{"id":506,"date":"2022-03-23T14:05:46","date_gmt":"2022-03-23T14:05:46","guid":{"rendered":"http:\/\/choosebiz.me\/?p=506"},"modified":"2022-05-27T02:17:29","modified_gmt":"2022-05-27T02:17:29","slug":"nmn%e5%8f%af%e6%94%b9%e5%96%84%e5%b9%b2%e7%9c%bc%e7%97%85%ef%bc%8c%e5%b9%b6%e5%87%8f%e5%b0%91%e7%9c%bc%e9%83%a8%e7%82%8e%e7%97%87","status":"publish","type":"post","link":"http:\/\/johnhealth.blog\/ch\/?p=506","title":{"rendered":"NMN\u53ef\u6539\u5584\u5e72\u773c\u75c5\uff0c\u5e76\u51cf\u5c11\u773c\u90e8\u708e\u75c7"},"content":{"rendered":"<p>\u5e72\u773c\u75c7\u662f\u4ee5\u773c\u775b\u5e72\u6da9\u4e3a\u4e3b\u8981\u75c7\u72b6\u7684\u6cea\u6db2\u5206\u6ccc\u969c\u788d\u6027\u773c\u75c5\uff0c\u53ef\u80fd\u4f1a\u9020\u6210\u773c\u8868\u53d7\u4f24\uff0c\u751a\u81f3\u662f\u89c6\u529b\u969c\u788d\u7b49\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-17393\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/03\/244238410_357914172796284_2723858395893828182_n.jpg\" alt=\"\" width=\"960\" height=\"540\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/03\/244238410_357914172796284_2723858395893828182_n.jpg 960w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/03\/244238410_357914172796284_2723858395893828182_n-300x169.jpg 300w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/03\/244238410_357914172796284_2723858395893828182_n-768x432.jpg 768w\" sizes=\"auto, (max-width: 960px) 100vw, 960px\" \/><\/p>\n<p>\u957f\u671f\u70b9\u67d0\u4e9b\u4e0d\u826f\u773c\u836f\u6c34\u4e36\u957f\u671f\u6234\u9690\u5f62\u773c\u955c\u4e36\u7f3a\u4e4f\u7ef4\u751f\u7d20A1\u7b49\u90fd\u6709\u53ef\u80fd\u5bfc\u81f4\u5e72\u773c\u75c5\u3002<\/p>\n<p>\u5e38\u719f\u5e02\u7b2c\u4e8c\u4eba\u6c11\u533b\u9662\u5728\u300a<span style=\"color: #ff6600;\"><strong>Journal of Inflammation Research<\/strong><\/span>\u300b\u6742\u5fd7\u4e0a\u53d1\u8868\u4e86\u4e00\u9879\u7814\u7a76\uff0c\u53d1\u73b0NMN\u5bf9\u773c\u7ec6\u80de\u5177\u6709\u663e\u7740\u7684\u4fdd\u62a4\u4f5c\u7528\u3002<!--more--><\/p>\n<p>\u7814\u7a76\u4eba\u5458\u5e0c\u671b\u627e\u5230\u5728\u9ad8\u6e17\u6027\u635f\u4f24\u5f8c\u4fdd\u6301\u773c\u7ec6\u80de\u529f\u80fd\u7684\u65b9\u6cd5\uff0c\u6765\u627e\u5230\u66f4\u597d\u7684\u5e72\u773c\u75c7\u6cbb\u7597\u7b56\u7565\u3002<br \/>\nNMN\u901a\u8fc7\u6fc0\u6d3bDNA\u7ef4\u6301\u548c\u4ee3\u8c22\u5065\u5eb7\u86cb\u767dSirtuin1\uff08SIRT1\uff09\uff0c\u6765\u4fdd\u62a4\u773c\u7ec6\u80de\uff0c\u9884\u9632\u9ad8\u6e17\u5e94\u6fc0\u5bfc\u81f4\u7684\u7ec6\u80de\u6b7b\u4ea1\uff0c\u589e\u5f3a\u4e86\u5e72\u773c\u6761\u4ef6\u4e0b\u7684\u773c\u7ec6\u80de\u5b58\u6d3b\u7387\u3002<\/p>\n<p>\u5728\u7531\u9ad8\u6e17\u538b\u5f15\u8d77\u7684\u7ec6\u80de\u4e2d\uff0cSIRT1\u86cb\u767d\u964d\u4f4e\uff0c\u708e\u75c7\u6807\u5fd7\u7269IL-17a\u6c34\u5e73\u5347\u9ad8\u3002<br \/>\n\u5728\u9ad8\u6e17\u6027\u6761\u4ef6\u4e0b\uff0c\u8865\u5145NMN\uff0c\u773c\u7ec6\u80de\u4e2dSIRT1\u86cb\u767d\u7684\u542b\u91cf\u589e\u52a0\uff0c\u5bfc\u81f4\u708e\u75c7\u6807\u5fd7\u7269IL-17a\u7684\u542b\u91cf\u964d\u4f4e\u3002\u8fd9\u4e9b\u53d1\u73b0\u8868\u660e\uff0c\u5728\u9ad8\u6e17\u6761\u4ef6\u4e0b\uff0c\u901a\u8fc7\u589e\u52a0\u548c\u6fc0\u6d3bSIRT1\uff0cNMN\u53ef\u51cf\u8f7b\u773c\u90e8\u708e\u75c7\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-17394\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/03\/244508585_357914236129611_6285832553214534838_n.jpg\" alt=\"\" width=\"960\" height=\"640\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/03\/244508585_357914236129611_6285832553214534838_n.jpg 960w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/03\/244508585_357914236129611_6285832553214534838_n-300x200.jpg 300w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/03\/244508585_357914236129611_6285832553214534838_n-768x512.jpg 768w\" sizes=\"auto, (max-width: 960px) 100vw, 960px\" \/><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-17395\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/03\/244681106_357914262796275_323547612604378289_n.jpg\" alt=\"\" width=\"699\" height=\"678\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/03\/244681106_357914262796275_323547612604378289_n.jpg 699w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/03\/244681106_357914262796275_323547612604378289_n-300x291.jpg 300w\" sizes=\"auto, (max-width: 699px) 100vw, 699px\" \/><\/p>\n<div class=\"pvc_clear\"><\/div>\n<p id=\"pvc_stats_506\" class=\"pvc_stats all  \" data-element-id=\"506\" style=\"\"><i class=\"pvc-stats-icon medium\" aria-hidden=\"true\"><svg aria-hidden=\"true\" focusable=\"false\" data-prefix=\"far\" data-icon=\"chart-bar\" role=\"img\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\" class=\"svg-inline--fa fa-chart-bar fa-w-16 fa-2x\"><path fill=\"currentColor\" d=\"M396.8 352h22.4c6.4 0 12.8-6.4 12.8-12.8V108.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v230.4c0 6.4 6.4 12.8 12.8 12.8zm-192 0h22.4c6.4 0 12.8-6.4 12.8-12.8V140.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v198.4c0 6.4 6.4 12.8 12.8 12.8zm96 0h22.4c6.4 0 12.8-6.4 12.8-12.8V204.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v134.4c0 6.4 6.4 12.8 12.8 12.8zM496 400H48V80c0-8.84-7.16-16-16-16H16C7.16 64 0 71.16 0 80v336c0 17.67 14.33 32 32 32h464c8.84 0 16-7.16 16-16v-16c0-8.84-7.16-16-16-16zm-387.2-48h22.4c6.4 0 12.8-6.4 12.8-12.8v-70.4c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v70.4c0 6.4 6.4 12.8 12.8 12.8z\" class=\"\"><\/path><\/svg><\/i> <img loading=\"lazy\" decoding=\"async\" width=\"16\" height=\"16\" alt=\"Loading\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/plugins\/page-views-count\/ajax-loader-2x.gif\" border=0 \/><\/p>\n<div class=\"pvc_clear\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u5e72\u773c\u75c7\u662f\u4ee5\u773c\u775b\u5e72\u6da9\u4e3a\u4e3b\u8981\u75c7\u72b6\u7684\u6cea\u6db2\u5206\u6ccc\u969c\u788d\u6027\u773c\u75c5\uff0c\u53ef\u80fd\u4f1a\u9020\u6210\u773c\u8868\u53d7\u4f24\uff0c\u751a\u81f3\u662f\u89c6\u529b\u969c\u788d\u7b49\u3002 \u957f\u671f\u70b9\u67d0\u4e9b\u4e0d\u826f\u773c\u836f\u6c34\u4e36\u957f\u671f\u6234\u9690\u5f62\u773c\u955c\u4e36\u7f3a\u4e4f\u7ef4\u751f\u7d20A1\u7b49\u90fd\u6709\u53ef\u80fd\u5bfc\u81f4\u5e72\u773c\u75c5\u3002 \u5e38\u719f\u5e02\u7b2c\u4e8c\u4eba\u6c11\u533b\u9662\u5728\u300aJournal of Inflammation Research\u300b\u6742\u5fd7\u4e0a\u53d1\u8868\u4e86\u4e00\u9879\u7814\u7a76\uff0c\u53d1\u73b0NMN\u5bf9\u773c\u7ec6\u80de\u5177\u6709\u663e\u7740\u7684\u4fdd\u62a4\u4f5c\u7528\u3002<\/p>\n<div class=\"pvc_clear\"><\/div>\n<p id=\"pvc_stats_506\" class=\"pvc_stats all  \" data-element-id=\"506\" style=\"\"><i class=\"pvc-stats-icon medium\" aria-hidden=\"true\"><svg aria-hidden=\"true\" focusable=\"false\" data-prefix=\"far\" data-icon=\"chart-bar\" role=\"img\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\" class=\"svg-inline--fa fa-chart-bar fa-w-16 fa-2x\"><path fill=\"currentColor\" d=\"M396.8 352h22.4c6.4 0 12.8-6.4 12.8-12.8V108.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v230.4c0 6.4 6.4 12.8 12.8 12.8zm-192 0h22.4c6.4 0 12.8-6.4 12.8-12.8V140.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v198.4c0 6.4 6.4 12.8 12.8 12.8zm96 0h22.4c6.4 0 12.8-6.4 12.8-12.8V204.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v134.4c0 6.4 6.4 12.8 12.8 12.8zM496 400H48V80c0-8.84-7.16-16-16-16H16C7.16 64 0 71.16 0 80v336c0 17.67 14.33 32 32 32h464c8.84 0 16-7.16 16-16v-16c0-8.84-7.16-16-16-16zm-387.2-48h22.4c6.4 0 12.8-6.4 12.8-12.8v-70.4c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v70.4c0 6.4 6.4 12.8 12.8 12.8z\" class=\"\"><\/path><\/svg><\/i> <img loading=\"lazy\" decoding=\"async\" width=\"16\" height=\"16\" alt=\"Loading\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/plugins\/page-views-count\/ajax-loader-2x.gif\" border=0 \/><\/p>\n<div class=\"pvc_clear\"><\/div>\n","protected":false},"author":1,"featured_media":17393,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[172,272],"tags":[171,291],"class_list":["post-506","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-nmn-","category-272","tag-nmn","tag-291"],"aioseo_notices":[],"_links":{"self":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts\/506","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=506"}],"version-history":[{"count":3,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts\/506\/revisions"}],"predecessor-version":[{"id":17397,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts\/506\/revisions\/17397"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/media\/17393"}],"wp:attachment":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=506"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=506"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=506"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}