{"id":2806,"date":"2017-08-26T02:23:23","date_gmt":"2017-08-26T02:23:23","guid":{"rendered":"http:\/\/health-anything.com\/?p=2806"},"modified":"2022-05-25T14:10:32","modified_gmt":"2022-05-25T14:10:32","slug":"%e7%99%bd%e8%97%9c%e8%8a%a6%e9%86%87%e7%94%a8%e4%ba%8e%e5%88%b6%e5%a4%87%e6%b2%bb%e7%96%97%e6%8a%91%e9%83%81%e7%97%87%e8%8d%af%e7%89%a9%e7%9a%84%e7%94%a8%e9%80%94-cn-101721396-a","status":"publish","type":"post","link":"http:\/\/johnhealth.blog\/ch\/?p=2806","title":{"rendered":"\u767d\u85dc\u82a6\u9187\u7528\u4e8e\u5236\u5907\u6cbb\u7597\u6291\u90c1\u75c7\u836f\u7269\u7684\u7528\u9014 CN 101721396 A"},"content":{"rendered":"
\n
\n\n\n\n\n
Inventors<\/td>\n\u5f90\u82f1, <\/span>\u6f58\u5efa\u6625, <\/span>\u674e\u9ad8\u6587, <\/span>\u674e \u5584, <\/span>\u5c24\u6587\u633a<\/span><\/span><\/td>\n<\/tr>\n
Applicant<\/td>\n\u6e29\u5dde\u533b\u5b66\u9662<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n
ABSTRACT<\/span><\/div>\n
\n
\u672c\u53d1\u660e\u6d89\u53ca\u767d\u85dc\u82a6\u9187\u7528\u4e8e\u5236\u5907\u6cbb\u7597\u6291\u90c1\u75c7\u836f\u7269\u7684\u7528\u9014\uff0c\u7ecf\u8fc7\u52a8\u7269\u5b9e\u9a8c\u8bc1\u660e\u767d\u85dc\u82a6\u9187\u5177\u6709\u8f83\u597d\u7684\u6297\u6291\u90c1\u4f5c\u7528\uff0c\u662f\u4e00\u79cd\u8f83\u6709\u53d1\u5c55\u524d\u9014\u7684\u5929\u7136\u6297\u6291\u90c1\u5242\uff0c\u53ef\u7528\u4e8e\u5236\u5907\u6cbb\u7597\u6291\u90c1\u75c7\u7684\u836f\u7269\u3002<\/div>\n<\/div>\n<\/div>\n
\n
<\/div>\n
CLAIMS(1)<\/span><\/span><\/div>\n
\n
\n
\n
\n
1.\u767d\u85dc\u82a6\u9187\u7528\u4e8e\u5236\u5907\u6cbb\u7597\u6291\u90c1\u75c7\u836f\u7269\u7684\u7528\u9014\u3002<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n
\n
DESCRIPTION<\/span><\/div>\n
\n
\n

\u767d\u85dc\u82a6\u9187\u7528\u4e8e\u5236\u5907\u6cbb\u7597\u6291\u90c1\u75c7\u836f\u7269\u7684\u7528\u9014[0001] \u6280\u672f\u9886\u57df<\/p>\n

[0002] \u672c\u53d1\u660e\u6d89\u53ca\u767d\u85dc\u82a6\u9187\u7684\u4e00\u79cd\u65b0\u7528\u9014\uff0c\u7279\u522b\u662f\u6d89\u53ca\u767d\u85dc\u82a6\u9187\u7528\u4e8e\u5236\u5907\u6cbb\u7597\u6291\u90c1\u75c7\u836f\u7269\u7684\u7528\u9014\u3002<\/p>\n

[0003] \u80cc\u666f\u6280\u672f<\/p>\n

[0004] \u6291\u90c1\u75c7\u662f\u4e00\u79cd\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u81f4\u6b8b\u6027\u75be\u75c5\uff0c\u968f\u7740\u793e\u4f1a\u73b0\u4ee3\u5316\u8fdb\u7a0b\u7684\u52a0\u5feb\uff0c\u5404\u79cd\u5e94\u6fc0\u56e0\u7d20\u5bfc\u81f4\u7684\u6291\u90c1\u75c7\u5df2\u6210\u4e3a\u73b0\u4ee3\u793e\u4f1a\u7684\u5e38\u89c1\u75c5\u548c\u591a\u53d1\u75c5\u3002\u76ee\u524d\u5168\u4e16\u754c\u7ea6\u67093\uff05-5\uff05\u7684\u4eba\u7f79\u60a3\u6291\u90c1\u75c7\uff0c\u4f4d\u5c45\u81f4\u6b8b\u6027\u75be\u75c5\u7684\u9996\u4f4d<\/span>\u3002\u53d1\u75c5\u7387\u9ad8\u4e14\u96be\u4ee5\u6839\u6cbb\u7684\u6291\u90c1\u75c7\u6b63\u6084\u6084\u5730\u6784\u5efa\u53ef\u89c2\u7684\u6297\u6291\u90c1\u836f\u5e02\u573a\uff0c\u8fd9\u6b63\u662f\u8fd1\u5e74\u6765\u56fd\u5185\u5916\u5bf9\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u836f\u7269\u7684\u7814\u7a76\u548c\u5f00\u53d1\u7279\u522b\u6d3b\u8dc3\u7684\u4e3b\u8981\u539f\u56e0\u4e4b\u4e00\u3002\u6240\u4ee5\uff0c\u7814\u7a76\u548c\u5f00\u53d1\u65b0\u578b\u3001\u9ad8\u6548\u3001\u4f4e\u6bd2\u526f\u4f5c\u7528\u7684\u6297\u6291\u90c1\u836f\u59cb\u7ec8\u662f\u7cbe\u795e\u836f\u7406\u5b66\u9886\u57df\u7684\u4e00\u4e2a\u91cd\u8981\u7814\u7a76\u8bfe\u9898\u3002<\/p>\n

