{"id":663,"date":"2022-04-29T01:32:52","date_gmt":"2022-04-29T01:32:52","guid":{"rendered":"http:\/\/choosebiz.me\/?p=663"},"modified":"2022-05-27T01:50:15","modified_gmt":"2022-05-27T01:50:15","slug":"%e3%80%90%e7%a7%91%e6%8a%80%e6%96%87%e7%8c%ae%e3%80%91nmn-%e7%94%9f%e6%88%90%e9%85%b6%e9%a9%b1%e5%8a%a8%e4%b8%8e%e7%a6%81%e9%a3%9f%e7%9b%b8%e5%85%b3%e7%9a%84%e8%84%82%e8%82%aa%e7%87%83%e7%83%a7","status":"publish","type":"post","link":"http:\/\/johnhealth.blog\/ch\/?p=663","title":{"rendered":"\u3010\u79d1\u6280\u6587\u732e\u3011NMN \u751f\u6210\u9176\u9a71\u52a8\u4e0e\u7981\u98df\u76f8\u5173\u7684\u8102\u80aa\u71c3\u70e7"},"content":{"rendered":"<p class=\"subtitle\">\u5723\u8def\u6613\u65af\u534e\u76db\u987f\u5927\u5b66\u533b\u5b66\u9662\u7684\u7814\u7a76\u4eba\u5458\u8868\u660e\uff0cNMN \u751f\u7269\u5408\u6210\u80cc\u540e\u7684\u9176 NAMPT \u53ef\u9006\u8f6c\u80a5\u80d6\u5c0f\u9f20\u7684\u4ee3\u8c22\u7d0a\u4e71\u3002<\/p>\n<div class=\"single-article-image\">\u4f5c\u8005\uff1a <span class=\"main-color-g\">Jonathan D. Grinstein\uff0c\u535a\u58eb<\/span><\/div>\n<div class=\"content-header\">\n<div class=\"author-and-date\">\n<div class=\"date\"><time>\u53d1\u5e03\u65f6\u95f4\uff1a\u00a0\u592a\u5e73\u6d0b\u6807\u51c6\u65f6\u95f4 2022 \u5e74 4 \u6708 1 \u65e5\u4e0b\u5348 2:56\u00a0|\u00a0<\/time><\/div>\n<\/div>\n<\/div>\n<ul>\n<li><em>NAMPT \u662f\u4e00\u79cd\u4ea7\u751f NMN \u7684\u9176\uff0c\u5b83\u662f\u589e\u5f3a\u4ee3\u8c22\u5e94\u6fc0\u5c0f\u9f20\u7684\u8102\u80aa\uff08\u8102\u8d28\uff09\u548c\u7cd6\uff08\u8461\u8404\u7cd6\uff09\u5e73\u8861\u6240\u5fc5\u9700\u7684\u3002<\/em><\/li>\n<li><em>\u5728\u7cd6\u5c3f\u75c5\u5c0f\u9f20\u4e2d\uff0cNAMPT \u4f1a\u589e\u52a0\u4ea7\u70ed\u2014\u2014\u751f\u7269\u4f53\u71c3\u70e7\u5361\u8def\u91cc\u4ee5\u4ea7\u751f\u70ed\u91cf\u7684\u4ee3\u8c22\u8fc7\u7a0b\u3002<\/em><\/li>\n<li><em>\u8fd9\u4e9b\u6570\u636e\u5f3a\u8c03\u4e86 NAMPT \u6fc0\u6d3b\u548c NMN \u5728\u809d\u7ec6\u80de\u4e2d\u7684\u76f4\u63a5\u6cbb\u7597\u4f5c\u7528\uff0c\u4ee5\u6a21\u62df\u7981\u98df\u7684\u6548\u679c\u3002<\/em><\/li>\n<\/ul>\n<p><!