{"id":51,"date":"2015-12-19T14:47:10","date_gmt":"2015-12-19T19:47:10","guid":{"rendered":"http:\/\/www.deepthinkgohelper.com\/wp\/?p=51"},"modified":"2022-05-23T02:55:20","modified_gmt":"2022-05-23T02:55:20","slug":"51","status":"publish","type":"post","link":"http:\/\/johnhealth.blog\/ch\/?p=51","title":{"rendered":"\u4e16\u754c\u8457\u540d\u7684 \u79d1\u5b66\u6742\u5fd7\u201cScience\uff02\u4ecb\u7ecd \u767d\u85dc\u82a6\u9187"},"content":{"rendered":"
<\/div>\n
\n

\"\"\u4e00\u9879\u65b0\u7814\u7a76\u4e3a\u7814\u7a76\u4eba\u5458\u63d0\u4f9b\u4e86\u786e\u51ff\u7684\u8bc1\u636e\uff0c\u8bc1\u5b9e\u7ea2\u8461\u8404\u9152\u5316\u5408\u7269\u767d\u85dc\u82a6\u9187\uff08resveratrol\uff09\u53ef\u76f4\u63a5\u6fc0\u6d3b\u4e00\u79cd\u86cb\u767d\u8d28\uff0c\u4fc3\u4f7f\u52a8\u7269\u6a21\u578b\u5065\u5eb7\u548c\u957f\u5bff\u3002\u6b64\u5916\uff0c\u7814\u7a76\u4eba\u5458\u8fd8\u63ed\u793a\u4e86\u8fd9\u4e00\u76f8\u4e92\u4f5c\u7528\u7684\u5206\u5b50\u673a\u5236\uff0c\u5e76\u8bc1\u660e\u4e86\u5f53\u524d\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u7684\u4e00\u7c7b\u66f4\u6709\u6548\u7684\u836f\u7269\u80fd\u591f\u4ee5\u76f8\u4f3c\u7684\u65b9\u5f0f\u53d1\u6325\u4f5c\u7528\u3002\u4e0e\u767d\u85dc\u82a6\u9187\u76f8\u4f3c\u7684\u836f\u7269\u5316\u5408\u7269\u53ef\u80fd\u6709\u6f5c\u529b\u6cbb\u7597\u548c\u9884\u9632\u4e0e\u4eba\u7c7b\u8870\u8001\u76f8\u5173\u7684\u75be\u75c5\u3002\u8fd9\u4e9b\u7814\u7a76\u7ed3\u679c\u53d1\u8868\u5728\u6700\u65b0\u4e00\u671f\u7684\u300a\u79d1\u5b66\u300b\uff08Science\uff09\u6742\u5fd7\u4e0a\u3002<\/strong><\/p>\n

\u5728\u8fc7\u53bb\u7684\u5341\u5e74\u91cc\uff0c\u8870\u8001\u79d1\u5b66\u65e5\u76ca\u5c06\u7126\u70b9\u653e\u5230\u4e00\u7ec4\u79f0\u4f5csirtuins\u7684\u57fa\u56e0\u4e0a\uff0c\u4eba\u4eec\u8ba4\u4e3a\u8fd9\u4e9b\u57fa\u56e0\u80fd\u591f\u4fdd\u62a4\u5305\u62ec\u54fa\u4e73\u52a8\u7269\u5728\u5185\u7684\u8bb8\u591a\u751f\u7269\u5bf9\u6297\u8870\u8001\u75be\u75c5\u3002\u8d8a\u6765\u8d8a\u591a\u7684\u8bc1\u636e\u8868\u660e\uff0c\u767d\u85dc\u82a6\u9187\uff0c\u8fd9\u4e00\u5b58\u5728\u4e8e\u8461\u8404\u76ae\u3001\u82b1\u751f\u548c\u6d46\u679c\u4e2d\u7684\u5316\u5408\u7269\uff0c\u80fd\u591f\u63d0\u9ad8\u4e00\u79cd\u7279\u5f02sirtuin??SIRT1\u7684\u6d3b\u6027\u3002 SIRT1\u53ef\u901a\u8fc7\u52a0\u901f\u7ebf\u7c92\u4f53\u4fdd\u62a4\u673a\u4f53\u8fdc\u79bb\u75be\u75c5\u3002\u968f\u7740\u6211\u4eec\u7684\u8870\u8001\u7ebf\u7c92\u4f53\u8fd9\u4e00\u7ec6\u80de\u7535\u6c60\u4f1a\u6162\u6162\u505c\u6b62\u8fd0\u8f6c\u3002\u901a\u8fc7\u7ed9\u8fd9\u4e9b\u7535\u6c60\u91cd\u65b0\u5145\u7535\uff0cSIRT1\u53ef\u4ee5\u5bf9\u5065\u5eb7\u4ea7\u751f\u6df1\u8fdc\u7684\u5f71\u54cd\u3002<\/strong><\/p>\n

