{"id":2809,"date":"2017-08-26T02:57:46","date_gmt":"2017-08-26T02:57:46","guid":{"rendered":"http:\/\/health-anything.com\/?p=2809"},"modified":"2022-08-01T01:39:29","modified_gmt":"2022-08-01T01:39:29","slug":"%e7%99%bd%e8%97%9c%e8%8a%a6%e9%86%87%e4%b8%8e%e8%83%a1%e6%a4%92%e7%a2%b1%e8%81%94%e7%94%a8%e7%94%a8%e4%ba%8e%e5%88%b6%e5%a4%87%e6%b2%bb%e7%96%97%e6%8a%91%e9%83%81%e7%97%87%e8%8d%af%e7%89%a9%e7%9a%84","status":"publish","type":"post","link":"http:\/\/johnhealth.blog\/ch\/?p=2809","title":{"rendered":"\u767d\u85dc\u82a6\u9187\u4e0e\u80e1\u6912\u78b1\u8054\u7528\u7528\u4e8e\u5236\u5907\u6cbb\u7597\u6291\u90c1\u75c7\u836f\u7269\u7684\u7528\u9014 CN 102973563 A"},"content":{"rendered":"
\n\n\n\n\n
Inventors<\/td>\n\u6f58\u5efa\u6625, <\/span>\u5f90\u82f1<\/span><\/span><\/td>\n<\/tr>\n
Applicant<\/td>\n\u6e29\u5dde\u533b\u5b66\u9662<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n
\n
ABSTRACT<\/span><\/div>\n
\n
\u672c\u53d1\u660e\u6d89\u53ca\u4e00\u79cd\u8054\u5408\u7528\u836f\uff0c\u767d\u85dc\u82a6\u9187\u4e0e\u80e1\u6912\u78b1\u8054\u7528\u7528\u4e8e\u6cbb\u7597\u6291\u90c1\u75c7\u3002\u7ecf\u8fc7\u52a8\u7269\u5b9e\u9a8c\u8bc1\u660e\uff0c\u5177\u6709\u8f83\u597d\u7684\u6297\u6291\u90c1\u4f5c\u7528\uff0c\u662f\u4e00\u79cd\u8f83\u6709\u524d\u9014\u7684\u5929\u7136\u6297\u6291\u90c1\u836f\u5242\uff0c\u53ef\u7528\u4e8e\u5236\u5907\u6cbb\u7597\u6291\u90c1\u75c7\u7684\u836f\u7269\u3002<\/div>\n<\/div>\n<\/div>\n
\n
CLAIMS(1)<\/span><\/span><\/div>\n
\n
\n
\n
\n
1.\u767d\u85dc\u82a6\u9187\u4e0e\u80e1\u6912\u78b1\u8054\u7528\u7528\u4e8e\u5236\u5907\u6cbb\u7597\u6291\u90c1\u75c7\u836f\u7269\u7684\u7528\u9014\u3002<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n
\n
DESCRIPTION<\/span><\/div>\n
\n
\n

\u767d\u85dc\u82a6\u9187\u4e0e\u80e1\u6912\u78b1\u8054\u7528\u7528\u4e8e\u5236\u5907\u6cbb\u7597\u6291\u90c1\u75c7\u836f\u7269\u7684\u7528\u9014<\/p>\n

\u6280\u672f\u9886\u57df<\/p>\n

[0001] \u672c\u53d1\u660e\u6d89\u53ca\u767d\u85dc\u82a6\u9187\u4e0e\u80e1\u6912\u78b1\u8054\u7528\u7684\u4e00\u79cd\u65b0\u7528\u9014\uff0c\u7279\u522b\u662f\u6d89\u53ca\u7528\u4e8e\u5236\u5907\u6cbb\u7597\u6291\u90c1\u75c7\u836f\u7269\u7684\u7528\u9014\u3002<\/p>\n

\u80cc\u666f\u6280\u672f<\/p>\n

[0002] \u6291\u90c1\u75c7\u662f\u4e00\u79cd\u4e25\u91cd\u5f71\u54cd\u8eab\u5fc3\u5065\u5eb7\u7684\u60c5\u611f\u969c\u788d\u6027\u7cbe\u795e\u75be\u75c5\u3002\u968f\u7740\u4eba\u4eec\u751f\u5b58\u548c\u53d1\u5c55\u538b\u529b\u65e5\u76ca\u589e\u52a0\uff0c\u6291\u90c1\u75c7\u5df2\u6210\u4e3a\u73b0\u4ee3\u793e\u4f1a\u7684\u5e38\u89c1\u75c5\u3002\u91cd\u5ea6\u6291\u90c1\u75c7\u60a3\u8005\u8868\u73b0\u4e3a\u8111\u5185\u5355\u80fa\u795e\u7ecf\u9012\u8d28\u7279\u522b\u662f\u53bb\u7532\u80be\u4e0a\u817a\u7d20\uff08NE)\u548c5-\u7f9f\u8272\u80fa\uff085-HT)\u53cd\u5c04\u6027\u5730\u6539\u53d8\u3002\u76ee\u524d\uff0c\u836f\u7269\u6cbb\u7597\u662f\u5bf9\u6291\u90c1\u75c7\u6cbb\u7597\u7684\u9996\u9009\u9009\u62e9\u3002\u4e34\u5e8a\u4e0a\u6709\u51e0\u79cd\u5178\u578b\u7684\u6297\u6291\u90c1\u836f\u90fd\u662f\u901a\u8fc7\u63d0\u9ad8\u5355\u80fa\u7c7b\u7269\u8d28\u6c34\u00b7\u5e73\u59825-HT\u3001NE\u53d1\u6325\u6297\u6291\u90c1\u4f5c\u7528\u3002\u4f46\u662f\u5927\u591a\u6570\u836f\u7269\u90fd\u5177\u6709\u4e0d\u826f\u53cd\u5e94\uff0c\u800c\u4e14\u6cbb\u7597\u6548\u679c\u4e0d\u662f\u5f88\u597d\u3002\u6240\u4ee5\uff0c\u5bf9\u836f\u7269\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6cbb\u7597\u56e0\u7d20\u7684\u7814\u7a76\u663e\u5f97\u610f\u4e49\u91cd\u5927\u3002\u7531\u4e8e\u4e2d\u56fd\u4f20\u7edf\u836f\u7528\u690d\u7269\u5177\u6709\u826f\u597d\u7684\u987a\u5e94\u6027\u548c\u6e29\u548c\u7684\u526f\u4f5c\u7528\uff0c\u88ab\u5e7f\u6cdb\u5e94\u7528\u4e8e\u7cbe\u795e\u75be\u75c5\u7684\u6cbb\u7597\u3002\u5728\u6211\u56fd\u7684\u5386\u53f2\u4e2d\uff0c\u864e\u6756\u662f\u4e00\u79cd\u5bf9\u7cbe\u795e\u75be\u75c5\u5177\u6709\u826f\u597d\u6cbb\u7597\u4f5c\u7528\u7684\u690d\u7269\u3002\u5176\u4e3b\u8981\u6709\u6548\u6210\u5206\u53cd\u5f0f\u767d\u85dc\u82a6\u9187\u5177\u6709\u591a\u79cd\u836f\u7406\u6d3b\u6027\uff0c\u5982\u6539\u5584\u5b66\u4e60\u8bb0\u5fc6\u3001\u6297\u708e\u3001\u6297\u6c27\u5316\u53ca\u795e\u7ecf\u4fdd\u62a4\u7b49\u3002\u7814\u7a76\u663e\u793a\uff0c\u53cd\u5f0f\u767d\u85dc\u82a6\u9187\u5177\u6709\u6291\u5236\u795e\u7ecf\u80f6\u8d28\u7ec6\u80de\u7684\u5355\u80fa\u6c27\u5316\u9176\uff08MAO)\u6d3b\u6027\u7684\u80fd\u529b\u3002MAO\u662f\u7ebf\u7c92\u4f53\u540c\u5de5\u9176\uff0c\u53ef\u7279\u5f02\u6027\u50ac\u5316\u4ee3\u8c22\u5355\u80fa\u7c7b\u795e\u7ecf\u9012\u8d28\uff0c\u59825-HT\u3001NE\u3001DA\u53ca\u5176\u4ed6\u5fae\u91cf\u80fa\u7c7b\u7269\u8d28\u3002MAO\u6291\u5236\u5242\u5bf9\u4e00\u4e9b\u795e\u7ecf\u7cbe\u795e\u75be\u75c5\u6709\u5f88\u597d\u7684\u6cbb\u7597\u4f5c\u7528\uff0c\u6bd4\u5982\u60c5\u7eea\u969c\u788d\u3001\u5e15\u91d1\u68ee\u7efc\u5408\u75c7\u7b49\u3002\u8fd1\u671f\u5bf9\u5927\u9f20\u7684\u7814\u7a76\u663e\u793a\uff0c\u53cd\u5f0f\u767d\u85dc\u82a6\u9187\u53ef\u6291\u5236\u5927\u9f20\u8111\u5185NE\u548c5-HT\u7684\u518d\u6444\u53d6\u3002\u4f46\u662f\u53cd\u5f0f\u767d\u85dc\u82a6\u9187\u662f\u5426\u662f\u901a\u8fc7\u5bf9MAO\u6d3b\u6027\u7684\u6291\u5236\uff0c\u8fdb\u800c\u589e\u52a0\u8111\u5185\u80fa\u7c7b\u795e\u7ecf\u9012\u8d28\u7684\u6c34\u5e73\u5c1a\u65e0\u5b9a\u8bba\u3002<\/p>\n