--more-->\u95f4\u6b47\u6027\u7981\u98df\u548c\u70ed\u91cf\u9650\u5236\u53ef\u6539\u5584\u5c0f\u9f20\u548c\u4eba\u7c7b\u7684\u65b0\u9648\u4ee3\u8c22\u548c\u708e\u75c7\u3002\u8fd9\u5c31\u662f\u4e3a\u4ec0\u4e48\u95f4\u6b47\u6027\u7981\u98df\u548c\u70ed\u91cf\u9650\u5236\u90fd\u88ab\u89c6\u4e3a\u51cf\u8f7b\u8870\u8001\u3001\u8425\u517b\u8fc7\u5269\u548c\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u7b49\u75be\u75c5\u7684\u6709\u5e0c\u671b\u7684\u65b9\u6cd5\u3002\u70ed\u91cf\u9650\u5236\u901a\u8fc7\u6fc0\u6d3b\u4ee3\u8c22\u4fe1\u53f7\u901a\u8def\uff08\u5305\u62ec\u70df\u9170\u80fa\u817a\u560c\u5464\u4e8c\u6838\u82f7\u9178 (NAD+) \u5408\u6210\u901a\u8def\uff09\u6765\u51cf\u8f7b\u8870\u8001\u548c\u5fc3\u810f\u4ee3\u8c22\u75be\u75c5\u3002<\/p>\n<p>\u6765\u81ea\u5723\u8def\u6613\u65af\u534e\u76db\u987f\u5927\u5b66\u533b\u5b66\u9662\u7684\u7814\u7a76\u4eba\u5458\u53d1\u8868\u5728<em><a href=\"https:\/\/translate.google.com\/website?sl=auto&amp;tl=zh-CN&amp;hl=en&amp;client=webapp&amp;u=https:\/\/pubmed.ncbi.nlm.nih.gov\/35228549\/\">\u300a\u81ea\u7136\u901a\u8baf\u300b\u4e0a\uff0c\u8868\u660e NAMPT\u2014\u2014\u4e00\u79cd\u5408\u6210 NAD+ \u524d\u4f53 NMN \u6240\u5fc5\u9700\u7684\u9176\u2014\u2014\u5728\u809d\u810f\u4e2d\u9a71\u52a8\u4e86\u7981\u98df\u53cd\u5e94\u7684\u5173\u952e\u65b9\u9762\u3002<\/a><\/em>\u4e00\u65b9\u9762\uff0c\u809d\u7ec6\u80de\u4e2d\u7f3a\u4e4f NAMPT \u7684\u5c0f\u9f20\u5728\u7981\u98df\u671f\u95f4\u8868\u73b0\u51fa\u70ed\u8c03\u8282\u7f3a\u9677\uff0c\u5e76\u5bf9\u996e\u98df\u8bf1\u5bfc\u7684\u8461\u8404\u7cd6\u4e0d\u8010\u53d7\u654f\u611f\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u809d\u7ec6\u80de\u4e2d NAMPT \u6c34\u5e73\u7684\u589e\u52a0\u4f1a\u8bf1\u5bfc\u80a5\u80d6\u5c0f\u9f20\u7684\u8102\u80aa\u8910\u53d8\u3001\u6539\u5584\u8461\u8404\u7cd6\u5e73\u8861\u5e76\u51cf\u8f7b\u9ad8\u8840\u8102\u6c34\u5e73\uff08\u8840\u8102\u5f02\u5e38\uff09\u3002\u8fd9\u9879\u5de5\u4f5c\u8868\u660e\uff0c\u8c03\u8282\u809d\u7ec6\u80de\u4e2d\u7684 NAD+ \u6c34\u5e73\u53ef\u4ee5\u6f5c\u5728\u5730\u51cf\u8f7b\u4e0e\u7981\u98df\u76f8\u5173\u7684\u75be\u75c5\u3002<\/p>\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter is-resized\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-17339\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/04\/pasted-image-0.png\" alt=\"\" width=\"849\" height=\"791\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/04\/pasted-image-0.png 849w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/04\/pasted-image-0-300x280.png 300w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/04\/pasted-image-0-768x716.png 768w\" sizes=\"auto, (max-width: 849px) 100vw, 849px\" \/><figcaption><a