{"id":551,"date":"2022-03-25T04:03:45","date_gmt":"2022-03-25T04:03:45","guid":{"rendered":"http:\/\/choosebiz.me\/?p=551"},"modified":"2022-05-27T03:23:58","modified_gmt":"2022-05-27T03:23:58","slug":"%e3%80%90%e7%a7%91%e6%8a%80%e8%bf%9b%e5%b1%95%e3%80%91%e7%a7%91%e5%ad%a6%e5%ae%b6%e4%bb%ac%e6%8f%90%e5%87%ba%ef%bc%8c%e7%bb%86%e8%83%9e%e4%b8%adnad-%e7%9a%84%e6%b0%b4%e5%b9%b3%e5%8f%af%e8%b0%83","status":"publish","type":"post","link":"http:\/\/johnhealth.blog\/ch\/?p=551","title":{"rendered":"\u3010\u79d1\u6280\u8fdb\u5c55\u3011\u79d1\u5b66\u5bb6\u4eec\u63d0\u51fa\uff0c\u7ec6\u80de\u4e2dNAD +\u7684\u6c34\u5e73\u53ef\u8c03\u8282\u5bf9COVID-19\u7684\u514d\u75ab\u53cd\u5e94"},"content":{"rendered":"

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NAD +\u53c2\u4e0e\u591a\u79cd\u7ec6\u80de\u53cd\u5e94\uff0c\u4ee5\u4ea7\u751f\u80fd\u91cf\u5e76\u7ef4\u6301\u7ec6\u80de\u5065\u5eb7\uff0c\u5305\u62ec\u5bf9\u75c5\u6bd2\u611f\u67d3\u7684\u514d\u75ab\u53cd\u5e94\u3002 \u7814\u7a76\u663e\u793a\uff0c\u968f\u7740\u5e74\u9f84\u7684\u589e\u957f\uff0c\u7ec6\u80de\u4e2dNAD +\u7684\u542b\u91cf\u4f1a\u964d\u4f4e<\/a>\uff0c\u800c\u4e0e\u5e74\u9f84\u76f8\u5173\u7684NAD +\u542b\u91cf\u7684\u964d\u4f4e\u4f1a\u4e0d\u5229\u5730\u5f71\u54cd\u5bf9\u611f\u67d3\u7684\u514d\u75ab\u53cd\u5e94\uff0c\u5305\u62ec\u5bf9COVID-19\u7684\u53cd\u5e94\u3002 COVID-19\u7684\u6b7b\u4ea1\u7387\u968f\u7740\u5e74\u9f84\u7684\u589e\u957f\u800c\u589e\u52a0\uff0c\u5bf9\u65bc80\u5c81\u4ee5\u4e0a\u7684\u4eba\uff0c\u6b7b\u4ea1\u7387\u8d85\u8fc714\uff05\uff0c\u8fd9\u8868\u660e\u4e0e\u5e74\u9f84\u6709\u5173\u7684\u514d\u75ab\u7cfb\u7edf\u529f\u80fd\u969c\u788d\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\uff08Omran\u548cAlmaliki\uff0c2020\u5e74|\u300a\u611f\u67d3\u4e0e\u516c\u5171\u536b\u751f\u6742\u5fd7\u300b(Journal of Infection and Public Health) \uff09<\/a><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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NAD +\u5728\u673a\u4f53\u7684\u6297\u75c5\u6bd2\u53cd\u5e94\u4e2d\u8d77\u7740\u81f3\u5173\u91cd\u8981\u7684\u4f5c\u7528\u3002 \u4e00\u79cd\u79f0\u4e3a\u805aADP\u6838\u7cd6\u805a\u5408\u9176-1\uff08PARP-1\uff09\u7684\u5927\u86cb\u767d\u53ef\u50ac\u5316NAD +\u7684\u964d\u89e3\uff0c\u4ee5\u53d1\u6325\u5176\u6297\u75c5\u6bd2\u529f\u80fd\u3002 \u4f7f\u7528ADP-\u6838\u7cd6\uff08NAD +\u5206\u89e3\u5f8c\u6765\u81eaNAD +\u7684\u4e00\u79cd\u6210\u5206\uff09\u65f6\uff0cPARP-1\u53ef\u4ee5\u6807\u8bb0\u75c5\u6bd2\u57fa\u56e0\u7ec4\u5e76\u6291\u5236\u75c5\u6bd2\u57fa\u56e0\u7a0b\u5e8f\u7684\u6fc0\u6d3b\u3002 \u4f46\u662fSARS-CoV-2\u6765\u81ea\u51a0\u72b6\u75c5\u6bd2\u79d1\u7684\u75c5\u6bd2\u5bb6\u65cf\uff0c\u4e14\u5177\u6709\u53bb\u9664ADP-\u6838\u7cd6\u5206\u5b50\u6807\u7b7e\u7684\u5206\u5b50\u673a\u5236\uff0c\u4ece\u800c\u6291\u5236\u4e86PARP-1\u7684\u4fdd\u62a4\u4f5c\u7528\u3002 \u8fd9\u79cd\u60c5\u51b5\u5bfc\u81f4\u8fc7\u5ea6\u7684PARP-1\u6fc0\u6d3b\u5e76\u4f34\u6709\u708e\u75c7\u53cd\u5e94\u3002<\/p>\n

