{"id":2388,"date":"2022-05-25T14:34:32","date_gmt":"2022-05-25T14:34:32","guid":{"rendered":"http:\/\/www.deepthinkgohelper.com\/wp\/?p=2388"},"modified":"2022-06-11T19:45:37","modified_gmt":"2022-06-11T19:45:37","slug":"%e7%99%bd%e8%97%9c%e8%8a%a6%e9%86%87%e7%a5%9e%e7%bb%8f%e4%bf%9d%e6%8a%a4%e4%bd%9c%e7%94%a8%e7%9a%84%e7%a0%94%e7%a9%b6%e8%bf%9b%e5%b1%95","status":"publish","type":"post","link":"http:\/\/johnhealth.blog\/ch\/?p=2388","title":{"rendered":"\u767d\u85dc\u82a6\u9187\u795e\u7ecf\u4fdd\u62a4\u4f5c\u7528\u7684\u7814\u7a76\u8fdb\u5c55"},"content":{"rendered":"<p>\u767d\u85dc\u82a6\u9187\u662f\u67d0\u4e9b\u79cd\u5b50\u7c7b\u690d\u7269 (spermatophytes)\uff0c \u5728\u62b5\u6297\u75c5\u539f\u83cc\u3001\u635f\u4f24\u7b49\u4fb5\u88ad\u65f6\u4ea7\u751f\u7684\u690d\u7269\u6297\u6bd2\u7d20 (phytoalexin)\uff0c\u5e7f\u6cdb\u5b58\u5728\u4e8e\u8461\u8404\u79d1\u3001\u767e\u5408\u79d1\u3001\u8c46\u79d1\u3001 \u84fc\u79d1\u3001\u4f1e\u5f62\u79d1\u7b49 70 \u591a\u79cd\u690d\u7269\u4e2d\uff0c\u5176\u4e2d\u5305\u62ec\u85dc\u82a6\u3001 \u864e\u4ed7\u548c\u89c9\u660e\u7b49\u836f\u7528\u690d\u7269\uff0c\u4ee5\u53ca\u82b1\u751f\u3001\u8349\u8393\u53ca\u8461\u8404\u7b49 \u98df\u7269\u3002\u767d\u85dc\u82a6\u9187\u5f15\u8d77\u79d1\u5b66\u5bb6\u7684\u5173\u6ce8\u6e90\u4e8e\u4e00\u9879\u6d41\u884c\u75c5 \u5b66\u8c03\u67e5\u4e2d\u53d1\u73b0\u7684\u201cThe French Paradox\u201d\u73b0\u8c61\uff0c\u5373\u6cd5 \u56fd\u4eba\u867d\u7136\u6444\u5165\u9ad8\u8102\u3001\u9ad8\u80c6\u56fa\u9187\u996e\u98df\uff0c\u4f46\u5fc3\u8840\u7ba1\u75be\u75c5 \u53d1\u75c5\u7387\u5374\u5f88\u4f4e\uff0c\u4e00\u822c\u8ba4\u4e3a\u8fd9\u4e0e\u6cd5\u56fd\u4eba\u7ecf\u5e38\u996e\u7528\u8461\u8404 \u9152\u6709\u5173 [1] \u3002<span style=\"color: #ff0000;\"><strong>\u968f\u7740\u5bf9\u767d\u85dc\u82a6\u9187\u7814\u7a76\u7684\u6df1\u5165\uff0c\u53d1\u73b0\u6b64\u5316 \u5408\u7269\u5177\u6709\u975e\u5e38\u5e7f\u6cdb\u7684\u751f\u7269\u6d3b\u6027\uff0c\u5982\u6297\u80bf\u7624\u3001\u6297\u5fc3\u8840 \u7ba1\u75be\u75c5\u3001\u6297\u708e\u514d\u75ab\u3001\u96cc\u6fc0\u7d20\u6837\u6d3b\u6027\u548c\u795e\u7ecf\u4fdd\u62a4\u4f5c \u7528\u7b49<\/strong><\/span>\u3002<!--more--><\/p>\n<h1>1 \u767d\u85dc\u82a6\u9187\u53ca\u5176\u884d\u751f\u7269\u4e0e\u6297\u6c27\u5316\u6d3b\u6027<\/h1>\n<p>\u767d\u85dc\u82a6\u9187\u53ca\u5176\u884d\u751f\u7269\u662f\u4ee5\u5747\u4e8c\u82ef\u4ee3\u4e59\u70ef (C6-C2-C6) \u4e3a\u57fa\u672c\u9aa8\u67b6\u7684\u915a\u7c7b\u5316\u5408\u7269\u3002\u767d\u85dc\u82a6\u9187\u7684\u5316 \u5b66\u540d\u4e3a 3,5,4&#8242; \uff0d\u4e09\u7f9f\u57fa\u830b (3,5,4&#8242;-trihydroxystilbene)\uff0c \u5206\u5b50\u5f0f C14H12O3\uff0c\u76f8\u5bf9\u5206\u5b50\u8d28\u91cf 228.24\uff0c\u6709\u53cd\u5f0f (trans-) \u548c\u987a\u5f0f (cis-) \u4e24\u79cd\u6784\u8c61 ( \u56fe 1)\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-17235 alignright\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2017\/08\/resveratrol.jpg\" alt=\"\" width=\"322\" height=\"145\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2017\/08\/resveratrol.jpg 322w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2017\/08\/resveratrol-300x135.jpg 300w\" sizes=\"auto, (max-width: 322px) 100vw, 322px\" \/><\/p>\n<p>\u53cd\u5f0f\u6784\u8c61\u662f\u5176\u7a33\u5b9a\u7ed3\u6784\uff0c\u4e14\u53cd\u5f0f\u5f02\u6784\u4f53\u7684\u751f\u7269 \u6d3b\u6027\u5f3a\u4e8e\u987a\u5f0f\uff0c\u6bd2\u6027\u4e5f\u4f4e\u4e8e\u987a\u5f0f\uff0c\u6709\u8f83\u597d\u7684\u8010\u53d7\u6027 \u548c\u5b89\u5168\u6027\uff0c\u4f46\u5728\u8840\u6d46\u4e2d\u6eb6\u89e3\u5ea6\u76f8\u5bf9\u8f83\u4f4e [2-3]\u3002<\/p>\n<p>\u767d\u85dc \u82a6\u9187\u4f5c\u4e3a\u591a\u915a\u7c7b\u5316\u5408\u7269\uff0c\u662f\u5f88\u5f3a\u7684\u6297\u6c27\u5316\u5242\uff0c\u5176\u915a \u7f9f\u57fa\u662f\u6781\u597d\u7684\u6c22\u6216\u7535\u5b50\u4f9b\u4f53\uff0c\u5f62\u6210\u7684\u915a\u7c7b\u6e38\u79bb\u57fa\u4e2d \u95f4\u4f53\u6bd4\u8f83\u7a33\u5b9a\uff0c\u56e0\u5176\u4e0d\u5b58\u5728\u9002\u5408\u4e8e\u5206\u5b50\u6c27\u8fdb\u653b\u7684\u4f4d \u7f6e\uff0c\u4e0d\u4f1a\u8bf1\u53d1\u4ea7\u751f\u65b0\u7684\u6e38\u79bb\u57fa\u6216\u8005\u94fe\u53cd\u5e94 ( \u56fe 2)\u3002 \u901a\u8fc7\u5bf9\u767d\u85dc\u82a6\u9187\u53ca\u5176\u7c7b\u4f3c\u7269\u7684\u6c27\u5316\u4ea7\u7269\u7684\u5206\u79bb\u9274 \u5b9a\uff0c\u5df2\u7ecf\u786e\u5b9a\u767d\u85dc\u82a6\u9187\u7684\u6297\u6c27\u5316\u6d3b\u6027\u4e3b\u8981\u6765\u81ea 4&#8242;- \u7f9f\u57fa [4]\u3002<\/p>\n<p>\u673a\u4f53\u6709\u591a\u79cd\u6297\u6c27\u5316\u9632\u5fa1\u7cfb\u7edf\uff0c\u6297\u6c27\u5316\u5242\u4e3b \u8981\u662f\u901a\u8fc7\u7ec8\u6b62\u81ea\u7531\u57fa\u94fe\u53cd\u5e94\uff0c\u6e05\u9664\u81ea\u7531\u57fa\u800c\u4fdd\u62a4\u673a \u4f53\u3002\u6b64\u5916\uff0c\u901a\u8fc7\u5bf9\u767d\u85dc\u82a6\u9187\u529f\u80fd\u57fa\u56e2\u82ef\u73af\u8fdb\u884c\u7ed3\u6784 \u4fee\u9970\uff0c\u53ef\u83b7\u5f97\u5177\u6709\u8f83\u5f3a\u6297\u6c27\u5316\u6d3b\u6027\u7684\u8bf1\u5bfc\u836f\uff0c\u5c06\u82ef \u73af\u4e0a\u7684\u7f9f\u57fa\u7532\u57fa\u919a\u5316\u3001\u7cd6\u82f7\u5316\u548c\u5f62\u6210\u4e8c\u805a\u4f53\u540e\uff0c\u80fd \u5728\u80bf\u7624\u3001\u5fc3\u8840\u7ba1\u75be\u75c5\u3001\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u4e2d\u4ea7\u751f\u5e7f\u6cdb \u7684\u836f\u7406\u6548\u5e94 [5-8]\u3002\u76ee\u524d\u8ba4\u4e3a\u767d\u85dc\u82a6\u9187\u53ca\u5176\u884d\u751f\u7269\u7684 \u5fc3\u8840\u7ba1\u4fdd\u62a4\u4f5c\u7528\u3001\u795e\u7ecf\u4fdd\u62a4\u4f5c\u7528\u7b49\u751f\u7269\u6d3b\u6027\u5747\u4e0e\u5176 \u6297\u6c27\u5316\u6d3b\u6027\u76f8\u5173\u3002<\/p>\n<p>\u9664\u6297\u6c27\u5316\u6d3b\u6027\u5916\uff0c\u8fd1\u5e74\u6765\u591a\u9879\u7814\u7a76\u53d1\u73b0\uff0c\u767d\u85dc \u82a6\u9187\u53ef\u80fd\u4ee5\u4e00\u79cd\u65b0\u7684\u65b9\u5f0f\u2014\u2014\u8c03\u63a7\u975e\u7f16\u7801\u5c0f RNA \u7684\u8868\u8fbe\u800c\u5448\u73b0\u591a\u6837\u7684\u751f\u7269\u6d3b\u6027\u3002\u4eba\u4f53\u4e2d\u5df2\u9274\u5b9a\u51fa\u7ea6 1 500 \u4e2a miRNA (20~22 nt)\u3002\u6210\u719f\u7684 miRNA \u4e0e RNA \u8bf1\u5bfc\u57fa\u56e0\u6c89\u9ed8\u590d\u5408\u7269 (RNA-induce gene silencing complex, RISC) \u76f8\u4e92\u4f5c\u7528\uff0c\u7136\u540e\u901a\u8fc7\u78b1\u57fa\u4e92\u8865\u4e0e \u9776\u4fe1\u4f7f RNA (mRNA) \u914d\u5bf9\uff0c\u5207\u5272 mRNA \u6216\u6291\u5236\u5176 \u8f6c\u5f55\uff0c\u4ece\u800c\u51cf\u4f4e\u5176\u7f16\u7801\u86cb\u767d\u7684\u8868\u8fbe\u3002miRNA \u4e0e\u80bf\u7624\u3001 \u5fc3\u8840\u7ba1\u75be\u75c5\u3001\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u3001\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u7b49 \u5bc6\u5207\u76f8\u5173 [9]\u3002\u5728 SW480 \u7ec6\u80de\u7cfb\u4e2d\u9996\u6b21\u53d1\u73b0\u767d\u85dc\u82a6 \u9187\u5bf9\u5185\u6e90\u6027 