href=\"https:\/\/translate.google.com\/website?sl=auto&amp;tl=zh-CN&amp;hl=en&amp;client=webapp&amp;u=https:\/\/pubmed.ncbi.nlm.nih.gov\/35228549\/\"><strong>(Higgins et al., 2022 |\u00a0<em>Nature Communications<\/em>\u00a0)<\/strong><\/a>\u00a0<strong>\u809d\u810f\u4e2d\u7684 NAMPT \u5e73\u8861\u80fd\u91cf\u4ee3\u8c22\u3002<\/strong>\u809d\u7ec6\u80de NAMPT \u6fc0\u6d3b\u4fc3\u8fdb\u5149\u548c\u6697\u5faa\u73af\u80fd\u91cf\u4ee3\u8c22\u548c\u809d\u810f\u80f0\u5c9b\u7d20\u654f\u611f\u6027\uff0c\u540c\u65f6\u963b\u6b62\u8102\u80aa\u7684\u5f62\u6210\uff08\u4ece\u5934\u8102\u80aa\u751f\u6210\uff09\u3002<span class=\"\">NAMPT \u53ef\u4ee5\u901a\u8fc7\u963b\u65ad\u8461\u8404\u7cd6\u8f6c\u8fd0\u86cb\u767d (GLUT) \u6216\u901a\u8fc7\u8865\u5145 NAD+ \u524d\u4f53\u70df\u9170\u80fa\u6838\u82f7 (NR) \u548c\u70df\u9170\u80fa\u5355\u6838\u82f7\u9178 (NMN) \u6765\u6fc0\u6d3b\u3002<\/span>NAMPT = \u70df\u9170\u80fa\u78f7\u9178\u6838\u7cd6\u57fa\u8f6c\u79fb\u9176\uff0cSIRT1 = \u6c89\u9ed8\u8c03\u8282\u86cb\u767d 1\uff0cFGF21 = \u6210\u7ea4\u7ef4\u7ec6\u80de\u751f\u957f\u56e0\u5b50 21\u3002<\/figcaption><\/figure>\n<\/div>\n<h2><strong><em>\u809d\u810f\u662f\u4ee3\u8c22\u8c03\u8282\u7684\u6838\u5fc3<\/em><\/strong><\/h2>\n<p>\u809d\u810f\u72ec\u7279\u5730\u4f4d\u4e8e\u6765\u81ea\u6d88\u5316\u7cfb\u7edf\u7684\u8840\u6db2\u548c\u88ab\u9001\u56de\u5fc3\u810f\u4ee5\u6cf5\u9001\u5230\u5927\u8111\u3001\u56db\u80a2\u548c\u8eab\u4f53\u5176\u4ed6\u90e8\u4f4d\u7684\u8840\u6db2\u4e4b\u95f4\u7684\u8fde\u63a5\u5904\u3002\u5728\u8fd9\u91cc\uff0c\u809d\u810f\u53ef\u4ee5\u611f\u77e5\u3001\u534f\u8c03\u548c\u8f6c\u6362\u4f9d\u8d56\u4e8e\u8fdb\u98df\u6216\u7f3a\u4e4f\uff08\u4e5f\u79f0\u4e3a\u7981\u98df\uff09\u7684\u4e0d\u540c\u4ee3\u8c22\u72b6\u6001\u3002\u517b\u5206\u64a4\u9000\u5bf9\u4e00\u4e2a\u6709\u673a\u4f53\uff0c\u7279\u522b\u662f\u5bf9\u809d\u7ec6\u80de\u6765\u8bf4\uff0c\u662f\u4e00\u4e2a\u9002\u5e94\u6216\u706d\u4ea1\u7684\u547d\u9898\u3002\u7cd6\u7684\u7f3a\u4e4f\u8feb\u4f7f\u4f9d\u8d56\u4e8e\u5168\u8eab\u7684\u8102\u80aa\u5206\u89e3\uff0c\u8102\u80aa\u5728\u809d\u810f\u4e2d\u4ee3\u8c22\u3002\u5f53\u8fd9\u79cd\u60c5\u51b5\u53d1\u751f\u65f6\uff0c\u809d\u810f\u9700\u8981\u505a\u51fa\u51e0\u4e2a\u5173\u952e\u7684\u8c03\u6574\u3002<span class=\"\">NAD+ \u5408\u6210\u7edf\u4e00\u4e86\u5bf9\u8425\u517b\u53d7\u9650\u809d\u810f\u4e2d\u6bcf\u79cd\u538b\u529b\u7684\u9002\u5e94\u6027\u53cd\u5e94\u3002<\/span>\u56e0\u6b64\uff0c<\/p>\n<h2><strong><em>\u809d\u810f