[0003] \u80e1\u6912\u78b1\u662f\u201c\u9999\u6599\u4e4b\u738b\u201d\u80e1\u6912\u4e2d\u7684\u4e3b\u8981\u6d3b\u6027\u5316\u5b66\u7269\u8d28\uff0c\u5c5e\u4e8e\u6842\u76ae\u9170\u80fa\u751f\u7269\u78b1\uff0c\u80e1\u6912\u78b1\u7684\u836f\u7406\u4f5c\u7528\u8f83\u4e3a\u5e7f\u6cdb\uff0c\u5177\u6709\u6297\u6c27\u5316\u3001\u514d\u75ab\u8c03\u8282\u7b49\u4f5c\u7528\uff0c\u662f\u4e00\u79cd\u751f\u7269\u6d3b\u6027\u589e\u5f3a\u5242\uff0c\u540c\u65f6\u5bf9\u6162\u6027\u5e94\u6fc0\u8bf1\u5bfc\u7684\u4e0b\u4e18\u8111-\u5782\u4f53-\u80be\u4e0a\u817a\u8f74\u529f\u80fd\u5931\u8c03\u6709\u4e00\u5b9a\u7684\u8c03\u8282\u4f5c\u7528\u3002\u80e1\u6912\u78b1\u4e0e\u4e00\u4e9b\u591a\u915a\u7c7b\u5316\u5408\u7269\u5408\u7528\uff0c\u53ef\u4ee5\u660e\u663e\u63d0\u9ad8\u591a\u915a\u7c7b\u5316\u5408\u7269\u7684\u751f\u7269\u5229\u7528\u5ea6\uff0c\u4f7f\u4f4e\u5242\u91cf\u7684\u591a\u915a\u7c7b\u5316\u5408\u7269\u8868\u73b0\u51fa\u5f88\u5f3a\u7684\u836f\u7406\u6d3b\u6027\u3002\u591a\u6570\u591a\u915a\u7c7b\u5316\u5408\u7269\u5177\u6709\u6291\u5236\u5355\u80fa\u6c27\u5316\u9176\u7684\u4f5c\u7528\uff0c\u5c06\u591a\u915a\u7c7b\u5316\u5408\u7269\u4e0e\u80e1\u6912\u78b1\u8054\u5408\u5e94\u7528\uff0c\u53ef\u4ee5\u4f5c\u7528\u4e8e\u6291\u90c1\u75c7\u53d1\u751f\u7684\u4e0d\u540c\u75c5\u7406\u8fc7\u7a0b\uff0c\u4ee5\u8fbe\u5230\u964d\u4f4e\u7528\u836f\u5242\u91cf\uff0c\u63d0\u9ad8\u836f\u7269\u7597\u6548\u7684\u76ee\u7684\uff0c\u4e3a\u5f00\u53d1\u65b0\u4e00\u4ee3\u9ad8\u6548\u4f4e\u6bd2\u7684\u5929\u7136\u6297\u6291\u90c1\u836f\u63d0\u4f9b\u65b0\u7684\u601d\u8def\u3002<\/p>\n

\u53d1\u660e\u5185\u5bb9<\/p>\n

[0004] \u672c\u53d1\u660e\u7684\u76ee\u7684\u63d0\u4f9b\u767d\u85dc\u82a6\u9187\u4e0e\u80e1\u6912\u78b1\u8054\u7528\u7684\u4e00\u79cd\u65b0\u7528\u9014\u3002<\/p>\n

[0005] \u7ecf\u8fc7\u52a8\u7269\u5b9e\u9a8c\u53d1\u73b0\u767d\u85dc\u82a6\u9187\u4e0e\u80e1\u6912\u78b1\u8054\u7528\u5177\u6709\u8f83\u597d\u7684\u6297\u6291\u90c1\u4f5c\u7528\uff0c\u662f\u4e00\u79cd\u8f83\u6709\u53d1\u5c55\u524d\u9014\u7684\u5929\u7136\u6297\u6291\u90c1\u5242\uff0c\u53ef\u7528\u4e8e\u5236\u5907\u6cbb\u7597\u6291\u90c1\u75c7\u7684\u836f\u7269\u3002<\/p>\n