\u7531\u4e8e\u6291\u90c1\u75c7\u7684\u75c5\u56e0\u590d\u6742\uff0c\u6d89\u53ca\u5230\u4ea4\u611f\u795e\u7ecf\u3001\u5185\u5206\u6ccc\u548c\u514d\u75ab\u7cfb\u7edf\u7b49\u673a\u4f53\u591a\u4e2a\u65b9\u9762\u3002\u201c\u5355\u80fa\u5047\u8bf4\u201d\u662f\u6291\u90c1\u75c7\u673a\u5236\u7814\u7a76\u7684\u4e3b\u6d41\u89c2\u70b9\uff0c\u8ba4\u4e3a\u5355\u80fa\u7c7b\u795e\u7ecf\u9012\u8d28(5-\u7f9f\u8272\u80fa\u3001\u53bb\u7532\u80be\u4e0a\u817a\u7d20\u548c\u591a\u5df4\u80fa\u795e\u7ecf\u9012\u8d28)\u5728\u6291\u90c1\u75c7\u7684\u75c5\u56e0\u3001\u75c5\u7406\u4e2d\u8d77\u5173\u952e\u4f5c\u7528\u3002\u76ee\u524d\u4e34\u5e8a\u4e0a\u4f7f\u7528\u7684\u6297\u6291\u90c1\u836f\u4e00\u822c\u662f\u901a\u8fc7\u5f71\u54cd\u5355\u80fa\u9012\u8d28\u7684\u91cd\u5438\u6536\u3001\u6291\u5236\u5355\u80fa\u7684\u4ee3\u8c22\u6216\u963b\u65ad\u7a81\u89e6\u524d\u6291\u5236\u6027\u81ea\u4e3b\u6216\u975e\u81ea\u4e3b\u53d7\u4f53\u800c\u53d1\u6325\u4f5c\u7528\u3002\u836f\u7269\u5927\u81f4\u53ef\u5206\u6210\u4e09\u7c7b\uff1a1.\u5355\u80fa\u91cd\u6444\u53d6\u6291\u5236\u5242\uff1b2.\u5355\u80fa\u6c27\u5316\u9176\u6291\u5236\u5242\uff1b3.5-HT\u53d7\u4f53\u62ee\u6297\u5242\u3002\u7531\u4e8e\u4e34\u5e8a\u4e0a\u4f7f\u7528\u7684\u8fd9\u4e9b\u836f\u7269\u5927\u7ea6\u53ea\u5bf965\uff05\u7684\u75c5\u4eba\u8d77\u6548\uff0c\u800c\u4e14\u8bb8\u591a\u836f\u7269\u7597\u6548\u5e76\u4e0d\u7a33\u5b9a\uff0c\u6bd2\u526f\u4f5c\u7528\u8f83\u5927\uff0c\u751f\u7269\u5229\u7528\u5ea6\u4e0d\u9ad8\uff0c\u4e00\u822c\u8981\u57282-4\u5468\u8d77\u6548\u3002\u56e0\u6b64\uff0c\u4ece\u5929\u7136\u690d\u7269\u4e2d\u5f00\u53d1\u5b89\u5168\u6709\u6548\u3001\u6bd2\u526f\u4f5c\u7528\u5c0f\uff0c\u751f\u7269\u5229\u7528\u5ea6\u9ad8\u7684\u5929\u7136\u6297\u6291\u90c1\u836f\u6210\u4e3a\u8fd9\u4e00\u9886\u57df\u7684\u7814\u7a76\u65b9\u5411\u3002\u767d\u85dc\u82a6\u9187(Resveratrol)\u662f\u4e00\u79cd\u591a\u915a\u7c7b\u7269\u8d28\uff0c\u5176\u5316\u5b66\u5f0f\u4e3a3\uff0c5\uff0c4\u2032-\u4e09\u7f9f\u57fa\u4e8c\u82ef\u4e59\u70ef(3\uff0c5\uff0c4\u2032-trihydroxysitlbene)\uff0c\u5e7f\u6cdb\u5b58\u5728\u4e8e\u5929\u7136\u690d\u7269\u4e2d\uff0c\u5c24\u5176\u5728\u8461\u8404\u79d1\u690d\u7269\u679c\u76ae\u4e2d\u542b\u91cf\u6700\u9ad8\u3002\u767d\u85dc\u82a6\u9187\u4e3a\u8102\u6eb6\u6027\u7269\u8d28\uff0c\u6613\u901a\u8fc7\u8840\u8111\u5c4f\u969c\u3002\u7814\u7a76\u8868\u660e\uff0c\u767d\u85dc\u82a6\u9187\u5177\u6709\u6297\u6c27\u5316\u3001\u514d\u75ab\u8c03\u8282\u3001\u6297\u8870\u8001\u53ca\u9884\u9632\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u7b49\u4f5c\u7528<\/span><\/strong>\uff0c\u76ee\u524d\u5c1a\u672a\u89c1\u5c06\u767d\u85dc\u82a6\u9187\u7528\u4e8e\u6cbb\u7597\u6291\u90c1\u75c7\u7684\u7814\u7a76\u62a5\u9053\u3002<\/p>\n

[0005] \u53d1\u660e\u5185\u5bb9<\/p>\n

[0006] \u672c\u53d1\u660e\u7684\u76ee\u7684\u63d0\u4f9b\u767d\u85dc\u82a6\u9187\u7684\u4e00\u79cd\u65b0\u7528\u9014\u3002<\/p>\n

[0007] \u7ecf\u8fc7\u52a8\u7269\u5b9e\u9a8c\u53d1\u73b0\u767d\u85dc\u82a6\u9187\u5177\u6709\u8f83\u597d\u7684\u6297\u6291\u90c1\u4f5c\u7528\uff0c\u662f\u4e00\u79cd\u8f83\u6709\u53d1\u5c55\u524d\u9014\u7684\u5929\u7136\u6297\u6291\u90c1\u5242\uff0c\u53ef\u7528\u4e8e\u5236\u5907\u6cbb\u7597\u6291\u90c1\u75c7\u7684\u836f\u7269\u3002<\/span><\/strong><\/p>\n

[0008] \u5177\u4f53\u5b9e\u65bd\u65b9\u5f0f<\/p>\n

[0009] \u4ee5\u4e0b\u901a\u8fc7\u5b9e\u65bd\u4f8b\u8bf4\u660e\u672c\u53d1\u660e\u3002<\/p>\n

[0010] \u5b9e\u65bd\u4f8b1\uff1a\u5c0f\u9f20\u60ac\u5c3e\u5b9e\u9a8c\uff0c\u5f3a\u8feb\u6e38\u6cf3\u5b9e\u9a8c\uff0c\u81ea\u4e3b\u6d3b\u52a8\u5b9e\u9a8c<\/p>\n

[0011] 1\u3001\u53d7\u8bd5\u836f\u7269<\/p>\n

[0012] \u540d\u79f0\uff1a\u767d\u85dc\u82a6\u9187(Resveratrol)<\/p>\n

[0013] \u6027\u72b6\uff1a\u7c7b\u767d\u8272\u7cbe\u7ec6\u7c89\u672b\uff0c\u6c14\u7279\u6b8a\uff0c\u5473\u6de1\uff0c\u4ece\u864e\u6756\u4e2d\u63d0\u53d6<\/p>\n

[0014] \u6765\u6e90\uff1a\u8d2d\u81ea\u9655\u897f\u68ee\u4f5b\u751f\u7269\u6280\u672f\u6709\u9650\u516c\u53f8\uff0c\u7eaf\u5ea6\u4e3a98\uff05<\/p>\n

[0015] \u836f\u7269\u7684\u914d\u7f6e\uff1a\u75280.5\uff05\u6d53\u5ea6\u7684\u7fa7\u7532\u57fa\u7ea4\u7ef4\u7d20\u94a0(CMC-Na)\u6eb6\u89e3\u767d\u85dc\u82a6\u9187\uff0c\u5206\u522b\u914d\u621010mg\/kg\uff0c20mg\/kg\uff0c40mg\/kg\u548c80mg\/kg\u56db\u4e2a\u5242\u91cf\uff0c\u63090.1ml\/10g\u5242\u91cf\u7ed9\u4e88\u5c0f\u9f20\u704c\u80c3\u53e3\u670d\u3002<\/p>\n

