{"id":500,"date":"2022-03-23T04:09:35","date_gmt":"2022-03-23T04:09:35","guid":{"rendered":"http:\/\/choosebiz.me\/?p=500"},"modified":"2022-05-27T03:25:41","modified_gmt":"2022-05-27T03:25:41","slug":"%e7%a0%94%e7%a9%b6%e4%ba%ba%e5%93%a1%e6%8f%90%e5%87%ba-nmn%e5%8f%af%e4%bb%a5%e5%be%9e%e5%b0%8f%e9%bc%a0%e4%b8%ad%e9%a3%8e%e6%8d%9f%e4%bc%a4%e4%b8%ad%e4%bf%9d%e6%8a%a4%e5%a4%a7%e8%84%91","status":"publish","type":"post","link":"http:\/\/johnhealth.blog\/ch\/?p=500","title":{"rendered":"\u7814\u7a76\u4eba\u54e1\u63d0\u51fa NMN\u53ef\u4ee5\u5f9e\u5c0f\u9f20\u4e2d\u98ce\u635f\u4f24\u4e2d\u4fdd\u62a4\u5927\u8111"},"content":{"rendered":"

\u4f86\u81ea\u4e2d\u570b\u7684\u7814\u7a76\u4eba\u54e1\u767c\u73fe\uff0c\u7159\u9170\u80fa\u55ae\u6838\u82f7\u9178 (NMN) \u53ef\u4ee5\u4fdd\u8b77\u8166\u51fa\u8840\u5f8c\u5c0f\u9f20\u7684\u8166\u7d44\u7e54\u548c\u529f\u80fd\u3002<\/p>\n

\"\"<\/p>\n

By\u00a0Brett J. Weiss\u00a0Published:\u00a04:34 p.m. PST Mar 7, 2020\u00a0| Updated:\u00a012:08 p.m. PST Sep 22, 2020<\/p>\n

\u5373\u4f7f\u5728\u904e\u53bb\u7684 20 \u5e74\u88e1\u91ab\u5b78\u6709\u5f88\u591a\u7684\u9032\u6b65\uff0c\u8166\u51fa\u8840\u7684\u6b7b\u4ea1\u7387\u4e5f\u5e7e\u4e4e\u6c92\u6709\u8b8a\u5316\u2014\u2014\u8166\u5167\u51fa\u8840\u662f\u4e00\u7a2e\u7dca\u6025\u60c5\u6cc1\uff0c\u5176\u4e2d\u8840\u7ba1\u7834\u88c2\u5c0e\u81f4\u8166\u5167\u51fa\u8840\u3002<\/p>\n

\u73fe\u5728\uff0c\u4e0a\u6d77\u4ea4\u901a\u5927\u5b78\u7684\u4e00\u500b\u7814\u7a76\u5c0f\u7d44\u8868\u660e\uff0c\u6ce8\u5c04\u7159\u9170\u80fa\u55ae\u6838\u82f7\u9178\uff08NMN\uff09\u53ef\u986f\u8457\u964d\u4f4e\u4e2d\u98a8\u6b7b\u4ea1\u7387\u4e26\u4fc3\u9032\u5c0f\u9f20\u5f9e\u4e2d\u98a8\u4e2d\u7684\u529f\u80fd\u6062\u5fa9\u3002\u00a0\u201cNMN\u53ef\u4ee5\u6709\u6548\u6539\u5584\u8166\u51fa\u8840\u5c0d\u5c0f\u9f20\u7684\u7d44\u7e54\u3001\u7d30\u80de\u548c\u795e\u7d93\u7684\u640d\u50b7\uff0c\u63d0\u9ad8\u5c0f\u9f20\u7684\u5b58\u6d3b\u7387\u3002\u201dShu\u53ca\u5176\u540c\u4e8b\u7e3d\u7d50\u9053\u3002<\/p>\n

NMN \u4fdd\u8b77\u5c0f\u9f20\u5927\u8166\u514d\u53d7\u8166\u51fa\u8840\u640d\u50b7<\/p>\n

\u5728\u9019\u9805\u7814\u7a76\u4e2d\uff0cShu \u53ca\u5176\u540c\u4e8b\u6bcf\u5929\u5411\u8166\u51fa\u8840\u7684\u5c0f\u9f20\u6ce8\u5c04 NMN\uff08500 mg\/kg\uff09\u4e00\u6b21\uff0c\u6301\u7e8c\u4e00\u9031\u591a\u3002\u00a0\u5728\u63a5\u53d7\u9019\u7a2e\u6cbb\u7642\u5f8c\uff0c\u4f4d\u65bc\u4e0a\u6d77\u7684\u7814\u7a76\u5c0f\u7d44\u6aa2\u67e5\u4e86\u9019\u4e9b\u5c0f\u9f20\u7684\u9ad4\u91cd\u3001\u795e\u7d93\u529f\u80fd\u548c\u7d30\u80de\u61c9\u6fc0\u7684\u6062\u5fa9\u60c5\u6cc1\u3002<\/p>\n

Shu \u53ca\u5176\u540c\u4e8b\u767c\u73fe\uff0cNMN \u6709\u52a9\u65bc\u8166\u7d30\u80de\uff08\u795e\u7d93\u5143\uff09\u514d\u53d7\u8166\u51fa\u8840\u6642\u7684\u58d3\u529b\u3002\u00a0\u4e0a\u6d77\u4ea4\u901a\u5927\u5b78\u7684\u7814\u7a76\u5c0f\u7d44\u9084\u767c\u73fe\uff0c\u63a5\u53d7 NMN \u6cbb\u7642\u7684\u8166\u51fa\u8840\u5c0f\u9f20\u7684\u795e\u7d93\u529f\u80fd\u6709\u6240\u6539\u5584\u3002<\/p>\n

