{"id":3685,"date":"2017-10-09T03:17:51","date_gmt":"2017-10-09T03:17:51","guid":{"rendered":"http:\/\/health-anything.com\/?p=3685"},"modified":"2022-05-24T04:22:31","modified_gmt":"2022-05-24T04:22:31","slug":"%e7%99%bd%e8%97%9c%e8%8a%a6%e9%86%87-%e5%af%b9%e7%9a%ae%e8%82%a4%e7%99%8c%e7%9a%84%e9%98%b2%e6%b2%bb%e4%bd%9c%e7%94%a8","status":"publish","type":"post","link":"http:\/\/johnhealth.blog\/ch\/?p=3685","title":{"rendered":"\u3010\u75be\u75c5\u89e3\u8bfb\u3011\u767d\u85dc\u82a6\u9187 \u2014 \u5bf9\u76ae\u80a4\u764c\u7684\u9632\u6cbb\u4f5c\u7528"},"content":{"rendered":"<p>1997 \u5e74\u7f8e\u56fd\u829d\u52a0\u54e5\u4f0a\u5229\u8bfa\u5927\u5b66 JohnPezzuto \u6559\u6388\u6240\u9886\u5bfc\u7684\u7814\u7a76\u5c0f\u7ec4\uff0c\u5728\u56fd\u9645\u77e5\u540d\u300a\u79d1\u5b66\u300b\u6742\u5fd7\uff0c<span style=\"color: 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18 \u5468\u4e4b\u540e\uff0c\u8eab\u4e0a\u76ae\u80a4\u80bf\u7624\u7684\u6570\u76ee\u6bd4\u672a\u5403\u8865\u5145\u5242\u7684\u5b9e\u9a8c\u52a8\u7269\u8981\u5c11\u4e86 98%\uff0c\u5728\u7814\u7a76\u4eba\u7c7b\u767d\u8840\u75c5\u7ec6\u80de\u65f6\uff0c\u767d\u85dc\u82a6\u9187\u4e5f\u663e\u793a\u80fd\u6291\u5236\u5f02\u5e38\u7ec6\u80de\u7684\u5f62\u6210\uff0c\u5b83\u80fd\u5c06\u6076\u6027\u7ec6\u80de\u53d8\u56de\u6b63\u5e38\u7ec6\u80de\u3002 Kundu \u7b49\u8fd8\u53d1\u73b0\u6291\u5236\u5b9e\u9a8c\u52a8\u7269\u76ae\u80a4\u7ec4\u7ec7\u4e2d COX-2 \u7684\u8868\u8fbe\u6765\u963b\u65adMAPKs \u548c AP-1 \u7684\u6fc0\u6d3b\uff0c\u53ef\u80fd\u662f\u767d\u85dc\u82a6\u9187\u6297\u76ae\u80a4\u764c\u7684\u91cd\u8981\u673a\u5236\u4e4b\u4e00\u3002Roy P \u7b49\u901a\u8fc7\u5b9e\u9a8c\u53d1\u73b0\u767d\u85dc\u82a6\u9187\u80fd\u8c03\u8282 PI,K\/AKT \u4fe1\u53f7\u901a\u8def\u6291\u5236\u52a8\u7269\u76ae\u80a4\u764c\u3002<\/p>\n<p>2009 \u5e74\u4e2d\u56fd\u5927\u9646\u9996\u90fd\u533b\u79d1\u5927\u5b66\u7126\u6167\u7434\u7b49\u5728\u201c\u767d\u85dc\u82a6\u9187\u5bf9\u4eba\u76ae\u80a4\u764c\u7ec6\u80de\u682a A431 \u751f\u957f\u6291\u5236\u201d\u5b9e\u9a8c\u7814\u7a76\uff0c\u7ed3\u8bba\u8868\u660e\uff1a<\/p>\n<p style=\"padding-left: 30px;\"><span style=\"color: #0000ff;\">\u767d\u85dc\u82a6\u9187\u5bf9\u76ae\u80a4\u764c\u7ec6\u80de\u682a A431 \u7684\u589e\u751f\u5177\u6709\u4e00\u5b9a\u7684\u6291\u5236\u4f5c\u7528\uff0c\u4e14\u4e0d\u826f\u53cd\u5e94\u8f83\u987a\u94c2\uff08DDP\uff09\u5f31\uff0c\u767d\u85dc\u82a6\u9187\u5e76\u53ef\u8bf1\u5bfc A431 \u53d1\u751f\u51cb\u4ea1\uff0c\u53ef\u80fd\u4e0e\u6291\u5236 BCL-2 \u8868\u8fbe\u3001\u4fc3\u8fdbCASPASE-3 \u8868\u8fbe\u6709\u5173<\/span><\/p>\n<p>\u4e2d\u56fd\u77e5\u7f51\uff1a<\/p>\n<ul>\n<li><a