{"id":410,"date":"2022-03-11T04:05:00","date_gmt":"2022-03-11T04:05:00","guid":{"rendered":"http:\/\/choosebiz.me\/?p=410"},"modified":"2022-05-30T03:59:13","modified_gmt":"2022-05-30T03:59:13","slug":"nmn%e5%8f%af%e4%bb%a5%e5%81%9a%e4%bb%80%e4%b9%88","status":"publish","type":"post","link":"http:\/\/johnhealth.blog\/ch\/?p=410","title":{"rendered":"NMN\u53ef\u4ee5\u505a\u4ec0\u4e48?"},"content":{"rendered":"

NMN\u7a76\u7adf\u662f\u4ec0\u4e48? \u5403\u4e86\u6709\u4ec0\u9ebd\u7528\u5462?<\/p>\n

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\u5728\u8870\u8001\u7684\u8fc7\u7a0b\u4e2d\uff0cNAD+ \u6c34\u5e73\u7684\u964d\u4f4e\u4e0e\u591a\u79cd\u548c\u5e74\u9f84\u76f8\u5173\u7684\u75be\u75c5\u6709\u5173\uff0c\u4e00\u4e9b\u7814\u7a76\u63d0\u4f9b\u8bc1\u636e\u8868\u660e\u589e\u52a0\u4f53\u5185\u7684NAD+\u6c34\u5e73\u53ef\u4ee5\u5bf9\u6297\u8fd9\u4e9b\u75be\u75c5\u3002 \u4f8b\u5982\uff0c\u4e00\u9879\u7814\u7a76\u8868\u660e\u8865\u5145 NMN \u53ef \u589e\u5f37\u8001\u5e74\u7537\u6027\u7684\u808c\u8089\u529f\u80fd<\/a>\uff0c\u800c\u53e6\u4e00\u9879\u7814\u7a76\u8868\u660e\u5b83\u4f1a\u589e\u52a0\u8001\u5e74\u5973\u6027\u7684\u80f0\u5c9b\u7d20\u654f\u611f\u6027<\/a>\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u54c8\u4f5b\u5927\u5b66\u548c\u534e\u76db\u987f\u5927\u5b66\u7b49\u673a\u6784\u7684 NMN \u7814\u7a76\u8868\u660e\uff0c\u8865\u5145NMN\u6216\u589e\u5f3a NMN \u7684\u5408\u6210\uff0c\u53ef\u4ee5\u4fc3\u8fdb\u556e\u9f7f\u52a8\u7269\u8870\u8001\u671f\u95f4\u7684\u957f\u5bff\u548c\u5065\u5eb7\u3002 Sinclair \u53ca\u5176\u540c\u4e8b\u53d1\u73b0\uff0c\u5f53\u8001\u5e74\u8001\u9f20\u559d\u4e86\u6ce8\u5165 NMN \u7684\u6c34\u65f6\uff0c\u5b83\u4eec\u7684\u8dd1\u6b65\u8010\u529b\u51e0\u4e4e\u7ffb\u4e86\u4e00\u756a<\/a>\u3002 \u8fdb\u4e00\u6b65\u7684\u7814\u7a76\u8868\u660e\uff0c\u7ed9\u5c0f\u9f20\u6ce8\u5c04\u00a0NMN \u53ef\u4ee5\u5728\u8870\u8001\u904e\u7a0b\u4e2d\u4fdd\u6301\u8ba4\u77e5\u80fd\u529b<\/a>\u3002 \u6b64\u5916\uff0cImai \u53ca\u5176\u540c\u4e8b\u7684\u4e00\u9805\u7814\u7a76\u8868\u660e\uff0cNMN \u5408\u6210\u7684\u6fc0\u589e\u4f7f\u5c0f\u9f20\u7684\u5269\u4f59\u5bff\u547d\u589e\u52a0\u4e86\u4e00\u500d\u4ee5\u4e0a<\/a>\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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(Das et al., 2018 | Cell)<\/a>\u00a0NMN \u663e\u8457\u63d0\u9ad8\u8001\u5e74\u5c0f\u9f20\u7684\u8dd1\u6b65\u8010\u529b\u3002<\/strong> \u5728\u996e\u7528\u6c34\u4e2d\u7ed9\u4e88 400 mg\/kg\/\u5929\u7684 NMN \u7684\u8001\u5e74\u5c0f\u9f20\uff0820 \u500b\u6708\u5927\uff09\u5728\u5b83\u4eec\u56e0\u75b2\u5907\u800c\u505c\u6b62\u8dd1\u6b65\u4e4b\u524d\u663e\u793a\u51fa\u663e\u8457\u5ef6\u9577\u7684\u8dd1\u6b65\u6642\u9593\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\"\"<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n