\u767d\u85dc\u82a6\u9187\u5582\u9972\u5c0f\u9f20\u8010\u529b\u589e\u5927\u4e24\u500d\uff0c\u76f8\u5bf9\u514d\u53d7\u80a5\u80d6\u548c\u8870\u8001\u7684\u5f71\u54cd\u3002\u5728\u9175\u6bcd\u3001\u7ebf\u866b\u3001\u679c\u8747\u548c\u5c0f\u9f20\u4e2d\u5b9e\u9a8c\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u5747\u8bc1\u5b9e\u5176\u80fd\u5ef6\u957f\u5bff\u547d\u3002<\/strong><\/p>\n

\u201c\u5728\u5236\u836f\u53f2\u4e0a\uff0c\u8fd8\u6ca1\u6709\u4e00\u79cd\u836f\u7269\u80fd\u591f\u4ee5\u767d\u85dc\u82a6\u9187\u6fc0\u6d3bSIRT1\u7684\u65b9\u5f0f\uff0c\u4f7f\u4e00\u79cd\u86cb\u767d\u8d28\u66f4\u5feb\u901f\u8fd0\u8f6c\u3002\u51e0\u4e4e\u6240\u6709\u7684\u836f\u7269\u90fd\u53ea\u53ef\u4ee5\u51cf\u6162\u6216\u662f\u963b\u65ad\u5b83\u4eec\uff0c\u201d\u8bba\u6587\u7684\u8d44\u6df1\u4f5c\u8005\u3001\u54c8\u4f5b\u5927\u5b66\u533b\u5b66\u9662\u9057\u4f20\u5b66\u6559\u6388David Sinclair\u8bf4<\/strong><\/p>\n

\u57282006\u5e74\uff0cSinclair\u7814\u7a76\u5c0f\u7ec4\u53d1\u8868\u4e86\u4e00\u9879\u7814\u7a76\uff0c\u8bc1\u5b9e\u767d\u85dc\u82a6\u9187\u80fd\u591f\u5ef6\u957f\u5c0f\u9f20\u7684\u5bff\u547d\u3002\u54c8\u4f5b\u5927\u5b66\u533b\u5b66\u9662\u7684\u7814\u7a76\u4eba\u5458\u542f\u52a8\u521b\u7acb\u4e86Sirtris\u5236\u836f\u516c\u53f8\uff0c\u65e8\u5728\u5236\u9020\u51fa\u6bd4\u767d\u85dc\u82a6\u9187\u66f4\u6709\u6548\u7684\u836f\u7269\u3002 \uff08Sinclair\u662f\u845b\u5170\u7d20\u53f2\u514b\u516c\u53f8\u65d7\u4e0bSirtris\u7684\u5171\u540c\u521b\u59cb\u4eba\uff0c\u76ee\u524d\u4ecd\u62c5\u4efb\u79d1\u5b66\u987e\u95ee\u3002\u76ee\u524dSirtris\u516c\u53f8\u62e5\u6709\u4e00\u6279sirtuin\u6fc0\u6d3b\u5316\u5408\u7269\u8fdb\u5165\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff09\u3002<\/strong><\/p>\n

\u7136\u800c\uff0c\u5c3d\u7ba1Sinclair\u5b9e\u9a8c\u5ba4\u548c\u522b\u5904\u7684\u7814\u7a76\u56e2\u4f53\u7684\u5927\u91cf\u7814\u7a76\uff0c\u5747\u5f3a\u8c03\u4e86\u767d\u85dc\u82a6\u9187\u548cSIRT1\u4e4b\u95f4\u5b58\u5728\u76f4\u63a5\u7684\u56e0\u679c\u5173\u7cfb\uff0c\u4e00\u4e9b\u79d1\u5b66\u5bb6\u5374\u8ba4\u4e3a\u8fd9\u4e9b\u7814\u7a76\u5b58\u5728\u7f3a\u9677\u3002<\/strong><\/p>\n