NAMPT \u662f\u7981\u98df\u76ca\u5904\u6240\u5fc5\u9700\u7684<\/em><\/strong><\/h2>\n<p>\u5728\u8fd9\u9879\u7814\u7a76\u4e2d\uff0c\u5723\u8def\u6613\u65af\u534e\u76db\u987f\u533b\u79d1\u5927\u5b66\u7684\u7814\u7a76\u4eba\u5458\u5256\u6790\u4e86\u809d\u7ec6\u80de\u4e2d\u7684 NAMPT \u5982\u4f55\u8c03\u8282\u4ee3\u8c22\u5e73\u8861\u3002Higgins \u53ca\u5176\u540c\u4e8b\u8bc1\u660e\uff0c\u809d\u810f NAMPT \u5728\u7981\u98df\u671f\u95f4\u4ecb\u5bfc\u4e86\u4e00\u4e2a\u5173\u952e\u7684\u809d\u810f\u4fe1\u53f7\u7ea7\u8054\u53cd\u5e94\u3002<span class=\"\">\u8be5\u7814\u7a76\u8868\u660e\uff0c\u7981\u98df\u548c\u8461\u8404\u7cd6\u8f6c\u8fd0\u6291\u5236\u4f1a\u4e0a\u8c03\u809d\u810f\u4e2d\u7684 NAMPT\uff0c\u800c\u809d\u810f\u7279\u5f02\u6027 NAMPT \u7f3a\u4e4f\u4f1a\u635f\u5bb3\u51e0\u4e2a\u5173\u952e\u7684\u7a7a\u8179\u4ee3\u8c22\u8fc7\u7a0b\u3002<\/span>\u66f4\u5177\u4f53\u5730\u8bf4\uff0c\u809d\u810f\u4e2d\u7f3a\u4e4f NAMPT \u7684\u5c0f\u9f20\u8868\u73b0\u51fa\u8461\u8404\u7cd6\u4ee3\u8c22\u7f3a\u9677\uff0c\u800c\u75c5\u6bd2\u4ecb\u5bfc\u7684\u809d\u810f NAMPT \u589e\u52a0\u589e\u5f3a\u4e86\u996e\u98df\u8bf1\u5bfc\u548c\u9057\u4f20\u80a5\u80d6\u6a21\u578b\u4e2d\u7684\u4ea7\u70ed\u548c\u8461\u8404\u7cd6\u4ee3\u8c22\u3002<span class=\"\">\u8fd9\u4e9b\u53d1\u73b0\u8868\u660e\uff0c\u809d\u810f NAMPT \u6c34\u5e73\u5bf9\u4e8e\u9632\u6b62\u996e\u98df\u5f15\u8d77\u7684\u8461\u8404\u7cd6\u4e0d\u8010\u53d7\u548c\u5f15\u53d1\u7981\u98df\u7684\u4ee3\u8c22\u76ca\u5904\u81f3\u5173\u91cd\u8981\u3002\u00a0<\/span><\/p>\n<figure class=\"wp-block-image is-resized\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-17340\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/04\/pasted-image-0-1.png\" alt=\"\" width=\"1600\" height=\"511\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/04\/pasted-image-0-1.png 1600w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/04\/pasted-image-0-1-300x96.png 300w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/04\/pasted-image-0-1-1024x327.png 1024w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/04\/pasted-image-0-1-768x245.png 768w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/04\/pasted-image-0-1-1536x491.png 1536w\" sizes=\"auto, (max-width: 1600px) 100vw, 1600px\" \/><figcaption><a href=\"https:\/\/translate.google.com\/website?sl=auto&amp;tl=zh-CN&amp;hl=en&amp;client=webapp&amp;u=https:\/\/pubmed.ncbi.nlm.nih.gov\/35228549\/\"><strong><span