{"id":628,"date":"2022-04-05T04:18:21","date_gmt":"2022-04-05T04:18:21","guid":{"rendered":"http:\/\/choosebiz.me\/?p=628"},"modified":"2022-05-27T01:51:08","modified_gmt":"2022-05-27T01:51:08","slug":"%e3%80%90%e7%a7%91%e6%8a%80%e8%bf%9b%e5%b1%95%e3%80%91nmn-%e4%bf%9d%e6%8a%a4%e5%a4%a7%e8%84%91%ef%bc%9a%e9%a2%84%e9%98%b2%e7%a5%9e%e7%bb%8f%e5%85%83%e6%ad%bb%e4%ba%a1%e5%92%8c%e6%94%b9%e5%96%84","status":"publish","type":"post","link":"http:\/\/johnhealth.blog\/ch\/?p=628","title":{"rendered":"\u3010\u79d1\u6280\u8fdb\u5c55\u3011NMN \u4fdd\u62a4\u5927\u8111\uff1a\u9884\u9632\u795e\u7ecf\u5143\u6b7b\u4ea1\u548c\u6539\u5584\u8ba4\u77e5"},"content":{"rendered":"

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\u6839\u636e \u7f8e\u570b\u75be\u75c5\u63a7\u5236\u8207\u9810\u9632\u4e2d\u5fc3 (CDC)<\/a> \u7684\u9884\u6d4b\uff0c\u5230 2060 \u5e74\uff0c\u7f8e\u56fd\u963f\u5179\u6d77\u9ed8\u75c7\u60a3\u8005\u7684\u6570\u91cf\u5c06\u589e\u957f\u5230 1390 \u4e07\u4eba\uff0c\u662f 2018 \u5e74\u7684\u4e24\u500d\u591a\u3002 \u5c3d\u7ba1\u4e16\u754c\u6b63\u5728\u8001\u9f84\u5316\uff0c\u963f\u5179\u6d77\u9ed8\u75c7\u60a3\u8005\u7684\u4eba\u6570\u4e5f\u5728\u589e\u52a0\uff0c\u4f46\u76ee\u524d\u8fd8\u6ca1\u6709\u6cbb\u6108\u8fd9\u79cd\u75be\u75c5\u7684\u65b9\u6cd5\u3002 \u4e00\u7fa4\u6765\u81ea\u4e2d\u56fd\u548c\u65e5\u672c\u7684\u79d1\u5b66\u5bb6\u60f3\u8981\u6539\u53d8\u8fd9\u79cd\u72b6\u51b5\u3002<\/p>\n

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\u7814\u7a76\u4eba\u5458\u7528 NMN\uff08\u4e00\u79cd\u53ef\u4f5c\u4e3a NAD+ \u4fc3\u8fdb\u5242\u7684\u7269\u8d28\uff09\u63d0\u9ad8 NAD+ \u6c34\u5e73\uff0c\u4ee5\u6539\u5584\u8111\u80fd\u91cf\u4ee3\u8c22\uff0c\u5e76\u53d1\u73b0NMN\u53ef\u4ee5\u6062\u590d\u963f\u5179\u6d77\u9ed8\u75c7\u5927\u9f20\u6a21\u578b\u7684\u8ba4\u77e5\u80fd\u529b\u3002 \u8fd9\u79cd\u6062\u590d\u6765\u81ea\u6539\u5584\u7684\u795e\u7ecf\u5143\u5b58\u6d3b\u548c\u65b0\u9648\u4ee3\u8c22\uff0c\u4ee5\u53ca\u51cf\u5c11\u7684\u7ec6\u80de\u538b\u529b\u3002 \u79d1\u5b66\u5bb6\u4eec\u5728\u7814\u7a76\u4e2d\u8868\u793a\uff0c\u7814\u7a76\u7ed3\u679c\u8868\u660e NMN \u53ef\u80fd\u6784\u6210\u4e00\u79cd\u6709\u524d\u9014\u7684\u963f\u5179\u6d77\u9ed8\u75c7\u6cbb\u7597\u836f\u7269\u3002<\/p>\n