href=\"http:\/\/cdmd.cnki.com.cn\/Article\/CDMD-10161-1015625586.htm\" target=\"_blank\" rel=\"noopener\">\u767d\u85dc\u82a6\u9187\u5bf9\u4eba\u76ae\u80a4\u9cde\u72b6\u7ec6\u80de\u764cARHI\u8868\u8fbe\u548cSTAT3\u4fe1\u53f7\u901a\u8def\u6d3b\u5316\u7684\u53cc\u5411\u8c03\u63a7\u4f5c\u7528 \u5927\u8fde\u533b\u79d1\u5927\u5b66 \u949f\u9e23\u9a8f<\/a><\/li>\n<\/ul>\n<p style=\"padding-left: 30px;\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-17168\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2017\/10\/\u5c4f\u5e55\u622a\u56fe-2019-03-08-09.16.45.png\" alt=\"\" width=\"1920\" height=\"1080\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2017\/10\/\u5c4f\u5e55\u622a\u56fe-2019-03-08-09.16.45.png 1920w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2017\/10\/\u5c4f\u5e55\u622a\u56fe-2019-03-08-09.16.45-300x169.png 300w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2017\/10\/\u5c4f\u5e55\u622a\u56fe-2019-03-08-09.16.45-1024x576.png 1024w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2017\/10\/\u5c4f\u5e55\u622a\u56fe-2019-03-08-09.16.45-768x432.png 768w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2017\/10\/\u5c4f\u5e55\u622a\u56fe-2019-03-08-09.16.45-1536x864.png 1536w\" sizes=\"auto, (max-width: 1920px) 100vw, 1920px\" \/><\/p>\n<ul>\n<li><a href=\"http:\/\/kns.cnki.net\/KCMS\/detail\/detail.aspx?dbcode=CJFQ&amp;dbname=CJFDLAST2016&amp;filename=ZLXZ201608005&amp;v=MDAwNDlPWm5GQ3ZrV3I3SVB5SFRkTEc0SDlmTXA0OUZZWVI4ZVgxTHV4WVM3RGgxVDNxVHJXTTFGckNVUkxPZlo=\" target=\"_blank\" rel=\"noopener\">\u767d\u85dc\u82a6\u9187\u4e0b\u8c03Cyclin\u5bb6\u65cf\u8868\u8fbe\u8c03\u8282\u76ae\u80a4\u764cHS-4\u7ec6\u80de\u7684\u589e\u6b96<\/a>\u00a0 \uff082016-08\uff09<\/li>\n<\/ul>\n<p style=\"padding-left: 30px;\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-17169\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2017\/10\/\u5c4f\u5e55\u622a\u56fe-2019-03-08-09.08.49.png\" alt=\"\" width=\"1920\" height=\"1080\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2017\/10\/\u5c4f\u5e55\u622a\u56fe-2019-03-08-09.08.49.png 1920w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2017\/10\/\u5c4f\u5e55\u622a\u56fe-2019-03-08-09.08.49-300x169.png 300w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2017\/10\/\u5c4f\u5e55\u622a\u56fe-2019-03-08-09.08.49-1024x576.png 1024w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2017\/10\/\u5c4f\u5e55\u622a\u56fe-2019-03-08-09.08.49-768x432.png 768w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2017\/10\/\u5c4f\u5e55\u622a\u56fe-2019-03-08-09.08.49-1536x864.png 1536w\" sizes=\"auto, (max-width: 1920px) 100vw, 1920px\" \/><\/p>\n<ul>\n<li><a