{"id":483,"date":"2022-03-21T03:41:22","date_gmt":"2022-03-21T03:41:22","guid":{"rendered":"http:\/\/choosebiz.me\/?p=483"},"modified":"2022-05-29T02:28:53","modified_gmt":"2022-05-29T02:28:53","slug":"%e9%95%bf%e5%af%bf%e8%9b%8b%e7%99%bdsirt%e5%ae%b6%e6%97%8f%e4%bb%8b%e7%bb%8d","status":"publish","type":"post","link":"http:\/\/johnhealth.blog\/ch\/?p=483","title":{"rendered":"\u957f\u5bff\u86cb\u767dSirt\u5bb6\u65cf\u4ecb\u7ecd"},"content":{"rendered":"

Sirtuins\u5bb6\u65cf\u7684\u86cb\u767d\u8fd8\u6709\u53e6\u4e00\u4e2a\u540d\u53f7\uff1a\u957f\u5bff\u86cb\u767d<\/strong><\/span>\u3002\u8bb8\u591a\u6211\u4eec\u8033\u719f\u80fd\u8be6\u7684\u6240\u8c13”\u795e\u836f”\u90fd\u9700\u8981\u4f9d\u9760\u8fd9\u4e2a\u5bb6\u65cf\u6765\u53d1\u6325\u795e\u529b\uff01\u4eca\u5929\u6211\u4eec\u5c31\u6765\u770b\u770bSirtuins\u86cb\u767d\u5bb6\u65cf\u5230\u5e95\u662f\u4e2a\u4ec0\u4e48\u5927\u5bb6\u65cf\uff01<\/p>\n

\u4e00\u3001\u957f\u5bff\u86cb\u767dSirt\u5bb6\u65cf\u4ecb\u7ecd<\/h1>\n

1979\u5e74\uff0c\u6709\u4e00\u4f4d\u8001\u4eba\u5728\u52a0\u5dde\u5927\u5b66\u4f2f\u514b\u5229\u5206\u6821\u5bf9\u9175\u6bcd\u7684\u7814\u7a76\u4e2d\u53d1\u73b0\u4e86\u4e00\u79cd\u53ef\u4ee5\u4f7f\u57fa\u56e0\u5ea7\u6c89\u9ed8\u7684\u86cb\u767d\uff08MAR1\uff09\uff0c\u540c\u5e74\u665a\u4e9b\u65f6\u5019\u53c8\u6709\u4e09\u79cd\u5177\u6709\u7c7b\u4f3c\u529f\u80fd\u7684\u86cb\u767d\u8d28\u88ab\u53d1\u73b0\uff0c\u7ecf\u8fc7\u7edf\u4e00\u547d\u540d\uff0c\u5b83\u4eec\u6210\u4e3a\u4e86Sir\u86cb\u767d\u5bb6\u65cf\uff08\u6c89\u9ed8\u4fe1\u606f\u8c03\u8282\u86cb\u767d\uff09\uff0c\u800cMAR1\u4e5f\u88ab\u66f4\u540d\u4e3aSir2\u3002<\/p>\n

\u8fd9\u662fSirtuins\u7684\u975e\u4eba\u524d\u4e16\uff0c\u968f\u7740\u5728\u5176\u5b83\u5404\u7269\u79cd\u4e2dSir2\u540c\u6e90\u86cb\u767d\u7684\u53d1\u73b0\uff0c\u73b0\u5df2\u5c06\u5b83\u4eec\u7edf\u79f0\u4e3aSir2\u76f8\u5173\u9176\u7c7b\uff0c\u4e5f\u5c31\u662f\u4eca\u5929\u6211\u4eec\u7684\u4e3b\u89d2\uff1aSirtuins\u3002<\/p>\n