\u5728\u8fd9\u9879\u7814\u7a76\u4e2d\uff0cNMN \u6539\u5584\u4e86\u5177\u6709 A\u03b2 \u5be1\u805a\u4f53\u7684\u5927\u9f20\u7684\u8ba4\u77e5\u80fd\u529b\uff0c\u8fd9\u4e9b\u5be1\u805a\u4f53\u662f\u5728\u963f\u5179\u6d77\u9ed8\u75c7\u60a3\u8005\u5927\u8111\u4e2d\u53d1\u73b0\u7684\u91cd\u590d\u5206\u5b50\u5355\u5143\uff0c\u8fd9\u4e9b\u5206\u5b50\u5355\u5143\u88ab\u6ce8\u5165\u5230\u4ed6\u4eec\u7684\u5927\u8111\u4e2d\u3002 \u79d1\u5b66\u5bb6\u4eec\u8fd8\u53d1\u73b0\uff0cNMN \u6cbb\u7597\u53ef\u51cf\u5c11\u6d77\u9a6c\u5207\u7247\uff08\u53d6\u81ea\u5927\u8111\u7684\u6807\u672c\uff09\u4e2d\u7684\u795e\u7ecf\u5143\u7ec6\u80de\u6b7b\u4ea1\u3002 NMN \u901a\u8fc7\u964d\u4f4e\u53d7\u75be\u75c5\u5f71\u54cd\u7684\u5927\u9f20\u5927\u8111\u4e2d\u7684\u6d3b\u6027\u6c27\u6c34\u5e73\u4e36\u542b\u6c27\u5316\u5b66\u53cd\u5e94\u5206\u5b50\u7684\u6c34\u5e73\u6765\u964d\u4f4e\u795e\u7ecf\u5143\u4e2d\u7684\u7ec6\u80de\u538b\u529b\u3002<\/p>\n

\u79d1\u5b66\u5bb6\u4eec\u6d4b\u8bd5\u4e86 NMN \u5bf9\u963f\u5179\u6d77\u9ed8\u75c7\u6807\u5fd7\u6027\u75c7\u72b6\u2014\u2014\u8ba4\u77e5\u80fd\u529b\u4e0b\u964d\u2014\u2014\u7684\u5f71\u54cd\uff0c\u53d1\u73b0 NMN \u663e\u7740\u6539\u5584\u4e86\u963f\u5179\u6d77\u9ed8\u75c7\u5927\u9f20\u6a21\u578b\u7684\u8ba4\u77e5\u529f\u80fd\u3002 \u79d1\u5b66\u5bb6\u4eec\u4f7f\u7528\u6c34\u8ff7\u5bab\u6d4b\u91cf\u8ba4\u77e5\u80fd\u529b\uff0c\u53d1\u73b0\u8865\u5145 NMN \u7684\u963f\u5179\u6d77\u9ed8\u75c7\u5927\u9f20\u7684\u8ba4\u77e5\u80fd\u529b\u4f18\u65bc\u6ca1\u6709\u670d\u7528NMN \u7684\u963f\u5179\u6d77\u9ed8\u75c7\u5927\u9f20\u3002 \u8fd9\u4e9b\u7ed3\u679c\u8868\u660e\uff0cNMN \u663e\u7740\u6539\u5584\u4e86\u8fd9\u79cd\u963f\u5179\u6d77\u9ed8\u75c7\u5927\u9f20\u6a21\u578b\u7684\u8ba4\u77e5\u529f\u80fd\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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(Wang et al., 2016 |<\/strong><\/a>\u00a0Brain Research<\/strong><\/em><\/a>)<\/strong><\/a> NMN \u5bf9 A\u03b21-42 \u5be1\u805a\u4f53\u8bf1\u5bfc\u7684\u8ba4\u77e5\u969c\u788d\u7684\u5f71\u54cd<\/strong>\u3002\u00a0\u8be5\u56fe\u663e\u793a\uff0c\u7528 Morris \u6c34\u8ff7\u5bab\u6d4b\u91cf\u7684\u8ba4\u77e5\u5728 A\u00df \u5be1\u805a\u4f53\u8f93\u6ce8\u963f\u5179\u6d77\u9ed8\u75c7\u5927\u9f20\u6a21\u578b\u4e2d\u663e\u7740\u6539\u5584\u3002<\/p>\n