\u4e89\u8fa9\u5728\u4e8e\u4f53\u5916\u7814\u7a76SIRT1\u7684\u65b9\u5f0f\uff0c\u7814\u7a76\u4eba\u5458\u5c06\u4e00\u79cd\u7279\u5f02\u7684\u5316\u5b66\u57fa\u56e2\u9644\u7740\u5230SIRT1\u9776\u70b9\u4e0a\uff0c\u5f53SIRT1\u6d3b\u6027\u589e\u9ad8\u65f6\u4f1a\u53d1\u51fa\u66f4\u660e\u4eae\u7684\u8367\u5149\u3002\u7136\u800c\uff0c\u8fd9\u4e00\u5316\u5b66\u57fa\u56e2\u662f\u5408\u6210\u7684\uff0c\u5e76\u4e0d\u5b58\u5728\u4e8e\u7ec6\u80de\u6216\u81ea\u7136\u754c\uff0c\u800c\u6ca1\u6709\u5b83\u5b9e\u9a8c\u5219\u65e0\u6cd5\u8fd0\u884c\u3002\u4f5c\u4e3a\u4e00\u79cd\u56de\u5e94\uff0c2010\u5e74\u53d1\u8868\u7684\u4e00\u7bc7\u8bba\u6587\u63a8\u6d4b\u767d\u85dc\u82a6\u9187\u6fc0\u6d3bSIRT1\u662f\u4e00\u79cd\u53ea\u5b58\u5728\u4e8e\u5b9e\u9a8c\u5ba4\u4e2d\uff0c\u800c\u5e76\u4e0d\u5b58\u5728\u4e8e\u73b0\u5b9e\u52a8\u7269\u4e2d\u7684\u5b9e\u9a8c\u5047\u8c61\uff0c\u8be5\u8bba\u6587\u8ba4\u4e3a\uff0c\u5c0f\u9f20\u4e2d\u7684SIRT1\u6d3b\u6027\u5145\u5176\u91cf\u662f\u767d\u85dc\u82a6\u9187\u7684\u4e00\u4e2a\u95f4\u63a5\u7ed3\u679c\uff0c\u751a\u81f3\u591a\u534a\u662f\u4e00\u79cd\u5de7\u5408\u3002<\/strong><\/p>\n

\u56e0\u6b64\uff0c\u5c31\u767d\u85dc\u82a6\u9187\u548c\u76f8\u4f3c\u5316\u5408\u7269\u5f71\u54cd\u7684\u7279\u5f02\u4fe1\u53f7\u901a\u8def\u5f15\u53d1\u4e86\u4e00\u573a\u6fc0\u70c8\u7684\u8fa9\u8bba\u3002\u767d\u85dc\u82a6\u9187\u662f\u76f4\u63a5\u6fc0\u6d3b\u4e86SIRT1\u8fd8\u662f\u95f4\u63a5\u5f71\u54cd\uff1f Sinclair \u8bf4\uff1a\u201c\u6211\u4eec\u901a\u8fc7\u516d\u5e74\u7684\u7814\u7a76\u5de5\u4f5c\uff0c\u786e\u8bc1\u8fd9\u7edd\u4e0d\u662f\u4e00\u79cd\u5047\u8c61\u3002\u6211\u4eec\u4ecd\u7136\u9700\u8981\u5f04\u6e05\u695a\u767d\u85dc\u82a6\u9187\u53d1\u6325\u4f5c\u7528\u7684\u673a\u5236\u3002\u7b54\u6848\u662f\u6781\u5176\u5de7\u5999\u7684\u3002\u201d<\/strong><\/p>\n

Sinclair\u548c\u5b9e\u9a8c\u5ba4\u7684\u535a\u58eb\u751fBasil Hubbard\uff0c\u4e0e\u6765\u81ea\u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u7814\u7a76\u9662\u548cSirtris\u5236\u836f\u516c\u53f8\u7684\u7814\u7a76\u4eba\u5458\u5c55\u5f00\u5408\u4f5c\uff0c\u89e3\u7b54\u4e86\u8fd9\u4e2a\u95ee\u9898\u3002<\/strong><\/p>\n