[0016] 2\u3001\u5bf9\u7167\u836f\u7269<\/p>\n

[0017] \u76d0\u9178\u4e19\u54aa\u55ea(Imipramine)\uff1a\u8d2d\u81ea\u7f8e\u56fdSigma\u516c\u53f8\uff0c\u4e34\u7528\u524d\u7528\u53cc\u84b8\u6c34\u914d\u7f6e\u621010mg\/kg\u6d53\u5ea6\uff0c\u6309\u4e0a\u8ff0\u89c4\u683c\u7ed9\u4e88\u5c0f\u9f20\u8179\u8154\u6ce8\u5c04\u3002<\/p>\n

[0018] 3\u3001\u52a8\u7269\u53ca\u5206\u7ec4<\/p>\n

[0019] ICR\u96c4\u6027\u5c0f\u9f20\uff0c\u4f53\u91cd20-24g\u3002\u6e29\u5dde\u533b\u5b66\u9662\u5b9e\u9a8c\u52a8\u7269\u4e2d\u5fc3\u63d0\u4f9b\u3002<\/p>\n

[0020] \u52a8\u7269\u968f\u673a\u5206\u4e3a6\u7ec4\uff0c\u6b63\u5e38\u5bf9\u7167\u7ec4\uff0c\u767d\u85dc\u82a6\u918710mg\/kg\uff0c20mg\/kg\uff0c40mg\/kg\u548c80mg\/kg\u56db\u4e2a\u5242\u91cf\u7ec4\u4ee5\u53ca\u9633\u6027\u5bf9\u7167\u836f\u4e19\u54aa\u55ea\u7ec4\uff0c\u6bcf\u7ec4\u52a8\u726912\u53ea\u3002<\/p>\n

[0021] 4\u3001\u5b9e\u9a8c\u65b9\u6cd5<\/p>\n

[0022] \u2460\u5c0f\u9f20\u60ac\u5c3e\u5b9e\u9a8c\uff1a\u6309\u7167\u6587\u732e(SteruL\uff0cChermatR\uff0cThierryB\uff0cetal.Thetail\u00a0suspensiontest\uff1aa\u00a0new\u00a0method\u00a0for\u00a0screeningantidepressants\u00a0in\u00a0mice[J].Psychopharmacol\uff0c1985\uff0c85\uff1a367.)\u8fdb\u884c\uff0c\u7ed9\u836f\u540e60min(\u767d\u85dc\u82a6\u9187i.g.)\u6216\u800530min(\u4e19\u54aa\u55ea\uff0ci.p.)\uff0c\u5728\u8ddd\u5c0f\u9f20\u5c3e\u5c16\u90e8\u672b\u68a2\u7ea62cm\u7684\u90e8\u4f4d\u7528\u80f6\u5e03\u56fa\u5b9a\u4e8e\u94c1\u67b6\u53f0\u4e0a\uff0c\u4f7f\u5c0f\u9f20\u5934\u5411\u4e0b\u60ac\u6302\uff0c\u5012\u6302\u4e8e\u7bb1\u5b50(30cm\u00d730cm\u00d725cm)\u4e2d\uff0c\u5934\u90e8\u8ddd\u79bb\u7bb1\u5e9515cm\u3002\u5f00\u59cb\u65f6\uff0c\u5c0f\u9f20\u5934\u90e8\u4e0a\u4e0b\u5de6\u53f3\u6d3b\u52a8\uff0c\u4f01\u56fe\u627e\u5230\u6500\u6293\u7684\u5730\u65b9\uff0c\u4e00\u6bb5\u65f6\u95f4\u540e\u56e0\u5931\u671b\u800c\u6d3b\u52a8\u6b21\u6570\u51cf\u5c11\uff0c\u5373\u51fa\u73b0\u95f4\u65ad\u6027\u4e0d\u52a8\u3002\u89c2\u5bdf6min\u5185\u5b9e\u9a8c\u52a8\u7269\u884c\u4e3a\uff0c\u5e76\u8bb0\u5f55\u540e4min\u5185\u5c0f\u9f20\u7684\u4e0d\u52a8\u65f6\u95f4\u3002<\/p>\n

[0023] \u2461\u5c0f\u9f20\u5f3a\u8feb\u6e38\u6cf3\u5b9e\u9a8c\uff1a\u6309\u7167\u6587\u732e(Porsolt\uff0cRD\uff0cBertin\uff0cA\uff0cJalfreM\uff0cetal.Behavioral\u00a0despair\u00a0in\u00a0mice\uff1aa\u00a0primary\u00a0screening\u00a0test\u00a0forantidepressants[J].Arch\u00a0lnt\u00a0Pharmacadyn\u00a0Ther\uff0c1977\uff0c229\uff1a327.)\u8fdb\u884c\uff0c\u6b63\u5f0f\u6d4b\u8bd5\u524d24h\uff0c\u5c06\u5c0f\u9f20\u7f6e\u4e8e\u6c34\u6df110cm\u7684\u73bb\u7483\u5927\u70e7\u676f(1500ml)\u4e2d\uff0c\u6c34\u6e29(24\u00b11)\u2103\uff0c\u4f5c\u6e38\u6cf3\u8bad\u7ec315min\u3002\u7ed9\u836f\u540e60min(\u767d\u85dc\u82a6\u9187\uff0ci.g.)\u6216\u800530min(\u4e19\u54aa\u55ea\uff0ci.p.)\uff0c\u518d\u6b21\u5c06\u5c0f\u9f20\u7f6e\u4e8e\u6c34\u6df110cm\u7684\u73bb\u7483\u5927\u70e7\u676f\u5185\u5f3a\u8feb\u6e38\u6cf36min\uff0c\u89c2\u5bdf\u8bb0\u5f55\u540e4min\u5185\u5c0f\u9f20\u7684\u4e0d\u52a8\u65f6\u95f4\u3002\u5c0f\u9f20\u653e\u5165\u6c34\u4e2d\u540e\u5373\u6e38\u6cf3\uff0c\u5bfb\u627e\u6816\u606f\u7684\u5730\u65b9\uff0c\u4e00\u6bb5\u65f6\u95f4\u540e\u4fbf\u56e0\u5931\u671b\u800c\u6f02\u6d6e\u4e0d\u52a8\uff0c\u5f53\u5c0f\u8001\u9f20\u505c\u6b62\u6323\u624e\uff0c\u6d6e\u5728\u6c34\u4e2d\u4fdd\u6301\u4e0d\u52a8\uff0c\u6216\u4ec5\u4f5c\u4e00\u4e9b\u5fc5\u8981\u7684\u8f7b\u5fae\u52a8\u4f5c\u4fdd\u6301\u5934\u90e8\u6d6e\u5728\u6c34\u9762\u4e0a\u7684\u65f6\u95f4\u89c6\u4e3a\u4e0d\u52a8\u65f6\u95f4\u3002<\/p>\n