\u5177\u4f53\u5b9e\u65bd\u65b9\u5f0f<\/p>\n

[0006] \u4ee5\u4e0b\u901a\u8fc7\u5b9e\u65bd\u4f8b\u8bf4\u660e\u672c\u53d1\u660e<\/p>\n

[0007] \u5b9e\u65bd\u4f8bI :\u5c0f\u9f20\u60ac\u5c3e\u5b9e\u9a8c\uff0c\u5f3a\u8feb\u6e38\u6cf3\u5b9e\u9a8c\uff0c\u81ea\u4e3b\u6d3b\u52a8\u5b9e\u9a8c\uff0cPCPA\u5b9e\u9a8c\uff0c\u5229\u8840\u5e73\u5b9e\u9a8c<\/p>\n

[0008] I\u3001\u53d7\u8bd5\u836f\u7269[0009]\u540d\u79f0\uff1a\u767d\u85dc\u82a6\u9187\uff08Resveratrol)\u3001\u80e1\u6912\u558a\uff08Piperine)<\/p>\n

[0010] \u6027\u72b6\uff1a\u767d\u9ece\u82a6\u9187\uff0c\u7c7b\u767d\u8272\u7cbe\u7ec6\u7c89\u672b\uff0c\u6c14\u7279\u6b8a\uff0c\u5473\u6de1\uff0c\u4ece\u864e\u6756\u4e2d\u63d0\u53d6\u80e1\u6912\u558a\uff0c\u767d\u8272\u6676\u4f53\u7c89\u672b<\/p>\n

[0011] \u6765\u6e90\uff1a\u8d2d\u81ea\u9655\u897f\u68ee\u5f17\u751f\u7269\u6280\u672f\u6709\u9650\u516c\u53f8\uff0c\u7eaf\u5ea6\u4e3a98%<\/p>\n

[0012] \u836f\u7269\u914d\u5236\uff1a\u80e1\u6912\u78b1\u7528O. 5%\u7fa7\u7532\u57fa\u7ea4\u7ef4\u7d20\u94a0\u6eb6\u89e3\uff0c\u914d\u62102. 5mg\/kg,\u6309O. lml\/10g\u5242\u91cf\u8fdb\u884c\u5c0f\u9f20\u8179\u8154\u6ce8\u5c04\u3002\u767d\u85dc\u82a6\u9187\u7528O. 5%\u7fa7\u7532\u57fa\u7ea4\u7ef4\u7d20\u94a0 \u6eb6\u89e3\uff0c\u5206\u522b\u914d\u62101.25mg\/kg\uff0c<\/p>\n

2. 5mg\/kg, 5mg\/kg, 10mg\/kg, 20mg\/kg \u4e94\u4e2a\u5242\u91cf,\u6309 O. lml\/10g \u5242\u91cf\u8fdb\u884c\u5c0f\u9f20\u704c\u80c3\u53e3\u670d\u3002<\/p>\n

[0013] 2\u3001\u5bf9\u7167\u836f\u7269<\/p>\n

[0014]\u76d0\u9178\u4e19\u54aa\u55ea\uff08imipramine hydrochloride)\u3001\u6c1f\u897f\u6c40\uff08fluoxetinehydrochloride) > PCPA(p-chlorophenylalanine HCl):\u8d2d\u81ea\u7f8e\u56fd Sigma \u516c\u53f8\u3002\u4f7f\u7528\u524d\u5c06\u4e19\u54aa\u55ea\u4e0e\u6c1f\u897f\u6c40\u7528\u53cc\u84b8\u6c34\u914d\u5236\u621010mg\/kg\u6d53\u5ea6,PCPA\u7528\u53cc\u84b8\u6c34\u914d\u5236\u6210300mg\/kg\u6d53\u5ea6,\u6309\u4e0a\u8ff0\u89c4\u683c\u7ed9\u4e88\u5c0f\u9f20\u8179\u8154\u6ce8\u5c04\u3002\u5229\u8840\u5e73\uff08Reserpine):\u8d2d\u81ea\u4e2d\u56fd\u836f\u54c1\u751f\u7269\u5236\u54c1\u68c0\u5b9a\u6240\u3002\u4f7f\u7528\u524d\u7528I %\u51b0\u918b\u9178\u914d\u5236\u62102. 5mg\/kg\u6d53\u5ea6\uff0c\u6309\u4e0a\u8ff0\u5242\u91cf\u7ed9\u4e88\u5c0f\u9f20\u76ae\u4e0b\u6ce8\u5c04<\/p>\n

[0015] 3\u3001\u52a8\u7269\u53ca\u5206\u7ec4<\/p>\n

[0016] ICR\u96c4\u6027\u5c0f\u9f20\uff0c\u4f53\u91cd20_24g\u3002\u6e29\u5dde\u533b\u5b66\u9662\u5b9e\u9a8c\u52a8\u7269\u4e2d\u5fc3\u63d0\u4f9b\u3002<\/p>\n

[0017] \u52a8\u7269\u968f\u673a\u5206\u62107\u7ec4\uff0c\u5bf9\u7167\u7ec4\u80e1\u6912\u78b12. 5mg\/kg,\u4e94\u4e2a\u5242\u91cf\u7ec4\u80e1\u6912\u78b12. 5mg\/kg+\u767d\u85dc\u82a6\u9187I. 25mg\/kg, 2. 5mg\/kg, 5mg\/kg, 10mg\/kg, 20mg\/kg\u4ee5\u53ca\u9633\u6027\u5bf9\u7167\u836f\u7ec4\u4e19\u54aa\u55ea\u7ec4,\u6bcf\u7ec412\u53ea\u3002<\/p>\n

[0018] 4\u3001\u5b9e\u9a8c\u65b9\u6cd5<\/p>\n

[0019]\u2460\u5c0f\u9f20\u60ac\u5c3e\u5b9e\u9a8c\uff1a\u6839\u636e\u6587\u732e(Steru, L.\uff0cChermat, R.\uff0cThierry, B.\uff0cand Simon,P. (1985)The Tail Suspension Test \uff1aA New Method for Screening Antidepressants inMice. Psychopharmacology (Berl) 85 :367-370.)\u8fdb\u884c\u3002\u7528\u80f6\u5e03\u5728\u8ddd\u5c0f\u9f20\u5c3e\u7aef Icm\u5904\u56fa\u5b9a,\u5e76\u60ac\u6302\u4e8e\u79bb\u573050cm\u5904\u3002\u5f00\u59cb\u65f6\uff0c\u5c0f\u9f20\u6323\u624e\u6d3b\u52a8\uff0c\u4e00\u6bb5\u65f6\u95f4\u540e\u56e0\u7edd\u671b\u800c\u9759\u6b62\u4e0d\u52a8\uff0c\u89c2\u5bdf6min\u5185\u5b9e\u9a8c\u52a8\u7269\u884c\u4e3a\uff0c\u5e76\u8bb0\u5f55\u540e4min\u5185\u7d2f\u8ba1\u7684\u4e0d\u52a8\u65f6\u95f4\u3002<\/p>\n