\u9996\u5148\uff0c\u7814\u7a76\u5c0f\u7ec4\u89e3\u7b54\u4e86\u5173\u4e8e\u8367\u5149\u5316\u5b66\u57fa\u56e2\u7684\u95ee\u9898\u3002\u4e3a\u4ec0\u4e48\u5b83\u662f\u8bd5\u7ba1\u4e2d\u767d\u85dc\u82a6\u9187\u52a0\u901fSIRT1\u7684\u5fc5\u8981\u6761\u4ef6\uff1f\u7814\u7a76\u4eba\u5458\u4e0d\u8ba4\u4e3a\u8fd9\u4e00\u7ed3\u679c\u662f\u4e00\u79cd\u5047\u8c61\uff0c\u4ed6\u4eec\u63a8\u6d4b\u5316\u5408\u7269\u53ef\u80fd\u6a21\u62df\u4e86\u5929\u7136\u5b58\u5728\u4e8e\u7ec6\u80de\u4e2d\u7684\u4e00\u4e9b\u5206\u5b50\u3002\u7ed3\u679c\u8bc1\u5b9e\u5b83\u4eec\u662f\u4e00\u7c7b\u7279\u5f02\u7684\u6c28\u57fa\u9178\u3002\u5728\u81ea\u7136\u754c\u4e2d\uff0c\u6709\u4e09\u79cd\u6c28\u57fa\u9178\u4e0e\u8367\u5149\u5316\u5b66\u57fa\u56e2\u76f8\u4f3c\uff0c\u5176\u4e2d\u4e00\u79cd\u662f\u8272\u6c28\u9178\u3002\u5728\u706b\u9e21\u8089\u4e2d\u5bcc\u542b\u8fd9\u79cd\u8272\u6c28\u9178\u5206\u5b50\uff0c\u5b83\u4ee5\u80fd\u591f\u8bf1\u5bfc\u55dc\u7761\u800c\u7740\u79f0\u3002\u5f53\u7814\u7a76\u4eba\u5458\u91cd\u590d\u8fd9\u4e00\u5b9e\u9a8c\u65f6\uff0c\u5c06\u5e95\u7269\u4e0a\u7684\u8367\u5149\u5316\u5b66\u57fa\u56e2\u4e0e\u4e00\u4e2a\u8272\u6c28\u9178\u6b8b\u57fa\u4ea4\u6362\uff0c\u767d\u85dc\u82a6\u9187\u548c\u7c7b\u4f3c\u5206\u5b50\u518d\u4e00\u6b21\u80fd\u591f\u6fc0\u6d3bSIRT1\u3002<\/strong><\/p>\n

Hubbard\u8bf4\uff1a\u201c\u6211\u4eec\u53d1\u73b0\u6fc0\u6d3b\u6807\u8bb0\u4e8b\u5b9e\u4e0a\u5b58\u5728\u4e8e\u7ec6\u80de\u4e2d\uff0c\u5e76\u4e0d\u9700\u8981\u5176\u4ed6\u7684\u8fd9\u4e9b\u5408\u6210\u57fa\u56e2\u3002\u8fd9\u662f\u4e00\u4e2a\u91cd\u8981\u7684\u7ed3\u679c\uff0c\u8ba9\u6211\u4eec\u5728\u751f\u7269\u5316\u5b66\u548c\u751f\u7406\u5b66\u7ed3\u679c\u4e4b\u95f4\u642d\u8d77\u4e86\u4e00\u5ea7\u6865\u3002\u201d<\/strong><\/p>\n

\u201c\u63a5\u4e0b\u6765\uff0c\u6211\u4eec\u9700\u8981\u786e\u5207\u9274\u5b9a\u767d\u85dc\u82a6\u9187\u65bd\u538bSIRT1\u52a0\u901f\u5668\u7684\u673a\u5236\uff0c\u201dSinclair\u8bf4\u3002\u7814\u7a76\u5c0f\u7ec4\u5bf9\u5927\u7ea62000\u79cdSIRT1\u57fa\u56e0\u7a81\u53d8\u8fdb\u884c\u4e86\u6d4b\u8bd5\uff0c\u6700\u7ec8\u53d1\u73b0\u4e00\u79cd\u7a81\u53d8\u5b8c\u5168\u963b\u65ad\u4e86\u767d\u85dc\u82a6\u9187\u7684\u6548\u5e94\u3002\u8fd9\u79cd\u7279\u5f02\u7684\u7a81\u53d8\u5bfc\u81f4\u4e86SIRT1\u86cb\u767d747\u4e2a\u6c28\u57fa\u9178\u4e2d\u7684\u4e00\u4e2a\u5355\u6c28\u57fa\u9178\u6b8b\u57fa\u53d1\u751f\u7f6e\u6362\u3002\u7814\u7a76\u4eba\u5458\u8fd8\u6d4b\u8bd5\u4e86\u6765\u81eaSirtris\u516c\u53f8\u5e93\u7684\u6570\u767e\u4e2a\u5206\u5b50\uff08\u5176\u4e2d\u8bb8\u591a\u6bd4\u767d\u85dc\u82a6\u9187\u6548\u529b\u66f4\u5f3a\uff09\u5bf9\u4e8e\u8fd9\u4e00\u7a81\u53d8SIRT1\u7684\u6548\u5e94\u3002\u53d1\u73b0\u6240\u6709\u7684\u5747\u65e0\u6cd5\u6fc0\u6d3b\u5b83\u3002<\/strong><\/p>\n