\u5728\u7528 NMN \u4ecb\u5165\u5927\u9f20\u5f8c\uff0c\u7814\u7a76\u5c0f\u7ec4\u8fd8\u53d1\u73b0\u963f\u5179\u6d77\u9ed8\u75c7\u52a8\u7269\u7684\u795e\u7ecf\u5143\u6b7b\u4ea1\u663e\u7740\u51cf\u5c11\u3002 \u5b75\u80b2 48 \u5c0f\u65f6\u5f8c\uff0c\u4e0e\u672a\u63a5\u53d7 NMN \u4ecb\u5165\u7684\u963f\u5179\u6d77\u9ed8\u75c7\u52a8\u7269\u76f8\u6bd4\uff0c\u63a5\u53d7 NMN \u4ecb\u5165\u7684\u60a3\u75c5\u5927\u9f20\u7684\u7ec6\u80de\u6b7b\u4ea1\u51cf\u5c11\u4e86\u7ea6 65%\u3002<\/p>\n

\u9664\u4e86\u53d1\u73b0\u8ba4\u77e5\u6539\u5584\u548c\u795e\u7ecf\u5143\u6b7b\u4ea1\u51cf\u5c11\u5916\uff0c\u7814\u7a76\u4eba\u5458\u8fd8\u53d1\u73b0\u4f7f\u7528 NMN \u4ecb\u5165\u7684\u963f\u5179\u6d77\u9ed8\u75c7\u5927\u9f20\u6a21\u578b\u4e2d\u7684\u7ec6\u80de\u5e94\u6fc0\u6c34\u5e73\u8f83\u4f4e\uff0c\u8fd9\u8868\u660e NMN \u5bf9\u795e\u7ecf\u7cfb\u7edf\u4fdd\u62a4\u7684\u5f71\u54cd\u3002 \u7136\u800c\uff0c\u5f53 NMN \u884d\u751f\u7684 NAD+ \u5931\u53bb\u6d3b\u6027\u65f6\uff0c\u8fd9\u79cd\u4fdd\u62a4\u4f5c\u7528\u88ab\u9006\u8f6c\uff0c\u8fd9\u8bc1\u5b9e\u4e86\u8111\u80fd\u91cf\u4ee3\u8c22\u5728\u963f\u5179\u6d77\u9ed8\u75c7\u4e2d\u7684\u4f5c\u7528\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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(Wang et al., 2016 |<\/strong><\/a>\u00a0Brain Research<\/strong><\/em><\/a>)<\/strong><\/a>\u00a0NMN\u5bf9\u8111\u5207\u7247\u57f9\u517b\u7269\u4e2dA\u03b21-42\u5be1\u805a\u4f53\u8bf1\u5bfc\u7684\u795e\u7ecf\u5143\u6b7b\u4ea1\u7684\u5f71\u54cd<\/strong>\u3002\u00a0\u57f9\u517b 10 \u5929\u5f8c\uff0c\u5c06\u8111\u5207\u7247\u5728\u5b9e\u9a8c\u57f9\u517b\u57fa\u4e2d\u5b75\u80b2\u3002 6 \u5c0f\u65f6\u548c 48 \u5c0f\u65f6\u5f8c\uff0c\u901a\u8fc7\u7898\u5316\u4e19\u5576 (PI) \u67d3\u8272\u8bc4\u4f30\u795e\u7ecf\u5143\u6b7b\u4ea1\u3002 \u5728\u6bcf\u6b21\u5904\u7406\u4e2d\uff0c\u4e0e 10 \u03bcM A\u03b21-42 \u5be1\u805a\u4f53\u5b75\u80b2 6 \u5c0f\u65f6\u4e0d\u4f1a\u5bfc\u81f4\u795e\u7ecf\u5143\u6b7b\u4ea1\u3002 \u4e0e 10 \u03bcM A\u03b21-42 \u5be1\u805a\u4f53\u5b75\u80b2 48 \u5c0f\u65f6\u53ef\u589e\u52a0\u795e\u7ecf\u5143\u6b7b\u4ea1\uff0c\u800c NMN \u53ef\u51cf\u5c11 A\u03b21-42 \u5be1\u805a\u4f53\u8bf1\u5bfc\u7684\u795e\u7ecf\u5143\u6b7b\u4ea1\u3002 3-AP \u7684\u5b58\u5728\u9006\u8f6c\u4e86 NMN \u7684\u4fdd\u62a4\u4f5c\u7528\uff0c\u5e76\u663e\u793a\u51fa\u795e\u7ecf\u5143\u6b7b\u4ea1\u6c34\u5e73\u7684\u589e\u52a0\u3002<\/p>\n