PARP-1\u7684\u8fc7\u5ea6\u6fc0\u6d3b\u548c\u5bf9SARS-CoV2\u7684\u708e\u75c7\u53cd\u5e94\uff0c\u5bfc\u81f4NAD +\u7684\u6d88\u8017\u91cf\u8fc7\u5927\uff0c\u4ece\u800c\u4fc3\u8fdb\u4e86\u7ec6\u80deNAD +\u6c34\u5e73\u7684\u8fdb\u4e00\u6b65\u964d\u4f4e\u3002\u8fd9\u6700\u7ec8\u6291\u5236\u4e86\u9700\u8981NAD +\u7684\u7ec6\u80de\u80fd\u91cf\u4ea7\u751f\uff0c\u5bfc\u81f4\u80fd\u91cf\u6d88\u8017\u548c\u7ec6\u80de\u6b7b\u4ea1\u3002\u6b64\u5916\uff0c\u7531\u65bc\u8fc7\u5ea6\u7684PARP-1\u6d3b\u6027\u800c\u5bfc\u81f4\u7684NAD +\u542b\u91cf\u964d\u4f4e\uff0c\u4f7f\u5f97sirtuin 1\uff08SIRT1\uff09\u7684\u6d3b\u6027\u964d\u4f4e\uff0cSIRT1\u662f\u4e00\u79cd\u53c2\u4e0e\u7ec6\u80de\u5065\u5eb7\u7ef4\u6301\u548c\u8870\u8001\u7684\u86cb\u767d\u8d28\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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(Omran & Almaliki, 2020 |\u00a0<\/a>Journal of Infection and Public Health<\/em><\/a>)<\/a>\u4e0e\u8870\u8001\u76f8\u5173\u7684DNA\u635f\u4f24\u5bfc\u81f4PARP-1\u6d3b\u5316\uff0c\u4ece\u800c\u964d\u4f4eNAD +\u6c34\u5e73\u3002\u8fd9\u79cd\u60c5\u51b5\u5bfc\u81f4SIRT1\u6d3b\u6027\u4e0b\u964d\uff0c\u4ece\u800c\u4fc3\u8fdb\u708e\u75c7\u589e\u52a0\u548c\u7c92\u7ebf\u4f53\u529f\u80fd\u964d\u4f4e\u3002<\/p>\n

\u201c\u901a\u8fc7\u5916\u6e90\u6027NAD +\u7ed9\u836f\u53ef\u4ee5\u9006\u8f6cPARP-1\u8fc7\u5ea6\u6fc0\u6d3b\u7684\u8fc7\u7a0b\uff0c\u201d\u7814\u7a76\u56e2\u961f\u5728\u5176\u5b66\u672f\u8bba\u6587\u4e2d\u6307\u51fa\u5bf9\u6297NAD+\u6c34\u5e73\u964d\u4f4e\u7684\u65b9\u6cd5\u3002\u7814\u7a76\u56e2\u961f\u7ee7\u7eed\u8bf4\uff0cNAD +\u53ef\u4ee5\u8c03\u8282\u86cb\u767d\u8d28\u590d\u5408\u7269NF-KB\uff0c\u5728\u5bf9SARS-CoV-2\u611f\u67d3\u7684\u708e\u75c7\u53cd\u5e94\u4e2d\u8d77\u5173\u952e\u4f5c\u7528\u3002\u4ed6\u4eec\u8bf4\uff0c\u8865\u5145NAD +\u5e76\u968f\u5f8c\u6291\u5236PARP-1\u53ef\u4ee5\u963b\u6b62NF-KB\u6d3b\u5316\uff0c\u4ece\u800c\u51cf\u5c11\u5bf9SARS-CoV-2\u7684\u708e\u75c7\u53cd\u5e94\u3002<\/p>\n

