{"id":407,"date":"2022-03-11T03:42:24","date_gmt":"2022-03-11T03:42:24","guid":{"rendered":"http:\/\/choosebiz.me\/?p=407"},"modified":"2022-05-27T03:26:58","modified_gmt":"2022-05-27T03:26:58","slug":"%e3%80%90%e7%a7%91%e6%8a%80%e8%bf%9b%e5%b1%95%e3%80%91%e7%a0%94%e7%a9%b6%e8%a1%a8%e6%98%8e-nmn-%e5%8f%af%e5%bb%b6%e8%bf%9f%e5%95%ae%e9%bd%bf%e5%8a%a8%e7%89%a9%e7%9a%84%e4%b8%ad%e9%a3%8e","status":"publish","type":"post","link":"http:\/\/johnhealth.blog\/ch\/?p=407","title":{"rendered":"\u3010\u79d1\u6280\u8fdb\u5c55\u3011\u7814\u7a76\u8868\u660e NMN \u53ef\u5ef6\u8fdf\u556e\u9f7f\u52a8\u7269\u7684\u4e2d\u98ce"},"content":{"rendered":"<p>\u8840\u538b\u5347\u9ad8\u548c\u4e2d\u98ce\u503e\u5411\u7684\u5927\u9f20 NAD+ \u6c34\u5e73\u964d\u4f4e<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-17427\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/03\/brain.jpg\" alt=\"\" width=\"671\" height=\"655\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/03\/brain.jpg 671w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/03\/brain-300x293.jpg 300w\" sizes=\"auto, (max-width: 671px) 100vw, 671px\" \/><\/p>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"s-component-content s-font-body\">\n<p>By\u00a0Jonathan D. Grinstein, Ph.D.\u00a0Published:\u00a011:38 am PST Mar 22, 2021\u00a0| Updated:\u00a01:57 p.m. PST Mar 30, 2021<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"s-component-content s-font-body\">\n<p><u><em><strong>\u91cd\u5927\u4eae\u70b9<\/strong><\/em><\/u><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"s-component-content s-font-body\">\n<ul>\n<li>\u00a0\u5728\u5582\u98df\u9ad8\u76d0\u996e\u98df\u7684\u5927\u9f20\u4e2d\uff0c\u6709\u7f3a\u9677\u7684\u7ec6\u80de\u56de\u6536\u8fc7\u7a0b\u6709\u5229\u65bc\u4e0e\u9ad8\u8840\u538b\u76f8\u5173\u7684\u81ea\u53d1\u6027\u4e2d\u98ce\u3002<\/li>\n<li>\u00a0NMN \u6cbb\u7597\u9006\u8f6c\u4e86\u8fd9\u4e9b\u8fc7\u7a0b\uff0c\u4ee5\u9632\u6b62\u8fd9\u4e9b\u556e\u9f7f\u52a8\u7269\u53d1\u751f\u4e2d\u98ce\u3002<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<p><!--more--><\/p>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"s-component-content s-font-body\">\n<p>\u4e2d\u98ce\u662f\u5bfc\u81f4\u6b7b\u4ea1\u548c\u6b8b\u75be\u7684\u4e3b\u8981\u539f\u56e0\uff0c\u5e76\u4e14\u5177\u6709\u4e00\u7cfb\u5217\u98ce\u9669\u56e0\u7d20\uff0c\u5305\u62ec\u6211\u4eec\u7684\u57fa\u56e0\u6784\u6210\u548c\u751f\u6d3b\u65b9\u5f0f\u4f1a\u589e\u52a0\u9ad8\u8840\u538b\u7684\u5f62\u6210\u3002\u00a0\u8fc4\u4eca\u4e3a\u6b62\uff0c\u8fd9\u79cd\u75be\u75c5\u8fd8\u6ca1\u6709\u6709\u6548\u7684\u6cbb\u7597\u65b9\u6cd5\uff0c\u56e0\u6b64\u5f04\u6e05\u695a\u9ad8\u8840\u538b\u5982\u4f55\u4f7f\u4eba\u4eec\u5bb9\u6613\u5f15\u53d1\u4e2d\u98ce\u53ef\u80fd\u4f1a\u6539\u5584\u5176\u9884