2015 \u5e74\u7684\u8fd9\u9879\u7814\u7a76\u5f3a\u8c03\u4e86 NMN \u4f5c\u4e3a\u963f\u5179\u6d77\u9ed8\u75c7\u6cbb\u7597\u5242\u7684\u6f5c\u529b<\/span><\/strong>\u3002 \u300c\u6211\u4eec\u7684\u7814\u7a76\u4e3a NMN \u5728\u00a0\u963f\u5179\u6d77\u9ed8\u75c7\u00a0\u6cbb\u7597\u4e2d\u7684\u6f5c\u5728\u5e94\u7528\u63d0\u4f9b\u4e86\u4e00\u4e2a\u65b0\u7684\u65b9\u5411\u3002\u300d\u79d1\u5b66\u5bb6\u4eec\u5728\u4ed6\u4eec\u7684\u7814\u7a76\u4e2d\u8bf4\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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Xiaonan Wang, Wuejun Hu, Yang Yang, Toshihiro Takata, Takashi Sakurai.\u00a0Nicotinamide mononucleotide protects against \u00df-amyloid oligomer-induced cognitive impairment and neuronal death<\/strong>.\u00a0Brain Res, 2016; DOI: 10.1016\/j.brainres.2016.04.060.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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https:\/\/www.nmn.com\/news\/nmn-protects-the-central-nervous-system-preventing-neuronal-death-and-improving-cognition<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u6765\u81ea\u65e5\u672c\u548c\u4e2d\u56fd\u7684\u79d1\u5b66\u5bb6\u53d1\u73b0\uff0c\u5728\u963f\u8328\u6d77\u9ed8\u75c7\u7684\u5927\u9f20\u6a21\u578b\u4e2d\uff0cNMN \u6539\u5584\u4e86\u8ba4\u77e5\u80fd\u529b\uff0c\u589e\u52a0\u4e86\u795e\u7ecf\u5143\u7684\u5b58\u6d3b\u548c\u65b0\u9648\u4ee3\u8c22\u3002 \u6839\u636e \u7f8e\u570b\u75be\u75c5\u63a7\u5236\u8207\u9810\u9632\u4e2d\u5fc3 (CDC) \u7684\u9884\u6d4b\uff0c\u5230 2060 \u5e74\uff0c\u7f8e\u56fd\u963f\u5179\u6d77\u9ed8\u75c7\u60a3\u8005\u7684\u6570\u91cf\u5c06\u589e\u957f\u5230 1390 \u4e07\u4eba\uff0c\u662f 2018 \u5e74\u7684\u4e24\u500d\u591a\u3002 \u5c3d\u7ba1\u4e16\u754c\u6b63\u5728\u8001\u9f84\u5316\uff0c\u963f\u5179\u6d77\u9ed8\u75c7\u60a3\u8005\u7684\u4eba\u6570\u4e5f\u5728\u589e\u52a0\uff0c\u4f46\u76ee\u524d\u8fd8\u6ca1\u6709\u6cbb\u6108\u8fd9\u79cd\u75be\u75c5\u7684\u65b9\u6cd5\u3002 \u4e00\u7fa4\u6765\u81ea\u4e2d\u56fd\u548c\u65e5\u672c\u7684\u79d1\u5b66\u5bb6\u60f3\u8981\u6539\u53d8\u8fd9\u79cd\u72b6\u51b5\u3002  <\/p>\n

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