Sirtuins\u662f\u4e00\u79cd\u4ece\u7ec6\u83cc\u5230\u4eba\u7c7b\u9ad8\u5ea6\u4fdd\u5b88\u7684\u53bb\u4e59\u9170\u5316\u9176<\/strong>\u7c7b\u3002\u4e59\u9170\u5316\u662f\u4e00\u79cd\u86cb\u767d\u8d28\u7684\u7ffb\u8bd1\u540e\u4fee\u9970\uff0c\u5b83\u53ef\u4ee5\u5f71\u54cd\u86cb\u767d\u8d28\u7684\u50ac\u5316\u6d3b\u6027\u3001\u7a33\u5b9a\u6027\u4ee5\u53ca\u4e0e\u5176\u5b83\u86cb\u767d\u8d28\u6216\u67d3\u8272\u8d28\u7ed3\u5408\u7684\u80fd\u529b\u3002Sirtuins\u53ef\u4ee5\u4f7f\u7ec4\u86cb\u767d\u3001\u4e00\u4e9b\u8f6c\u5f55\u56e0\u5b50\u548c\u80de\u8d28\u5185\u7684\u86cb\u767d\u53bb\u4e59\u9170\u5316\uff0c\u4ece\u800c\u8c03\u63a7\u5b83\u4eec\u7684\u529f\u80fd\u2026\u2026Sirtuins\u4e5f\u6b63\u662f\u901a\u8fc7\u8fd9\u4e2a\u529f\u80fd\u6765\u6c89\u9ed8\u86cb\u767d\u7684\u3002<\/p>\n

\"\"<\/p>\n

\u53e6\u4e00\u65b9\u9762\uff0cSirtuins\u5c5e\u4e8eIII\u7c7b\u7ec4\u86cb\u767d\u53bb\u4e59\u9170\u5316\u9176\uff08HDAC\uff09\u3002\u8fd9\u7c7bHDAC\u7684\u663e\u8457\u7279\u70b9\u662f\u9176\u7684\u50ac\u5316\u6d3b\u6027\u53d6\u51b3\u4e8eNAD+\uff0c\u5e76\u53d7NAD+\/NADH\u6bd4\u7684\u52a8\u6001\u53d8\u5316\u8c03\u8282<\/strong>\uff0c\u8fd9\u8868\u660e\uff0cSirtuins\u53ef\u80fd\u5df2\u7ecf\u6f14\u5316\u4e3a\u7ec6\u80de\u4e2d\u80fd\u91cf\u548c\u6c27\u5316\u8fd8\u539f\u72b6\u6001\u7684\u4f20\u611f\u5668\u3002<\/p>\n

\"\"<\/p>\n

<\/figure>\n

\u5728\u4eba\u7c7b\u4e2d\uff0c\u5df2\u7ecf\u53d1\u73b0\u4e867\u4e2aSirtuins\u5bb6\u65cf\u6210\u5458\uff1aSIRT1~SIRT7<\/strong>\uff0c\u5b83\u4eec\u7684\u50ac\u5316\u7ed3\u6784\u57df\u7531275\u4e2a\u6c28\u57fa\u9178\u7ec4\u6210\uff0c\u662f\u6240\u6709\u5bb6\u65cf\u6210\u5458\u5171\u6709\u7684\u3002<\/p>\n

\u76ee\u524d\u5bf9\u8fd9\u4e9b\u86cb\u767d\u7684\u5b9a\u4f4d\u3001\u76f8\u4e92\u4f5c\u7528\u86cb\u767d\u3001\u529f\u80fd\u7b49\u603b\u7ed3\u5982\u4e0b<\/p>\n