[0024] \u2462\u5c0f\u9f20\u81ea\u53d1\u6d3b\u52a8\u5b9e\u9a8c\uff1a\u6309\u7167\u6587\u732e(Li\u00a0J\u00a0X\uff0cZhang\u00a0Q\uff0cLiang\u00a0J\u00a0H\uff0cetal.Valproate\u00a0prevents\u00a0the\u00a0inductiong\uff0cbut\u00a0not\u00a0the\u00a0expresionof\u00a0morphine\u00a0sensitization\u00a0in\u00a0mice[J].Behav\u00a0Brain\u00a0Res\uff0c2004\uff0c52\uff1a251.)\u8fdb\u884c\uff0c\u7ed9\u836f\u540e60min(\u767d\u85dc\u82a6\u9187\uff0ci.g.)\u6216\u800530min(\u4e19\u54aa\u55ea\uff0ci.p.)\u540e\u5c06\u5c0f\u9f20\u653e\u4eba\u81ea\u4e3b\u6d3b\u52a8\u6d4b\u8bd5\u4eea\u7684\u5c0f\u5ba4\u5185\uff0c\u7531\u5185\u7f6e\u7684\u6444\u50cf\u5934\u62cd\u6444\u8bb0\u5f55\u5c0f\u9f20\u6d3b\u52a8\u3002\u5c0f\u9f20\u9002\u5e94\u73af\u588310min\u540e\uff0c\u8bb0\u5f5510min\u5185\u5c0f\u9f20\u7684\u6d3b\u52a8\u6b21\u6570\u4f5c\u4e3a\u81ea\u4e3b\u6d3b\u52a8\u7684\u8bc4\u4ef7\u6307\u6807\u3002<\/p>\n

[0025] 5\u3001\u6570\u636e\u7edf\u8ba1\u5904\u7406<\/p>\n

[0026] \u7ed3\u679c\u6570\u636e\u7528\u5747\u6570\u00b1\u6807\u51c6\u5dee\u8868\u793a\uff0c\u7528SPSS11.0\u7edf\u8ba1\u8f6f\u4ef6\uff0c\u9009\u7528\u5355\u56e0\u7d20\u65b9\u5dee\u5206\u6790(one-way\u00a0ANOVA)\uff0c\u7ec4\u95f4\u5dee\u5f02\u6bd4\u8f83\u7528Dunnett\u2019s\u00a0test\u68c0\u9a8c\u3002<\/p>\n

[0027] 6\u3001\u7ed3\u679c\u7edf\u8ba1<\/p>\n

[0028] \u2460\u5c0f\u9f20\u60ac\u5c3e\u5b9e\u9a8c\u7ed3\u679c\uff1a<\/p>\n

[0029]<\/p>\n

Image not available. View PDF<\/a><\/span><\/p>\n

[0030] \u6ce8\uff1a\u4e0e\u6b63\u5e38\u7ec4\u76f8\u6bd4\uff0c*P\uff1c0.05\uff0c**P\uff1c0.01<\/p>\n

[0031] \u2461\u5c0f\u9f20\u5f3a\u8feb\u6e38\u6cf3\u5b9e\u9a8c\u7ed3\u679c\uff1a<\/p>\n

[0032]<\/p>\n

Image not available. View PDF<\/a><\/span><\/p>\n

[0033] \u6ce8\uff1a\u4e0e\u6b63\u5e38\u7ec4\u76f8\u6bd4\uff0c*P\uff1c0.05\uff0c**P\uff1c0.01\uff0c***P\uff1c0.001<\/p>\n

[0034] \u2462\u5c0f\u9f20\u81ea\u53d1\u6d3b\u52a8\u5b9e\u9a8c\u7ed3\u679c\uff1a<\/p>\n

[0035]<\/p>\n

Image not available. View PDF<\/a><\/span><\/p>\n

[0036] \u5b9e\u65bd\u4f8b2\uff1a\u5c0f\u9f20\u5355\u80fa\u6c27\u5316\u9176\uff0c\u5355\u80fa\u9012\u8d28\u53ca\u5176\u4ee3\u8c22\u7269\u542b\u91cf\u6d4b\u5b9a<\/p>\n

[0037] 1\u3001\u53d7\u8bd5\u836f\uff1a\u540c\u5b9e\u65bd\u4f8b1<\/p>\n

[0038] 2\u3001\u9633\u6027\u5bf9\u7167\u836f\uff1a\u4e8c\u6c22\u6eb4\u72ac\u8132\u80fa\uff0c4-\u6c22\u55b9\u5549\uff0c\u53f8\u7acb\u5409\u6797\uff0c\u6c2f\u5409\u6797\uff0c5-\u7f9f\u8272\u80fa(5-HT)\uff0c\u53bb\u7532\u80be\u4e0a\u817a\u7d20(NA)\uff0c\u591a\u5df4\u80fa(DA)\uff0c5-\u7f9f\u57fa\u5f02\u4e01\u9178(5-HIAA)\uff0c\u4e8c\u7f9f\u82ef\u4e59\u9178(DOPAC)\u5747\u8d2d\u81ea\u7f8e\u56fdSigma\u516c\u53f8\u3002\u5417\u6c2f\u8d1d\u80fa\u7531\u519b\u4e8b\u533b\u5b66\u79d1\u5b66\u9662\u6bd2\u7269\u4e0e\u836f\u7269\u7814\u7a76\u6240\u63d0\u4f9b\uff0c\u7eaf\u5ea6\u4e3a95\uff05\u3002<\/p>\n

[0039] 3\u3001\u5b9e\u9a8c\u65b9\u6cd5<\/p>\n

[0040] \u2460\u5355\u80fa\u6c27\u5316\u9176\u7684\u6d4b\u5b9a\uff1a<\/p>\n

[0041] \u7ed9\u836f\u540e60min(\u767d\u85dc\u82a6\u9187\uff0ci.g.)\u621630min(\u4e19\u54aa\u55ea\uff0ci.p.)\uff0c\u5c06\u5c0f\u9f20\u5feb\u901f\u65ad\u5934\u5904\u6b7b\uff0c\u5728\u51b0\u4e0a\u8fc5\u901f\u5206\u79bb\u51fa\u8111\u7ec4\u7ec7\uff0c\u79f0\u91cd\u540e\u52a0\u51654ml\u51b0\u51b7\u78f7\u9178\u7f13\u51b2\u6db2(pH\uff1d7.8\uff0c0.05mol\/l)\u5236\u6210\u5300\u6d46\u6db2\uff0c\u57282.5ml\u78f7\u9178\u7f13\u51b2\u6db2\u4e2d\u52a0\u516520\uff05\u66f2\u901a0.4ml\u548c\u7ec4\u7ec7\u5300\u6d46\u6db20.2ml\uff0c\u6eb6\u6db2\u6df7\u5408\u540e38\u2103\u9884\u5b75\u80b210min\uff0c\u5728\u53cd\u5e94\u6db2\u4e2d\u52a0\u516530\u03bcl\u00a02.19mmol\/L\u5e95\u7269(\u7ec8\u6d53\u5ea6\u4e3a22\u03bcmol\/L)\uff0c37\u2103\u9884\u5b75\u80b230min\uff0c\u5728\u53cd\u5e94\u6db2\u4e2d\u52a0\u51650.2ml\u00a05mol\/L\u9ad8\u6c2f\u9178\u6eb6\u6db2\uff0c\u51b7\u5374\u5e76\u79bb\u5fc3(1500\u00d7g\uff0c10min)\uff0c\u57280.5ml\u4e0a\u6e05\u6db2\u4e2d\u52a0\u51651mol\/L\u6c22\u6c27\u5316\u94a0\u6eb6\u6db22.5ml\u3002\u901a\u8fc7\u8367\u5149\u5206\u5149\u5149\u5ea6\u8ba1\u5728\u6fc0\u53d1\u5149318nm\uff0c\u53d1\u5c04\u5149380nm\u5904\u6d4b\u5b9a\u4ea7\u72694-\u6c22\u55b9\u5549\u7684\u8367\u5149\u5f3a\u5ea6\u3002\u5355\u80fa\u6c27\u5316\u9176\u6d3b\u6027\u4ee5nmol\/30min\/mg\u00a0protein\u8868\u793a\u3002\u91c7\u7528Bradford\u6cd5\u6d4b\u5b9a\u86cb\u767d\u542b\u91cf\u3002<\/p>\n