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(Tarantini et al., 2019 | Redox Biology)<\/a>\u00a0NMN \u63d0\u4f9b\u795e\u7ecf\u4fdd\u62a4\u76ca\u5904\uff0c\u4ee5\u4fdd\u6301\u8001\u5e74\u5c0f\u9f20\u7684\u8ba4\u77e5\u80fd\u529b\u3002<\/strong> \u663e\u793a\u8001\u9f20\u9003\u79bb\u6c34\u8ff7\u5bab\u7684\u8def\u5f84\u7684\u70ed\u56fe\u8868\u660e\uff0c\u8001\u5e74\u8001\u9f20\u6bd4\u5e74\u8f7b\u8001\u9f20\u72af\u4e86\u66f4\u591a\u7684\u9519\u8bef\uff0c\u4f46\u670d\u7528 NMN \u6539\u5584\u4e86\u8fd9\u4e9b\u9519\u8bef\u3002 \u53f3\u56fe\u663e\u793a\uff0c\u5728\u6c34\u8ff7\u5bab\u4e2d\uff0c\u8001\u5e74\u5c0f\u9f20\u7684\u8bb0\u5fc6\u9519\u8bef\u660e\u663e\u591a\u65bc\u5e74\u8f7b\u5c0f\u9f20\uff0c\u4f46 NMN \u633d\u6551\u4e86\u8001\u5e74\u5c0f\u9f20\u7684\u8bb0\u5fc6\u3002 \u8fd9\u4e9b\u53d1\u73b0\u652f\u6301 NMN \u5728\u8870\u8001\u8fc7\u7a0b\u4e2d\u589e\u5f3a\u8ba4\u77e5\u80fd\u529b\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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(Yoshida et al., 2019 | Cell Metabolism)<\/a> \u7ed9\u5c0f\u9f20\u6ce8\u5c04\u4e00\u7a2e\u80fd\u9a71\u52a8 NMN \u5408\u6210\u7684\u9176\uff0c\u53ef\u4f7f\u96cc\u6027\u5c0f\u9f20\u7684\u5269\u4f59\u5bff\u547d\u5ef6\u9577\u4e00\u500d\u4ee5\u4e0a\u3002<\/strong> \u7ed9\u96cc\u6027\u5c0f\u9f20\u6ce8\u5c04\u542b\u6709 NMN \u5408\u6210\u9176\u70df\u9170\u80fa\u78f7\u9178\u6838\u7cd6\u57fa\u8f6c\u79fb\u9176 (NAMPT) \u7684\u56ca\u6ce1\u5f8c\uff0c\u5b83\u4eec\u7684\u5269\u9980\u5bff\u547d\u589e\u52a0\u4e86\u4e00\u500d\u4ee5\u4e0a<\/span>\uff08\u56fe J\uff09\u3002 \u4ece\u5c0f\u9f20\u76ae\u6bdb\u7684\u5065\u5eb7\u72b6\u51b5\uff08\u56fe K \u4e2d\u6ce8\u5c04\u4e86\u542b\u6709 NAMPT \u7684\u56ca\u6ce1\u7684\u9876\u7ea7\u5c0f\u9f20\uff09\u53ef\u4ee5\u770b\u51fa\uff0cNMN \u5408\u6210\u7684\u6fc0\u589e\u4e5f\u6539\u5584\u4e86\u6574\u4f53\u5065\u5eb7\u72b6\u51b5\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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(Hong et al., 2021 | Frontiers in Cell and Developmental Biology)<\/a><\/p>\n

NMN \u901a\u8fc7\u589e\u52a0 NAD+ \u6c34\u5e73\u6765\u6539\u5584\u8bb8\u591a\u4e0e\u5e74\u9f84\u76f8\u5173\u7684\u75be\u75c5\u3002\u00a0NMN \u7684\u5065\u5eb7\u76f8\u5173\u76ca\u5904\u6269\u5c55\u5230\u4ece\u5fc3\u810f\u5230\u773c\u775b\u518d\u5230\u5927\u8111\u7684\u7ec4\u7ec7\u3002<\/p>\n

\u670d\u7528 NMN \u53ef\u80fd\u63d0\u4f9b\u4e00\u79cd\u6709\u5e0c\u671b\u7684\u65b9\u6cd5\u6765\u5bf9\u6297\u4e0e\u5e74\u9f84\u76f8\u5173\u7684\u75be\u75c5\u548c\u5c0f\u75c5\u3002 \u4ee5\u4e0b\u662f\u9610\u660e NMN \u6f5c\u5728\u76ca\u5904\u7684\u4e3b\u8981\u7814\u7a76\u6458\u8981\u3002<\/p>\n

1. \u9aa8\u5934\u4fee\u590d\uff1a<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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