protects against harmful stress in metabolic disorders like diabetes. Diabetes cases continue to rise sharply worldwide. These patients are more prone to stroke with a 50% greater risk of hemorrhagic stroke—blood vessels rupturing in the brain. This is thought to be caused by the dysfunction of brain-associated blood vessel cells—endothelial […]
NMN Stifles Mouse Inflammation Response Like NSAIDs
Similar to anti-inflammatory drugs, treating immune cells called macrophages with NMN inhibits chronic inflammation that can cause cancer and insulin resistance. Highlights · NMN treatment alleviates the inflammatory response of immune cells called macrophages. · Supplementing with the molecule also inhibits the buildup of inflammation-associated proteins, including COX-2. · By dampening COX-2 accumulation, NMN targets inflammation like non-steroidal anti-inflammatory drugs […]
Study Shows NMN Enhances Cancer-Preventing Immune Cell Activation
Taking NMN by under-the-skin injections or oral consumption improves immune cells that attack cancer and virally infected cells in mice. Highlights · NMN increases natural killer cell capabilities to destroy cancer cells (cytotoxicity) without increasing immune cell numbers. · The study supports that taking NMN may be a way to rejuvenate natural killer immune cell activation to preserve tissue health […]
NMN Makes Ears Resistant to Chemotherapy Poisoning in Mice
New research reveals that nicotinamide mononucleotide protects cells critical for hearing and balance from damage caused by the chemotherapeutic cisplatin. Highlights · Cisplatin causes ototoxicity — ear poisoning — and reductions in the cell essential molecule nicotinamide adenine dinucleotide (NAD+). · The NAD+ precursor nicotinamide mononucleotide (NMN) protects cochlear cells from cisplatin-induced ototoxicity in mice, preserving […]
Study Finds Protecting Skin Cells from UV Damage Depends on NMN Synthesis
Research indicates that preserving NAD+ levels is critical to skin cell survival responses to damage from UV rays. Highlights · UV radiation triggers the enzymes NAMPT and PARP — which produce and consume NAD+, respectively — in a tug of war between cell survival and dysfunction. · Inhibiting NAMPT allows PARP to exhaust the NAD+ supply, which hinders […]
Aged Lung Cells Protected from Functional Decline with NMN
Lung cells entering an aged, non-proliferating state (senescence) can trigger disease, which researchers can prevent with nicotinamide mononucleotide (NMN) in mice. Highlights · Supplementing aged mice with NMN protects lung cells from entering a stress and age-induced state called senescence that can facilitate lung disease. · NMN treatment reduces lung structural damage following exposure to a […]