\u4f5c\u8005\u4eec\u7531\u6b64\u63d0\u51fa\u4e86\u4e00\u79cd\u767d\u85dc\u82a6\u9187\u7684\u4f5c\u7528\u673a\u5236\u6a21\u578b\uff1a\u5f53\u8fd9\u4e00\u5206\u5b50\u7ed3\u5408\u65f6\uff0c\u4e00\u4e2a\u94f0\u94fe\u7ffb\u8f6c\uff0cSIRT1\u53d8\u5f97\u6781\u5ea6\u6d3b\u8dc3\u3002<\/strong><\/p>\n

\u5c3d\u7ba1\u8fd9\u4e9b\u5b9e\u9a8c\u662f\u5728\u8bd5\u7ba1\u4e2d\u5f00\u5c55\uff0c\u4e00\u65e6\u7814\u7a76\u4eba\u5458\u786e\u5b9a\u52a0\u901f\u5668\u8e29\u52a8SIRT1\u8e0f\u677f\u7684\u7cbe\u786e\u4f4d\u70b9\uff0c\u627e\u5230\u5207\u65ad\u5b83\u7684\u65b9\u5f0f\uff0c\u4ed6\u4eec\u5c31\u53ef\u4ee5\u5728\u7ec6\u80de\u4e2d\u6d4b\u8bd5\u4ed6\u4eec\u7684\u60f3\u6cd5\u3002\u4ed6\u4eec\u7528\u52a0\u901f\u5668\u65e0\u6d3b\u529b\u7a81\u53d8\u4f53\u7f6e\u6362\u808c\u8089\u548c\u76ae\u80a4\u7ec6\u80de\u4e2d\u7684\u6b63\u5e38SIRT1\u57fa\u56e0\u3002\u73b0\u5728\u4ed6\u4eec\u80fd\u591f\u5728\u5f00\u53d1\u7814\u7a76\u4e2d\u7cbe\u786e\u6d4b\u8bd5\u836f\u7269\uff0c\u786e\u5b9a\u5b83\u4eec\u662f\u5426\u80fd\u591f\u626d\u62c9SIRT1\uff08\u5728\u54ea\u79cd\u60c5\u51b5\u4e0b\u5b83\u4eec\u4e0d\u53d1\u6325\u4f5c\u7528\uff09\u6216\u7ec6\u80de\u4e2d\u5176\u4ed6\u6210\u5343\u4e0a\u4e07\u79cd\u86cb\u767d\u5176\u4e2d\u4e00\u79cd\uff08\u5728\u54ea\u79cd\u60c5\u51b5\u4e0b\u5b83\u4eec\u53d1\u6325\u4f5c\u7528\uff09\u3002\u867d\u7136\u767d\u85dc\u82a6\u9187\u548c\u6d4b\u8bd5\u836f\u7269\u5728\u6b63\u5e38\u7ec6\u80de\u4e0b\u80fd\u591f\u52a0\u901f\u7ebf\u7c92\u4f53\uff0c\u4f46\u7a81\u53d8\u7ec6\u80de\u5219\u5b8c\u5168\u4e0d\u53d7\u5f71\u54cd\u3002<\/strong><\/p>\n

Sinclair\u8bf4\uff1a\u201c\u8fd9\u662f\u6740\u624b\u950f\u5b9e\u9a8c\u3002\u9664\u4e86\u767d\u85dc\u82a6\u9187\u76f4\u63a5\u5728\u7ec6\u80de\u4e2d\u6fc0\u6d3b\u4e86SIRT1\uff0c\u6ca1\u6709\u5176\u4ed6\u7684\u5408\u7406\u89e3\u91ca\u3002\u73b0\u5728\u6211\u4eec\u77e5\u9053\u4e86\u767d\u85dc\u82a6\u9187\u4f5c\u7528\u4e8eSIRT1\u7684\u786e\u5207\u4f4d\u70b9\u548c\u673a\u5236\uff0c\u6211\u4eec\u751a\u81f3\u53ef\u4ee5\u66f4\u597d\u5730\u8bbe\u8ba1\u5206\u5b50\uff0c\u66f4\u7cbe\u786e\u66f4\u6709\u6548\u5730\u89e6\u53d1\u767d\u85dc\u82a6\u9187\u7684\u6548\u5e94\u3002\u201d<\/strong><\/p>\n

\n

 <\/p>\n

 <\/p>\n<\/div>\n

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