{"id":3732,"date":"2017-10-11T03:14:42","date_gmt":"2017-10-11T03:14:42","guid":{"rendered":"http:\/\/health-anything.com\/?p=3732"},"modified":"2023-04-08T03:13:13","modified_gmt":"2023-04-08T03:13:13","slug":"%e7%99%bd%e8%97%9c%e8%8a%a6%e9%86%87-%e6%8a%97%e5%8a%a8%e8%84%89%e7%b2%a5%e7%8a%b6%e7%a1%ac%e5%8c%96%e3%80%81%e4%bf%9d%e6%8a%a4%e5%bf%83%e8%82%8c","status":"publish","type":"post","link":"http:\/\/johnhealth.blog\/ch\/?p=3732","title":{"rendered":"\u3010\u75be\u75c5\u89e3\u8bfb\u3011\u767d\u85dc\u82a6\u9187 \u2014 \u6297\u52a8\u8109\u7ca5\u72b6\u786c\u5316\u3001\u4fdd\u62a4\u5fc3\u808c"},"content":{"rendered":"<p>\u533b\u754c\u5df2\u77e5<span style=\"color: #ff0000;\">\u51a0\u72b6\u52a8\u8109\u5fc3\u8840\u7ba1\u75be\u75c5\u3001\u4e73\u764c\u3001\u80c3\u764c\u3001\u80a0\u764c\u3001\u809d\u764c\u7b49\u75be\u75c5\uff0c\u5176\u53d1\u751f\u4e0e\u8f6c\u79fb\u5747\u4e0e<strong><span style=\"color: #0000ff;\">\u8840\u7ba1\u65b0\u751f<\/span><\/strong>\u6709\u5173<\/span>\uff0c\u82e5\u65e9\u4e00\u6b65\u5df2\u77e5\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\u751f\u957f\uff0c\u5c06\u53ef\u80fd\u4ece\u6839\u672c\u4e0a\uff0c\u9884\u9632\u591a\u79cd\u764c\u75c7\u4e0e\u5fc3\u8840\u7ba1\u75be\u75c5\u3002\u8fd9\u9879\u6297\u764c\u6f5c\u529b\u7814\u7a76\uff0c\u8fc7\u7a0b\u4e25\u8c28\u3001\u6548\u679c\u660e\u663e\uff0c\u53d7\u5230\u56fd\u9645\u77a9\u76ee\uff0c\u6765\u81ea\u53f0\u6e7e\u5927\u5b66\uff0c\u5df2\u520a\u767b\u5728\u77e5\u540d\u533b\u5b66\u671f\u520a\u300a\u5206\u5b50\u5b66\u6742\u5fd7\u300b\u4e2d\uff0c\u5e76\u5f15\u8d77\u56fd\u5916\u533b\u5b66\u4f1a\u9080\u7ea6\u7814\u7a76\u4eba\u5458\u5728\u56fd\u5185\u5916\u8fdb\u884c\u6f14\u8bb2\u3002<\/p>\n<p>2002 \u5e74 6 \u6708\u53f0\u5927\u533b\u5b66\u9662\u6bd2\u7406\u5b66\u7814\u7a76\u6240\u6797\u4f73\u4eea\u7814\u7a76\u8bba\u6587\u6307\u51fa\uff1a\u767d\u85dc\u82a6\u9187\u7684\u786e\u5728 invivo \u548c vitro \u90fd\u6709\u4e00\u81f4\u7684\u6291\u5236\u8840\u7ba1\u65b0\u751f\u6548\u679c\uff0c\u767d\u85dc\u82a6\u9187\u900f\u8fc7\u4e00\u81f4\u5185\u76ae\u7ec6\u80de\u7684\u7ed3\u5408\u70b9\u916a\u9178\u86cb\u767d\u78f7\u9178\u5316\uff0c\u7a33\u5b9a\u5185\u76ae\u7ec6\u80de\u7279\u5b9a\u7684\u5438\u9644\u5206\u5b50\u95f4\u7684\u4ea4\u4e92\u4f5c\u7528\uff0c\u8fdb\u800c\u4e00\u81f4\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\uff08VEGF165)\u6240\u5f15\u8d77\u8840\u7ba1\u65b0\u751f\u73b0\u8c61\u3002<\/p>\n<p>\u53f0\u5317\u8363\u603b\u524d\u5fc3\u810f\u5185\u79d1\u4e3b\u4efb\u6797\u5e78\u8363\u66fe\u4ee5\u5154\u5b50\u505a\u7814\u7a76\uff0c\u5148\u5582\u98df\u9ad8\u80c6\u56fa\u9187\u98df\u7269\uff0c\u8bf1\u53d1\u52a8\u8109\u786c\u5316\uff0c\u518d\u5582\u98df\u9002\u91cf\u767d\u85dc\u82a6\u9187\uff0c\u4e0d\u4f46\u53ef\u4ee5\u51cf\u5c11\u8840\u7ba1\u5185\u819c\u589e\u751f\uff0c\u52a8\u8109\u786c\u5316\u60c5\u51b5\u4e5f\u83b7\u6539\u5584\u3002 \u767d\u85dc\u82a6\u9187\u5177\u6709\u6297\u52a8\u8109\u7ca5\u72b6\u786c\u5316\uff0c\u7ecf\u7531 NO_cGMPcascade\uff0c\u4f7f\u8840\u7ba1\u6269\u5f20\uff0c\u56e0\u6b64\u6709\u5fc3\u808c\u4fdd\u62a4\u7684\u529f\u80fd\uff08Fitzpatricket al.,1993\uff09\u3002\u767d\u85dc\u82a6\u9187 \u6291 \u5236 PKC \u03b1 \u7684 \u6d3b \u6027 \uff0c \u85c9 \u7531 phosphatidylcholine\/phosphatidylserine \u7684\u6c34\u6ce1\uff0c\u5d4c\u5165\u7ec6\u80de\u819c\u4e0a\uff08Garcia-Garcia etal.,1999\uff09\uff0c\u53ef\u6709\u6548\u5730\u5f71\u54cd\u8840\u7ba1\u5185\u76ae\u548c\u5fc3\u808c\u7684\u529f\u80fd\uff08Slater etal.,2003\uff09\u3002\u7ed9\u4e88\u767d\u85dc\u82a6\u9187\u523a\u6fc0\u732a\u7684\u51a0\u72b6\u52a8\u8109\u4e4b\u540e\uff0c\u53d1\u73b0\u767d\u85dc\u82a6\u9187\uff0850\u03bcM\uff09\u6291\u5236 MAPK \u7684\u6d3b\u6027\uff0c\u7531\u514d\u75ab\u5206\u6790\u663e\u793a ERK1\/2\u3001JNK-1 \u548c p38 \u78f7\u9178\u5316\u90fd\u964d\u4f4e\uff0c\u8fd9\u8868\u793a\u767d\u85dc\u82a6\u9187\u5177\u6709\u4fdd\u62a4\u5fc3\u808c\uff0c\u56e0\u4e3a MAPK \u4f1a\u4fc3\u4f7f\u5e73\u6ed1\u808c\u589e\u6b96\u548c\u6536\u7f29\uff08E1-Mowafy and White,1999 \uff09\u3002<\/p>\n<p>Dr William Li \u6f14\u8bb2 &#8212; \u8840\u7ba1\u589e\u751f<\/p>\n<div style=\"width: 640px;\" class=\"wp-video\"><video class=\"wp-video-shortcode\" id=\"video-3732-1\" width=\"640\" height=\"360\" preload=\"metadata\" controls=\"controls\"><source type=\"video\/mp4\" src=\"http:\/\/johnhealth.blog\/youku\/TED_DrwilliamLi.mp4?_=1\" \/><a href=\"http:\/\/johnhealth.blog\/youku\/TED_DrwilliamLi.mp4\">http:\/\/johnhealth.blog\/youku\/TED_DrwilliamLi.mp4<\/a><\/video><\/div>\n<p>\u5f53\u6f14\u8bb2\u5230\u7b2c12\u520636\u79d2\u65f6\uff0c\u5a01\u5ec9.\u674e\u7740\u91cd\u63d0\u5230\u4e86\u201c\u767d\u85dc\u82a6\u9187\u201d\u5bf9\u4e8e\u6291\u5236\u5f02\u5e38\u8840\u7ba1\u589e\u751f\u548c\u6cbb\u7597\u764c\u75c7\u7684\u663e\u8457\u6548\u679c<\/p>\n<p>\u66f4\u591a\uff1a<\/p>\n<ul>\n<li class=\"reader_ab_test with-top-banner\"><span id=\"doc-tittle-0\">\u767d<wbr \/>\u85dc<wbr \/>\u82a6<wbr \/>\u9187<wbr \/>\u5728<wbr \/>\u52a8<wbr \/>\u8109<wbr \/>\u7ca5<wbr \/>\u6837<wbr \/>\u786c<wbr \/>\u5316<wbr \/>\u6cbb<wbr \/>\u7597<wbr \/>\u4e2d<wbr \/>\u7684<wbr \/>\u6297<wbr \/>\u708e<wbr \/>\u6297<wbr \/>\u6c27<wbr \/>\u5316<wbr \/>\u53ca<wbr \/>\u6297<wbr \/>\u589e<wbr \/>\u6b96<wbr \/>\u4f5c<wbr \/>\u7528<wbr \/>\u7814<wbr \/>\u7a76<wbr \/>\u8fdb<wbr \/>\u5c55<\/span><\/li>\n<\/ul>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-17144\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2017\/10\/\u52a8\u8109\u7ca5\u68371.jpg\" alt=\"\" width=\"824\" height=\"731\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2017\/10\/\u52a8\u8109\u7ca5\u68371.jpg 