\u9632\u548c\u6cbb\u7597\u7b56\u7565\u3002\u00a0\u5c3d\u7ba1\u6709\u8ff9\u8c61\u8868\u660e\u7ec6\u80de\u7684\u518d\u5faa\u73af\u8fc7\u7a0b\uff08\u79f0\u4e3a\u81ea\u566c\uff09\u5728\u9ad8\u8840\u538b\u76f8\u5173\u4e2d\u98ce\u7684\u53d1\u5c55\u4e2d\u6240\u8d77\u7684\u4f5c\u7528\uff0c\u4f46\u8fd9\u79cd\u5173\u8054\u6027\u4ecd\u4e0d\u6e05\u695a\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"s-component-content s-font-body\">\n<p>\u7f57\u9a6c\u5927\u5b66\u7684 Forte \u53ca\u5176\u540c\u4e8b\u5728 \u5b66\u672f\u671f\u520a\u300aAutophagy\u300b(\u81ea\u566c)\u4e0a\u53d1\u8868\u4e86\u4e00\u7bc7\u5b66\u672f\u8bba\u6587\uff0c\u8868\u660e\u6709<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31679456\/\" target=\"_blank\" rel=\"noopener\">\u7f3a\u9677\u7684\u81ea\u566c\u901a\u8fc7\u4fc3\u8fdb\u8d1f\u8d23\u4ea7\u751f\u80fd\u91cf\u7684\u7c92\u7ebf\u4f53\u529f\u80fd\u969c\u788d\u800c\u6709\u5229\u65bc\u9ad8\u8840\u538b\u76f8\u5173\u7684\u81ea\u53d1\u6027\u4e2d\u98ce<\/a>\u3002 \u610f\u5927\u5229\u7814\u7a76\u5c0f\u7ec4\u7ed9\u8001\u9f20\u5582\u98df\u9ad8\u76d0\u996e\u98df\u800c\u5bfc\u81f4\u9ad8\u8840\u538b\u5e76\u589e\u52a0\u4e2d\u98ce\u7684\u98ce\u9669\uff0c\u5e76\u53d1\u73b0\u556e\u9f7f\u52a8\u7269\u5927\u8111\u4e2d\u7684\u81ea\u566c\u51cf\u5c11\u3002<\/p>\n<p>\u8fd9\u79cd\u81ea\u566c\u53d7\u635f\u4e0e\u7c92\u7ebf\u4f53\u529f\u80fd\u969c\u788d\u548c\u5fc5\u9700\u751f\u7269\u80fd\u5206\u5b50\u70df\u9170\u80fa\u817a\u560c\u5464\u4e8c\u6838\u82f7\u9178 (NAD)+ \u7684\u6d88\u8017\u6709\u5173\u3002 \u5f53\u7814\u7a76\u4eba\u5458\u7528\u70df\u9170\u80fa\u5355\u6838\u82f7\u9178 (NMN) \u6062\u590d NAD+ \u6c34\u5e73\u65f6\uff0c\u4ed6\u4eec\u53d1\u73b0\u81ea\u566c\u91cd\u65b0\u6fc0\u6d3b\u5e76\u51cf\u5c11\u4e86\u6613\u60a3\u4e2d\u98ce\u7684\u5927\u9f20\u7684\u4e2d\u98ce\u53d1\u5c55\u3002 \u8fd9\u4e9b\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0c\u63d0\u9ad8 NAD+ \u6c34\u5e73\u548c\u6fc0\u6d3b\u81ea\u566c\u7684\u5e72\u9884\u63aa\u65bd\u53ef\u80fd\u4ee3\u8868\u4e86\u60a3\u4e2d\u98ce\u98ce\u9669\u8f83\u9ad8\u7684\u53d7\u8bd5\u8005\u7684\u65b0\u6cbb\u7597\u7b56\u7565\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"s-component-content s-font-body\">\n<h4><strong>\u81ea\u566c\u662f\u4e2d\u98a8\u7684\u6838\u5fc3\u55ce\uff1f<\/strong><\/h4>\n<p>\u5f9e\u55ae\u7d30\u80de\u751f\u7269\u5230\u6700\u8907\u96dc\u7684\u591a\u7d30\u80de\u751f\u7269\uff0c\u81ea\u566c\u5728\u53bb\u9664\u53d7\u640d\u7d30\u80de\u6210\u5206\u65b9\u9762\u8d77\u8457\u95dc\u9375\u4f5c\u7528\u3002 \u4e00\u7a2e\u7a31\u70ba\u7c92\u7dda\u9ad4\u81ea\u566c\u7684\u81ea\u566c\uff0c\u5c08\u9580\u7528\u65bc\u6e05\u9664\u53d7\u640d\u7684\u7c92\u7dda\u9ad4\uff0c\u78ba\u4fdd\u7c92\u7dda\u9ad4\u7684\u8cea\u91cf\u63a7\u5236\u3002 \u81ea\u566c\u901a\u5e38\u6703\u5728\u58d3\u529b\u4e0b\u88ab\u6fc0\u6d3b\uff0c\u4ee5\u53bb\u9664\u529f\u80fd\u5931\u8abf\u7684\u7c92\u7dda\u9ad4\uff0c\u7136\u5f8c\u7528\u65b0\u5f62\u6210\u7684\u5065\u5eb7\u7c92\u7dda\u9ad4\u4ee3\u66ff\u3002<\/p>\n<p>\u81ea\u566c\u53d7\u640d\u5c0e\u81f4\u7f3a\u4e4f\u9069\u7576\u7684\u7c92\u7dda\u9ad4\u5468\u8f49\uff0c\u5f9e\u800c\u5c0e\u81f4\u7c92\u7dda\u9ad4\u529f\u80fd\u969c\u7919\u7684\u767c\u5c55\uff0c\u9032\u800c\u4fc3\u9032\u5fc3\u8840\u7ba1\u75be\u75c5\uff08\u5305\u62ec\u4e2d\u98a8\uff09\u7684\u9032\u5c55\u3002 \u7c92\u7dda\u9ad4\u529f\u80fd\u969c\u7919\u6703\u5c0e\u81f4\u80fd\u91cf\u6d88\u8017\u3001\u6709\u5bb3\u7684\u542b\u6c27\u5206\u5b50\u7a4d\u805a\uff08\u6c27\u5316\u61c9\u6fc0\uff09\u548c\u708e\u75c7\uff0c\u9019\u4e9b\u90fd\u662f\u7531\u65bc\u8840\u6d41\u4e0d\u8db3\u5c0e\u81f4\u8166\u640d\u50b7\u7684\u4e3b\u8981\u6c7a\u5b9a\u56e0\u7d20\u3002 \u6cbf\u8457\u9019\u4e9b\u601d\u8def\uff0c\u81ea\u566c\u6291\u5236\u5c07\u6709\u5229\u65bc\u7c92\u7dda\u9ad4\u529f\u80fd\u969c\u7919\uff0c\u4e26\u5728\u5b58\u5728\u98a8\u96aa\u56e0\u7d20\u7684\u60c5\u6cc1\u4e0b\u589e\u52a0\u4e2d\u98a8\u7684\u6613\u611f\u6027\u3002 \u4f46\u81ea\u566c\u5728\u4e2d\u98a8\u767c\u5c55\u4e2d\u7684\u78ba\u5207\u4f5c\u7528\u4ecd\u672a\u5f97\u5230\u89e3\u6c7a\u3002<\/p>\n<h4><strong>NMN \u9006\u8f49\u81ea\u566c\u7f3a\u9677\u4e26\u9632\u6b62\u4e2d\u98a8\u767c\u751f<\/strong><\/h4>\n<p>Forte \u53ca\u5176\u540c\u4e8b\u5728\u4e2d\u98a8\u50be\u5411\u7684\u9ad8\u8840\u58d3\u5927\u9f20\u4e2d\u6e2c\u8a66\u4e86\u81ea\u566c\u640d\u50b7\u8207\u81ea\u767c\u6027\u4e2d\u98a8\u767c\u5c55\u4e4b\u9593\u7684\u95dc\u806f\u6027\uff0c\u9019\u662f\u4e00\u7a2e\u9069\u5408\u7814\u7a76\u4eba\u985e\u4e2d\u98a8\u7684\u6a21\u578b\u3002 \u8a72\u5927\u9f20\u6a21\u578b\u767c\u751f\u81ea\u767c\u6027\u4e2d\u98a8\uff0c\u9ad8\u9209\u4f4e\u9240\u98f2\u98df 7 \u9031\u5f8c\u767c\u75c5\u7387\u70ba 100%\u3002 \u5728\u8a72\u6a21\u578b\u4e2d\uff0c\u4e2d\u98a8\u7684\u767c\u751f\u5148\u65bc\u7c92\u7dda\u9ad4\u529f\u80fd\u969c\u7919\u3001\u6c27\u5316\u61c9\u6fc0\u4ee5\u53ca\u5927\u8166\u548c\u8166\u8840\u7ba1\u708e\u75c7\u7684\u767c\u5c55\uff0c\u6700\u7d42\u5c0e\u81f4\u8166\u6c34\u816b\u548c\u4e2d\u98a8\u3002<\/p>\n<p>\u610f\u5927\u5229\u7814\u7a76\u5c0f\u7d44\u767c\u73fe\uff0c\u9019\u4e9b\u6613\u60a3\u4e2d\u98a8\u7684\u5927\u9f20\u5c0d\u9ad8\u9e7d\u98f2\u98df\u7684\u81ea\u566c\u6291\u5236\u53d6\u6c7a\u65bc\u5927\u8166\u4e2d\u7d30\u80de\u5167 NAD+ \u6c34\u5e73\u7684\u6025\u5287\u4e0b\u964d\u3002 \u4f46\u662f\uff0c\u7576\u4ed6\u5011\u6bcf\u5929\u7d66\u9019\u4e9b\u5927\u6691\u6ce8\u5c04 NAD+ \u7684\u524d\u9ad4 NMN\uff08250 \u6beb\u514b\/\u516c\u65a4\uff09\u6642\uff0cForte \u53ca\u5176\u540c\u4e8b\u633d\u6551\u4e86\u5927\u8166\u4e2d\u7684 NAD+ \u6c34\u5e73\uff0c\u9019\u8207\u81ea\u566c\u3001\u53d7\u640d\u7c92\u7dda\u9ad4\u7684\u6e05\u9664\u548c\u7c92\u7dda\u9ad4\u529f\u80fd\u7684\u6539\u5584\u6709\u95dc\u3002 \u4ed6\u5011\u9084\u767c\u73fe\uff0c\u5728\u9ad8\u9e7d\u98f2\u98df\u6613\u60a3\u4e2d\u98a8\u7684\u5927\u9f20\u5927\u8166\u4e2d\u7684\u8840\u7ba1\u7d30\u80de\u7684\u5b58\u6d3b\u7387\u6709\u6240\u589e\u52a0\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-image\">\n<div class=\"s-component-content\">\n<div class=\"s-img-wrapper\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-17428\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/03\/244270_306717.webp\" alt=\"\" width=\"781\" height=\"337\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/03\/244270_306717.webp 781w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/03\/244270_306717-300x129.webp 300w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/03\/244270_306717-768x331.webp 768w\" sizes=\"auto, (max-width: 781px) 100vw, 781px\" \/><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"s-component-content s-font-body\">\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31679456\/\" target=\"_blank\" rel=\"noopener\"><strong>(Forte et al. 2020 |<\/strong><\/a>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31679456\/\" target=\"_blank\" rel=\"noopener\"><em><strong>Autophagy<\/strong><\/em><\/a><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31679456\/\" target=\"_blank\" rel=\"noopener\"><strong>)\u00a0<\/strong><\/a>NMN \u6539\u5584\u4e86\u57f9\u517b\u7ec6\u80de\u4e2d\u7684\u7c92\u7ebf\u4f53\u529f\u80fd\u548c\u7ec6\u80de\u6d3b\u529b\u3002\u00a0\u7528\u76d0 (NaCl) \u6216\u81ea\u566c\u6291\u5236\u5242 (siRNA) \u5904\u7406\u5c0f\u9f20\u8840\u7ba1\u7ec6\u80de\uff0c\u7136\u5f8c\u8bc4\u4f30\u7c92\u7ebf\u4f53\u635f\u4f24\u7684\u7a0b\u5ea6\uff08\u5de6\uff09\u548c\u6d3b\u529b\uff08\u53f3\uff09\u3002 \u76d0\u548c\u81ea\u566c\u6291\u5236\u5242\u6cbb\u7597\u90fd\u5bfc\u81f4\u7c92\u7ebf\u4f53\u635f\u4f24\u589e\u52a0\u548c\u6d3b\u7ec6\u80de\u767e\u5206\u6bd4\u4e0b\u964d\u3002 \u7136\u800c\uff0c\u8fd9\u4e24\u79cd\u60c5\u51b5\u4e0b\u7684\u8fd9\u4e9b\u5f71\u54cd\u90fd\u53ef\u4ee5\u901a\u8fc7\u8865\u5145 NMN \u6765\u9006\u8f6c\u3002<\/p>\n<p>\u91cd\u8981\u7684\u662f\uff0c\u5728\u9ad8\u76d0\u996e\u98df\u6613\u60a3\u4e2d\u98ce\u7684\u5927\u9f20\u4e2d\uff0cNMN \u5f3a\u70c8\u51cf\u5f31\u4e86\u4e2d\u98ce\u7684\u53d1\u751f\u3002 \u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u4e0e\u5582\u98df\u9ad8\u76d0\u996e\u98df\u7684\u672a\u6cbb\u7597\u5927\u9f20\u76f8\u6bd4\uff0c\u63a5\u53d7 NMN \u7684\u5927\u9f20\u4e2d\u6709\u4e00\u534a\u4ee5\u4e0a\u4ece\u4e2d\u98ce\u4e2d\u5b58\u6d3b\u4e0b\u6765\uff0c\u76f4\u5230\u7b2c 12 \u5468\u3002 Forte \u53ca\u5176\u540c\u4e8b\u968f\u5f8c\u8fdb\u4e00\u6b65\u8bc1\u660e\uff0c\u901a\u8fc7\u6fc0\u6d3b\u81ea\u566c\uff0c\u529f\u80fd\u5931\u8c03\u7684\u81ea\u566c\u662f\u9ad8\u76d0\u996e\u98df\u5582\u517b\u5927\u9f20\u4e2d\u98ce\u6613\u611f\u6027\u7684\u6839\u6e90\u3002 \u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u523a\u6fc0\u81ea\u566c\u5728\u9884\u9632\u4e2d\u98ce\u65b9\u9762\u7684\u4fdd\u62a4\u4f5c\u7528\u4e0e\u8840\u538b\u6c34\u5e73\u65e0\u5173\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-image\">\n<div class=\"s-component-content\">\n<div class=\"s-img-wrapper\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-17429\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/03\/347891_361889.webp\" alt=\"\" width=\"950\" height=\"294\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/03\/347891_361889.webp 950w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/03\/347891_361889-300x93.webp 300w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/03\/347891_361889-768x238.webp 768w\" sizes=\"auto, (max-width: 950px) 100vw, 950px\" \/><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"s-component-content s-font-body\">\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31679456\/\" target=\"_blank\" rel=\"noopener\"><strong>(Forte et al. 2020 |<\/strong><\/a>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31679456\/\" target=\"_blank\" rel=\"noopener\"><em><strong>Autophagy<\/strong><\/em><\/a><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31679456\/\" target=\"_blank\" rel=\"noopener\"><strong>)<\/strong><\/a>\u00a0<strong>\u7528 NMN \u523a\u6fc0\u81ea\u566c\u589e\u52a0\u4e86\u5582\u98df\u9ad8\u76d0\u996e\u98df\u7684\u5927\u9f20\u7684\u65e0\u4e2d\u98ce\u5b58\u6d3b\u7387<\/strong>\u3002\u00a0\u8be5\u56fe\u663e\u793a\u4e86\u5582\u98df\u9ad8\u76d0\u996e\u98df (JD) \u7684\u4e2d\u98ce\u503e\u5411\u9ad8\u8840\u538b\u5927\u9f20 (SHRSP) \u7684\u4e2d\u98ce\u53d1\u751f\u7387\u3002 \u7136\u5f8c\u7528 NMN (+NMN) \u6216\u81ea\u566c\u523a\u6fc0\u5242 (+TAT BEC) \u6cbb\u7597\u8fd9\u4e9b\u5c0f\u9f20\u3002 \u5728\u8fd9\u4e24\u79cd\u60c5\u51b5\u4e0b\uff0c\u4e2d\u98ce\u7684\u53d1\u75c5\u7387\u5ef6\u8fdf\u4e86\u8fd1\u4e24\u500d\u3002<\/p>\n<p>\u8fd9\u4e9b\u7ed3\u679c\u6e05\u695a\u5730\u8868\u660e\uff0c\u81ea\u566c\u635f\u4f24\u53ef\u80fd\u5bfc\u81f4\u8111\u8840\u7ba1\u635f\u4f24\u548c\u4e2d\u98ce\u7684\u53d1\u751f\u3002 \u81ea\u566c\u518d\u6fc0\u6d3b\u53ef\u80fd\u6709\u5229\u65bc\u53bb\u9664\u529f\u80fd\u5931\u8c03\u7684\u7c92\u7ebf\u4f53\uff0c\u5e76\u9650\u5236\u5185\u76ae\u7ec6\u80de\u548c\u8111\u7ec6\u80de\u5bf9\u9ad8\u76d0\u5904\u7406\u7684\u635f\u4f24\uff0c\u4ece\u800c\u5ef6\u7f13\u8111\u635f\u4f24\u7684\u53d1\u751f\u3002 \u603b\u4e4b\uff0c\u8fd9\u4e9b\u53d1\u73b0\u8868\u660e\uff0c\u6fc0\u6d3b\u81ea\u566c\u548c\u63d0\u9ad8 NAD+ \u6c34\u5e73\u7684\u5e72\u9884\u63aa\u65bd\u53ef\u80fd\u4ee3\u8868\u4e86\u5bf9\u65bc\u4e2d\u98ce\u98ce\u9669\u8f83\u9ad8\u7684\u53d7\u8bd5\u8005\u7684\u65b0\u6cbb\u7597\u7b56\u7565\u3002<\/p>\n<p>\u53c2\u8003\u6587\u732e:Forte M, Bianchi F, Cotugno M, Marchitti S, De Falco E, Raffa S, Stanzione R, Di Nonno F, Chimenti I, Palmerio S, Pagano F, Petrozza V, Micaloni A, Madonna M, Relucenti M, Torrisi MR, Frati G, Volpe M, Rubattu S, Sciarretta S.