[0042] \u2461\u5355\u80fa\u9012\u8d28\u53ca\u5176\u4ee3\u8c22\u7269\u542b\u91cf\u6d4b\u5b9a\uff1a<\/p>\n

[0043] \u7ed9\u836f\u540e60min(\u767d\u85dc\u82a6\u9187\uff0ci.g.)\u621630min(\u4e19\u54aa\u55ea\uff0ci.p.)\uff0c\u5c06\u5c0f\u9f20\u5feb\u901f\u65ad\u5934\u5904\u6b7b\uff0c\u5728\u51b0\u4e0a\u8fc5\u901f\u5206\u79bb\u51fa\u989d\u53f6\u76ae\u5c42\u3001\u6d77\u9a6c\u548c\u4e0b\u4e18\u8111\uff0c\u79f0\u91cd\u540e\u653e\u5165Eppendorf\u7ba1\u4e2d\uff0c\u7f6e\u4e8e-80\u2103\u51b0\u7bb1\u4e2d\u4fdd\u5b58\u3002<\/p>\n

[0044] \u6bcf100mg\u8111\u7ec4\u7ec7\u4e2d\u52a0\u5165200\u03bcl\u51b0\u51b7A\u6db2(0.4mol\/L\u00a0HCLO4)\uff0c\u51b0\u6d74\u4e2d\u8d85\u58f0\u5300\u6d46\uff0c4\u2103\u907f\u5149\u9759\u7f6e60min\uff0c\u79bb\u5fc320min(12,000rpm\uff0c4\u2103)\uff0c\u53d6\u4e0a\u6e05\u6db2\uff0c\u52a0\u5165\u534a\u91cf\u4f53\u79ef\u7684B\u6db2(0.2mol\/L\u67e0\u6aac\u9178\u94be\uff0c0.3mol\/L\u00a0K2HPO4\u548c0.2mol\/L\u00a0EDTA)\uff0c\u6da1\u65cb\u6df7\u530010min\uff0c4\u2103\u907f\u5149\u9759\u7f6e60min\uff0c\u518d\u6b21\u79bb\u5fc320min(12,000rpm\uff0c4\u2103)\uff0c\u53d6\u4e0a\u6e05\u6db2\u8fdb\u884c\u5355\u80fa\u6d4b\u5b9a\u3002<\/p>\n

[0045] \u8111\u7ec4\u7ec7\u4e2d5-HT\u3001NA\u3001DA\u30015-HIAA\u548cDOPAC\u7684\u542b\u91cf\u91c7\u7528\u9ad8\u6548\u6db2\u76f8\u7535\u5316\u5b66\u6cd5\u6d4b\u5b9a\u3002\u6837\u54c1\u4e0a\u6e05\u6db2\u8fc7\u6ee4(\u5b54\u5f840.22\u03bcm)\u5904\u7406\u540e\uff0c\u53d620\u03bcl\u81ea\u52a8\u8fdb\u6837\u3002\u8272\u8c31\u67f1\u4e3aDiamonsilim\u00a0C18(150\u00d74.6mm\u00a0I.D.\uff0c5\u03bcm)\uff0c\u6d41\u52a8\u76f8\u7ec4\u6210\uff1a125mmol\/L\u67b8\u6a7c\u9178-\u67e0\u6aac\u9178\u94a0\u7f13\u51b2\u6db2(pH\uff1d4.3)\uff0c0.1mmol\/LEDTA\uff0c1.2mmol\/L\u8f9b\u70f7\u57fa\u78fa\u9178\u94a0\uff0c16\uff05\u7532\u9187\u3002\u6d41\u901f\uff1a1.0ml\/min\u3002\u68c0\u6d4b\u5668\u5de5\u4f5c\u7535\u538b\u5206\u522b\u4e3a\uff1a50\uff0c100\uff0c200\uff0c300\uff0c400\u548c500mV\u3002\u8111\u7ec4\u7ec7\u4e2d\u5355\u80fa\u53ca\u5176\u4ee3\u8c22\u4ea7\u7269\u7684\u542b\u91cf\u4ee5ng\/g\u6e7f\u7ec4\u7ec7\u91cd\u8868\u793a\u3002<\/p>\n

[0046] 4\u3001\u5b9e\u9a8c\u7ed3\u679c\uff1a<\/p>\n

[0047] \u2460\u5c0f\u9f20\u8111\u5185\u5355\u80fa\u6c27\u5316\u9176\u6d3b\u6027\u7684\u6d4b\u5b9a(n\uff1d8\uff0c\u5747\u6570\u00b1\u6807\u51c6\u5dee)<\/p>\n

[0048]<\/p>\n

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[0049] \u6ce8\uff1a\u4e0e\u6b63\u5e38\u7ec4\u76f8\u6bd4\uff0c*P\uff1c0.05\uff0c**P\uff1c0.01\uff0c***P\uff1c0.001<\/p>\n

[0050] \u2461\u5c0f\u9f20\u4e0d\u540c\u8111\u533a\u5355\u80fa\u9012\u8d28\u53ca\u5176\u4ee3\u8c22\u4ea7\u7269\u542b\u91cf\u6d4b\u5b9a<\/p>\n

[0051] \u8868\u4e00\uff1a\u767d\u85dc\u82a6\u9187\u5bf9\u5c0f\u9f20\u989d\u53f6\u76ae\u5c42\u8111\u533a\u5355\u80fa\u9012\u8d28\u53ca\u5176\u4ee3\u8c22\u4ea7\u7269\u542b\u91cf\u7684\u5f71\u54cd(n\uff1d8\uff0c\u5747\u6570\u00b1\u6807\u51c6\u5dee)<\/p>\n

[0052]<\/p>\n

Image not available. View PDF<\/a><\/span><\/p>\n

[0053] \u6ce8\uff1a\u4e0e\u6b63\u5e38\u7ec4\u6bd4\u8f83\uff0c*P\uff1c0.05\uff0c**P\uff1c0.01\uff0c***P\uff1c0.001<\/p>\n

[0054] \u8868\u4e8c\uff1a\u767d\u85dc\u82a6\u9187\u5bf9\u5c0f\u9f20\u6d77\u9a6c\u8111\u533a\u5355\u80fa\u9012\u8d28\u53ca\u5176\u4ee3\u8c22\u4ea7\u7269\u542b\u91cf\u7684\u5f71\u54cd(n\uff1d8\uff0c\u5747\u6570\u00b1\u6807\u51c6\u5dee)<\/p>\n

[0055]<\/p>\n

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[0056] \u6ce8\uff1a\u4e0e\u6b63\u5e38\u7ec4\u6bd4\u8f83\uff0c*P\uff1c0.05\uff0c**P\uff1c0.01<\/p>\n