\"\"<\/p>\n

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  • \n
      \n
    • a. SIRT1\u3001SIRT6\u548cSIRT7\u4e3b\u8981\u4f4d\u4e8e\u7ec6\u80de\u6838\u4e2d\u3002\u5df2\u53d1\u73b0SIRT7\u662fRNA Pol I\u8f6c\u5f55\u673a\u5236\u7684\u4e00\u90e8\u5206\uff0c\u5e76\u5728\u6838\u4ec1\u4e2d\u8868\u8fbe\uff0c\u53ef\u4e0e\u7ec4\u86cb\u767d\u7ed3\u5408\u5e76\u6b63\u5411\u8c03\u8282\u6838\u7cd6\u4f53DNA\uff08rDNA\uff09\u8f6c\u5f55\u3002<\/li>\n
    • b. SIRT2\u4e3b\u8981\u5b58\u5728\u4e8e\u7ec6\u80de\u8d28\u4e2d\uff0c\u5176\u4e3b\u8981\u5e95\u7269\u662f\u03b1-tubulin\u3002\u4ecd\u7136\u6709\u4e00\u90e8\u5206SIRT2\u53ef\u4ee5\u8f6c\u79fb\u5230\u7ec6\u80de\u6838\u4e2d\uff0c\u53c2\u4e0e\u7ec6\u80de\u5468\u671f\u7684\u8c03\u8282\u3002<\/li>\n
    • c. SIRT3\u3001SIRT4\u548cSIRT5\u88ab\u79f0\u4e3a\u7ebf\u7c92\u4f53Sirtuins\u3002SIRT3\u88ab\u7ebf\u7c92\u4f53\u57fa\u8d28\u52a0\u5de5\u80bd\u9176\u5207\u5272\u6210\u5176\u6d3b\u6027\u5f62\u5f0f\u3002\u5168\u957fSIRT3\u9a7b\u7559\u5728\u7ec6\u80de\u6838\u4e2d\uff0c\u4f46\u662f\uff0c\u5f53\u54cd\u5e94\u538b\u529b\uff08\u4f8b\u5982DNA\u635f\u4f24\uff09\u65f6\uff0c\u5b83\u4f1a\u8fc1\u79fb\u5230\u7ebf\u7c92\u4f53\u5185\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

      \u4e8c\u3001 Sirt\u86cb\u767d\u5bb6\u65cf\u4e0e\u8870\u8001<\/h1>\n

      \u867d\u7136\u65e9\u57281979\u5e74\u5c31\u88ab\u53d1\u73b0\uff0c\u4f46\u4eba\u4eec\u771f\u6b63\u5f00\u59cb\u5bf9Sirtuins\u86cb\u767d\u5bb6\u65cf\u611f\u5174\u8da3\u8fd8\u662f\u57281999\u5e74\u53d1\u73b0Sir2\u7684\u8fc7\u8868\u8fbe\u53ef\u4ee5\u5c06\u9175\u6bcd\u7684\u5bff\u547d\u5ef6\u957f\u591a\u8fbe70%<\/strong>\u4e4b\u540e\u3002\u6b64\u5916\uff0cSirtuins\u7684\u8fc7\u5ea6\u8868\u8fbe\u4e5f\u4f1a\u5bfc\u81f4\u7ebf\u866b\u548c\u679c\u8747\u7684\u5bff\u547d\u5ef6\u957f\u2026\u2026\u7136\u800c\uff0c\u8fd8\u662f\u90a3\u53e5\u8bdd\uff0c\u8c01\u7ba1\u9175\u6bcd\u3001\u7ebf\u866b\u548c\u679c\u8747\u80fd\u6d3b\u591a\u4e45\uff0c\u6211\u53ea\u60f3\u77e5\u9053Sirtuins\u80fd\u4e0d\u80fd\u8ba9\u6211\u957f\u547d\u767e\u5c81\uff01<\/p>\n

      \u6211\u4eec\u6765\u770b\u770b\u4ee5\u4e0b\u8fd9\u4e9b\u7ebf\u7d22\u5427\uff1a<\/p>\n