[0020] \u2461\u5c0f\u9f20\u5f3a\u8feb\u6e38\u6cf3\u5b9e\u9a8c\uff1a\u6839\u636e\u6587\u732e\uff08Porsolt, R. D. , Bertin, A. , andJalfre, \u039c. (1977)Behavioral Despair in Mice \uff1aAPrimary Screening Test forAntidepressants. Arch Int Pharmacodyn Ther 229 :327-336.)\u8fdb\u884c\u3002\u4e8e\u6d4b\u8bd5\u524d 24h,\u5c06\u5c0f\u9f20\u7f6e\u4e8e\u73bb\u7483\u5bb9\u5668\u5185\uff08\u9ad825cm ;\u76f4\u5f84IOcm ;\u6c34\u6df1IOcm ;\u6c34\u6e2924\u00b1 1\u00b0C )\u8bad\u7ec315min\u3002\u5c0f\u9f20\u653e\u5165\u6c34\u4e2d\u5373\u5f00\u59cb\u6e38\u6cf3\uff0c\u4e00\u6bb5\u65f6\u95f4\u540e\u56e0\u7edd\u671b\u800c\u6f02\u6d6e\u4e0d\u52a8\uff0c\u5f53\u5c0f\u9f20\u505c\u6b62\u6323\u624e\uff0c\u6d6e\u5728\u6c34\u4e2d\uff0c\u53ea\u505a\u4e00\u4e9b\u5fc5\u8981\u7684\u52a8\u4f5c\u4fdd\u6301\u5934\u90e8\u6d6e\u4e8e\u6c34\u9762\u4e0a\uff0c\u5373\u89c6\u4e3a\u4e0d\u52a8\u65f6\u95f4\u3002\u89c2\u5bdf6min\u5185\u5b9e\u9a8c\u52a8\u7269\u884c\u4e3a\uff0c\u8ba1\u540e4min\u4e0d\u52a8\u65f6\u95f4\u3002<\/p>\n

[0021]\u2462\u5c0f\u9f20\u81ea\u53d1\u6d3b\u52a8\uff1a\u4f9d\u7167\u6587\u732e(Xu, Y. ,Ku, B. S. ,Yao, H. Y. ,Lin, Y. H.\uff0cMa\uff0cX. ,Zhang,Y. H. et al. (2005)Antidepressant Effects of Curcumin in the Forced Swim Test andOlfactory Bulbectomy Models of Depression in Rats. Pharmacol Biochem Behav 82 \uff1a200-206.)\u8fdb\u884c\u3002\u5c06\u5c0f\u9f20\u7f6e\u4e8e\u81ea\u53d1\u6d3b\u52a8\u6d4b\u8bd5\u4eea\u5185\uff0c\u5185\u7f6e\u6444\u50cf\u5934\u7eaa\u5f55\u5c0f\u9f20\u6d3b\u52a8\u3002\u5148\u653e\u5165\u9002\u5e945min\u540e,\u8bb0\u5f55IOmin\u5185\u5c0f\u9f20\u7684\u6d3b\u52a8\u6b21\u6570\u3002<\/p>\n

[0022]\u2463 PCPA \u5b9e\u9a8c\uff1a\u4f9d\u7167\u6587\u732e(Redrobe, J. P.\uff0cBourin, M.\uff0cColombel, M. C.\uff0cand Baker,G.B. (1998)Psychopharmacological Profile of the Selective Serotonin ReuptakeInhibitor,Paroxetine \uff1aImplication of Noradrenergic and Serotonergic Mechanisms.J Psychopharmacol 12:348-355.)\u8fdb\u884c\u3002\u8fde\u7eed 3 \u5929\uff0c\u6bcf\u5929\u6ce8\u8eab\u5bf8\u4e00\u6b21 PCPA (300mg\/kg)\u3002\u81f3\u7b2c4\u65e5\uff0c\u7ed9\u4e88\u80e1\u6912\u78b1\u3001\u767d\u85dc\u82a6\u9187\u6216\u6c1f\u897f\u6c4060min\u548c30min\u540e\uff0c\u5206\u522b\u8fdb\u884c\u5f3a\u8feb\u6e38\u6cf3\u548c\u60ac\u5c3e\u6d4b\u8bd5\u3002<\/p>\n

[0023]\u2464\u5229\u8840\u5e73\u5b9e\u9a8c\uff1a\u6839\u636e\u6587\u732e\uff08Bourin, M. , Poncelet, M. , Chermat, R. , andSimon, P. (1983)The Value of the Reserpine Test in Psychopharmacology.Arzneimittelforschung 33 :1173-1176.)\u8fdb\u884c\u3002\u5c06\u5c0f\u9f20\u76ae\u4e0b\u6ce8\u5c04 2. 5mg\/kg \u5229\u8840\u5e73\u3002\u7ed9\u836f\u524d\u6d4b\u5b9a\u809b\u6e29\u4f5c\u4e3a\u57fa\u7840\u4f53\u6e29\uff0c\u7ed9\u836f\u540e4h\u6d4b\u5b9a\u4f53\u6e29\u4e0b\u964d\u60c5\u51b5\u3002\u773c\u7751\u4e0b\u5782\u4e8e\u7ed9\u836f\u540eO. 5h\uff0cIh\u6d4b\u5b9a\uff0c\u5e76\u6839\u636e\u4ee5\u4e0b\u8981\u6c42\u8bc4\u5206\uff1a0\uff0c\u773c\u775b\u5b8c\u5168\u7741\u5f00\uff1b1\uff0c1\/4\u95ed\u773c\uff1b2\uff0c1\/2\u95ed\u773c\uff1b3\uff0c3\/4\u95ed\u773c\uff1b4\uff0c\u5b8c\u5168\u95ed\u773c\u3002<\/p>\n

[0024] 5\u3001\u6570\u636e\u7edf\u8ba1\u5904\u7406<\/p>\n

[0025] \u7ed3\u679c\u6570\u636e\u7528\u5747\u6570\u571f\u6807\u51c6\u8bef\u8868\u793a\uff0c\u7528SPSS13. O\u7edf\u8ba1\u8f6f\u4ef6\uff0c\u9009\u7528\u5355\u56e0\u7d20\u65b9\u5dee\u5206\u6790(one-wayANOVA),\u7ec4\u95f4\u5dee\u5f02\u6bd4\u8f83\u7528 Dunnett\u2019 s test \u68c0\u9a8c\u3002<\/p>\n

