{"id":463,"date":"2022-03-17T14:23:25","date_gmt":"2022-03-17T14:23:25","guid":{"rendered":"http:\/\/choosebiz.me\/?p=463"},"modified":"2022-05-27T03:26:21","modified_gmt":"2022-05-27T03:26:21","slug":"%e3%80%90%e7%a7%91%e6%8a%80%e8%bf%9b%e5%b1%95%e3%80%91%e7%a0%94%e7%a9%b6%e8%a1%a8%e6%98%8e-nmm%e5%8f%af%e8%83%bd%e5%af%b9%e7%bd%95%e8%a7%81%e7%9a%84%e4%bc%a0%e6%9f%93%e6%80%a7%e7%a5%9e%e7%bb%8f","status":"publish","type":"post","link":"http:\/\/johnhealth.blog\/ch\/?p=463","title":{"rendered":"\u3010\u79d1\u6280\u8fdb\u5c55\u3011\u7814\u7a76\u8868\u660e NMM\u53ef\u80fd\u5bf9\u7f55\u89c1\u7684\u4f20\u67d3\u6027\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u6709\u5e2e\u52a9"},"content":{"rendered":"<p>\u7528\u70df\u9170\u80fa\u5355\u6838\u82f7\u9178 \uff08NMN\uff09 \u63d0\u9ad8 NAD+ \u6c34\u5e73\u53ef\u6539\u5584\u7531\u670a\u75c5\u6bd2\u75be\u75c5\u5f15\u8d77\u7684\u53d7\u635f\u7c92\u7ebf\u4f53\u7684\u6e05\u9664\u7f3a\u9677\uff0c\u4ece\u800c\u4fdd\u62a4\u8fd9\u4e9b\u795e\u7ecf\u5143\u514d\u4e8e\u7ec6\u80de\u6b7b\u4ea1\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-17409\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/03\/nerve.jpg\" alt=\"\" width=\"672\" height=\"416\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/03\/nerve.jpg 672w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/03\/nerve-300x186.jpg 300w\" sizes=\"auto, (max-width: 672px) 100vw, 672px\" \/><\/p>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"s-component-content s-font-body\">\n<p class=\"author\">By\u00a0Jonathan D. Grinstein, Ph.D.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"s-component-content s-font-body\">\n<p class=\"date main-color-g\">Published:\u00a02:29 p.m. PST Feb 24, 2022\u00a0| Updated:\u00a010:49 am PST Mar 2, 2022<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"s-component-content s-font-body\">\n<p><strong>\u91cd\u5927\u4eae\u70b9<\/strong><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"s-component-content s-font-body\">\n<ul>\n<li>\u5728\u4e00\u79cd\u88ab\u79f0\u4e3a\u670a\u75c5\u6bd2\u75c5\u7684\u7f55\u89c1\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u7684\u5c0f\u9f20\u7ec6\u80de\u6a21\u578b\u4e2d\uff0c\u7c92\u7ebf\u4f53\u81ea\u566c&#8211;\u6e05\u9664\u53d7\u635f\u7684\u7c92\u7ebf\u4f53&#8211;\u7684\u529f\u80fd\u53d7\u635f\u3002<\/li>\n<li>\u5728\u60a3\u6709\u670a\u75c5\u6bd2\u75c5\u7684\u795e\u7ecf\u7ec6\u80de\u4e2d\u8865\u5145NMN\u6216\u5c3f\u77f3\u7d20A\uff08UA\uff09\u53ef\u660e\u663e\u6062\u590d\u7c92\u7ebf\u4f53\u541e\u566c\u4f5c\u7528\u3002<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<p><!