[0057] \u8868\u4e09\uff1a\u767d\u85dc\u82a6\u9187\u5bf9\u5c0f\u9f20\u4e0b\u4e18\u8111\u8111\u533a\u5355\u80fa\u9012\u8d28\u53ca\u5176\u4ee3\u8c22\u4ea7\u7269\u542b\u91cf\u7684\u5f71\u54cd(n\uff1d8\uff0c\u5747\u6570\u00b1\u6807\u51c6\u5dee)<\/p>\n

[0058]<\/p>\n

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[0059] \u6ce8\uff1a\u4e0e\u6b63\u5e38\u7ec4\u6bd4\u8f83\uff0c*P\uff1c0.05\uff0c**P\uff1c0.01<\/p>\n

[0060] \u672c\u5b9e\u9a8c\u5df2\u5bf9\u767d\u85dc\u82a6\u9187\u7684\u6297\u6291\u90c1\u4f5c\u7528\u505a\u4e86\u521d\u6b65\u7814\u7a76\uff0c\u91c7\u7528\u7ecf\u5178\u5c0f\u9f20\u884c\u4e3a\u7edd\u671b\u5b9e\u9a8c\u6a21\u578b(\u60ac\u5c3e\u548c\u5f3a\u8feb\u6e38\u6cf3\u5b9e\u9a8c)\uff0c\u4ece\u884c\u4e3a\u836f\u7406\u5b66\u548c\u795e\u7ecf\u5316\u5b66\u7684\u89d2\u5ea6\u63a2\u8ba8\u4e86\u767d\u85dc\u82a6\u9187\u7684\u6297\u6291\u90c1\u4f5c\u7528\u3002\u7ed3\u679c\u663e\u793a\uff0c\u767d\u85dc\u82a6\u9187\u5177\u6709\u4e00\u5b9a\u7684\u6297\u6291\u90c1\u4f5c\u7528\uff0c\u80fd\u663e\u8457\u51cf\u5c11\u5c0f\u9f20\u5728\u60ac\u5c3e\u548c\u5f3a\u8feb\u6e38\u6cf3\u5b9e\u9a8c\u4e2d\u7684\u4e0d\u52a8\u65f6\u95f4\u3002\u7814\u7a76\u663e\u793a\u767d\u85dc\u82a6\u9187\u80fd\u660e\u663e\u589e\u52a0\u5c0f\u9f20\u989d\u53f6\u76ae\u5c42\u548c\u6d77\u9a6c\u4e2d5-HT\u542b\u91cf\uff0c\u4e0b\u4e18\u8111\u548c\u7eb9\u72b6\u4f53\u4e2dNA\u548cDA\u542b\u91cf\u4e5f\u6709\u4e00\u5b9a\u589e\u52a0\u3002\u5355\u80fa\u6c27\u5316\u9176\u6d3b\u6027\u6d4b\u5b9a\u5b9e\u9a8c\u53d1\u73b0\uff0c\u767d\u85dc\u82a6\u9187\u80fd\u660e\u663e\u6291\u5236\u5355\u80fa\u6c27\u5316\u9176\u6d3b\u6027A\u7684\u6d3b\u6027\uff0c\u5bf9\u5355\u80fa\u6c27\u5316\u9176B\u6d3b\u6027\u4e5f\u6709\u4e00\u5b9a\u6291\u5236\u4f5c\u7528\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n

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REFERENCED BY<\/span><\/div>\n\n\n\n\n\n
CITING PATENT<\/th>\nFILING DATE<\/th>\nPUBLICATION DATE<\/th>\nAPPLICANT<\/th>\nTITLE<\/th>\n<\/tr>\n<\/thead>\n
CN103127245A<\/a> *<\/span><\/td>\nMar 15, 2013<\/td>\nJun 5, 2013<\/td>\n\u6cb3\u5357\u4e2d\u533b\u5b66\u9662<\/td>\n\u864e\u6756\u6df7\u60ac\u6db2\u3001\u63d0\u53d6\u7269\u5728\u5236\u5907\u6cbb\u7597\u6291\u90c1\u75c7\u836f\u7269\u4e2d\u7684\u5e94\u7528<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
* Cited by examiner<\/div>\n<\/div>\n
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CLASSIFICATIONS<\/span><\/div>\n\n\n\n\n\n
<\/th>\n<\/th>\n<\/tr>\n<\/thead>\n
International Classification<\/td>\nA61P25\/24<\/a><\/span>, A61K31\/05<\/a><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
<\/div>\n<\/div>\n
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LEGAL EVENTS<\/span><\/div>\n\n\n\n\n\n\n\n
DATE<\/th>\nCODE<\/th>\nEVENT<\/th>\nDESCRIPTION<\/th>\n<\/tr>\n<\/thead>\n
Jun 9, 2010<\/td>\nC06<\/td>\nPublication<\/td>\n<\/tr>\n
Aug 11, 2010<\/td>\nC10<\/td>\nRequest of examination as to substance<\/td>\n<\/tr>\n
Nov 30, 2011<\/td>\nC02<\/td>\nDeemed withdrawal of patent application after publication (patent law 2001)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

\u6587\u7ae0\uff1a \u6765\u6e90GOOGLE \u5b66\u672f\u6587\u7ae0\u67e5\u8be2<\/p>\n