[0026] 6\u3001\u7ed3\u679c\u7edf\u8ba1<\/p>\n

[0027] \u2460\u5c0f\u9f20\u60ac\u5c3e\u5b9e\u9a8c\u7ed3\u679c\uff1a<\/p>\n

\"\"<\/p>\n

[0029]\u6ce8\uff1a\u4e0e\u6b63\u5e38\u7ec4\u76f8\u6bd4\uff0c*P < O. 05\uff0c**P < 0.01<\/p>\n

[0030] \u2461\u5c0f\u9f20\u5f3a\u8feb\u6e38\u6cf3\u5b9e\u9a8c\u7ed3\u679c\uff1a<\/p>\n

[0031]<\/p>\n

\"\"<\/div>\n

[0032]\u6ce8\uff1a\u4e0e\u6b63\u5e38\u7ec4\u76f8\u6bd4\uff0c*P < 0. 05\uff0c**P < 0.01<\/p>\n

[0033] \u2462\u5c0f\u9f20\u81ea\u53d1\u6d3b\u52a8\u5b9e\u9a8c\u7ed3\u679c\uff1a<\/p>\n

[0034]<\/p>\n

\"\"<\/div>\n

\u00b7[0035] \u2463PCPA\u5b9e\u9a8c\u7ed3\u679c\uff1a<\/p>\n

[0036]<\/p>\n

\"\"<\/div>\n

[0037]\u6ce8\uff1a\u4e0e\u6b63\u5e38\u7ec4\u76f8\u6bd4\uff0c*\u03a1 < O. 05\uff0c**\u03a1 < O. 01<\/p>\n

[0038]<\/p>\n

\"\"<\/div>\n

[0039]\u6ce8\uff1a\u4e0e\u6b63\u5e38\u7ec4\u76f8\u6bd4\uff0c*P < O. 05\uff0c**P < O. 01<\/p>\n

[0040] \u2464\u5229\u8840\u5e73\u5b9e\u9a8c<\/p>\n

[0041]<\/p>\n

\"\"<\/div>\n

[0042] \u6ce8\uff1a\u4e0e\u5229\u8840\u5e73\u7ec4\u76f8\u6bd4\uff0c*\u03a1 < O. 05\uff0c**\u03a1 < O. 01<\/p>\n

[0043] \u5b9e\u65bd\u4f8b2 ;\u5c0f\u9f20\u5355\u80fa\u6c27\u5316\u9176\uff0c\u5355\u80fa\u9012\u8d28\u53ca\u5176\u4ee3\u8c22\u4ea7\u7269\u542b\u91cf\u6d4b\u5b9a<\/p>\n

[0044] I\u3001\u53d7\u8bd5\u836f\uff1a\u540c\u5b9e\u65bd\u4f8bI<\/p>\n

[0045] 2\u3001\u9633\u6027\u5bf9\u7167\u836f\uff1a\u4e8c\u6c22\u6eb4\u72ac\u8132\u80fa\uff0c4-\u6c22\u55b9\u5549\uff0c\u53f8\u7acb\u5409\u6797\uff0c\u6c2f\u5409\u6797\uff0c5-\u7f9f\u8272\u80fa\uff085-\u0397\u03a4)\uff0c\u53bb\u7532\u80be\u4e0a\u817a\u7d20\uff08NA)\uff0c\u591a\u5df4\u80fa\uff08DA)\uff0c5-\u7f9f\u57fa\u5f02\u4e01\u9178\uff085-\u0397\u0399\u0391\u0391)\uff0c\u4e8c\u7f9f\u82ef\u4e01\u9178\uff08DOPAC)\u5747\u8d2d\u81ea\u7f8e\u56fdSigma\u516c\u53f8\u3002\u5417\u6c2f\u8d1d\u80fa\u8d2d\u81ea\u4e2d\u56fd\u836f\u54c1\u751f\u7269\u5236\u54c1\u68c0\u5b9a\u6240\u3002<\/p>\n

[0046] 3\u3001\u5b9e\u9a8c\u65b9\u6cd5<\/p>\n

[0047] \u2460\u5355\u80fa\u9012\u8d28\u53ca\u5176\u4ee3\u8c22\u4ea7\u7269\u542b\u91cf\u6d4b\u5b9a\uff1a<\/p>\n

[0048] \u7ed9\u836f\u540e60min(\u80e1\u6912\u78b1i. p.;\u767d\u85dc\u82a6\u9187\uff0cp.o.;\u4e19\u54aa\u55ea\uff0ci. p.),\u5c06\u5c0f\u9f20\u5feb\u901f\u65ad\u5934\u5904\u6b7b,\u5728\u51b0\u4e0a\u8fc5\u901f\u5206\u79bb\u51fa\u989d\u53f6\u76ae\u5c42\u3001\u6d77\u9a6c\u3001\u7eb9\u72b6\u4f53\u548c\u4e0b\u4e18\u8111,\u79f0\u91cd\u540e\u653e\u5165Eppendorf\u7ba1\u4e2d\uff0c\u7f6e\u4e8e_80\u00b0C\u51b0\u7bb1\u4e2d\u4fdd\u5b58\u3002\u6bcfIOOmg\u8111\u7ec4\u7ec7\u4e2d\u52a0\u5165200 \u03bc I\u51b0O. 4mol\/L HCL04,\u51b0\u6d74\u4e2d\u8d85\u58f0\u5300\u6d46\uff0c4\u00b0C\u907f\u5149\u9759\u7f6e 60min,\u79bb\u5fc3 20min (12, OOOrpm, 4\u00b0C ),\u53d6\u4e0a\u6e05\u6db2\uff0c\u518d\u6b21\u79bb\u5fc3 20min (12, OOOrpm,4\u00b0C)\uff0c\u53d6\u4e0a\u6e05\u6db2\u8fdb\u884c\u5355\u80fa\u6d4b\u5b9a\u3002<\/p>\n

[0049] \u8111\u7ec4\u7ec7\u4e2d5-HT\u3001NE\u3001DA\u30015-HIAA\u548cDOPAC\u7684\u542b\u91cf\u91c7\u7528\u9ad8\u6548\u6db2\u76f8\u7535\u5316\u5b66\u6cd5\u6d4b\u5b9a\u3002\u6837\u54c1\u4e0a\u6e05\u6db2\u8fc7\u6ee4\uff08\u5b54\u5f840.22 \u03bc m)\u5904\u7406\u540e\uff0c\u53d620 \u03bc I\u81ea\u52a8\u8fdb\u6837\u3002\u8272\u8c31\u67f1\u4e3aDiamonsilimC18 (150X4. 6mm I. D. , 5 \u03bc m),\u6d41\u52a8\u76f8\u7ec4\u6210\uff1a125mmol\/L\u67b8\u6a7c\u9178\u4e00\u673d1\u6aac\u9178\u94a0\u7f13\u51b2\u6db2\uff08p H =<\/p>\n