--more--><\/p>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"s-component-content s-font-body\">\n<p>\u7136\u800c\uff0c\u53ea\u6709NMN\u800c\u4e0d\u662fUA\u80fd\u7f13\u89e3\u670a\u75c5\u6bd2\u5f15\u8d77\u7684\u7c92\u7ebf\u4f53\u635f\u4f24\u548c\u529f\u80fd\u969c\u788d\u4ee5\u53ca\u795e\u7ecf\u5143\u7ec6\u80de\u6b7b\u4ea1\u3002<\/p>\n<p><span style=\"font-size: 1rem;\">\u7531\u4e8e 2003 \u5e74\u82f1\u56fd\u7206\u53d1&#8221;\u75af\u725b\u75c5&#8221;\u800c\u5f15\u8d77\u516c\u4f17\u5173\u6ce8\u7684\u670a\u75c5\u6bd2\u75c5\u662f\u4e00\u7ec4\u53ef\u4ee5\u611f\u67d3\u4eba\u7c7b\u548c\u52a8\u7269\u7684\u6162\u6027\u3001\u81f4\u547d\u7684\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u3002 \u4e0e\u8bb8\u591a\u5176\u4ed6\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u4e00\u6837\uff0c\u5c24\u5176\u662f\u90a3\u4e9b\u4e0e\u5e74\u9f84\u76f8\u5173\u7684\u75be\u75c5\uff0c\u670a\u75c5\u6bd2\u75be\u75c5\u2014\u2014\u6216\u4f20\u67d3\u6027\u6d77\u7ef5\u72b6\u8111\u75c5 \uff08TSEs\uff09\u2014\u2014\u6d89\u53ca\u9519\u8bef\u6298\u53e0\u7684\u86cb\u767d\u8d28\uff0c\u5982\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u548c\u5e15\u91d1\u68ee\u75c5\uff0c\u901a\u5e38\u53d7\u5230\u795e\u7ecf\u5143\u4f53\u6301\u7eed\u79ef\u7d2f\u7684\u5f71\u54cd\u3002<\/span><\/p>\n<p><span style=\"font-size: 1rem;\">\u6765\u81ea\u4e2d\u56fd\u5317\u4eac\u7684\u4e2d\u56fd\u519c\u4e1a\u5927\u5b66\u7684\u7814\u7a76\u4eba\u5458Li\u53ca\u5176\u540c\u4e8b\u8868\u660e\uff0c\u4e24\u79cd<\/span><a style=\"background-color: #ffffff; font-size: 1rem;\" href=\"https:\/\/www.nature.com\/articles\/s41419-022-04613-2#Abs1\" target=\"_blank\" rel=\"noopener\">\u4fc3\u8fdbNAD+\u7684\u5316\u5408\u7269\u53ef\u4ee5\u4fdd\u62a4\u670a\u75c5\u6bd2\u75c5\u7684\u795e\u7ecf\u5143\u514d\u4e8e\u6b7b\u4ea1<\/a><span style=\"font-size: 1rem;\">\u3002 \u53d1\u8868\u5728\u5b66\u672f\u671f\u520a\u300a\u7ec6\u80de\u6b7b\u4ea1\u4e0e\u75be\u75c5\u300b\uff08<\/span><em style=\"font-size: 1rem;\">Cell Death &amp; Disease\uff09<\/em><span style=\"font-size: 1rem;\">\u4e0a\u7684\u7814\u7a76\u663e\u793a\uff0cNMN\u548c\u5c3f\u7d20A\u901a\u8fc7\u8bf1\u5bfc\u6709\u4e1d\u5206\u88c2&#8211;\u6e05\u9664\u53d7\u635f\u7c92\u7ebf\u4f53\u7684\u8fc7\u7a0b\uff0c\u6539\u5584\u4e86\u670a\u75c5\u6bd2\u75c5\u795e\u7ecf\u5143\u7684\u5065\u5eb7\u7c92\u7ebf\u4f53\u5e93\u3002 \u8fd9\u4e9b\u53d1\u73b0\u8868\u660e\uff0c\u50cf\u8fd9\u4e9b\u4fc3\u8fdbNAD+\u7684\u523a\u6fc0\u6709\u4e1d\u5206\u88c2\u7684\u5316\u5408\u7269\u53ef\u4ee5\u6210\u4e3a\u6cbb\u7597\u670a\u75c5\u6bd2\u75be\u75c5\u7684\u4ecb\u5165\u63aa\u65bd\u3002<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"s-component-content s-font-body\">\n<p>&nbsp;<\/p>\n<p><strong>\u53d7\u635f\u7684\u7c92\u7ebf\u4f53\u53ef\u80fd\u4f7f\u670a\u75c5\u6bd2\u75c5\u6301\u7eed\u5b58\u5728<\/strong><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"s-component-content s-font-body\">\n<p>&nbsp;<\/p>\n<p>&#8220;\u670a\u75c5\u6bd2&#8221;\u8fd9\u4e2a\u540d\u79f0\u662f\u6307\u5f02\u5e38\u7684\u3001\u81f4\u75c5\u7684\u56e0\u5b50\uff0c\u5b83\u4eec\u662f\u53ef\u4f20\u64ad\u7684\uff0c\u5e76\u4e14\u4f1a\u5bfc\u81f4\u7279\u5b9a\u7684\u6b63\u5e38\u7ec6\u80de\u86cb\u767d\uff08\u79f0\u4e3a\u670a\u75c5\u6bd2\u86cb\u767d\uff09\u7684\u4e0d\u6b63\u786e\u6298\u53e0\uff0c\u8fd9\u79cd\u86cb\u767d\u5728\u5927\u8111\u4e2d\u5f88\u666e\u904d\u3002 \u670a\u75c5\u6bd2\u75be\u75c5\uff0c\u5982\u514b\u96c5\u6c0f\u75c5\uff0c\u53ef\u80fd\u81ea\u53d1\u53d1\u751f\u3001\u9057\u4f20\u6216\u901a\u8fc7\u63a5\u89e6\u53d7\u611f\u67d3\u7684\u7ec4\u7ec7\u4f20\u64ad\uff0c\u4f8b\u5982\u5728\u79fb\u690d\u8fc7\u7a0b\u4e2d\u6216\u98df\u7528\u53d7\u6c61\u67d3\u7684\u8089\u7c7b\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"s-component-content s-font-body\">\n<p>\u867d\u7136\u76ee\u524d\u6b63\u5728\u7814\u7a76\u8fd9\u4e9b\u6b63\u5e38\u670a\u75c5\u6bd2\u86cb\u767d\u7684\u4f5c\u7528\uff0c\u4f46\u4f17\u6240\u5468\u77e5\uff0c\u670a\u75c5\u6bd2\u86cb\u767d\u7684\u5f02\u5e38\u6298\u53e0\u4f1a\u5bfc\u81f4\u8111\u635f\u4f24\u548c\u75be\u75c5\u7684\u5178\u578b\u4f53\u5f81\u548c\u75c7\u72b6\u3002 \u670a\u75c5\u6bd2\u75c5\u5df2\u88ab\u8bc1\u660e\u4f1a\u5bfc\u81f4\u4eba\u683c\u6539\u53d8\u3001\u7126\u8651\u3001\u6291\u90c1\u548c\u8bb0\u5fc6\u529b\u51cf\u9000\uff0c\u901a\u5e38\u5728\u51e0\u4e2a\u6708\u5185\uff0c\u8bb8\u591a\u4eba\u4f1a\u9677\u5165\u660f\u8ff7\u3002 \u670a\u75c5\u6bd2\u75be\u75c5\u901a\u5e38\u8fdb\u5c55\u8fc5\u901f\u5e76\u4e14\u603b\u662f\u81f4\u547d\u7684\uff0c\u4f46\u8fd9\u79cd\u5feb\u901f\u7684\u795e\u7ecf\u53d8\u6027\u662f\u5982\u4f55\u53d1\u751f\u7684\u4ecd\u7136\u6709\u70b9\u795e\u79d8\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"s-component-content s-font-body\">\n<p>\u795e\u7ecf\u5143\u4e2d\u53d7\u635f\u7c92\u7ebf\u4f53\u7684\u6301\u7eed\u79ef\u7d2f\u4e0e\u8870\u8001\u548c\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u6709\u5173\uff0c\u5305\u62ec\u670a\u75c5\u6bd2\u75c5\u3002 \u7c92\u7ebf\u4f53\u81ea\u566c\u662f\u7ec6\u80de\u5185\u7c92\u7ebf\u4f53\u8d28\u91cf\u63a7\u5236\u9014\u5f84\u4e4b\u4e00\uff0c\u53ef\u4ee5\u9009\u62e9\u6027\u5730\u53bb\u9664\u53d7\u635f\u7c92\u7ebf\u4f53\uff0c\u8fd9\u53ef\u80fd\u4e0e\u670a\u75c5\u6bd2\u75c5\u4e2d\u53d7\u635f\u7c92\u7ebf\u4f53\u7684\u79ef\u7d2f\u6709\u5173\u3002 \u8bb8\u591a\u7814\u7a76\u62a5\u544a\u4e86 PINK1-parkin \u4f9d\u8d56\u6027\u7c92\u7ebf\u4f53\u81ea\u566c\u901a\u8def\u5728\u795e\u7ecf\u5143\u4e2d\u7684\u91cd\u8981\u6027\uff1aPINK1-parkin \u5f62\u6210\u4e86\u4e00\u79cd\u4fe1\u53f7\u8f6c\u5bfc\u901a\u8def\uff0c\u53ef\u6807\u8bb0\u53d7\u635f\u7684\u7c92\u7ebf\u4f53\u4ee5\u8fdb\u884c\u6d88\u9664\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-image\">\n<div class=\"s-component-content\">\n<div class=\"s-img-wrapper\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-17411\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/03\/912674_707970.webp\" alt=\"\" width=\"550\" height=\"321\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/03\/912674_707970.webp 550w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/03\/912674_707970-300x175.webp 300w\" sizes=\"auto, (max-width: 550px) 100vw, 550px\" \/><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"s-component-content s-font-body\">\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24446486\/\" target=\"_blank\" rel=\"noopener\"><strong>\uff08McLelland et al.