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Inventors \u5f90\u82f1, \u6f58\u5efa\u6625, \u674e\u9ad8\u6587, \u674e \u5584, \u5c24\u6587\u633a Applicant \u6e29\u5dde\u533b\u5b66\u9662 ABSTRACT \u672c\u53d1\u660e\u6d89\u53ca\u767d\u85dc\u82a6\u9187\u7528\u4e8e\u5236\u5907\u6cbb\u7597\u6291\u90c1\u75c7\u836f\u7269\u7684\u7528\u9014\uff0c\u7ecf\u8fc7\u52a8\u7269\u5b9e\u9a8c\u8bc1\u660e\u767d\u85dc\u82a6\u9187\u5177\u6709\u8f83\u597d\u7684\u6297\u6291\u90c1\u4f5c\u7528\uff0c\u662f\u4e00\u79cd\u8f83\u6709\u53d1\u5c55\u524d\u9014\u7684\u5929\u7136\u6297\u6291\u90c1\u5242\uff0c\u53ef\u7528\u4e8e\u5236\u5907\u6cbb\u7597\u6291\u90c1\u75c7\u7684\u836f\u7269\u3002 CLAIMS(1) 1.\u767d\u85dc\u82a6\u9187\u7528\u4e8e\u5236\u5907\u6cbb\u7597\u6291\u90c1\u75c7\u836f\u7269\u7684\u7528\u9014\u3002 DESCRIPTION \u767d\u85dc\u82a6\u9187\u7528\u4e8e\u5236\u5907\u6cbb\u7597\u6291\u90c1\u75c7\u836f\u7269\u7684\u7528\u9014[0001] \u6280\u672f\u9886\u57df [0002] \u672c\u53d1\u660e\u6d89\u53ca\u767d\u85dc\u82a6\u9187\u7684\u4e00\u79cd\u65b0\u7528\u9014\uff0c\u7279\u522b\u662f\u6d89\u53ca\u767d\u85dc\u82a6\u9187\u7528\u4e8e\u5236\u5907\u6cbb\u7597\u6291\u90c1\u75c7\u836f\u7269\u7684\u7528\u9014\u3002 [0003] \u80cc\u666f\u6280\u672f [0004] \u6291\u90c1\u75c7\u662f\u4e00\u79cd\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u81f4\u6b8b\u6027\u75be\u75c5\uff0c\u968f\u7740\u793e\u4f1a\u73b0\u4ee3\u5316\u8fdb\u7a0b\u7684\u52a0\u5feb\uff0c\u5404\u79cd\u5e94\u6fc0\u56e0\u7d20\u5bfc\u81f4\u7684\u6291\u90c1\u75c7\u5df2\u6210\u4e3a\u73b0\u4ee3\u793e\u4f1a\u7684\u5e38\u89c1\u75c5\u548c\u591a\u53d1\u75c5\u3002\u76ee\u524d\u5168\u4e16\u754c\u7ea6\u67093\uff05-5\uff05\u7684\u4eba\u7f79\u60a3\u6291\u90c1\u75c7\uff0c\u4f4d\u5c45\u81f4\u6b8b\u6027\u75be\u75c5\u7684\u9996\u4f4d\u3002\u53d1\u75c5\u7387\u9ad8\u4e14\u96be\u4ee5\u6839\u6cbb\u7684\u6291\u90c1\u75c7\u6b63\u6084\u6084\u5730\u6784\u5efa\u53ef\u89c2\u7684\u6297\u6291\u90c1\u836f\u5e02\u573a\uff0c\u8fd9\u6b63\u662f\u8fd1\u5e74\u6765\u56fd\u5185\u5916\u5bf9\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u836f\u7269\u7684\u7814\u7a76\u548c\u5f00\u53d1\u7279\u522b\u6d3b\u8dc3\u7684\u4e3b\u8981\u539f\u56e0\u4e4b\u4e00\u3002\u6240\u4ee5\uff0c\u7814\u7a76\u548c\u5f00\u53d1\u65b0\u578b\u3001\u9ad8\u6548\u3001\u4f4e\u6bd2\u526f\u4f5c\u7528\u7684\u6297\u6291\u90c1\u836f\u59cb\u7ec8\u662f\u7cbe\u795e\u836f\u7406\u5b66\u9886\u57df\u7684\u4e00\u4e2a\u91cd\u8981\u7814\u7a76\u8bfe\u9898\u3002 \u7531\u4e8e\u6291\u90c1\u75c7\u7684\u75c5\u56e0\u590d\u6742\uff0c\u6d89\u53ca\u5230\u4ea4\u611f\u795e\u7ecf\u3001\u5185\u5206\u6ccc\u548c\u514d\u75ab\u7cfb\u7edf\u7b49\u673a\u4f53\u591a\u4e2a\u65b9\u9762\u3002\u201c\u5355\u80fa\u5047\u8bf4\u201d\u662f\u6291\u90c1\u75c7\u673a\u5236\u7814\u7a76\u7684\u4e3b\u6d41\u89c2\u70b9\uff0c\u8ba4\u4e3a\u5355\u80fa\u7c7b\u795e\u7ecf\u9012\u8d28(5-\u7f9f\u8272\u80fa\u3001\u53bb\u7532\u80be\u4e0a\u817a\u7d20\u548c\u591a\u5df4\u80fa\u795e\u7ecf\u9012\u8d28)\u5728\u6291\u90c1\u75c7\u7684\u75c5\u56e0\u3001\u75c5\u7406\u4e2d\u8d77\u5173\u952e\u4f5c\u7528\u3002\u76ee\u524d\u4e34\u5e8a\u4e0a\u4f7f\u7528\u7684\u6297\u6291\u90c1\u836f\u4e00\u822c\u662f\u901a\u8fc7\u5f71\u54cd\u5355\u80fa\u9012\u8d28\u7684\u91cd\u5438\u6536\u3001\u6291\u5236\u5355\u80fa\u7684\u4ee3\u8c22\u6216\u963b\u65ad\u7a81\u89e6\u524d\u6291\u5236\u6027\u81ea\u4e3b\u6216\u975e\u81ea\u4e3b\u53d7\u4f53\u800c\u53d1\u6325\u4f5c\u7528\u3002\u836f\u7269\u5927\u81f4\u53ef\u5206\u6210\u4e09\u7c7b\uff1a1.\u5355\u80fa\u91cd\u6444\u53d6\u6291\u5236\u5242\uff1b2.\u5355\u80fa\u6c27\u5316\u9176\u6291\u5236\u5242\uff1b3.5-HT\u53d7\u4f53\u62ee\u6297\u5242\u3002\u7531\u4e8e\u4e34\u5e8a\u4e0a\u4f7f\u7528\u7684\u8fd9\u4e9b\u836f\u7269\u5927\u7ea6\u53ea\u5bf965\uff05\u7684\u75c5\u4eba\u8d77\u6548\uff0c\u800c\u4e14\u8bb8\u591a\u836f\u7269\u7597\u6548\u5e76\u4e0d\u7a33\u5b9a\uff0c\u6bd2\u526f\u4f5c\u7528\u8f83\u5927\uff0c\u751f\u7269\u5229\u7528\u5ea6\u4e0d\u9ad8\uff0c\u4e00\u822c\u8981\u57282-4\u5468\u8d77\u6548\u3002\u56e0\u6b64\uff0c\u4ece\u5929\u7136\u690d\u7269\u4e2d\u5f00\u53d1\u5b89\u5168\u6709\u6548\u3001\u6bd2\u526f\u4f5c\u7528\u5c0f\uff0c\u751f\u7269\u5229\u7528\u5ea6\u9ad8\u7684\u5929\u7136\u6297\u6291\u90c1\u836f\u6210\u4e3a\u8fd9\u4e00\u9886\u57df\u7684\u7814\u7a76\u65b9\u5411\u3002\u767d\u85dc\u82a6\u9187(Resveratrol)\u662f\u4e00\u79cd\u591a\u915a\u7c7b\u7269\u8d28\uff0c\u5176\u5316\u5b66\u5f