4. 3),0. lmmol\/L EDTA\uff0cI. 2mmol\/L \u8f9b\u70f7\u57fa\u78fa\u9178\u94a0\uff0c16% \u7532\u9187\u3002\u6d41\u901f\uff1aI. Oml\/min\u3002\u68c0\u6d4b\u5668\u5de5\u4f5c\u7535\u538b\u5206\u522b\u4e3a\uff1a50\uff0c100\uff0c200\uff0c300\uff0c400\u548c500mV\u3002\u8111\u7ec4\u7ec7\u4e2d\u5355\u80fa\u53ca\u5176\u4ee3\u8c22\u4ea7\u7269\u7684\u542b\u91cf\u4ee5ng\/g\u6e7f\u7ec4\u7ec7\u91cd\u8868\u793a\u3002<\/p>\n

[0050] \u2461\u5355\u80fa\u6c27\u5316\u9176\u7684\u6d4b\u5b9a\uff1a<\/p>\n

[0051] \u7ed9\u836f\u540e60min(\u80e1\u6912\u78b1i. p.;\u767d\u85dc\u82a6\u9187,\u53e3.0.;\u4e19\u54aa\u55ea,i. p.)\u621660min (\u5417\u6c2f\u8d1d\u80fa\uff0cP. \u03bf.)\uff0c\u5c06\u5c0f\u9f20\u5feb\u901f\u65ad\u5934\u5904\u6b7b\uff0c\u5728\u51b0\u4e0a\u8fc5\u901f\u5206\u79bb\u51fa\u8111\u7ec4\u7ec7\uff0c\u79f0\u91cd\u540e\u52a0\u51654ml\u51b0\u78f7\u9178\u7f13\u51b2\u6db2\uff08pH=7. 8,0. 05mol\/L)\u5236\u6210\u5300\u6d46\u6db2\uff0c\u57282. 5ml\u78f7\u9178\u7f13\u51b2\u6db2\u4e2d\u52a0\u516520%\u66f2\u901a0. 4ml\u548c\u7ec4\u7ec7\u5300\u6d46\u6db20. 2mL\uff0c\u6eb6\u6db2\u6df7\u5408\u540e37\u00b0C\u9884\u5b75\u80b2lOmin\uff0c\u5728\u53cd\u5e94\u6db2\u4e2d\u52a0\u516530 \u03bc L 2. 19mmol\/L\u5e95\u7269\uff08\u7ec8\u6d53\u5ea6\u4e3a22\u03bc mol\/L)\uff0c37\u00b0C\u9884\u5b75\u80b230min\uff0c\u5728\u53cd\u5e94\u6db2\u4e2d\u52a0\u51650. 2m 5mol\/L\u9ad8\u6c2f\u9178\u6eb6\u6db2\uff0c\u51b7\u5374\u5e76\u79bb\u5fc3\uff081500Xg, IOmin),\u57280. 5mL\u4e0a\u6e05\u6db2\u4e2d\u52a0\u5165lmol\/L\u6c22\u6c27\u5316\u94a0\u6eb6\u6db22. 5mL\u3002\u901a\u8fc7\u7a81\u5149\u5206\u5149\u5149\u5ea6\u8ba1\u5728\u6fc0\u53d1\u5149318nm\uff0c\u53d1\u5c04\u5149380nm\u5904\u6d4b\u5b9a\u4ea7\u72694-\u6c22\u55b9\u5549\u7684\u8367\u5149\u5f3a\u5ea6\u3002\u5355\u80fa\u6c27\u5316\u9176\u6d3b\u6027\u4ee5nmol\/30min\/mg protein\u8868\u793a\u3002\u91c7\u7528Bradford\u6cd5\u6d4b\u5b9a\u86cb\u767d\u542b\u91cf\u3002<\/p>\n

[0052] 4\u3001\u5b9e\u9a8c\u7ed3\u679c\uff1a<\/p>\n

[0053] \u2460\u5c0f\u9f20\u4e0d\u540c\u8111\u533a\u5355\u80fa\u9012\u8d28\u53ca\u5176\u4ee3\u8c22\u4ea7\u7269\u542b\u91cf\u7684\u6d4b\u5b9a<\/p>\n

[0054] \u8868\u4e00\uff1a\u767d\u85dc\u82a6\u9187\u4e0e\u80e1\u6912\u78b1\u8054\u7528\u5bf9\u5c0f\u9f20\u989d\u53f6\u76ae\u5c42\u8111\u533a\u5355\u80fa\u9012\u8d28\u53ca\u5176\u4ee3\u8c22\u4ea7\u7269\u542b\u91cf\u7684\u5f71\u54cd\uff08\u03b7 = 8,\u5747\u6570\u571f\u6807\u51c6\u8bef\uff09<\/p>\n

[0055]<\/p>\n

\"\"<\/div>\n

[0056]\u4e0e\u6b63\u5e38\u7ec4\u76f8\u6bd4\uff0c*\u03a1 < O. 05\uff0c**\u03a1 < O. 01<\/p>\n

[0057] \u8868\u4e8c \uff1a\u767d\u85dc\u82a6\u9187\u4e0e\u80e1\u6912\u78b1\u8054\u7528\u5bf9\u5c0f\u9f20\u6d77\u9a6c\u8111\u533a\u5355\u80fa\u9012\u8d28\u53ca\u5176\u4ee3\u8c22\u4ea7\u7269\u542b\u91cf\u7684\u5f71\u54cd(\u03b7 = 8,\u5747\u6570\u571f\u6807\u51c6\u8bef\uff09<\/p>\n

[0058]<\/p>\n

\"\"<\/div>\n

[0059]\u4e0e\u6b63\u5e38\u7ec4\u76f8\u6bd4\uff0c*P < O. 05\uff0c**P < 0.01<\/p>\n

[0060] \u8868\u4e09\uff1a\u767d\u85dc\u82a6\u9187\u4e0e\u80e1\u6912\u78b1\u8054\u7528\u5bf9\u5c0f\u9f20\u4e0b\u4e18\u8111\u8111\u533a\u5355\u80fa\u9012\u8d28\u53ca\u5176\u4ee3\u8c22\u4ea7\u7269\u542b\u91cf\u7684\u5f71\u54cd\uff08\u03b7 = 8,\u5747\u6570\u571f\u6807\u51c6\u8bef\uff09<\/p>\n

[0061]<\/p>\n

\"\"<\/div>\n

[0062]\u4e0e\u6b63\u5e38\u7ec4\u76f8\u6bd4\uff0c*P < 0\u00b7 05\uff0c**P < 0. 01<\/p>\n