824w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2017\/10\/\u52a8\u8109\u7ca5\u68371-300x266.jpg 300w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2017\/10\/\u52a8\u8109\u7ca5\u68371-768x681.jpg 768w\" sizes=\"auto, (max-width: 824px) 100vw, 824px\" \/> <img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-17145\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2017\/10\/\u52a8\u8109\u7ca5\u68372.jpg\" alt=\"\" width=\"842\" height=\"1300\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2017\/10\/\u52a8\u8109\u7ca5\u68372.jpg 842w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2017\/10\/\u52a8\u8109\u7ca5\u68372-194x300.jpg 194w, 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\/><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>#\u767d\u85dc\u82a6\u9187\u00a0 #\u75be\u75c5\u89e3\u8bfb #\u5fc3\u810f\u5065\u5eb7 #\u8840\u7ba1\u5065\u5eb7 #\u5927\u8111\u5065\u5eb7<\/p>\n<div class=\"pvc_clear\"><\/div>\n<p id=\"pvc_stats_3732\" class=\"pvc_stats all  \" data-element-id=\"3732\" style=\"\"><i class=\"pvc-stats-icon medium\" aria-hidden=\"true\"><svg aria-hidden=\"true\" focusable=\"false\" data-prefix=\"far\" data-icon=\"chart-bar\" role=\"img\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\" class=\"svg-inline--fa fa-chart-bar fa-w-16 fa-2x\"><path fill=\"currentColor\" d=\"M396.8 352h22.4c6.4 0 12.8-6.4 12.8-12.8V108.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v230.4c0 6.4 6.4 12.8 12.8 12.8zm-192 0h22.4c6.4 0 12.8-6.4 12.8-12.8V140.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v198.4c0 6.4 6.4 12.8 12.8 12.8zm96 0h22.4c6.4 0 12.8-6.4 12.8-12.8V204.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v134.4c0 6.4 6.4 12.8 12.8 12.8zM496 400H48V80c0-8.84-7.16-16-16-16H16C7.16 64 0 71.16 0 80v336c0 17.67 14.33 32 32 32h464c8.84 0 16-7.16 16-16v-16c0-8.84-7.16-16-16-16zm-387.2-48h22.4c6.4 0 12.8-6.4 12.8-12.8v-70.4c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v70.4c0 6.4 6.4 12.8 12.8 12.8z\" class=\"\"><\/path><\/svg><\/i> <img loading=\"lazy\" decoding=\"async\" width=\"16\" height=\"16\" alt=\"Loading\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/plugins\/page-views-count\/ajax-loader-2x.gif\" border=0 \/><\/p>\n<div class=\"pvc_clear\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u533b\u754c\u5df2\u77e5\u51a0\u72b6\u52a8\u8109\u5fc3\u8840\u7ba1\u75be\u75c5\u3001\u4e73\u764c\u3001\u80c3\u764c\u3001\u80a0\u764c\u3001\u809d\u764c\u7b49\u75be\u75c5\uff0c\u5176\u53d1\u751f\u4e0e\u8f6c\u79fb\u5747\u4e0e\u8840\u7ba1\u65b0\u751f\u6709\u5173\uff0c\u82e5\u65e9\u4e00\u6b65\u5df2\u77e5\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\u751f\u957f\uff0c\u5c06\u53ef\u80fd\u4ece\u6839\u672c\u4e0a\uff0c\u9884\u9632\u591a\u79cd\u764c\u75c7\u4e0e\u5fc3\u8840\u7ba1\u75be\u75c5\u3002\u8fd9\u9879\u6297\u764c\u6f5c\u529b\u7814\u7a76\uff0c\u8fc7\u7a0b\u4e25\u8c28\u3001\u6548\u679c\u660e\u663e\uff0c\u53d7\u5230\u56fd\u9645\u77a9\u76ee\uff0c\u6765\u81ea\u53f0\u6e7e\u5927\u5b66\uff0c\u5df2\u520a\u767b\u5728\u77e5\u540d\u533b\u5b66\u671f\u520a\u300a\u5206\u5b50\u5b66\u6742\u5fd7\u300b\u4e2d\uff0c\u5e76\u5f15\u8d77\u56fd\u5916\u533b\u5b66\u4f1a\u9080\u7ea6\u7814\u7a76\u4eba\u5458\u5728\u56fd\u5185\u5916\u8fdb\u884c\u6f14\u8bb2\u3002 