(Shu et al., 2020 |<\/strong><\/a>\u00a0Saudi J Biol Sci<\/strong><\/em><\/a>)<\/strong><\/a>\u00a0NMN \u6539\u5584\u4e86\u8166\u51fa\u8840\u5c0f\u9f20\u7684\u795e\u7d93\u529f\u80fd\u3002<\/strong>\u00a0\u7d66\u85e5\u4e00\u5929\u5f8c\uff0c\u63a5\u53d7 NMN (cICH+NMN) \u6cbb\u7642\u7684\u8166\u51fa\u8840\u5c0f\u9f20\u5728\u6e2c\u8a66\u795e\u7d93\u529f\u80fd\u7684\u6a6b\u6881\u884c\u8d70\u8a66\u9a57\u4e2d\u6bd4\u672a\u63a5\u53d7\u6cbb\u7642\u7684\u5c0f\u9f20 (cICH) \u8868\u73fe\u66f4\u597d\u3002<\/p>\n

\u66f4\u91cd\u8981\u7684\u662f\uff0cShu \u53ca\u5176\u540c\u4e8b\u8868\u660e\uff0cNMN \u63d0\u9ad8\u4e86\u8166\u51fa\u8840\u5f8c\u8166\u7d30\u80de\u7684\u5b58\u6d3b\u7387\u3002 \u5728\u5c0f\u9f20\u8166\u5167\u51fa\u8840\u5f8c\uff0c\u795e\u7d93\u5143\u7684\u7d30\u80de\u6b7b\u4ea1\u96a8\u8457 NMN \u7684\u7d66\u85e5\u800c\u6e1b\u5c11\u3002<\/p>\n

\"\"<\/div>\n

(Shu et al., 2020 |<\/strong><\/a>\u00a0Saudi J Biol Sci<\/strong><\/em><\/a>)<\/strong><\/a>\u00a0NMN \u53ef\u9632\u6b62\u5c0f\u9f20\u8166\u5167\u51fa\u8840\u5f15\u8d77\u7684\u8166\u7d30\u80de\u6b7b\u4ea1\u3002\u00a0<\/strong>\u8a72\u5718\u968a\u4f7f\u7528\u4e00\u7a2e\u7a31\u70ba TUNEL \u67d3\u8272\u7684\u65b9\u6cd5\u5c0d\u55ae\u500b\u6b7b\u7d30\u80de\u9032\u884c\u8a08\u6578\u3002 \u5728\u5927\u8166\u548c\u4e2d\u98a8\u7684\u5927\u8166\u6700\u5916\u5c64\u4e4b\u9593\u7684\u8840\u6db2\u805a\u96c6\u5340\u57df\uff0c\u79d1\u5b78\u5bb6\u5011\u89c0\u5bdf\u5230\u66f4\u9ad8\u6fc3\u5ea6\u7684 TUNEL \u67d3\u8272\u3002<\/p>\n

\u7d50\u679c\u8868\u660e\uff0cNMN\u5c0d\u2026\u2026\u5c0f\u9f20ICH\u7684\u4fdd\u8b77\u4f5c\u7528\u660e\u986f\u512a\u65bc\u5176\u4ed6\u5169\u7d44\uff0c\u4e3b\u8981\u8868\u73fe\u5728\u5c0f\u9f20\u7684\u795e\u7d93\u529f\u80fd\u3001\u8166\u6c34\u816b\u3001\u708e\u75c7\u56e0\u5b50\u3001\u9ad4\u91cd\u548c\u7d30\u80de[\u6b7b\u4ea1]\u65b9\u9762\uff0c\u201dShu\u7e3d\u7d50\u9053\u3002 \u9019\u9805\u7814\u7a76\u8868\u660e\uff0cNMN \u53ef\u80fd\u662f\u958b\u767c\u6cbb\u7642\u8166\u51fa\u8840\u4e2d\u98a8\u65b0\u7b56\u7565\u7684\u95dc\u9375\u3002<\/p>\n

\u7136\u800c\uff0c\u9019\u9805\u7814\u7a76\u6709\u4e00\u4e9b\u4e3b\u8981\u4fb7\u9650\u6027\u3002 \u4f8b\u5982\uff0cShu \u53ca\u5176\u540c\u4e8b\u4f7f\u7528\u7684\u6a23\u672c\u592a\u5c11\uff0c\u7121\u6cd5\u7522\u751f\u4ee4\u4eba\u4fe1\u670d\u7684\u7d50\u679c\u3002 \u9019\u4e9b\u5be6\u9a57\u9700\u8981\u7528\u66f4\u591a\u7684\u6a23\u672c\u91cd\u8907\u9032\u884c\uff0c\u4ee5\u66f4\u597d\u5730\u5efa\u7acb NMN \u4fdd\u8b77\u8166\u7d44\u7e54\u548c\u529f\u80fd\u7684\u80fd\u529b\u3002<\/p>\n

\u53c3\u8003\u6587\u737b:Liang Shu, Xiaolei Shen, Yaxue Zhao, Xinwei He, Jiawen Yin, Jingjing Su, Qiang Li, Jianren Liu.\u00a0\u00a0Mechanisms of transformation of nicotinamide mononucleotides to cerebral infarction hemorrhage based on MCAO model.\u00a0\u00a0Saudi J Biol Sci, 2020; DOI:\u00a010.1016\/j.sjbs.2019.12.023<\/a>.<\/p>\n

\u6587\u7ae0\u4f86\u6e90: https:\/\/www.nmn.com\/news\/nmn-protects-brain-tissue-in-intracerebral-hemorrhage-mouse-model<\/p>\n

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<\/div>\n","protected":false},"excerpt":{"rendered":"

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