[0063] \u2461\u5c0f\u9f20\u8111\u5185\u5355\u80fa\u6c27\u5316\u9176\u6d3b\u6027\u7684\u6d4b\u5b9a\uff08\u03b7 = 8\uff0c\u5747\u6570\u571f\u6807\u51c6\u8bef)<\/p>\n

[0064]<\/p>\n

\"\"<\/div>\n

[0065]\u4e0e\u6b63\u5e38\u7ec4\u76f8\u6bd4\uff0c*\u03a1 < O. 05\uff0c**\u03a1 < O. 01\uff0c***\u03a1 < O. 001<\/p>\n

[0066] \u4e0a\u8ff0\u5b9e\u9a8c\u91c7\u7528\u5c0f\u9f20\u60ac\u5c3e\u3001\u5f3a\u8feb\u6e38\u6cf3\u3001PCPA\u3001\u5229\u8840\u5e73\u6a21\u578b\uff0c\u6d4b\u5b9a\u4e0d\u540c\u8111\u533a\u5355\u80fa\u6c27\u5316\u9176\u6d3b\u6027\uff0c\u4ece\u836f\u7406\u5b66\u548c\u795e\u7ecf\u5316\u5b66\u7684\u89d2\u5ea6\u63a2\u8ba8\u4e86\u767d\u85dc\u82a6\u9187\u4e0e\u80e1\u6912\u78b1\u8054\u7528\u7684\u6297\u6291\u90c1\u4f5c\u7528\uff0c\u7ed3\u679c\u663e\u793a\uff0c\u7ed9\u836f\u540e\u767d\u85dc\u82a6\u9187\u7684\u6297\u6291\u90c1\u4f5c\u7528\u4e0e\u7ecf\u5178\u6297\u6291\u90c1\u836f\u4e19\u54aa\u55ea\u4f5c\u7528\u76f8\u4f3c\uff0c\u80fd\u663e\u8457\u51cf\u5c11\u5c0f\u9f20\u5728\u60ac\u5c3e\u548c\u5f3a\u8feb\u6e38\u6cf3\u5b9e\u9a8c\u4e2d\u7684\u4e0d\u52a8\u65f6\u95f4\uff0c\u800c\u5bf9\u81ea\u4e3b\u6d3b\u52a8\u6ca1\u6709\u660e\u663e\u5f71\u54cd\u3002\u767d\u85dc\u82a6\u9187\u80fd\u6291\u5236\u5355\u80fa\u6c27\u5316\u9176A\u7684\u6d3b\u6027\uff0c\u5bf9\u5355\u80fa\u9012\u8d28\u5408\u6210\u548c\u4ee3\u8c22\u7684\u5f71\u54cd\u662f\u767d\u85dc\u82a6\u9187\u6297\u6291\u90c1\u4f5c\u7528\u7684\u673a\u5236\u4e4b\u4e00\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n

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\n

 <\/p>\n

PATENT CITATIONS<\/span><\/div>\n\n\n\n\n\n\n
Cited Patent<\/th>\nFiling date<\/th>\nPublication date<\/th>\nApplicant<\/th>\nTitle<\/th>\n<\/tr>\n<\/thead>\n
CN101801361A<\/a> *<\/span><\/td>\nJun 20, 2008<\/td>\nAug 11, 2010<\/td>\ne-\u751f\u7269\u6709\u9650\u516c\u53f8<\/td>\n\u6291\u90c1\u75c7\u7684\u6cbb\u7597<\/td>\n<\/tr>\n
CN101985440A<\/a> *<\/span><\/td>\nOct 30, 2010<\/td>\nMar 16, 2011<\/td>\n\u66a8\u5357\u5927\u5b66<\/td>\n\u4e00\u79cd\u80e1\u6912\u78b1\u7684\u751f\u4ea7\u65b9\u6cd5<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
* Cited by examiner<\/div>\n<\/div>\n
\n

 <\/p>\n

NON-PATENT CITATIONS<\/span><\/div>\n\n\n\n\n\n
Reference<\/th>\n<\/tr>\n<\/thead>\n
1<\/td>\n*<\/span><\/td>\nJEREMY J ET AL.: “Enhancing the bioavailability of resveratrol by combining it with piperine<\/a>“, \u300aMOLECULAR NUTRITION & FOOD RESEARCH\u300b, vol. 55, no. 8, 31 August 2011 (2011-08-31), pages 1169 – 1176<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
* Cited by examiner<\/div>\n<\/div>\n
\n

 <\/p>\n

CLASSIFICATIONS<\/span><\/div>\n\n\n\n\n\n
<\/th>\n<\/th>\n<\/tr>\n<\/thead>\n
International Classification<\/td>\nA61P25\/24<\/a><\/span>, A61K31\/05<\/a><\/span>, A61K31\/4525<\/a><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
<\/div>\n<\/div>\n
\n
LEGAL EVENTS<\/span><\/div>\n\n\n\n\n\n\n\n
Date<\/th>\nCode<\/th>\nEvent<\/th>\nDescription<\/th>\n<\/tr>\n<\/thead>\n
Mar 20, 2013<\/td>\nC06<\/td>\nPublication<\/td>\n<\/tr>\n
Jun 5, 2013<\/td>\nC10<\/td>\nEntry into substantive examination<\/td>\n<\/tr>\n
Mar 25, 2015<\/td>\nC02<\/td>\nDeemed withdrawal of patent application after publication (patent law 2001)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

\u6587\u7ae0\uff1a \u6765\u6e90GOOGLE \u5b66\u672f\u6587\u7ae0\u67e5\u8be2<\/p>\n