\uff0c 2014 |<\/strong><\/a>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24446486\/\" target=\"_blank\" rel=\"noopener\"><em><strong>The EMBO Journal<\/strong><\/em><\/a><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24446486\/\" target=\"_blank\" rel=\"noopener\"><strong>\uff09<\/strong><\/a>\u00a0<strong>Parkin \u548c PINK1 \u5728\u8c03\u8282\u7c92<\/strong><strong>\u7ebf<\/strong>\u00a0<strong>\u4f53\u8d28\u91cf\u63a7\u5236\u4e2d\u8d77\u4f5c\u7528\u3002\u00a0<\/strong>\u4f5c\u4e3a\u5bf9\u7c92\u7ebf\u4f53\u5e94\u6fc0\u7684\u53cd\u5e94\uff0cParkin\u8bf1\u5bfc\u7c92\u7ebf\u4f53\u56ca\u6ce1\u7684 PINK1 \u4f9d\u8d56\u6027\u5f62\u6210\uff0c\u8fd9\u4e9b\u56ca\u6ce1\u9776\u5411\u79f0\u4e3a\u6eb6\u9176\u4f53\u7684\u7ec6\u80de\u7ed3\u6784\uff0c\u8fd9\u4e9b\u7ec6\u80de\u7ed3\u6784\u5305\u88f9\u7740\u8d27\u7269\u8fdb\u884c\u964d\u89e3\u3002 \u8fd9\u4e2a\u8fc7\u7a0b\u79f0\u4e3a\u7c92\u7ebf\u4f53\u81ea\u566c\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"s-component-content s-font-body\">\n<p>NAD+ \u4fc3\u8fdb\u5242\u6539\u5584\u670a\u75c5\u6bd2\u75c5\u795e\u7ecf\u5143\u7ec6\u80de\u7684\u7ebf\u7c92\u4f53\u81ea\u566c<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"s-component-content s-font-body\">\n<p>\u7531\u4e8e\u7c92\u7ebf\u4f53\u635f\u4f24\u662f\u795e\u7ecf\u5143\u635f\u4f24\u7684\u65e9\u671f\u6307\u6807\uff0c\u56e0\u6b64\u53d1\u73b0\u7c92\u7ebf\u4f53\u81ea\u566c\u7f3a\u9677\u4e0e\u7c92\u7ebf\u4f53\u635f\u4f24\u4e4b\u95f4\u7684\u5173\u8054\u5bf9\u4e8e\u670a\u75c5\u6bd2\u75be\u75c5\u7684\u65e9\u671f\u9884\u9632\u5177\u6709\u91cd\u8981\u610f\u4e49\u3002 \u5728\u8fd9\u9879\u7814\u7a76\u4e2d\uff0cLi \u53ca\u5176\u540c\u4e8b\u7814\u7a76\u4e86\u670a\u75c5\u6bd2\u75be\u75c5\u7ec6\u80de\u6a21\u578b\u4e2d\u53d7\u635f\u7684\u7c92\u7ebf\u4f53\u79ef\u7d2f\u3002 \u5bf9\u4e8e\u8be5\u6a21\u578b\uff0c\u5317\u4eac\u7684\u7814\u7a76\u5c0f\u7ec4\u7528\u4e00\u79cd\u5f71\u54cd\u670a\u75c5\u6bd2\u7684\u6709\u6bd2\u86cb\u767d\u8d28\u7247\u6bb5\u611f\u67d3\u5c0f\u9f20\u7684\u795e\u7ecf\u5143\u7ec6\u80de\uff0c\u79f0\u4e3a\u670a\u75c5\u6bd2\u86cb\u767d 106-126 \uff08PrP106-126\uff09\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"s-component-content s-font-body\">\n<p>\u8fd9\u79cd\u4ecb\u5165\u5bfc\u81f4\u5927\u91cf\u7ec6\u80de\u6b7b\u4ea1\uff0c\u4f7f\u6d3b\u529b\u964d\u4f4e50-60%\u3002 \u6b64\u5916\uff0c\u7c92\u7ebf\u4f53\u660e\u663e\u788e\u7247\u5316\uff0c\u8868\u660e\u4e25\u91cd\u7684\u7c92\u7ebf\u4f53\u635f\u4f24\uff0cPINK1-Parkin \u4ecb\u5bfc\u7684\u7c92\u7ebf\u4f53\u81ea\u566c\u5df2\u5931\u6548\u4e14\u51e0\u4e4e\u4e0d\u6d3b\u8dc3\u3002 \u4f46\u662f\u5f53\u7528 NMN \u6cbb\u7597\u65f6\uff0c\u670a\u75c5\u6bd2\u6a21\u578b\u795e\u7ecf\u5143\u7ec6\u80de\u88ab\u4fdd\u62a4\u514d\u4e8e\u6b7b\u4ea1\u3002 \u76f8\u6bd4\u4e4b\u4e0b\uff0cUA\u4e0d\u80fd\u663e\u8457\u51cf\u8f7b PrP106-126 \u8bf1\u5bfc\u7684\u7ec6\u80de\u6b7b\u4ea1\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"s-component-content s-font-body\">\n<p>\u5f53Li\u53ca\u5176\u540c\u4e8b\u5bf9\u670a\u75c5\u6bd2\u6a21\u578b\u7684\u795e\u7ecf\u5143\u7ec6\u80de\u8fdb\u884c\u57fa\u56e0\u64cd\u4f5c\u4ee5\u4ea7\u751f\u8fc7\u91cf\u7684 Pink1 \u548c Parkin \u65f6\uff0c\u7c92\u7ebf\u4f53\u81ea\u566c\u7f3a\u9677\u5f97\u5230\u7f13\u89e3\u3002 \u540c\u6837\uff0c\u8865\u5145\u4e24\u79cd\u7c92\u7ebf\u4f53\u81ea\u566c\u8bf1\u5bfc\u5242\uff0c\u70df\u9170\u80fa\u5355\u6838\u82f7\u9178\uff08NMN\uff09\u6216\u5c3f\u77f3\u7d20A \uff08UA\uff09\uff0c\u663e\u8457\u523a\u6fc0 PINK1-Parkin \u4ecb\u5bfc\u7684\u7c92\u7ebf\u4f53\u81ea\u566c\u3002 \u7136\u800c\uff0c\u4e0e NMN \u76f8\u6bd4\uff0cUA \u5e76\u4e0d\u80fd\u7f13\u89e3\u670a\u75c5\u6bd2\u5f15\u8d77\u7684\u7c92\u7ebf\u4f53\u65ad\u88c2\u548c\u529f\u80fd\u969c\u788d\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-image\">\n<div class=\"s-component-content\">\n<div class=\"s-img-wrapper\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-17412\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/03\/486933_29179.webp\" alt=\"\" width=\"1200\" height=\"625\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/03\/486933_29179.webp 1200w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/03\/486933_29179-300x156.webp 300w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/03\/486933_29179-1024x533.webp 1024w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/03\/486933_29179-768x400.webp 768w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"s-component-content s-font-body\">\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41419-022-04613-2#Sec10\" target=\"_blank\" rel=\"noopener\"><strong>\uff08Li et al.\uff0c 2022 |<\/strong><\/a>\u00a0<a href=\"https:\/\/www.nature.com\/articles\/s41419-022-04613-2#Sec10\" target=\"_blank\" rel=\"noopener\"><em><strong>Cell Death &amp; Disease<\/strong><\/em><\/a><a href=\"https:\/\/www.nature.com\/articles\/s41419-022-04613-2#Sec10\" target=\"_blank\" rel=\"noopener\"><strong>\uff09<\/strong><\/a>\u00a0<strong>\u7528 NMN \u800c\u975e\u5c3f\u77f3\u7d20 A \u6fc0\u6d3b\u7c92\u7ebf\u4f53\u81ea\u566c\u53ef\u51cf\u8f7b\u6a21\u62df\u670a\u75c5\u6bd2\u75c5\u7684\u795e\u7ecf\u5143\u4e2d\u7684\u7ec6\u80de\u6b7b\u4ea1\u3002\u00a0<\/strong>Li \u53ca\u5176\u540c\u4e8b\u6d4b\u8bd5\u4e86 NMN \u548c\u5c3f\u77f3\u7d20 A \uff08UA\uff09 \u5bf9\u6709\u6216\u6ca1\u6709\u88ab\u670a\u75c5\u6bd2\u81f4\u75c5\u5242 \uff08PrP106-126\uff09 \u611f\u67d3\u7684\u795e\u7ecf\u5143\u7ec6\u80de\u4e2d\u7c92\u7ebf\u4f53\u788e\u7247\u548c\u7ec6\u80de\u6d3b\u529b\u7684\u5f71\u54cd\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"s-component-content