      1\u3001Sirtuins\u4e0eDNA\u4fee\u590d<\/strong><\/span><\/p>\n

      \u4eba\u4eec\u8ba4\u4e3a\u4e0d\u53ef\u4fee\u590d\u7684DNA\u635f\u4f24\u662f\u7ec6\u80de\u8870\u8001\u7684\u57fa\u672c\u539f\u56e0\u4e4b\u4e00\uff0c\u4e0e\u5e74\u9f84\u76f8\u5173\u7684DNA\u4fee\u590d\u80fd\u529b\u4e0b\u964d\u4f1a\u5bfc\u81f4\u635f\u4f24\u79ef\u7d2f\u589e\u52a0\uff0c\u8fdb\u800c\u5bfc\u81f4\u7ec6\u80de\u8870\u8001\u3002Sirtuins\u5bf9\u4e8eDNA\u4fee\u590d\u3001\u63a7\u5236\u708e\u75c7\u548c\u6297\u6c27\u5316\u9632\u5fa1\u5fc5\u4e0d\u53ef\u5c11<\/strong>\uff0c\u8fd9\u4f7f\u5176\u6210\u4e3a\u826f\u597d\u7684\u6297\u8870\u8001\u9776\u70b9\u3002\uff08\u76f8\u5173Sirtuins\u86cb\u767d\uff1aSIRT1<\/strong>\u3001SIRT6<\/strong>\u3001SIRT4\uff09<\/p>\n

      2\u3001Sirtuins\u4e0e\u6c27\u5316\u5e94\u6fc0\u548c\u80fd\u91cf\u4ee3\u8c22<\/strong><\/span><\/p>\n

      \u5728Sirtuins\u4e2d\uff0cSIRT3\u5728\u6297\u6c27\u5316\u9632\u5fa1\u4e2d\u8d77\u7740\u6700\u91cd\u8981\u7684\u4f5c\u7528\u3002 SIRT3\u4f7f\u7ebf\u7c92\u4f53\u590d\u5408\u7269I\u548cIII\u53bb\u4e59\u9170\u5316\u5bfc\u81f4\u7535\u5b50\u4f20\u8f93\u6548\u7387\u63d0\u9ad8\uff0c\u4ece\u800c\u963b\u6b62\u4e86ROS\u7684\u4ea7\u751f\u3002\u53e6\u5916\uff0cSirtuins\u8fd8\u53ef\u4ee5\u901a\u8fc7\u8c03\u8282\u6297\u6c27\u5316\u9176\u7684\u6c34\u5e73\u548c\u6d3b\u6027\u6765\u62b5\u6d88\u6c27\u5316\u5e94\u6fc0\u3002\uff08\u76f8\u5173Sirtuins\u86cb\u767d\uff1aSIRT3<\/strong>\u3001SIRT1<\/strong>\u3001SIRT5\uff09<\/p>\n

      3\u3001Sirtuins\u4e0e\u548c\u5bff\u547d\u76f8\u5173\u7684\u4fe1\u53f7\u901a\u8def<\/strong><\/span><\/p>\n

      \u4ece\u4e0a\u9762\u7684\u8868\u4e2d\u6211\u4eec\u53ef\u4ee5\u770b\u5230\uff0cSirtuins\u6fc0\u6d3b\u4fc3\u8fdb\u957f\u5bff\u7684AMPK\u3001FOXO\u7b49\u4fe1\u53f7\u901a\u8def\uff0c\u6291\u5236mTOR\u4fe1\u53f7\u901a\u8def\uff0c\u6bcf\u4e00\u6b65\u90fd\u662f\u5728\u5411\u957f\u5bff\u8fc8\u8fd1\u2026\u2026<\/p>\n

      \"\"<\/p>\n

      4\u3001Sirtuins\u4e0e\u70ed\u91cf\u9650\u5236\uff08\u5c11\u5403\uff09<\/strong><\/span><\/p>\n