\u00a0Pharmacological restoration of autophagy reduces hypertension-related stroke occurrence. Autophagy. 2020 Aug;16(8):1468-1481.<\/p>\n<p>doi:\u00a0<a href=\"https:\/\/doi.org\/10.1080\/15548627.2019.1687215\" target=\"_blank\" rel=\"noopener\">10.1080\/15548627.2019.1687215<\/a>. Epub 2019 Nov 12. PMID: 31679456; PMCID: PMC7469607.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"s-component-content s-font-body\">\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"s-component-content s-font-body\">\n<p>\u6587\u7ae0\u4f86\u6e90: https:\/\/www.nmn.com\/news\/study-shows-nmn-delays-stroke-rodents<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"s-component-content s-font-body\">\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<p>&nbsp;<\/p>\n<div class=\"pvc_clear\"><\/div>\n<p id=\"pvc_stats_407\" class=\"pvc_stats all  \" data-element-id=\"407\" style=\"\"><i class=\"pvc-stats-icon medium\" aria-hidden=\"true\"><svg aria-hidden=\"true\" focusable=\"false\" data-prefix=\"far\" data-icon=\"chart-bar\" role=\"img\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\" class=\"svg-inline--fa fa-chart-bar fa-w-16 fa-2x\"><path fill=\"currentColor\" d=\"M396.8 352h22.4c6.4 0 12.8-6.4 12.8-12.8V108.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v230.4c0 6.4 6.4 12.8 12.8 12.8zm-192 0h22.4c6.4 0 12.8-6.4 12.8-12.8V140.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v198.4c0 6.4 6.4 12.8 12.8 12.8zm96 0h22.4c6.4 0 12.8-6.4 12.8-12.8V204.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v134.4c0 6.4 6.4 12.8 12.8 12.8zM496 400H48V80c0-8.84-7.16-16-16-16H16C7.16 64 0 71.16 0 80v336c0 17.67 14.33 32 32 32h464c8.84 0 16-7.16 16-16v-16c0-8.84-7.16-16-16-16zm-387.2-48h22.4c6.4 0 12.8-6.4 12.8-12.8v-70.4c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v70.4c0 6.4 6.4 12.8 12.8 12.8z\" class=\"\"><\/path><\/svg><\/i> <img loading=\"lazy\" decoding=\"async\" width=\"16\" height=\"16\" alt=\"Loading\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/plugins\/page-views-count\/ajax-loader-2x.gif\" border=0 \/><\/p>\n<div class=\"pvc_clear\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u8840\u538b\u5347\u9ad8\u548c\u4e2d\u98ce\u503e\u5411\u7684\u5927\u9f20 NAD+ \u6c34\u5e73\u964d\u4f4e By\u00a0Jonathan D. Grinstein, Ph.D.