class=\"\">(Higgins et al., 2022 |\u00a0<\/span><em><span class=\"\">Nature Communications<\/span><\/em><span class=\"\">\u00a0)<\/span><\/strong><\/a>\u00a0<strong><span class=\"\">\u809d\u810f NAMPT \u53ef\u589e\u5f3a\u7cd6\u5c3f\u75c5\u5c0f\u9f20\u7684\u8461\u8404\u7cd6\u7a33\u6001\u3002<\/span><\/strong>\u80a5\u80d6\u3001\u7cd6\u5c3f\u75c5\u5c0f\u9f20 (db\/db AdNAMPT) \u4e2d NAMPT \u6c34\u5e73\u7684\u589e\u52a0\u5bfc\u81f4\u6574\u4e2a\u8461\u8404\u7cd6\u548c\u80f0\u5c9b\u7d20\u8010\u91cf\u6d4b\u8bd5\u4e2d\u7684\u8840\u6d46\u8461\u8404\u7cd6\u964d\u4f4e\uff0c\u8868\u660e\u8461\u8404\u7cd6\u4ee3\u8c22\u548c\u80f0\u5c9b\u7d20\u654f\u611f\u6027\u5f97\u5230\u6539\u5584\u3002<\/figcaption><\/figure>\n<p>Higgins \u53ca\u5176\u540c\u4e8b\u53d1\u73b0\uff0c\u63d0\u9ad8\u80a5\u80d6\u7cd6\u5c3f\u75c5\u5c0f\u9f20\u7684 NAMPT \u6c34\u5e73\u4f1a\u589e\u52a0\u8102\u80aa\u7ec4\u7ec7\u8910\u53d8\u6807\u5fd7\u7269\u3002\u8102\u80aa\u7ec4\u7ec7\uff08\u901a\u5e38\u662f\u767d\u8272\uff09\u5728\u751f\u70ed\u6d3b\u8dc3\u65f6\u4f1a\u53d8\u6210\u68d5\u8272\uff0c\u8fd9\u610f\u5473\u7740\u5b83\u5728\u71c3\u70e7\u5361\u8def\u91cc\u7684\u540c\u65f6\u4f1a\u4ea7\u751f\u66f4\u591a\u7684\u70ed\u91cf\u3002\u6cbf\u7740\u8fd9\u4e9b\u601d\u8def\uff0c\u809d\u810f NAMPT \u5347\u9ad8\u7684\u5c0f\u9f20\u7684\u4ea7\u70ed\u6c34\u5e73\u9ad8\u4e8e\u5bf9\u7167\u7ec4\u3002\u63d0\u9ad8\u809d\u7ec6\u80de NAMPT \u4f1a\u5bfc\u81f4\u5c0f\u9f20\u5728\u5149\u5faa\u73af\u548c\u6697\u5faa\u73af\u671f\u95f4\u589e\u52a0\u70ed\u91cf\u4ea7\u751f\u548c\u6c14\u4f53\u4ea4\u6362\u2014\u2014\u5728\u547c\u5438\u8fc7\u7a0b\u4e2d\u66f4\u591a\u7684\u6c27\u6c14\u548c\u4e8c\u6c27\u5316\u78b3\u6392\u51fa\u2014\u2014\u800c NAMPT \u7f3a\u5931\u4f1a\u5bfc\u81f4\u6697\u5faa\u73af\u70ed\u7f3a\u9677\u3002\u6570\u636e\u8868\u660e\uff0c\u809d\u7ec6\u80de NAMPT \u4fe1\u53f7\u5728\u8c03\u8282\u80fd\u91cf\u63a7\u5236\u65f6\u533a\u5206\u5149\u5468\u671f\u548c\u6697\u5468\u671f\u3002<\/p>\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter is-resized\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-17341\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/04\/nampt_sirt1_thermogenesis_1.jpg\" alt=\"\" width=\"1600\" height=\"887\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/04\/nampt_sirt1_thermogenesis_1.jpg 