      \u8fc4\u4eca\u4e3a\u6b62\uff0c\u70ed\u91cf\u9650\u5236\uff08\u5c11\u5403\uff09\u662f\u65e0\u9700\u9057\u4f20\u6216\u836f\u7269\u5e72\u9884\u5ef6\u957f\u5bff\u547d\u7684\u552f\u4e00\u6709\u6548\u65b9\u6cd5<\/strong>\u3002\u70ed\u91cf\u9650\u5236\u7684\u5f71\u54cd\uff08\u9664\u4e86\u5ef6\u957f\u5bff\u547d\uff09\u8868\u73b0\u4e3a\u751f\u7406\u548c\u884c\u4e3a\u4e0a\u7684\u53d8\u5316\uff0c\u4f8b\u5982\u4f53\u91cd\u51cf\u5c11\uff0c\u751f\u957f\u56e0\u5b50\u3001\u8461\u8404\u7cd6\u3001\u7518\u6cb9\u4e09\u9178\u916f\u6c34\u5e73\u964d\u4f4e\u4ee5\u53ca\u8fd0\u52a8\u548c\u89c5\u98df\u6d3b\u52a8\u589e\u52a0\u3002\u9664SIRT4\u5916\uff0c\u51e0\u4e4e\u6240\u6709\u7684Sirtuins\u86cb\u767d\u6c34\u5e73\u90fd\u4f1a\u56e0\u70ed\u91cf\u9650\u5236\u800c\u589e\u52a0\u3002\u56e0\u6b64\uff0c\u6211\u4eec\u6709\u7406\u7531\u76f8\u4fe1Sirtuins\u4ecb\u5bfc\u4e86\u7531\u70ed\u91cf\u9650\u5236\u996e\u98df\u5f15\u8d77\u7684\u8fd9\u4e9b\u6709\u76ca\u4f5c\u7528\u3002<\/p>\n

      \u5f53\u7136\uff0cSirtuins\u5bb6\u65cf\u6d89\u53ca\u52307\u4e2a\u86cb\u767d\uff0c\u4e14\u53c2\u4e0e\u7684\u529f\u80fd\u4f17\u591a\uff0c\u603b\u7684\u6765\u8bf4Sirtuins\u6fc0\u6d3b\u4fc3\u8fdb\u957f\u5bff\u7684\u4fe1\u53f7\uff0c\u6291\u5236\u4fc3\u8fdb\u8870\u8001\u7684\u4fe1\u53f7\uff0c\u6240\u4ee5Sirtuins\u7684\u6fc0\u6d3b\u5242\uff08\u65e0\u8bba\u662f\u529f\u80fd\u6027\u98df\u54c1\u8fd8\u662f\u8425\u517b\u4fdd\u5065\u54c1\u6216\u836f\u54c1\uff09\u5bf9\u4fc3\u8fdb\u5065\u5eb7\u548c\u957f\u5bff\u4ee5\u53ca\u9884\u9632\u4e0e\u5e74\u9f84\u76f8\u5173\u7684\u75be\u75c5\u90fd\u662f\u5de8\u5927\u7684\u5e0c\u671b\u3002<\/p>\n

      \u4e09\u3001\u5982\u4f55\u6fc0\u6d3b\u5b83\u4eec\uff1f<\/h1>\n

      1\u3001\u8425\u517b\u54c1\u6216\u836f\u7269\u5e72\u9884<\/strong><\/p>\n

      \u76ee\u524d\u5df2\u7ecf\u53d1\u73b0\u7684\u6709\u6548\u7684Sirtuins\u6fc0\u6d3b\u5242\u5305\u62ec\u51e0\u7c7b\u690d\u7269\u884d\u751f\u7684\u4ee3\u8c22\u7269\uff0c\u4f8b\u5982\u9ec4\u916e\u7c7b\u3001\u82aa\u7c7b\u3001\u67e5\u8033\u916e\u3001\u82b1\u9752\u7d20<\/strong>\u548c\u59dc\u9ec4\u7d20<\/strong><\/span>\uff0c\u5b83\u4eec\u90fd\u80fd\u591f\u5728\u4f53\u5916\u76f4\u63a5\u6fc0\u6d3bSIRT1\u3002<\/p>\n