href=\"http:\/\/www.cnki.com.cn\/Article\/CJFDTOTAL-QLZL201205002.htm\" target=\"_blank\" rel=\"noopener\">\u767d\u85dc\u82a6\u9187\u5bf9\u9ed1\u8272\u7d20\u7624\u7ec6\u80de\u589e\u6b96\u7684\u6291\u5236\u4f5c\u7528<\/a> &#8212; 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sizes=\"auto, (max-width: 1920px) 100vw, 1920px\" \/><\/p>\n<p>&nbsp;<\/p>\n<p>#\u767d\u85dc\u82a6\u9187\u00a0 #\u75be\u75c5\u89e3\u8bfb #\u764c\u75c7<\/p>\n<div class=\"pvc_clear\"><\/div>\n<p id=\"pvc_stats_3685\" class=\"pvc_stats all  \" data-element-id=\"3685\" style=\"\"><i class=\"pvc-stats-icon medium\" aria-hidden=\"true\"><svg aria-hidden=\"true\" focusable=\"false\" data-prefix=\"far\" data-icon=\"chart-bar\" role=\"img\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\" class=\"svg-inline--fa fa-chart-bar fa-w-16 fa-2x\"><path fill=\"currentColor\" d=\"M396.8 352h22.4c6.4 0 12.8-6.4 12.8-12.8V108.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v230.4c0 6.4 6.4 12.8 12.8 12.8zm-192 0h22.4c6.4 0 12.8-6.4 12.8-12.8V140.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v198.4c0 6.4 6.4 12.8 12.8 12.8zm96 0h22.4c6.4 0 12.8-6.4 12.8-12.8V204.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v134.4c0 6.4 6.4 12.8 12.8 12.8zM496 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\u6559\u6388\u6240\u9886\u5bfc\u7684\u7814\u7a76\u5c0f\u7ec4\uff0c\u5728\u56fd\u9645\u77e5\u540d\u300a\u79d1\u5b66\u300b\u6742\u5fd7\uff0c\u9996\u5148\u62a5\u9053\u4e86\u767d\u85dc\u82a6\u9187\u53ef\u6291\u5236\u764c\u524d\u635f\u5bb3\uff0c\u5728\u76ae\u80a4\u764c\u7684\u52a8\u7269\u6a21\u5f0f\u4e2d\u663e\u793a\u6709\u6291\u5236\u80bf\u7624\u4ea7\u751f\u7684\u6548\u679c\u3002 \u65e5\u672c\u7684\u7814\u7a76\u767d\u85dc\u82a6\u9187\u6297\u5f81\u5316\u5408\u7269\uff0c\u53ef\u964d\u4f4e\u5b9e\u9a8c\u52a8\u7269\u7684\u80c6\u56fa\u9187\uff0c\u5728\u4eba\u7c7b\u8eab\u4e0a\u4e5f\u53ef\u80fd\u5177\u6709\u540c\u6837\u7684\u529f\u6548\u3002\u7814\u7a76\u663e\u793a\u767d\u85dc\u82a6\u9187\u53ef\u6709\u6548\u9884\u9632\u5fc3\u810f\u75c5\uff0c\u5b83\u53ef\u6291\u5236\u8840\u5757\u7684\u5f62\u6210\uff0c\u5b83\u4ea6\u53ef\u534f\u52a9\u80c6\u56fa\u9187\u65b0\u9648\u4ee3\u8c22\uff0c\u9884\u9632\u963b\u585e\u52a8\u8109\u7684\u6591\u5757\u5f62\u6210\uff0c\u767d\u85dc\u82a6\u9187\u5728\u6297\u764c\u4e00\u9879\u5b9e\u9a8c\u4e2d\uff0c\u7f79\u60a3\u76ae\u80a4\u764c\u7684\u5b9e\u9a8c\u52a8\u7269\u5728\u5582\u98df\u767d\u85dc\u82a6\u9187\u8865\u5145\u5242 18 \u5468\u4e4b\u540e\uff0c\u8eab\u4e0a\u76ae\u80a4\u80bf\u7624\u7684\u6570\u76ee\u6bd4\u672a\u5403\u8865\u5145\u5242\u7684\u5b9e\u9a8c\u52a8\u7269\u8981\u5c11\u4e86 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