1600w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/04\/nampt_sirt1_thermogenesis_1-300x166.jpg 300w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/04\/nampt_sirt1_thermogenesis_1-1024x568.jpg 1024w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/04\/nampt_sirt1_thermogenesis_1-768x426.jpg 768w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/04\/nampt_sirt1_thermogenesis_1-1536x852.jpg 1536w\" sizes=\"auto, (max-width: 1600px) 100vw, 1600px\" \/><figcaption><a href=\"https:\/\/translate.google.com\/website?sl=auto&amp;tl=zh-CN&amp;hl=en&amp;client=webapp&amp;u=https:\/\/pubmed.ncbi.nlm.nih.gov\/35228549\/\"><strong>(Higgins et al., 2022 |\u00a0<em>Nature Communications<\/em>\u00a0)<\/strong><\/a>\u00a0<strong>NAMPT \u5728\u7cd6\u5c3f\u75c5\u5c0f\u9f20\u4e2d\u8bf1\u5bfc\u8102\u80aa\u7ec4\u7ec7\u8910\u53d8\u548c\u4ea7\u70ed\u3002<\/strong>\u4e3a\u4e86\u6d4b\u91cf NAMPT \u5728\u4ea7\u70ed\u548c\u80fd\u91cf\u8c03\u8282\u4e2d\u7684\u4f5c\u7528\uff0c\u7cd6\u5c3f\u75c5\u5c0f\u9f20 (db\/db) \u7528\u643a\u5e26 NAMPT (AdNAMPT) \u7684\u75c5\u6bd2\u8fdb\u884c\u6cbb\u7597\u3002\u4e0e\u5bf9\u7167\u7ec4\u76f8\u6bd4\uff0c\u8fd9\u4e9b\u5c0f\u9f20\u8868\u73b0\u51fa\u663e\u7740\u66f4\u9ad8\u7684\u6697\u5faa\u73af\u548c\u5149\u5faa\u73af\u4ea7\u70ed\u548c\u547c\u5438\u4ea4\u6362\u7387 (RER)\u3002<\/figcaption><\/figure>\n<\/div>\n<p>Higgins \u53ca\u5176\u540c\u4e8b\u5f97\u51fa\u7ed3\u8bba\uff0c\u809d\u810f\u4e2d\u7684 NAMPT \u5728\u809d\u7ec6\u80de\u4e2d\u5e7f\u6cdb\u7981\u98df\u548c\u8461\u8404\u7cd6\u8f6c\u8fd0\u6291\u5236\u7684\u4e0b\u6e38\u53d1\u6325\u5e7f\u6cdb\u7684\u7981\u98df\u6a21\u62df\u6548\u5e94\u3002\u8fd9\u9879\u7814\u7a76\u8868\u660e\uff0c\u4ee3\u8c22\u75be\u75c5\u53ef\u4ee5\u901a\u8fc7 NMN \u5728 NAD+ \u751f\u7269\u5408\u6210\u6c34\u5e73\u4e0a\u8fdb\u884c\u5e72\u9884\u3002<span class=\"\">\u809d\u810f\u4e2d\u7684 NAMPT \u6fc0\u6d3b\u53ef\u80fd\u4f1a\u5bf9\u6297\u8870\u8001\u3001\u80a5\u80d6\u548c\u5176\u4ed6\u7a7a\u8179\u53cd\u5e94\u6027\u75be\u75c5\u3002<\/span>\u6709\u8da3\u7684\u662f\uff0c\u6709\u4e00\u4e9b\u5316\u5408\u7269\u53ef\u4ee5\u6fc0\u6d3b NAMPT\uff0c\u4f8b\u5982<a href=\"https:\/\/www-nmn-com.translate.goog\/news\/small-molecule-activates-nampt-boosts-nad-levels?