      \u53e6\u5916\u4e00\u4e9b\u5316\u5408\u7269\uff08\u5305\u62ec\u591a\u79cd\u836f\u7269\uff09\u4e5f\u5728\u4f53\u5916\u8868\u73b0\u51fa\u4e86\u6297\u8870\u8001\u7684\u4f5c\u7528\uff0c\u6bd4\u5982\u767d\u85dc\u82a6\u9187\u3001\u897f\u6d1b\u4ed6\u5511\u3001\u4e39\u76ae\u915a\u3001\u4ed6\u6c40\u7c7b\u836f\u7269\u3001\u786b\u5316\u6c22<\/strong>\u7b49\u3002<\/p>\n

      \u5176\u4e2d\u7814\u7a76\u6700\u591a\u7684\u5929\u7136\u5316\u5408\u7269\u5c31\u662f\u767d\u85dc\u82a6\u9187<\/strong><\/span>\uff0c\u8bb8\u591a\u8bba\u6587\u90fd\u603b\u7ed3\u4e86\u5176\u5728\u7ec6\u80de\u548c\u751f\u7269\u6c34\u5e73\u4e0a\u5bf9Sirtuins\u7684\u6fc0\u6d3b\u4f5c\u7528\u3002\u901a\u8fc7\u8865\u5145\u767d\u85dc\u82a6\u9187\u6fc0\u6d3bSIRT1\u53ef\u4ee5\u5ef6\u957f\u4e00\u4e9b\u7269\u79cd\u7684\u5bff\u547d\u5e76\u6539\u5584\u5176\u5065\u5eb7\u72b6\u51b5\uff0c\u8fd9\u4e00\u4f5c\u7528\u662f\u901a\u8fc7\u6a21\u62df\u70ed\u91cf\u9650\u5236\u6765\u5b9e\u73b0\u7684\u3002\u5728\u4eba\u7c7b\u4e8c\u500d\u4f53\u6210\u7ea4\u7ef4\u7ec6\u80de\u4e2d\uff0c\u767d\u85dc\u82a6\u9187\u51cf\u5c11\u6216\u5ef6\u8fdf\u4e86\u7ec6\u80de\u8870\u8001\u3002<\/p>\n

      \u5176\u5b83\u7684\u5929\u7136\u6297\u8870\u8001\u5316\u5408\u7269\u5305\u62ec\uff1a\u69f2\u76ae\u7d20\u3001\u4e01\u9178\u3001\u975e\u745f\u916e\u3001\u5c71\u5948\u915a\u3001\u513f\u8336\u7d20\u548c\u539f\u82b1\u9752\u7d20<\/strong><\/span>\u3002\u6211\u4eec\u770b\u5230\u7684\u51e0\u4efd\u62a5\u544a\u5f3a\u8c03\uff0c\u81b3\u98df\u4e2d\u7684\u591a\u915a<\/strong>\uff08\u5305\u62ec\u767d\u85dc\u82a6\u9187\u3001\u59dc\u9ec4\u7d20\u7b49\uff09\u7684\u8865\u5145\u53ef\u4ee5\u901a\u8fc7\u589e\u5f3aSIRT1\u7684\u53bb\u4e59\u9170\u57fa\u9176\u6d3b\u6027\u6765\u9884\u9632\u795e\u7ecf\u53d8\u6027\u3001\u5fc3\u8840\u7ba1\u75be\u75c5\u3001\u708e\u75c7\u3001\u4ee3\u8c22\u6027\u75be\u75c5\u548c\u764c\u75c7\u2026\u2026<\/p>\n

      2013\u5e74\u6297\u8870\u8001\u5148\u9a71\uff1a\u54c8\u4f5b\u6559\u6388David Sinclair \u53c8\u4e00\u60ca\u4eba\u53d1\u73b0\uff1a\u8865\u5145NMN\u53ef\u4ee5\u589e\u52a0\u4f53\u5185NAD+\u6c34\u5e73\uff0c\u6fc0\u6d3b\u548c\u542f\u52a8\u5168\u90e8\u4eba\u7684 7\u4e2a\u957f\u5bff\u57fa\u56e0<\/p>\n

      \"\"<\/p>\n

      \"\"<\/p>\n

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