s-font-body\">\n<p>\u4e3a\u4ec0\u4e48\u662fNMN \u800c\u975e\u5c3f\u77f3\u7d20\u53ef\u4ee5\u4fdd\u62a4\u670a\u75c5\u6bd2\u75c5\u795e\u7ecf\u5143\u514d\u4e8e\u6b7b\u4ea1\uff1f<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"s-component-content s-font-body\">\n<p>Li \u53ca\u5176\u540c\u4e8b\u8868\u660e\uff0c\u53d7\u670a\u75c5\u6bd2\u75c5\u5f71\u54cd\u7684\u7ec6\u80de\u5177\u6709\u4e25\u91cd\u7684\u7c92\u7ebf\u4f53\u65ad\u88c2\u548c\u529f\u80fd\u969c\u788d\u3002 \u7c92\u7ebf\u4f53\u81ea\u566c\u6fc0\u6d3b\u5242 NMN \u5728\u670a\u75c5\u6bd2\u75c5\u7ec6\u80de\u6a21\u578b\u4e2d\u6fc0\u6d3b PINK1-Parkin \u4ecb\u5bfc\u7684\u7c92\u7ebf\u4f53\u81ea\u566c\u5e76\u6062\u590d\u7c92\u7ebf\u4f53\u5f62\u6001\u548c\u529f\u80fd\uff0c\u4ece\u800c\u51cf\u8f7b PrP106-126 \u8bf1\u5bfc\u7684\u795e\u7ecf\u5143\u7ec6\u80de\u6b7b\u4ea1\u3002 NMN \u7684\u6cbb\u7597\u6548\u679c\u4e5f\u88ab\u62a5\u9053\u5728\u5176\u4ed6\u75be\u75c5\u4e2d\uff0c\u4f8b\u5982\u4e0e\u8fc7\u65e9\u8870\u8001\u76f8\u5173\u7684\u5171\u6d4e\u5931\u8c03\u6027\u6bdb\u7ec6\u8840\u7ba1\u6269\u5f20\u75c7\u548c\u4e0e\u9ad8\u8840\u538b\u76f8\u5173\u7684\u4e2d\u98ce\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"s-component-content s-font-body\">\n<p>\u53e6\u4e00\u65b9\u9762\uff0c\u867d\u7136 UA \u6fc0\u6d3b\u4e86\u7c92\u7ebf\u4f53\u81ea\u566c\uff0c\u4f46\u5b83\u5e76\u4e0d\u80fd\u51cf\u8f7b\u53d7\u670a\u75c5\u6bd2\u5f71\u54cd\u7684\u7ec6\u80de\u53d7\u635f\u7684\u7c92\u7ebf\u4f53\u788e\u7247\u3002 \u4ea7\u751f\u7684\u7ec6\u80de\u53ea\u5269\u4e0b\u5f88\u5c11\u7684\u529f\u80fd\u6027\u7c92\u7ebf\u4f53\u4f9b UA \u53d1\u6325\u4f5c\u7528\u3002 \u8fd9\u5c31\u662f\u4e3a\u4ec0\u4e48\u5317\u4eac\u7684\u7814\u7a76\u4eba\u5458\u8ba4\u4e3a\u8865\u5145 UA \u5e76\u4e0d\u80fd\u51cf\u8f7b\u670a\u75c5\u6bd2\u75c5\u5f15\u8d77\u7684\u795e\u7ecf\u5143\u6b7b\u4ea1\u3002 UA\u4e0d\u80fd\u7f13\u89e3\u7531PrP106-126\u5f15\u8d77\u7684\u7c92\u7ebf\u4f53\u65ad\u88c2\u548c\u529f\u80fd\u969c\u788d\uff0c\u6700\u7ec8\u5bfc\u81f4\u7ec6\u80de\u6b7b\u4ea1\u548c\u6d3b\u529b\u4e0b\u964d\uff0c\u8fd9\u662f\u4e00\u4e2a\u6709\u8da3\u7684\u73b0\u8c61\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"s-component-content s-font-body\">\n<p>NMN\u548cUA\u6fc0\u6d3b\u7c92\u7ebf\u4f53\u81ea\u566c\u7684\u4e0d\u540c\u673a\u5236\u9700\u8981\u8fdb\u4e00\u6b65\u7814\u7a76\uff0c\u8fd9\u53ef\u80fd\u6709\u52a9\u4e8e\u6211\u4eec\u627e\u5230\u6cbb\u7597\u514b\u96c5\u6c0f\u75c5\u7b49\u670a\u75c5\u6bd2\u75be\u75c5\u7684\u7cbe\u786e\u9776\u70b9\u3002 \u7531\u4e8e\u5728\u5176\u4ed6\u75be\u75c5\uff08\u5982\u963f\u8328\u6d77\u9ed8\u75c5\u548c\u5e15\u91d1\u68ee\u75c5\u4ee5\u53ca\u5fc3\u808c\u75c5\uff09\u4e2d\u5df2\u7ecf\u62a5\u9053\u4e86\u8fd9\u79cd\u7c92\u7ebf\u4f53\u81ea\u566c\u9014\u5f84\u7684\u7f3a\u9677\uff0c\u56e0\u6b64\u7c92\u7ebf\u4f53\u81ea\u566c\u6fc0\u6d3b\u5242\u53ef\u80fd\u5177\u6709\u5e7f\u6cdb\u7684\u6cbb\u7597\u6f5c\u529b\u3002 \u4e0d\u540c\u7684\u7c92\u7ebf\u4f53\u81ea\u566c\u6fc0\u6d3b\u5242\u53ef\u80fd\u66f4\u597d\u5730\u6cbb\u7597\u7279\u5b9a\u75be\u75c5\uff0c\u56e0\u6b64\u9700\u8981\u7b5b\u9009\u5728\u6bcf\u79cd\u7279\u5b9a\u75be\u75c5\u80cc\u666f\u4e0b\u4fc3\u8fdb\u7ec6\u80de\u5065\u5eb7\u548c\u6d3b\u529b\u7684\u7c92\u7ebf\u4f53\u81ea\u566c\u6fc0\u6d3b\u5242\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"s-component-content s-font-body\">\n<p>\u53c2\u8003\u6587\u732e\uff1a<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"s-component-content s-font-body\">\n<p>Li J, Lai M, Zhang X, Li Z, Yang D, Zhao M, Wang D, Sun Z, Ehsan S, Li W, Gao H, Zhao D, Yang L. PINK1-parkin-mediated neuronal mitophagy deficiency in prion disease. Cell Death Dis. 2022 Feb 18; 13(2):162. doi: 10.1038\/s41419-022-04613-2. PMID: 35184140.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"s-component-content s-font-body\">\n<p>\u6587\u7ae0\u6765\u6e90 \uff1a<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"s-component-content s-font-body\">\n<p>https:\/\/www.nmn.com\/news\/nmn-neurodegenerative-disorder<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"pvc_clear\"><\/div>\n<p id=\"pvc_stats_463\" class=\"pvc_stats all  \" data-element-id=\"463\" style=\"\"><i class=\"pvc-stats-icon medium\" aria-hidden=\"true\"><svg aria-hidden=\"true\" focusable=\"false\" data-prefix=\"far\" data-icon=\"chart-bar\" role=\"img\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\" class=\"svg-inline--fa fa-chart-bar fa-w-16 fa-2x\"><path fill=\"currentColor\" d=\"M396.8 352h22.4c6.4 0 12.8-6.4 12.8-12.8V108.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v230.4c0 6.4 6.4 12.8 12.8 12.8zm-192 0h22.4c6.4 0 12.8-6.4 12.8-12.8V140.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v198.4c0 6.4 6.4 12.8 12.8 12.8zm96 0h22.4c6.4 0 12.8-6.4 12.8-12.8V204.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v134.4c0 6.4 6.4 12.8 12.8 12.8zM496 400H48V80c0-8.84-7.16-16-16-16H16C7.16 64 0 71.16 0 80v336c0 17.67 14.33 32 32 32h464c8.84 0 16-7.16 16-16v-16c0-8.84-7.16-16-16-16zm-387.2-48h22.4c6.4 0 12.8-6.4 12.8-12.8v-70.4c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v70.4c0 6.4 6.4 12.8 12.8 12.8z\" class=\"\"><\/path><\/svg><\/i> <img loading=\"lazy\" decoding=\"async\" width=\"16\" height=\"16\" alt=\"Loading\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/plugins\/page-views-count\/ajax-loader-2x.gif\" border=0 \/><\/p>\n<div class=\"pvc_clear\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u7528\u70df\u9170\u80fa\u5355\u6838\u82f7\u9178 \uff08NMN\uff09 \u63d0\u9ad8 NAD+ \u6c34\u5e73\u53ef\u6539\u5584\u7531\u670a\u75c5\u6bd2\u75be\u75c5\u5f15\u8d77\u7684\u53d7\u635f\u7c92\u7ebf\u4f53\u7684\u6e05\u9664\u7f3a\u9677\uff0c\u4ece\u800c\u4fdd\u62a4\u8fd9\u4e9b\u795e\u7ecf\u5143\u514d\u4e8e\u7ec6\u80de\u6b7b\u4ea1\u3002 By\u00a0Jonathan D. Grinstein, Ph.D. Published:\u00a02:29 p.m. PST Feb 