\u00a0Published:\u00a011:38 am PST Mar 22, 2021\u00a0| Updated:\u00a01:57 p.m. PST Mar 30, 2021 \u91cd\u5927\u4eae\u70b9 \u00a0\u5728\u5582\u98df\u9ad8\u76d0\u996e\u98df\u7684\u5927\u9f20\u4e2d\uff0c\u6709\u7f3a\u9677\u7684\u7ec6\u80de\u56de\u6536\u8fc7\u7a0b\u6709\u5229\u65bc\u4e0e\u9ad8\u8840\u538b\u76f8\u5173\u7684\u81ea\u53d1\u6027\u4e2d\u98ce\u3002 \u00a0NMN \u6cbb\u7597\u9006\u8f6c\u4e86\u8fd9\u4e9b\u8fc7\u7a0b\uff0c\u4ee5\u9632\u6b62\u8fd9\u4e9b\u556e\u9f7f\u52a8\u7269\u53d1\u751f\u4e2d\u98ce\u3002<\/p>\n<div class=\"pvc_clear\"><\/div>\n<p id=\"pvc_stats_407\" class=\"pvc_stats all  \" data-element-id=\"407\" style=\"\"><i class=\"pvc-stats-icon medium\" aria-hidden=\"true\"><svg aria-hidden=\"true\" focusable=\"false\" data-prefix=\"far\" data-icon=\"chart-bar\" role=\"img\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\" class=\"svg-inline--fa fa-chart-bar fa-w-16 fa-2x\"><path fill=\"currentColor\" d=\"M396.8 352h22.4c6.4 0 12.8-6.4 12.8-12.8V108.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v230.4c0 6.4 6.4 12.8 12.8 12.8zm-192 0h22.4c6.4 0 12.8-6.4 12.8-12.8V140.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v198.4c0 6.4 6.4 12.8 12.8 12.8zm96 0h22.4c6.4 0 12.8-6.4 12.8-12.8V204.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v134.4c0 6.4 6.4 12.8 12.8 12.8zM496 400H48V80c0-8.84-7.16-16-16-16H16C7.16 64 0 71.16 0 80v336c0 17.67 14.33 32 32 32h464c8.84 0 16-7.16 16-16v-16c0-8.84-7.16-16-16-16zm-387.2-48h22.4c6.4 0 12.8-6.4 12.8-12.8v-70.4c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v70.4c0 6.4 6.4 12.8 12.8 12.8z\" class=\"\"><\/path><\/svg><\/i> <img loading=\"lazy\" decoding=\"async\" width=\"16\" height=\"16\" alt=\"Loading\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/plugins\/page-views-count\/ajax-loader-2x.gif\" border=0 \/><\/p>\n<div class=\"pvc_clear\"><\/div>\n","protected":false},"author":1,"featured_media":17428,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[172,272],"tags":[171,286,304],"class_list":["post-407","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-nmn-","category-272","tag-nmn","tag-286","tag-304"],"aioseo_notices":[],"_links":{"self":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts\/407","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=407"}],"version-history":[{"count":3,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts\/407\/revisions"}],"predecessor-version":[{"id":17532,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts\/407\/revisions\/17532"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/media\/17428"}],"wp:attachment":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=407"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=407"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=407"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}