0f\u4e3a3\uff0c5\uff0c4\u2032-\u4e09\u7f9f\u57fa\u4e8c\u82ef\u4e59\u70ef(3\uff0c5\uff0c4\u2032-trihydroxysitlbene)\uff0c\u5e7f\u6cdb\u5b58\u5728\u4e8e\u5929\u7136\u690d\u7269\u4e2d\uff0c\u5c24\u5176\u5728\u8461\u8404\u79d1\u690d\u7269\u679c\u76ae\u4e2d\u542b\u91cf\u6700\u9ad8\u3002\u767d\u85dc\u82a6\u9187\u4e3a\u8102\u6eb6\u6027\u7269\u8d28\uff0c\u6613\u901a\u8fc7\u8840\u8111\u5c4f\u969c\u3002\u7814\u7a76\u8868\u660e\uff0c\u767d\u85dc\u82a6\u9187\u5177\u6709\u6297\u6c27\u5316\u3001\u514d\u75ab\u8c03\u8282\u3001\u6297\u8870\u8001\u53ca\u9884\u9632\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u7b49\u4f5c\u7528\uff0c\u76ee\u524d\u5c1a\u672a\u89c1\u5c06\u767d\u85dc\u82a6\u9187\u7528\u4e8e\u6cbb\u7597\u6291\u90c1\u75c7\u7684\u7814\u7a76\u62a5\u9053\u3002 [0005] \u53d1\u660e\u5185\u5bb9 [0006] \u672c\u53d1\u660e\u7684\u76ee\u7684\u63d0\u4f9b\u767d\u85dc\u82a6\u9187\u7684\u4e00\u79cd\u65b0\u7528\u9014\u3002 [0007] \u7ecf\u8fc7\u52a8\u7269\u5b9e\u9a8c\u53d1\u73b0\u767d\u85dc\u82a6\u9187\u5177\u6709\u8f83\u597d\u7684\u6297\u6291\u90c1\u4f5c\u7528\uff0c\u662f\u4e00\u79cd\u8f83\u6709\u53d1\u5c55\u524d\u9014\u7684\u5929\u7136\u6297\u6291\u90c1\u5242\uff0c\u53ef\u7528\u4e8e\u5236\u5907\u6cbb\u7597\u6291\u90c1\u75c7\u7684\u836f\u7269\u3002 [0008] \u5177\u4f53\u5b9e\u65bd\u65b9\u5f0f [0009] \u4ee5\u4e0b\u901a\u8fc7\u5b9e\u65bd\u4f8b\u8bf4\u660e\u672c\u53d1\u660e\u3002 [0010] \u5b9e\u65bd\u4f8b1\uff1a\u5c0f\u9f20\u60ac\u5c3e\u5b9e\u9a8c\uff0c\u5f3a\u8feb\u6e38\u6cf3\u5b9e\u9a8c\uff0c\u81ea\u4e3b\u6d3b\u52a8\u5b9e\u9a8c [0011] 1\u3001\u53d7\u8bd5\u836f\u7269 [0012] \u540d\u79f0\uff1a\u767d\u85dc\u82a6\u9187(Resveratrol) [0013] \u6027\u72b6\uff1a\u7c7b\u767d\u8272\u7cbe\u7ec6\u7c89\u672b\uff0c\u6c14\u7279\u6b8a\uff0c\u5473\u6de1\uff0c\u4ece\u864e\u6756\u4e2d\u63d0\u53d6 [0014] \u6765\u6e90\uff1a\u8d2d\u81ea\u9655\u897f\u68ee\u4f5b\u751f\u7269\u6280\u672f\u6709\u9650\u516c\u53f8\uff0c\u7eaf\u5ea6\u4e3a98\uff05 [0015] \u836f\u7269\u7684\u914d\u7f6e\uff1a\u75280.5\uff05\u6d53\u5ea6\u7684\u7fa7\u7532\u57fa\u7ea4\u7ef4\u7d20\u94a0(CMC-Na)\u6eb6\u89e3\u767d\u85dc\u82a6\u9187\uff0c\u5206\u522b\u914d\u621010mg\/kg\uff0c20mg\/kg\uff0c40mg\/kg\u548c80mg\/kg\u56db\u4e2a\u5242\u91cf\uff0c\u63090.1ml\/10g\u5242\u91cf\u7ed9\u4e88\u5c0f\u9f20\u704c\u80c3\u53e3\u670d\u3002 [0016] 2\u3001\u5bf9\u7167\u836f\u7269 [0017] \u76d0\u9178\u4e19\u54aa\u55ea(Imipramine)\uff1a\u8d2d\u81ea\u7f8e\u56fdSigma\u516c\u53f8\uff0c\u4e34\u7528\u524d\u7528\u53cc\u84b8\u6c34\u914d\u7f6e\u621010mg\/kg\u6d53\u5ea6\uff0c\u6309\u4e0a\u8ff0\u89c4\u683c\u7ed9\u4e88\u5c0f\u9f20\u8179\u8154\u6ce8\u5c04\u3002 [0018] 3\u3001\u52a8\u7269\u53ca\u5206\u7ec4 [0019] ICR\u96c4\u6027\u5c0f\u9f20\uff0c\u4f53\u91cd20-24g\u3002\u6e29\u5dde\u533b\u5b66\u9662\u5b9e\u9a8c\u52a8\u7269\u4e2d\u5fc3\u63d0\u4f9b\u3002 [0020] \u52a8\u7269\u968f\u673a\u5206\u4e3a6\u7ec4\uff0c\u6b63\u5e38\u5bf9\u7167\u7ec4\uff0c\u767d\u85dc\u82a6\u918710mg\/kg\uff0c20mg\/kg\uff0c40mg\/kg\u548c80mg\/kg\u56db\u4e2a\u5242\u91cf\u7ec4\u4ee5\u53ca\u9633\u6027\u5bf9\u7167\u836f\u4e19\u54aa\u55ea\u7ec4\uff0c\u6bcf\u7ec4\u52a8\u726912\u53ea\u3002 [0021] 4\u3001\u5b9e\u9a8c\u65b9\u6cd5 [0022] \u2460\u5c0f\u9f20\u60ac\u5c3e\u5b9e\u9a8c\uff1a\u6309\u7167\u6587\u732e(SteruL\uff0cChermatR\uff0cThierryB\uff0cetal.Thetail\u00a0suspensiontest\uff1aa\u00a0new\u00a0method\u00a0for\u00a0screeningantidepressants\u00a0in\u00a0mice[J].Psychopharmacol\uff0c1985\uff0c85\uff1a367.)\u8fdb\u884c\uff0c\u7ed9\u836f\u540e60min(\u767d\u85dc\u82a6\u9187i.g.)\u6216\u800530min(\u4e19\u54aa\u55ea\uff0ci.p.)\uff0c\u5728\u8ddd\u5c0f\u9f20\u5c3e\u5c16\u90e8\u672b\u68a2\u7ea62cm\u7684\u90e8\u4f4d\u7528\u80f6\u5e03\u56fa\u5b9a\u4e8e\u94c1\u67b6\u53f0\u4e0a\uff0c\u4f7f\u5c0f\u9f20\u5934\u5411\u4e0b\u60ac\u6302\uff0c\u5012\u6302\u4e8e\u7bb1\u5b50(30cm\u00d730cm\u00d725cm)\u4e2d\uff0c\u5934\u90e8\u8ddd\u79bb\u7bb1\u5e9515cm\u3002\u5f00\u59cb\u65f6\uff0c\u5c0f\u9f20\u5934\u90e8\u4e0a\u4e0b\u5de6\u53f3\u6d3b\u52a8\uff0c\u4f01\u56fe\u627e\u5230\u6500\u6293\u7684\u5730\u65b9\uff0c\u4e00\u6bb5\u65f6\u95f4\u540e\u56e0\u5931\u671b\u800c\u6d3b\u52a8\u6b21\u6570\u51cf\u5c11\uff0c\u5373\u51fa\u73b0\u95f4\u65ad\u6027\u4e0d\u52a8\u3002\u89c2\u5bdf6min\u5185\u5b9e\u9a8c\u52a8\u7269\u884c\u4e3a\uff0c\u5e76\u8bb0\u5f55\u540e4min\u5185\u5c0f\u9f20\u7684\u4e0d\u52a8\u65f6\u95f4\u3002 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