24, 2022\u00a0| Updated:\u00a010:49 am PST Mar 2, 2022 \u91cd\u5927\u4eae\u70b9 \u5728\u4e00\u79cd\u88ab\u79f0\u4e3a\u670a\u75c5\u6bd2\u75c5\u7684\u7f55\u89c1\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u7684\u5c0f\u9f20\u7ec6\u80de\u6a21\u578b\u4e2d\uff0c\u7c92\u7ebf\u4f53\u81ea\u566c&#8211;\u6e05\u9664\u53d7\u635f\u7684\u7c92\u7ebf\u4f53&#8211;\u7684\u529f\u80fd\u53d7\u635f\u3002 \u5728\u60a3\u6709\u670a\u75c5\u6bd2\u75c5\u7684\u795e\u7ecf\u7ec6\u80de\u4e2d\u8865\u5145NMN\u6216\u5c3f\u77f3\u7d20A\uff08UA\uff09\u53ef\u660e\u663e\u6062\u590d\u7c92\u7ebf\u4f53\u541e\u566c\u4f5c\u7528\u3002<\/p>\n<div class=\"pvc_clear\"><\/div>\n<p id=\"pvc_stats_463\" class=\"pvc_stats all  \" data-element-id=\"463\" style=\"\"><i class=\"pvc-stats-icon medium\" aria-hidden=\"true\"><svg aria-hidden=\"true\" focusable=\"false\" data-prefix=\"far\" data-icon=\"chart-bar\" role=\"img\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\" class=\"svg-inline--fa fa-chart-bar fa-w-16 fa-2x\"><path fill=\"currentColor\" d=\"M396.8 352h22.4c6.4 0 12.8-6.4 12.8-12.8V108.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v230.4c0 6.4 6.4 12.8 12.8 12.8zm-192 0h22.4c6.4 0 12.8-6.4 12.8-12.8V140.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v198.4c0 6.4 6.4 12.8 12.8 12.8zm96 0h22.4c6.4 0 12.8-6.4 12.8-12.8V204.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v134.4c0 6.4 6.4 12.8 12.8 12.8zM496 400H48V80c0-8.84-7.16-16-16-16H16C7.16 64 0 71.16 0 80v336c0 17.67 14.33 32 32 32h464c8.84 0 16-7.16 16-16v-16c0-8.84-7.16-16-16-16zm-387.2-48h22.4c6.4 0 12.8-6.4 12.8-12.8v-70.4c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v70.4c0 6.4 6.4 12.8 12.8 12.8z\" class=\"\"><\/path><\/svg><\/i> <img loading=\"lazy\" decoding=\"async\" width=\"16\" height=\"16\" alt=\"Loading\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/plugins\/page-views-count\/ajax-loader-2x.gif\" border=0 \/><\/p>\n<div class=\"pvc_clear\"><\/div>\n","protected":false},"author":1,"featured_media":17412,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[172,272],"tags":[171,289],"class_list":["post-463","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-nmn-","category-272","tag-nmn","tag-289"],"aioseo_notices":[],"_links":{"self":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts\/463","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=463"}],"version-history":[{"count":3,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts\/463\/revisions"}],"predecessor-version":[{"id":17530,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts\/463\/revisions\/17530"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/media\/17412"}],"wp:attachment":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=463"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=463"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=463"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}