Dr. David Sinclair has revolutionized the way that people view aging. As a scientist and pioneer in genetics and longevity research, he’s been listed by TIME as one of the “100 Most Influential People in the World,” has received more than 35 awards and honors, and is currently working as a professor in the Department of Genetics and co-director of […]
David Sinclair and Anti-Aging Supplements – 2022
If aging is a disease, the best solution is …
r David Sinclair is a Professor in the Department of Genetics and co-Director of the Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School. He is best known for his work on understanding why we age and how to slow its effects. His new book “Life Span – Why we aging ,why we don’t have to […]
NAD+ Boosting Molecule Protects Mice from Hearing Loss
Scientists find injecting mice with NAD+ booster protects against hearing loss through the activation of SIRT3, a protein that prevents damage to nerve connections between the ear and the brain.
Study Indicates NMN Has Anti-Aging Potential for Kidneys
NMN’s restoration of youthful kidney protein levels in aged mice may translate therapeutically to humans. The world’s population of older adults continues to expand at an unprecedented pace. So, there is a need for a better understanding of aging processes to mitigate age-related diseases and disorders. But not all organs age at the same pace, so it’s important for scientists […]
NMN May Improve the Brain-Associated Blood Vessel Cell Response to Stress
NMN treatment improves brain associated blood vessel cell survival and protects against harmful stress in metabolic disorders like diabetes. Diabetes cases continue to rise sharply worldwide. These patients are more prone to stroke with a 50% greater risk of hemorrhagic stroke—blood vessels rupturing in the brain. This is thought to be caused by the dysfunction of brain-associated blood vessel cells—endothelial […]
NMN Stifles Mouse Inflammation Response Like NSAIDs
Similar to anti-inflammatory drugs, treating immune cells called macrophages with NMN inhibits chronic inflammation that can cause cancer and insulin resistance. Highlights · NMN treatment alleviates the inflammatory response of immune cells called macrophages. · Supplementing with the molecule also inhibits the buildup of inflammation-associated proteins, including COX-2. · By dampening COX-2 accumulation, NMN targets inflammation like non-steroidal anti-inflammatory drugs […]
Study Shows NMN Enhances Cancer-Preventing Immune Cell Activation
Taking NMN by under-the-skin injections or oral consumption improves immune cells that attack cancer and virally infected cells in mice. Highlights · NMN increases natural killer cell capabilities to destroy cancer cells (cytotoxicity) without increasing immune cell numbers. · The study supports that taking NMN may be a way to rejuvenate natural killer immune cell activation to preserve tissue health […]
NMN Makes Ears Resistant to Chemotherapy Poisoning in Mice
New research reveals that nicotinamide mononucleotide protects cells critical for hearing and balance from damage caused by the chemotherapeutic cisplatin. Highlights · Cisplatin causes ototoxicity — ear poisoning — and reductions in the cell essential molecule nicotinamide adenine dinucleotide (NAD+). · The NAD+ precursor nicotinamide mononucleotide (NMN) protects cochlear cells from cisplatin-induced ototoxicity in mice, preserving […]
Study Finds Protecting Skin Cells from UV Damage Depends on NMN Synthesis
Research indicates that preserving NAD+ levels is critical to skin cell survival responses to damage from UV rays. Highlights · UV radiation triggers the enzymes NAMPT and PARP — which produce and consume NAD+, respectively — in a tug of war between cell survival and dysfunction. · Inhibiting NAMPT allows PARP to exhaust the NAD+ supply, which hinders […]
Aged Lung Cells Protected from Functional Decline with NMN
Lung cells entering an aged, non-proliferating state (senescence) can trigger disease, which researchers can prevent with nicotinamide mononucleotide (NMN) in mice. Highlights · Supplementing aged mice with NMN protects lung cells from entering a stress and age-induced state called senescence that can facilitate lung disease. · NMN treatment reduces lung structural damage following exposure to a […]