_x_tr_sl=auto&amp;_x_tr_tl=zh-CN&amp;_x_tr_hl=en&amp;_x_tr_pto=wapp\">SBI-797812\uff0c\u5b83\u5c06 NAMPT \u53d8\u6210\u66f4\u6709\u6548\u5730\u751f\u6210 NMN \u7684\u201c\u8d85\u7ea7\u50ac\u5316\u5242\u201d<\/a>\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u670d\u7528 SBI-797812 \u7684\u5c0f\u9f20\u809d\u810f NAD+ \u5347\u9ad8\u3002\u636e\u6211\u4eec\u6240\u77e5\uff0c\u8fd9\u53ef\u80fd\u662f\u957f\u671f\u4ee5\u6765\u5907\u53d7\u8ffd\u6367\u7684\u5947\u8ff9\u7981\u98df\u4e38\u7684\u57fa\u7840\u3002<\/p>\n<p><!--more--><\/p>\n<div class=\"footer-content\">\n<div class=\"footer-block\">\n<div class=\"header\">\u6545\u4e8b\u6765\u6e90<\/div>\n<p>Higgins CB, Mayer AL, Zhang Y, Franczyk M, Ballentine S, Yoshino J, DeBosch BJ\u3002SIRT1 \u9009\u62e9\u6027\u5730\u53d1\u6325\u809d\u7ec6\u80de\u70df\u9170\u80fa\u78f7\u9178\u6838\u7cd6\u57fa\u8f6c\u79fb\u9176\u7684\u4ee3\u8c22\u4fdd\u62a4\u4f5c\u7528\u3002\u7eb3\u5eb7\u30022022 \u5e74 2 \u6708 28 \u65e5\uff1b13(1):1074\u3002doi: 10.1038\/s41467-022-28717-7\u3002PMID\uff1a35228549\uff1bPMCID\uff1aPMC8885655\u3002<\/p>\n<\/div>\n<\/div>\n<div class=\"pvc_clear\"><\/div>\n<p id=\"pvc_stats_663\" 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6.4-12.8 12.8v70.4c0 6.4 6.4 12.8 12.8 12.8z\" class=\"\"><\/path><\/svg><\/i> <img loading=\"lazy\" decoding=\"async\" width=\"16\" height=\"16\" alt=\"Loading\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/plugins\/page-views-count\/ajax-loader-2x.gif\" border=0 \/><\/p>\n<div class=\"pvc_clear\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u5723\u8def\u6613\u65af\u534e\u76db\u987f\u5927\u5b66\u533b\u5b66\u9662\u7684\u7814\u7a76\u4eba\u5458\u8868\u660e\uff0cNMN \u751f\u7269\u5408\u6210\u80cc\u540e\u7684\u9176 NAMPT \u53ef\u9006\u8f6c\u80a5\u80d6\u5c0f\u9f20\u7684\u4ee3\u8c22\u7d0a\u4e71\u3002 \u4f5c\u8005\uff1a Jonathan D. Grinstein\uff0c\u535a\u58eb \u53d1\u5e03\u65f6\u95f4\uff1a\u00a0\u592a\u5e73\u6d0b\u6807\u51c6\u65f6\u95f4 2022 \u5e74 4 \u6708 1 \u65e5\u4e0b\u5348 2:56\u00a0|\u00a0 NAMPT \u662f\u4e00\u79cd\u4ea7\u751f NMN \u7684\u9176\uff0c\u5b83\u662f\u589e\u5f3a\u4ee3\u8c22\u5e94\u6fc0\u5c0f\u9f20\u7684\u8102\u80aa\uff08\u8102\u8d28\uff09\u548c\u7cd6\uff08\u8461\u8404\u7cd6\uff09\u5e73\u8861\u6240\u5fc5\u9700\u7684\u3002 \u5728\u7cd6\u5c3f\u75c5\u5c0f\u9f20\u4e2d\uff0cNAMPT \u4f1a\u589e\u52a0\u4ea7\u70ed\u2014\u2014\u751f\u7269\u4f53\u71c3\u70e7\u5361\u8def\u91cc\u4ee5\u4ea7\u751f\u70ed\u91cf\u7684\u4ee3\u8c22\u8fc7\u7a0b\u3002 \u8fd9\u4e9b\u6570\u636e\u5f3a\u8c03\u4e86 NAMPT \u6fc0\u6d3b\u548c NMN \u5728\u809d\u7ec6\u80de\u4e2d\u7684\u76f4\u63a5\u6cbb\u7597\u4f5c\u7528\uff0c\u4ee5\u6a21\u62df\u7981\u98df\u7684\u6548\u679c\u3002<\/p>\n<div class=\"pvc_clear\"><\/div>\n<p id=\"pvc_stats_663\" class=\"pvc_stats all  \" data-element-id=\"663\" style=\"\"><i class=\"pvc-stats-icon medium\" aria-hidden=\"true\"><svg aria-hidden=\"true\" focusable=\"false\" data-prefix=\"far\" data-icon=\"chart-bar\" role=\"img\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\" class=\"svg-inline--fa fa-chart-bar fa-w-16 fa-2x\"><path fill=\"currentColor\" d=\"M396.8 352h22.4c6.4 0 12.8-6.4 12.8-12.8V108.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v230.4c0 6.4 6.4 12.8 12.8 12.8zm-192 0h22.4c6.4 0 12.8-6.4 12.8-12.8V140.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v198.4c0 6.4 6.4 12.8 12.8 12.8zm96 0h22.4c6.4 0 12.8-6.4 12.8-12.8V204.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v134.4c0 6.4 6.4 12.8 12.8 12.8zM496 400H48V80c0-8.84-7.16-16-16-16H16C7.16 64 0 71.16 0 80v336c0 17.67 14.33 32 32 32h464c8.84 0 16-7.16 16-16v-16c0-8.84-7.16-16-16-16zm-387.2-48h22.4c6.4 0 12.8-6.4 12.8-12.8v-70.4c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v70.4c0 6.4 6.4 12.8 12.8 12.8z\" class=\"\"><\/path><\/svg><\/i> <img loading=\"lazy\" decoding=\"async\" width=\"16\" height=\"16\" alt=\"Loading\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/plugins\/page-views-count\/ajax-loader-2x.gif\" border=0 \/><\/p>\n<div class=\"pvc_clear\"><\/div>\n","protected":false},"author":1,"featured_media":17339,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[172,272],"tags":[171,305,304,306],"class_list":["post-663","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-nmn-","category-272","tag-nmn","tag-305","tag-304","tag-306"],"aioseo_notices":[],"_links":{"self":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts\/663","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=663"}],"version-history":[{"count":3,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts\/663\/revisions"}],"predecessor-version":[{"id":17385,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts\/663\/revisions\/17385"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/media\/17339"}],"wp:attachment":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=663"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=663"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=663"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}