2002 \u5e74 6 \u6708\u53f0\u5927\u533b\u5b66\u9662\u6bd2\u7406\u5b66\u7814\u7a76\u6240\u6797\u4f73\u4eea\u7814\u7a76\u8bba\u6587\u6307\u51fa\uff1a\u767d\u85dc\u82a6\u9187\u7684\u786e\u5728 invivo \u548c vitro \u90fd\u6709\u4e00\u81f4\u7684\u6291\u5236\u8840\u7ba1\u65b0\u751f\u6548\u679c\uff0c\u767d\u85dc\u82a6\u9187\u900f\u8fc7\u4e00\u81f4\u5185\u76ae\u7ec6\u80de\u7684\u7ed3\u5408\u70b9\u916a\u9178\u86cb\u767d\u78f7\u9178\u5316\uff0c\u7a33\u5b9a\u5185\u76ae\u7ec6\u80de\u7279\u5b9a\u7684\u5438\u9644\u5206\u5b50\u95f4\u7684\u4ea4\u4e92\u4f5c\u7528\uff0c\u8fdb\u800c\u4e00\u81f4\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\uff08VEGF165)\u6240\u5f15\u8d77\u8840\u7ba1\u65b0\u751f\u73b0\u8c61\u3002 \u53f0\u5317\u8363\u603b\u524d\u5fc3\u810f\u5185\u79d1\u4e3b\u4efb\u6797\u5e78\u8363\u66fe\u4ee5\u5154\u5b50\u505a\u7814\u7a76\uff0c\u5148\u5582\u98df\u9ad8\u80c6\u56fa\u9187\u98df\u7269\uff0c\u8bf1\u53d1\u52a8\u8109\u786c\u5316\uff0c\u518d\u5582\u98df\u9002\u91cf\u767d\u85dc\u82a6\u9187\uff0c\u4e0d\u4f46\u53ef\u4ee5\u51cf\u5c11\u8840\u7ba1\u5185\u819c\u589e\u751f\uff0c\u52a8\u8109\u786c\u5316\u60c5\u51b5\u4e5f\u83b7\u6539\u5584\u3002 \u767d\u85dc\u82a6\u9187\u5177\u6709\u6297\u52a8\u8109\u7ca5\u72b6\u786c\u5316\uff0c\u7ecf\u7531 NO_cGMPcascade\uff0c\u4f7f\u8840\u7ba1\u6269\u5f20\uff0c\u56e0\u6b64\u6709\u5fc3\u808c\u4fdd\u62a4\u7684\u529f\u80fd\uff08Fitzpatricket al.,1993\uff09\u3002\u767d\u85dc\u82a6\u9187 \u6291 \u5236 PKC \u03b1 \u7684 \u6d3b \u6027 \uff0c \u85c9 \u7531 phosphatidylcholine\/phosphatidylserine \u7684\u6c34\u6ce1\uff0c\u5d4c\u5165\u7ec6\u80de\u819c\u4e0a\uff08Garcia-Garcia etal.,1999\uff09\uff0c\u53ef\u6709\u6548\u5730\u5f71\u54cd\u8840\u7ba1\u5185\u76ae\u548c\u5fc3\u808c\u7684\u529f\u80fd\uff08Slater etal.,2003\uff09\u3002\u7ed9\u4e88\u767d\u85dc\u82a6\u9187\u523a\u6fc0\u732a\u7684\u51a0\u72b6\u52a8\u8109\u4e4b\u540e\uff0c\u53d1\u73b0\u767d\u85dc\u82a6\u9187\uff0850\u03bcM\uff09\u6291\u5236 MAPK \u7684\u6d3b\u6027\uff0c\u7531\u514d\u75ab\u5206\u6790\u663e\u793a ERK1\/2\u3001JNK-1 \u548c p38 \u78f7\u9178\u5316\u90fd\u964d\u4f4e\uff0c\u8fd9\u8868\u793a\u767d\u85dc\u82a6\u9187\u5177\u6709\u4fdd\u62a4\u5fc3\u808c\uff0c\u56e0\u4e3a MAPK \u4f1a\u4fc3\u4f7f\u5e73\u6ed1\u808c\u589e\u6b96\u548c\u6536\u7f29\uff08E1-Mowafy and White,1999 \uff09\u3002 Dr William Li \u6f14\u8bb2 &#8212; \u8840\u7ba1\u589e\u751f 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