\u201c\u6211\u4eec\u5efa\u8bae\u5728\u8001\u5e74\u60a3\u8005\u4e2d\u4f7f\u7528NAD +\u4f5c\u4e3a\u5bf9\u6297COVID-19\u7684\u514d\u75ab\u8c03\u8282\u5242\u3002 \u6062\u590d\u6b63\u5e38\u7684NAD +\u6c34\u5e73\u53ef\u4ee5\u964d\u4f4e\u8fd9\u4e9b\u60a3\u8005\u7684\u514d\u75ab\u53cd\u5e94\u4e25\u91cd\u7a0b\u5ea6\u5e76\u6539\u5584\u4ed6\u4eec\u7684\u4e34\u5e8a\u72b6\u51b5\uff0c\u201d\u7814\u7a76\u56e2\u961f\u5728\u5176\u5b66\u672f\u8bba\u6587\u4e2d\u8868\u793a\u3002 \u4ed6\u4eec\u5f97\u51fa\u7ed3\u8bba\uff0c\u5bf9SARS-CoV-2\u514d\u75ab\u5e94\u7b54\u673a\u5236\u7684\u900f\u5f7b\u4e86\u89e3\u5c06\u6709\u52a9\u65bc\u5f00\u53d1\u9488\u5bf9\u8be5\u75c5\u6bd2\u7684\u9884\u9632\u548c\u6cbb\u7597\u7b56\u7565\u3002<\/p>\n

\u53c2\u8003\u6587\u732e: Omran HM, Almaliki MS. Influence of NAD+ as an ageing-related immunomodulator on COVID 19 infection: A hypothesis. J Infect Public Health. 2020 Sep;13(9):1196-1201. doi: 10.1016\/j.jiph.2020.06.004. Epub 2020 Jun 7. PMID: 32534944; PMCID: PMC7275989.<\/p>\n

\u5f15\u7528\u6587\u732e:<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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Halaschek-Wiener J, Vulto I, Fornika D, Collins J, Connors JM, Le ND, Lansdorp PM, Brooks-Wilson A. Reduced telomere length variation in healthy oldest old. Mech Ageing Dev. 2008 Nov;129(11):638-41. doi: 10.1016\/j.mad.2008.07.004. Epub 2008 Aug 14. PMID: 18765247.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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Sanders JL, Newman AB. Telomere length in epidemiology: a biomarker of aging, age-related disease, both, or neither? Epidemiol Rev. 2013;35(1):112-31. doi: 10.1093\/epirev\/mxs008. Epub 2013 Jan 9. PMID: 23302541; PMCID: PMC4707879.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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Tu W, Rao S. Mechanisms Underlying T Cell Immunosenescence: Aging and Cytomegalovirus Infection. Front Microbiol. 2016 Dec 27;7:2111. doi: 10.3389\/fmicb.2016.02111. PMID: 28082969; PMCID: PMC5186782.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u6587\u7ae0\u4f86\u6e90: https:\/\/www.nmn.com\/news\/nad-levels-immune-response-covid-19<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u7814\u7a76\u4eba\u5458\u63d0\u51fa\uff0c\u589e\u52a0NAD +\u6c34\u5e73\u53ef\u6539\u5584COVID-19(\u65b0\u51a0\u75c5\u6bd2\u75c5)\u611f\u67d3\u7684\u514d\u75ab\u529f\u80fd\u3002 NAD +\u53c2\u4e0e\u591a\u79cd\u7ec6\u80de\u53cd\u5e94\uff0c\u4ee5\u4ea7\u751f\u80fd\u91cf\u5e76\u7ef4\u6301\u7ec6\u80de\u5065\u5eb7\uff0c\u5305\u62ec\u5bf9\u75c5\u6bd2\u611f\u67d3\u7684\u514d\u75ab\u53cd\u5e94\u3002 \u7814\u7a76\u663e\u793a\uff0c\u968f\u7740\u5e74\u9f84\u7684\u589e\u957f\uff0c\u7ec6\u80de\u4e2dNAD +\u7684\u542b\u91cf\u4f1a\u964d\u4f4e\uff0c\u800c\u4e0e\u5e74\u9f84\u76f8\u5173\u7684NAD +\u542b\u91cf\u7684\u964d\u4f4e\u4f1a\u4e0d\u5229\u5730\u5f71\u54cd\u5bf9\u611f\u67d3\u7684\u514d\u75ab\u53cd\u5e94\uff0c\u5305\u62ec\u5bf9COVID-19\u7684\u53cd\u5e94\u3002 COVID-19\u7684\u6b7b\u4ea1\u7387\u968f\u7740\u5e74\u9f84\u7684\u589e\u957f\u800c\u589e\u52a0\uff0c\u5bf9\u65bc80\u5c81\u4ee5\u4e0a\u7684\u4eba\uff0c\u6b7b\u4ea1\u7387\u8d85\u8fc714\uff05\uff0c\u8fd9\u8868\u660e\u4e0e\u5e74\u9f84\u6709\u5173\u7684\u514d\u75ab\u7cfb\u7edf\u529f\u80fd\u969c\u788d\u3002<\/p>\n

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