\u4e0b\u8f7d PDF \u6587\u4ef6<\/a><\/p>\n

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Inventors \u6f58\u5efa\u6625, \u5f90\u82f1 Applicant \u6e29\u5dde\u533b\u5b66\u9662 ABSTRACT \u672c\u53d1\u660e\u6d89\u53ca\u4e00\u79cd\u8054\u5408\u7528\u836f\uff0c\u767d\u85dc\u82a6\u9187\u4e0e\u80e1\u6912\u78b1\u8054\u7528\u7528\u4e8e\u6cbb\u7597\u6291\u90c1\u75c7\u3002\u7ecf\u8fc7\u52a8\u7269\u5b9e\u9a8c\u8bc1\u660e\uff0c\u5177\u6709\u8f83\u597d\u7684\u6297\u6291\u90c1\u4f5c\u7528\uff0c\u662f\u4e00\u79cd\u8f83\u6709\u524d\u9014\u7684\u5929\u7136\u6297\u6291\u90c1\u836f\u5242\uff0c\u53ef\u7528\u4e8e\u5236\u5907\u6cbb\u7597\u6291\u90c1\u75c7\u7684\u836f\u7269\u3002 CLAIMS(1) 1.\u767d\u85dc\u82a6\u9187\u4e0e\u80e1\u6912\u78b1\u8054\u7528\u7528\u4e8e\u5236\u5907\u6cbb\u7597\u6291\u90c1\u75c7\u836f\u7269\u7684\u7528\u9014\u3002 DESCRIPTION \u767d\u85dc\u82a6\u9187\u4e0e\u80e1\u6912\u78b1\u8054\u7528\u7528\u4e8e\u5236\u5907\u6cbb\u7597\u6291\u90c1\u75c7\u836f\u7269\u7684\u7528\u9014 \u6280\u672f\u9886\u57df [0001] \u672c\u53d1\u660e\u6d89\u53ca\u767d\u85dc\u82a6\u9187\u4e0e\u80e1\u6912\u78b1\u8054\u7528\u7684\u4e00\u79cd\u65b0\u7528\u9014\uff0c\u7279\u522b\u662f\u6d89\u53ca\u7528\u4e8e\u5236\u5907\u6cbb\u7597\u6291\u90c1\u75c7\u836f\u7269\u7684\u7528\u9014\u3002 \u80cc\u666f\u6280\u672f [0002] \u6291\u90c1\u75c7\u662f\u4e00\u79cd\u4e25\u91cd\u5f71\u54cd\u8eab\u5fc3\u5065\u5eb7\u7684\u60c5\u611f\u969c\u788d\u6027\u7cbe\u795e\u75be\u75c5\u3002\u968f\u7740\u4eba\u4eec\u751f\u5b58\u548c\u53d1\u5c55\u538b\u529b\u65e5\u76ca\u589e\u52a0\uff0c\u6291\u90c1\u75c7\u5df2\u6210\u4e3a\u73b0\u4ee3\u793e\u4f1a\u7684\u5e38\u89c1\u75c5\u3002\u91cd\u5ea6\u6291\u90c1\u75c7\u60a3\u8005\u8868\u73b0\u4e3a\u8111\u5185\u5355\u80fa\u795e\u7ecf\u9012\u8d28\u7279\u522b\u662f\u53bb\u7532\u80be\u4e0a\u817a\u7d20\uff08NE)\u548c5-\u7f9f\u8272\u80fa\uff085-HT)\u53cd\u5c04\u6027\u5730\u6539\u53d8\u3002\u76ee\u524d\uff0c\u836f\u7269\u6cbb\u7597\u662f\u5bf9\u6291\u90c1\u75c7\u6cbb\u7597\u7684\u9996\u9009\u9009\u62e9\u3002\u4e34\u5e8a\u4e0a\u6709\u51e0\u79cd\u5178\u578b\u7684\u6297\u6291\u90c1\u836f\u90fd\u662f\u901a\u8fc7\u63d0\u9ad8\u5355\u80fa\u7c7b\u7269\u8d28\u6c34\u00b7\u5e73\u59825-HT\u3001NE\u53d1\u6325\u6297\u6291\u90c1\u4f5c\u7528\u3002\u4f46\u662f\u5927\u591a\u6570\u836f\u7269\u90fd\u5177\u6709\u4e0d\u826f\u53cd\u5e94\uff0c\u800c\u4e14\u6cbb\u7597\u6548\u679c\u4e0d\u662f\u5f88\u597d\u3002\u6240\u4ee5\uff0c\u5bf9\u836f\u7269\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6cbb\u7597\u56e0\u7d20\u7684\u7814\u7a76\u663e\u5f97\u610f\u4e49\u91cd\u5927\u3002\u7531\u4e8e\u4e2d\u56fd\u4f20\u7edf\u836f\u7528\u690d\u7269\u5177\u6709\u826f\u597d\u7684\u987a\u5e94\u6027\u548c\u6e29\u548c\u7684\u526f\u4f5c\u7528\uff0c\u88ab\u5e7f\u6cdb\u5e94\u7528\u4e8e\u7cbe\u795e\u75be\u75c5\u7684\u6cbb\u7597\u3002\u5728\u6211\u56fd\u7684\u5386\u53f2\u4e2d\uff0c\u864e\u6756\u662f\u4e00\u79cd\u5bf9\u7cbe\u795e\u75be\u75c5\u5177\u6709\u826f\u597d\u6cbb\u7597\u4f5c\u7528\u7684\u690d\u7269\u3002\u5176\u4e3b\u8981\u6709\u6548\u6210\u5206\u53cd\u5f0f\u767d\u85dc\u82a6\u9187\u5177\u6709\u591a\u79cd\u836f\u7406\u6d3b\u6027\uff0c\u5982\u6539\u5584\u5b66\u4e60\u8bb0\u5fc6\u3001\u6297\u708e\u3001\u6297\u6c27\u5316\u53ca\u795e\u7ecf\u4fdd\u62a4\u7b49\u3002\u7814\u7a76\u663e\u793a\uff0c\u53cd\u5f0f\u767d\u85dc\u82a6\u9187\u5177\u6709\u6291\u5236\u795e\u7ecf\u80f6\u8d28\u7ec6\u80de\u7684\u5355\u80fa\u6c27\u5316\u9176\uff08MAO)\u6d3b\u6027\u7684\u80fd\u529b\u3002MAO\u662f\u7ebf\u7c92\u4f53\u540c\u5de5\u9176\uff0c\u53ef\u7279\u5f02\u6027\u50ac\u5316\u4ee3\u8c22\u5355\u80fa\u7c7b\u795e\u7ecf\u9012\u8d28\uff0c\u59825-HT\u3001NE\u3001DA\u53ca\u5176\u4ed6\u5fae\u91cf\u80fa\u7c7b\u7269\u8d28\u3002MAO\u6291\u5236\u5242\u5bf9\u4e00\u4e9b\u795e\u7ecf\u7cbe\u795e\u75be\u75c5\u6709\u5f88\u597d\u7684\u6cbb\u7597\u4f5c\u7528\uff0c\u6bd4\u5982\u60c5\u7eea\u969c\u788d\u3001\u5e15\u91d1\u68ee\u7efc\u5408\u75c7\u7b49\u3002\u8fd1\u671f\u5bf9\u5927\u9f20\u7684\u7814\u7a76\u663e\u793a\uff0c\u53cd\u5f0f\u767d\u85dc\u82a6\u9187\u53ef\u6291\u5236\u5927\u9f20\u8111\u5185NE\u548c5-HT\u7684\u518d\u6444\u53d6\u3002\u4f46\u662f\u53cd\u5f0f\u767d\u85dc\u82a6\u9187\u662f\u5426\u662f\u901a\u8fc7\u5bf9MAO\u6d3b\u6027\u7684\u6291\u5236\uff0c\u8fdb\u800c\u589e\u52a0\u8111\u5185\u80fa\u7c7b\u795e\u7ecf\u9012\u8d28\u7684\u6c34\u5e73\u5c1a\u65e0\u5b9a\u8bba\u3002<\/p>\n

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