miRNA \u5177\u6709\u8c03\u63a7\u4f5c\u7528\uff0c\u4e0d\u4ec5\u80fd\u4e0b\u8c03\u81f4 \u764c miRNA (miR-17\u300121\u300123a\u300123b\u300125\u300129\u3001146a\u3001 miR-520h \u7b49 ) \u7684\u8868\u8fbe\u6c34\u5e73\uff0c\u8fd8\u80fd\u63d0\u9ad8\u6291\u764c miR-663 \u7684\u8868\u8fbe\u6c34\u5e73\u3002<\/p>\n<p>\u8fd1\u4e24\u5e74\u7814\u7a76\u53d1\u73b0\uff0c\u767d\u85dc\u82a6\u9187\u5bf9 A549\u3001 16HBE-T\u3001CL1-5\u3001PCa \u524d\u5217\u817a\u7624\u7ec6\u80de\u4e2d\u76f8\u5e94\u7684 miRNA \u4e5f\u6709\u8c03\u63a7\u4f5c\u7528\uff0c\u5e76\u4e14\u4ee5\u5242\u91cf\u4f9d\u8d56\u6027\u65b9\u5f0f\u6291\u5236 Akt\uff0c\u8fdb\u800c\u4e0b\u8c03\u53c9\u5934\u6846 c2 (forkhead box c2, FOXC2) \u8f6c\u5f55\u56e0\u5b50\u7684\u8868\u8fbe\uff0c\u4ece\u800c\u964d\u4f4e A549\u3001CL1-5 \u7ec6\u80de\u7684 \u8f6c\u79fb\u548c\u4fb5\u88ad\u80fd\u529b\uff0c\u8fd9\u5bf9\u4e8e\u63a7\u5236\u80bf\u7624\u7684\u6076\u5316\u5177\u6709\u91cd\u8981 \u7684\u4e34\u5e8a\u610f\u4e49 [10-14]\u3002<\/p>\n<p>\u53e6\u5916\uff0c\u767d\u85dc\u82a6\u9187\u8fd8\u901a\u8fc7\u8c03\u63a7 miR- 133\u3001miR-20b\u3001miR-663\u3001miR-30a\uff0c\u5206\u522b\u5f71\u54cd\u9aa8\u9abc \u808c\u7ec6\u80de\u5206\u5316\u548c\u8f6c\u5316\u3001\u5927\u9f20\u5c40\u90e8\u7f3a\u8840 \/ \u518d\u704c\u6ce8\u635f\u4f24\u6a21 \u578b\u7684\u5fc3\u810f\u4fdd\u62a4\u4f5c\u7528\u3001\u708e\u75c7\u53cd\u5e94\u8fdb\u7a0b\u3001\u81ea\u566c\u57fa\u56e0 Beclin 1 \u7684\u8c03\u63a7 [15-18]\u3002\u4e0a\u8ff0\u7814\u7a76\u5de5\u4f5c\u4e3a\u767d\u85dc\u82a6\u9187\u7528 \u4e8e\u6cbb\u7597\u9aa8\u9abc\u808c\u529f\u80fd\u7d0a\u4e71\u3001\u708e\u75c7\u3001\u80bf\u7624\u4ee5\u53ca\u81ea\u8eab\u514d\u75ab \u6027\u7b49\u75be\u75c5\u63d0\u4f9b\u4e86\u91cd\u8981\u7ebf\u7d22\uff0c\u4f46\u76ee\u524d\u4ecd\u505c\u7559\u4e8e\u52a8\u7269\u5b9e \u9a8c\uff0c\u7f3a\u4e4f\u76f8\u5173\u7684\u4e34\u5e8a\u8bc1\u636e\u3002<\/p>\n<h1>2 \u767d\u85dc\u82a6\u9187\u5728\u795e\u7ecf\u7cfb\u7edf\u4e2d\u7684\u4f5c\u7528<\/h1>\n<p>\u8fd1\u5e74\u6765\uff0c\u767d\u85dc\u82a6\u9187\u5728\u795e\u7ecf\u7cfb\u7edf\u4e2d\u7684\u4f5c\u7528\u4e5f\u540c\u6837 \u5f15\u8d77\u5e7f\u6cdb\u5173\u6ce8\u3002\u767d\u85dc\u82a6\u9187\u5728\u591a\u79cd\u4f53\u5185\u5916\u6a21\u578b\u4e2d\u5177\u6709 \u660e\u663e\u7684\u795e\u7ecf\u4fdd\u62a4\u4f5c\u7528\uff0c\u5e76\u8bc1\u660e\u6709\u591a\u79cd\u673a\u5236\u53c2\u4e0e\u5176\u4e2d\uff0c \u5305\u62ec\u6e05\u9664\u8d85\u6c27\u7f9f\u81ea\u7531\u57fa\u3001\u8102\u6c27\u81ea\u7531\u57fa\u3001\u8d85\u6c27\u9634\u79bb\u5b50 \u81ea\u7531\u57fa\u7b49\u6297\u6c27\u5316\u4f5c\u7528\u4ee5\u53ca\u80de\u5185\u4fe1\u53f7\u8f6c\u5bfc\u9014\u5f84[19-21]\u7b49\u3002<\/p>\n<h2>2.1 \u767d\u85dc\u82a6\u9187\u4e0e\u8111\u7f3a\u8840\/\u7f3a\u6c27<\/h2>\n<p>\u6c27\u5316\u5e94\u6fc0\u635f\u4f24\u662f\u8111\u7f3a\u8840 \/ \u518d\u704c\u6ce8\u635f\u4f24\u7684\u91cd\u8981\u539f \u56e0\uff0c\u5e76\u5728\u8111\u7f3a\u8840 \/ \u518d\u704c\u6ce8\u635f\u4f24\u6025\u6027\u671f\u5404\u4e2a\u73af\u8282\u4e2d\u53d1 \u6325\u91cd\u8981\u4f5c\u7528\uff0c\u800c\u51cb\u4ea1\u662f\u8111\u7f3a\u8840 \/ \u518d\u704c\u6ce8\u635f\u4f24\u540e\u795e\u7ecf \u7ec6\u80de\u6b7b\u4ea1\u7684\u91cd\u8981\u5f62\u5f0f [22-23]\u3002<strong><span style=\"color: #ff0000;\">\u591a\u9879\u7814\u7a76\u8868\u660e\uff0c\u767d\u85dc\u82a6 \u9187\u80fd\u6709\u6548\u5bf9\u6297\u56e0\u8111\u7f3a\u8840 \/ \u518d\u704c\u6ce8\u9020\u6210\u7684\u795e\u7ecf\u635f\u4f24<\/span><\/strong>\u3002 \u767d\u85dc\u82a6\u9187\u9884\u5904\u7406\u660e\u663e\u7f29\u5c0f\u8111\u6897\u6b7b\u4f53\u79ef\uff0c\u53ef\u80fd\u673a\u5236\u4e0e \u57fa\u8d28\u91d1\u5c5e\u86cb\u767d\u6fc0\u9176 9 (matrix metalloprotein kinase 9, MMP9) \u7684\u6291\u5236\u6709\u5173 [24]\u3002\u5728\u7f3a\u8840\u635f\u4f24\u540e\u7ed9\u4e88\u767d\u85dc\u82a6 \u9187\u80fd\u6709\u6548\u51cf\u5c11\u6897\u6b7b\u4f53\u79ef\uff0c\u5e76\u6291\u5236\u7f3a\u8840\u76ae\u8d28\u4e2d\u767d\u7ec6 \u80de\u4ecb\u7d20 -1\u03b2 (interleukin-2, IL-1\u03b2) \u548c\u80bf\u7624\u574f\u6b7b\u56e0\u5b50 (tumor necrosis factor-\u03b1, TNF-\u03b1) \u7684\u8868\u8fbe\u548c\u5c0f\u795e\u7ecf\u80f6 \u8d28\u7ec6\u80de\u7684\u6fc0\u6d3b\u4ee5\u53ca\u6d3b\u6027\u6c27\u7c07 (reactive oxygen species, ROS) \u7684\u4ea7\u751f\uff0c\u63d0\u793a\u5176\u4f5c\u7528\u673a\u5236\u4e4b\u4e00\u4e0e\u6297\u708e\u6027\u53cd\u5e94 \u6709\u5173 [25]\u3002Bcl-2\u3001Bax \u548c Caspase-3 \u7b49\u51cb\u4ea1\u76f8\u5173\u86cb\u767d \u53c2\u4e0e\u4e86\u8111\u7f3a\u8840 \/ \u518d\u704c\u6ce8\u635f\u4f24\u8fc7\u7a0b\uff0c\u5728\u6c27\u5316\u6027\u4f4e\u5bc6\u5ea6<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-17236 alignright\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2017\/08\/resveratrol2.jpg\" alt=\"\" width=\"617\" height=\"245\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2017\/08\/resveratrol2.jpg 617w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2017\/08\/resveratrol2-300x119.jpg 300w\" sizes=\"auto, (max-width: 617px) 100vw, 617px\" \/><\/p>\n<p>\u8102\u86cb\u767d\u8bf1\u53d1\u7684\u5c0f\u9f20\u8111\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u635f\u4f24\u6a21\u578b\u4e2d\uff0c\u767d \u85dc\u82a6\u9187\u80fd\u6291\u5236\u51cb\u4ea1\u524d\u86cb\u767d Bax \u4ece\u7ec6\u80de\u8d28\u8f6c\u81f3\u7ebf\u7c92 \u4f53\u819c\uff0c\u963b\u6b62\u51cb\u4ea1\u56e0\u5b50 Cytc \u4ece\u7ebf\u7c92\u4f53\u4e0a\u91ca\u653e\uff0c\u964d\u4f4e Caspase-3 \u548c Caspase-9 \u7684\u6d3b\u6027\uff0c\u8868\u660e\u767d\u85dc\u82a6\u9187\u662f\u901a \u8fc7\u6297\u7ec6\u80de\u51cb\u4ea1\u800c\u53d1\u6325\u795e\u7ecf\u4fdd\u62a4\u4f5c\u7528 [26-27]\u3002<\/p>\n<p>\u5728\u5927\u9f20\u8111 \u5c40\u90e8\u7f3a\u8840 \/ \u518d\u704c\u6ce8\u635f\u4f24\u6a21\u578b\u8bd5\u9a8c\u4e2d\uff0c\u767d\u85dc\u82a6\u9187\u80fd\u4e0a \u8c03\u4e0e\u6c27\u5316\u5e94\u6fc0\u76f8\u5173\u7684\u6838\u56e0\u5b50 E2 \u76f8\u5173\u56e0\u5b50 -2 (nuclear factor erythroid-2-related-factor 2, Nrf2) \u548c\u8840\u7ea2\u7d20\u52a0 \u6c27\u9176 -1 (heme oxygenase, HO-1) \u7684\u8868\u8fbe\uff0c\u964d\u4f4e\u4e19\u4e8c \u919b (malondialdehyde, MDA) \u6c34\u5e73\uff0c\u6062\u590d\u8d85\u6c27\u6b67\u5316\u9176 (superoxide dismutase, SOD) \u6d3b\u6027\uff0c\u4ece\u800c\u51cf\u5c11\u6897\u6b7b \u4f53\u79ef\u548c\u5927\u8111\u6c34\u5bb9\u91cf\uff0c\u6539\u5584\u795e\u7ecf\u75c7\u72b6 [28]\u3002<\/p>\n<p>\u5728\u5c0f\u9f20\u6c38\u4e45 \u963b\u585e\u4e2d\u8111\u52a8\u8109\u6a21\u578b\u4e2d\u8fdb\u4e00\u6b65\u8bc1\u5b9e\u4e86\u4e0a\u8ff0\u7ed3\u8bba\uff0c\u5e76\u53d1 \u73b0\uff0c\u5982\u5c06\u5c0f\u9f20\u7684\u8fc7\u6c27\u5316\u7269\u9176\u4f53\u589e\u6b96\u7269\u6fc0\u6d3b\u53d7\u4f53 \u03b1 (peroxisome proliferator-activated receptor \u03b1, PPAR\u03b1) \u57fa\u56e0\u6572\u9664\uff0c\u767d\u85dc\u82a6\u9187\u5219\u4e0d\u80fd\u51cf\u5c0f\u8111\u6897\u6b7b\u7076\u7684\u4f53\u79ef [29]\u3002 PPARs \u662f\u4e00\u7c7b\u914d\u4f53\u4f9d\u8d56\u7684\u6838\u6fc0\u7d20\u53d7\u4f53\uff0c\u5305\u62ec\u4e09\u4e2a\u5f02 \u6784\u4f53 PPAR\u03b1\u3001PPAR\u03b2 \u548c PPAR\u03b3\u3002PPARs \u5728\u7cd6\u8102\u4ee3\u8c22\u3001 \u7ec6\u80de\u589e\u6b96\u548c\u5206\u5316\u4ee5\u53ca\u708e\u6027\u53cd\u5e94\u4e2d\u8d77\u4e0d\u540c\u4f5c\u7528\uff0c\u662f\u91cd \u8981\u7684\u836f\u7269\u4f5c\u7528\u9776\u70b9 [30-31]\u3002PPAR\u03b1 \u8fc7\u5ea6\u8868\u8fbe\u4e0d\u5229\u4e8e\u5c40 \u90e8\u7f3a\u8840 \/ \u518d\u704c\u6ce8\u635f\u4f24\u540e\u7684\u5fc3\u810f\u590d\u82cf\uff0c\u800c\u4f4e\u8868\u8fbe PPAR\u03b1 \u5219\u80fd\u5bf9\u6297\u5c40\u90e8\u7f3a\u8840\u540e\u635f\u4f24 [32]\u3002\u56e0\u6b64\uff0c\u8c03\u8282 PPAR\u03b1 \u53ef\u80fd\u662f\u767d\u85dc\u82a6\u9187\u53d1\u6325\u795e\u7ecf\u4fdd\u62a4\u4f5c\u7528\u7684\u91cd\u8981\u673a \u5236\u4e4b\u4e00\u3002<\/p>\n<h2>2.2 \u767d\u85dc\u82a6\u9187\u4e0e\u810a\u9ad3\u6025\u6027\u53ca\u7ee7\u53d1\u635f\u4f24<\/h2>\n<p>\u810a\u9ad3\u635f\u4f24\u548c\u7f3a\u8840\u662f\u56e0\u5916\u4f24\u6216\u5916\u79d1\u624b\u672f\u9020\u6210\u622a\u762b \u7684\u5e38\u89c1\u539f\u56e0\uff0c\u81f3\u4eca\u4ecd\u65e0\u6709\u6548\u7684\u9884\u9632\u6216\u6cbb\u7597\u624b\u6bb5\u3002\u9274 \u4e8e\u767d\u85dc\u82a6\u9187\u5bf9\u5fc3\u810f\u3001\u80be\u810f\u53ca\u8111\u7b49\u5668\u5b98\u7f3a\u8840\u635f\u4f24\u7684\u4fdd \u62a4\u4f5c\u7528\uff0c\u4eba\u4eec\u671f\u671b\u767d\u85dc\u82a6\u9187\u5bf9\u810a\u9ad3\u635f\u4f24\u548c\u7f3a\u8840\u4e5f\u6709 \u4fdd\u62a4\u4f5c\u7528\u3002\u767d\u85dc\u82a6\u9187\u5bf9\u91cd\u7269\u5760\u843d (weight-dropping) \u8bf1\u53d1\u7684\u5927\u9f20\u810a\u9ad3\u635f\u4f24\u6709\u4fdd\u62a4\u4f5c\u7528\uff0c\u53ef\u663e\u8457\u6539\u5584\u795e\u7ecf \u7ec6\u80de\u8d85\u5fae\u7ed3\u6784\u7684\u635f\u4f24\uff0c\u80fd\u5bf9\u6297\u635f\u4f24\u9020\u6210\u7684 MDA \u6c34 \u5e73\u5347\u9ad8\uff0c\u8fd8\u80fd\u901a\u8fc7\u63d0\u9ad8 SOD \u6d3b\u6027\u6291\u5236\u708e\u6027\u7ec6\u80de\u56e0 \u5b50 IL-1\u03b2\u3001IL-10\u3001TNF-\u03b1\u3001\u9ad3\u8fc7\u6c27\u5316\u7269\u9176(myeloperoxidase, MPO) \u7684\u8868\u8fbe\uff0c\u5f71\u54cd\u51cb\u4ea1\u76f8\u5173\u86cb\u767d (Bax\u3001Bcl-2\u3001 Caspase-3) \u7684\u8868\u8fbe\uff0c\u5bf9\u6297\u810a\u9ad3\u635f\u4f24\uff0c\u63d0\u793a\u5176\u4fdd\u62a4\u673a \u5236\u53ef\u80fd\u662f\u901a\u8fc7\u6297\u708e\u6027\u548c\u6297\u51cb\u4ea1\u4f5c\u7528 [33-34]\u3002\u5728\u4ee5\u5154\u4e3a \u5bf9\u8c61\u7684\u5b9e\u9a8c\u4e2d\u4e5f\u5f97\u5230\u7c7b\u4f3c\u7ed3\u679c \uff1a\u767d\u85dc\u82a6\u9187\u80fd\u51cf\u8f7b\u56e0 \u8840\u7ba1\u963b\u585e\u5bfc\u81f4\u810a\u9ad3\u7f3a\u8840 \/ \u518d\u704c\u6ce8\u800c\u9020\u6210\u7684\u635f\u4f24 \uff1b\u751f\u5316 \u6307\u6807\u663e\u793a\u767d\u85dc\u82a6\u9187\u53ef\u964d\u4f4e MDA \u6c34\u5e73\uff0c\u4e0e\u5927\u9f20\u5b9e\u9a8c\u7ed3 \u679c\u543b\u5408\uff0c\u63d0\u793a\u4fdd\u62a4\u673a\u5236\u53ef\u80fd\u662f\u901a\u8fc7\u6297\u6c27\u5316\u4f5c\u7528 [35]\u3002<\/p>\n<h2>2.3 \u767d\u85dc\u82a6\u9187\u4e0e\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5<\/h2>\n<p>\u963f\u5c14\u8328\u6d77\u9ed8\u75c5 (Alziheimer\u2019s disease, AD) \u662f\u4e00 \u79cd\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u9000\u884c\u6027\u75be\u75c5\uff0c\u5176\u7279\u5f81\u6027\u75c5\u7406\u6539\u53d8\u4e3a\u03b2 \u6dc0\u7c89\u6837\u86cb\u767d (amyloid \u03b2, A\u03b2) \u6c89\u79ef\u5f62\u6210\u7684\u7ec6\u80de\u5916\u8001 \u5e74\u6591\u548c tau \u86cb\u767d\u8fc7\u5ea6\u78f7\u9178\u5316\u5f62\u6210\u7684\u795e\u7ecf\u7ec6\u80de\u5185\u795e \u7ecf\u539f\u7ea4\u7ef4\u7f20\u7ed3\uff0c\u4ee5\u53ca\u795e\u7ecf\u5143\u4e22\u5931\u4f34\u80f6\u8d28\u7ec6\u80de\u589e\u751f\u7b49\u3002<\/p>\n<p>\u591a \u9879 \u6d41 \u884c \u75c5 \u5b66 \u8c03 \u67e5 \u663e \u793a\uff0c \u9002 \u91cf \u996e \u7528 \u7ea2 \u8461 \u8404 \u9152 (300~400 mL\/d) \u53ef\u964d\u4f4e\u8001\u5e74\u4eba\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u53d1\u75c5 \u7387 [36-39]\u3002\u767d\u85dc\u82a6\u9187\u53ef\u80fd\u901a\u8fc7\u6e05\u9664 ROS \u5bf9\u6297 A\u03b2 \u8bf1\u5bfc \u7684\u795e\u7ecf\u51cb\u4ea1\uff0c\u6216\u76f4\u63a5\u4fc3\u8fdbA\u03b2\u5728\u795e\u7ecf\u5143\u5185\u7684\u964d\u89e3 [40-44]\u3002<\/p>\n<p>\u767d\u85dc\u82a6\u9187\u5bf9\u795e\u7ecf\u7ec6\u80de\u7ebf\u7c92\u4f53\u4e5f\u6709\u4f5c\u7528\uff0c\u53ef\u901a\u8fc7\u6291\u5236 \u590d\u5408\u7269\u2162\u6291\u5236\u7ebf\u7c92\u4f53\u547c\u5438\u94fe\uff0c\u4ece\u800c\u4fc3\u8fdbROS\u7684\u6e05\u9664\uff0c \u6291\u5236 ROS \u7684\u4ea7\u751f [45]\u3002\u5728\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u6bd2\u7d20 1- \u7532 \u57fa 1-4- \u82ef\u57fa\u5421\u5576\u5904\u7406\u7684\u4e2d\u8111\u5207\u7247\uff0c\u767d\u85dc\u82a6\u9187\u80fd\u591f\u6291 \u5236\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u7684\u4e22\u5931\uff0c\u5e76\u53d1\u73b0\u767d\u85dc\u82a6\u9187\u5448\u6d53\u5ea6 \u4f9d\u8d56\u6027\u6291\u5236\u7ebf\u7c92\u4f53\u590d\u5408\u7269\u2163\u548c\u5c0f\u80f6\u8d28\u795e\u7ecf\u7ec6\u80de\u7684\u6d3b \u5316\uff0c\u4ece\u800c\u51cf\u5c11 ROS \u7684\u79ef\u7d2f [46]\u3002\u8fd9\u4e9b\u5b9e\u9a8c\u7ed3\u679c\u5370\u8bc1 \u4e86\u6d41\u884c\u75c5\u5b66\u7684\u8c03\u67e5\u7ed3\u679c\u3002 Sirtuins \u662f\u4e00\u7c7b\u4f9d\u8d56\u8f85\u9176\u2160\u7684\u53bb\u4e59\u9170\u5316\u9176\uff0c\u5728 \u57fa\u56e0\u6c89\u9ed8\u3001DNA \u4fee\u590d\u548c rDNA \u91cd\u7ec4\u4e2d\u8d77\u91cd\u8981\u4f5c\u7528\uff0c \u901a\u8fc7\u4f7f\u8f6c\u5f55\u56e0\u5b50 PGC1-\u03b1\u3001PPAR \u03b3 \u548c\u6838\u8f6c\u5f55\u56e0\u5b50 \u03baB (nuclear factor-kappaB, NF-\u03baB) \u8131\u4e59\u9170\u5316\u800c\u8c03\u8282\u5176\u6d3b \u6027\uff0c\u8fdb\u800c\u8c03\u63a7\u54fa\u4e73\u52a8\u7269\u7ec6\u80de\u5bff\u547d\u7684\u591a\u6761\u4fe1\u53f7\u901a\u8def\uff0c \u5e76\u4e0e\u7ec6\u80de\u7684\u5b58\u6d3b\u548c\u4ee3\u8c22\u8fc7\u7a0b\u4ee5\u53ca\u589e\u6b96\u3001\u8870\u8001\u3001\u51cb\u4ea1 \u7b49\u751f\u547d\u6d3b\u52a8\u5bc6\u5207\u76f8\u5173 [47]\u3002<\/p>\n<p>\u767d\u85dc\u82a6\u9187\u901a\u8fc7\u8bf1\u5bfc Sirt1 \u7684\u8868\u8fbe\uff0c\u8fdb\u800c\u6291\u5236 p53 \u548c FOXO \u86cb\u767d\u7684\u6d3b\u6027\u4ee5\u53ca\u963b \u788d NF-\u03baB \u4fe1\u53f7\u8f6c\u5bfc\uff0c\u4fdd\u62a4 AD \u795e\u7ecf\u5143\u514d\u53d7 ROS\u3001 \u8fc7\u6c27\u5316\u6c22\u3001NO\u3001A\u03b2 \u4ee5\u53ca\u5176\u4ed6\u80de\u5185\u80de\u5916\u7684\u635f\u4f24 [48-50]\u3002 \u66f4\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u767d\u85dc\u82a6\u9187\u548c\u8461\u8404\u7cd6\u4ee5\u53ca\u82f9\u679c\u9178\u76d0 \u6df7\u5408\u836f (NCT00678431) \u6b63\u5728\u8fdb\u884c\u2162\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u6709 \u671b\u6210\u4e3a\u4e00\u79cd\u6cbb\u7597\u8f7b\u5ea6\u548c\u4e2d\u5ea6 AD \u7684\u826f\u836f [51]\u3002<\/p>\n<p>\u5e15\u91d1\u68ee\u75c5 (Parkinson\u2019s disease, PD) \u662f\u4e00\u79cd\u4ee5\u9ed1 \u8d28\u3001\u7eb9\u72b6\u4f53\u5185\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u53d8\u6027\u6b7b\u4ea1\u4e3a\u7279\u5f81\u7684\u795e \u7ecf\u7cfb\u7edf\u9000\u884c\u6027\u75be\u75c5\u3002\u5927\u91cf\u7814\u7a76\u8868\u660e\uff0c\u9057\u4f20\u3001\u8001\u5316\u3001 \u514d\u75ab\u5f02\u5e38\u3001\u6c27\u81ea\u7531\u57fa\u635f\u4f24\u3001\u9499\u8d85\u8f7d\u3001\u5174\u594b\u6027\u795e\u7ecf\u6bd2 \u6027\u7b49\u8bf8\u591a\u56e0\u7d20\u4e0e\u591a\u5df4\u80fa\u795e\u7ecf\u5143\u53d8\u6027\u6b7b\u4ea1\u6709\u5173\uff0c\u5176\u4e2d \u6c27\u5316\u5e94\u6fc0\u5f15\u8d77\u7684\u7ec6\u80de\u51cb\u4ea1\u662f\u591a\u5df4\u80fa\u795e\u7ecf\u5143\u51cf\u5c11\u7684\u91cd \u8981\u73af\u8282 [52-53]\u3002\u56e0\u6b64\uff0c\u6539\u5584\u9ed1\u8d28\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u7684\u6c27 \u5316\u72b6\u6001\u53ef\u80fd\u662f\u9632\u6cbb\u5e15\u91d1\u68ee\u75c5\u7684\u91cd\u8981\u65b9\u6cd5\u4e4b\u4e00\u3002<\/p>\n<p>\u767d\u85dc \u82a6\u9187\u5728 PC12 \u7ec6\u80de\u4e2d\u53ef\u51cf\u8f7b 1- \u7532\u57fa -4- \u82ef\u57fa\u5421\u5576\u9020 \u6210\u7684\u6c27\u5316\u635f\u5bb3\uff0c\u5e76\u80fd\u4f7f\u8868\u8fbe\u964d\u4f4e\u7684\u591a\u5df4\u80fa\u8f6c\u8fd0\u4f53\u6062 \u590d\u5230\u6b63\u5e38\u6c34\u5e73\uff0c\u53ef\u80fd\u5bf9\u5e15\u91d1\u68ee\u75c5\u6709\u6cbb\u7597\u4f5c\u7528 [54]\u3002<strong>\u892a \u9ed1\u6fc0\u7d20\u80fd\u589e\u5f3a\u767d\u85dc\u82a6\u9187\u7684\u6297\u6c27\u5316\u4f5c\u7528<\/strong>\uff0c\u901a\u8fc7\u6291\u5236\u6cdb \u7d20\u5316\u4f9d\u8d56\u7684\u86cb\u767d\u9176\u4f53\u9014\u5f84\u63d0\u9ad8 HO-1 \u5728\u521d\u7ea7\u795e\u7ecf\u5143 \u548c\u661f\u5f62\u7ec6\u80de\u4e2d\u7684\u8868\u8fbe\u6c34\u5e73\uff0c\u800c HO-1 \u5177\u6709\u7ec4\u7ec7\u7279\u5f02 \u6027\u7684\u6297\u6c27\u5316\u6548\u5e94 [55-56]\u3002\u6b64\u5916\uff0c\u53e3\u670d\u767d\u85dc\u82a6\u9187\u53ef\u663e\u8457 \u6539\u5584\u6ce8\u5c04\u6d77\u4eba\u85fb\u9178\u5f15\u8d77\u7684\u5927\u9f20\u55c5\u8111\u548c\u6d77\u9a6c\u4e2d\u7684\u8c37\u6c28\u9178\u8131\u7fa7\u9176\u6c34\u5e73\u4e0b\u964d\uff0c\u9006\u8f6c\u8102\u8d28\u8fc7\u6c27\u5316\u53cd\u5e94\u7ec8\u4ea7\u7269 MDA \u6c34\u5e73\u5347\u9ad8\uff0c\u5e76\u4e14\u5448\u6d53\u5ea6\u4f9d\u8d56\u6027\u5730\u6291\u5236\u5927\u9f20\u6d77 \u9a6c\u795e\u7ecf\u5143\u5174\u594b\u6027\u7a81\u89e6\u4f20\u9012\u548c\u795e\u7ecf\u5143\u81ea\u53d1\u653e\u7535\uff0c\u8fd8\u660e \u663e\u6291\u5236 CA1 \u533a\u690e\u4f53\u795e\u7ecf\u5143\u6d77\u4eba\u85fb\u9178\u8bf1\u5bfc\u7684\u7535\u6d41\uff0c \u5bf9\u6297\u6d77\u4eba\u85fb\u9178\u5bfc\u81f4\u7684\u6d77\u9a6c\u533a\u795e\u7ecf\u9000\u884c\u6027\u53d8 [57-61]\uff0c\u8fd9 \u4e9b\u4e3a\u767d\u85dc\u82a6\u9187\u4fdd\u62a4\u795e\u7ecf\u7ec6\u80de\u514d\u53d7\u81ea\u7531\u57fa\u6c27\u5316\u548c\u5174\u594b \u6027\u6bd2\u6027\u63d0\u4f9b\u4e86\u4f9d\u636e\u3002 \u4ea8\u5ef7\u987f\u75c5 (Huntington disease, HD) \u662f\u4e00\u79cd\u663e\u6027 \u5bb6\u65cf\u9057\u4f20\u6027\u75be\u75c5\uff0c\u7531\u4e8e\u57fa\u56e0\u7a81\u53d8\u6216 CAG \u4e09\u6838\u82f7\u9178 \u91cd\u590d\u5e8f\u5217\u6269\u589e\u5f15\u8d77\u5f02\u5e38\u86cb\u767d\u79ef\u805a\u7ed3\u5757\uff0c\u4ece\u800c\u5bfc\u81f4\u795e \u7ecf\u7ec6\u80de\u9000\u5316\uff0c\u5c5e\u4e8e\u57fa\u56e0\u52a8\u6001\u7a81\u53d8\u75c5\u6216\u591a\u8c37\u6c28\u9170\u80fa\u91cd \u590d\u75c5\uff0c\u5176\u53d1\u75c5\u673a\u5236\u53ef\u80fd\u662f\u7531\u4e8e\u80fd\u91cf\u4ee3\u8c22\u5f02\u5e38\u5f15\u8d77\u6c27 \u5316\u635f\u4f24\u800c\u5bfc\u81f4\u795e\u7ecf\u7ec6\u80de\u7684\u5174\u594b\u6bd2\u6027\u51cb\u4ea1 [62] \u3002<\/p>\n<p>\u767d\u85dc\u82a6 \u9187\u7531\u4e8e\u5176\u6297\u6c27\u5316\u6d3b\u6027\u800c\u53d1\u6325\u6297\u795e\u7ecf\u51cb\u4ea1\u4f5c\u7528\u3002\u53e6\u5916\uff0c \u767d\u85dc\u82a6\u9187\u53ef\u5e72\u6270\u7ec6\u80de\u5468\u671f\uff0c\u4f7f\u7ec6\u80de\u505c\u6ede\u5728 S \u671f\uff0c\u5e76 \u80fd\u8c03\u63a7\u7ebf\u7c92\u4f53\u4ecb\u5bfc\u7684\u51cb\u4ea1\u4fe1\u53f7\u901a\u8def\u4e2d\u51cb\u4ea1\u76f8\u5173\u86cb\u767d \u57fa\u56e0 (Bcl-2\u3001Bcl-xL\u3001Mcl-1) \u7684\u8868\u8fbe\uff0c\u5f71\u54cd\u795e\u7ecf\u7ec6 \u80de\u7684\u51cb\u4ea1 [63] \u3002\u4e0d\u4ec5\u5982\u6b64\uff0c\u767d\u85dc\u82a6\u9187\u80fd\u5242\u91cf\u4f9d\u8d56\u6027\u5730 \u6fc0\u6d3b\u795e\u7ecf\u7ec6\u80de\u4e2d\u7684\u86cb\u767d\u6fc0\u9176 C (protein kinase C, PKC)\uff0c\u5176\u6700\u5927\u6548\u5e94\u6d53\u5ea6\u548c\u795e\u7ecf\u5143\u4fdd\u62a4\u6d53\u5ea6\u76f8\u8fd1\uff0c\u8868 \u660e\u80de\u5185\u4fe1\u53f7\u8f6c\u5bfc\u901a\u8def\u53c2\u4e0e\u767d\u85dc\u82a6\u9187\u7684\u6297\u795e\u7ecf\u7ec6\u80de\u51cb \u4ea1\u4f5c\u7528 [20] \u3002\u767d\u85dc\u82a6\u9187\u5728\u6297 A\u03b2 \u6bd2\u6027\u7684\u540c\u65f6\u53ef\u6291\u5236\u916a \u6c28\u9178\u6fc0\u9176\u53ca\u5176\u4e0b\u6e38\u6fc0\u9176 ERK1\/2 \u7684\u6d3b\u6027\uff0c\u63d0\u793a\u916a\u6c28 \u9178\u6fc0\u9176\u4fe1\u53f7\u8f6c\u5bfc\u9014\u5f84\u53ef\u80fd\u53c2\u4e0e\u767d\u85dc\u82a6\u9187\u7684\u795e\u7ecf\u4fdd\u62a4 \u4f5c\u7528 [19,64] \u3002<\/p>\n<p>\u8fd9\u4e9b\u90fd\u8868\u660e\uff0c\u767d\u85dc\u82a6\u9187\u901a\u8fc7\u591a\u79cd\u673a\u5236\u5c55 \u793a\u6297\u795e\u7ecf\u51cb\u4ea1\u4f5c\u7528\uff0c\u4ece\u800c\u5728\u4ea8\u5ef7\u987f\u75c5\u4e2d\u53d1\u6325\u4fdd\u62a4\u795e \u7ecf\u5143\u7684\u6548\u5e94\u3002 \u9664\u6297\u795e\u7ecf\u51cb\u4ea1\u4f5c\u7528\u5916\uff0c\u767d\u85dc\u82a6\u9187\u53ef\u901a\u8fc7\u6fc0\u6d3b\u4e3b \u8981\u80fd\u91cf\u4ee3\u8c22\u611f\u5e94\u5668 \/ \u6548\u5e94\u5668\u86cb\u767d\u8c03\u63a7\u7ec6\u80de\u8fdb\u7a0b\uff0c\u5bf9 \u6297\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5 [65-68] \u3002\u5728\u54fa\u4e73\u52a8\u7269\u795e\u7ecf\u7ec6\u80de\u4f53\u5916 \u5b9e\u9a8c\u4e2d\uff0c\u767d\u85dc\u82a6\u9187\u4f5c\u4e3a Sirtuins \u7684\u6fc0\u52a8\u5242\uff0c\u53ef\u5bf9\u6297 \u7a81\u53d8\u7684\u591a\u805a\u8c37\u6c28\u9170\u80fa\u6240\u9020\u6210\u7684\u86cb\u767d\u8d28\u53d8\u6027\u548c\u7ec6\u80de\u635f \u5bb3\u3001\u795e\u7ecf\u6bd2\u6027\uff0c\u5e76\u4f7f Ku70 \u86cb\u767d ( \u53c2\u4e0e DNA \u635f\u4f24\u3001 \u7ec6\u80de\u5b58\u6d3b ) \u53bb\u4e59\u9170\u5316\uff0c\u4e0a\u8ff0\u635f\u5bb3\u6b63\u4e0e\u4ea8\u5ef7\u987f\u53d1\u75c5\u673a \u5236\u5047\u8bf4\u76f8\u543b\u5408 [69-71] \uff1b\u4f46\u4e5f\u6709\u5b66\u8005\u5c06 Sirt1 \u57fa\u56e0\u6572\u9664\uff0c \u53d1\u73b0\u767d\u85dc\u82a6\u9187\u7684\u6d3b\u6027\u88ab\u90e8\u5206\u6291\u5236\uff0c\u63d0\u793a Sirt1 \u8fc7\u8868 \u8fbe\u53ef\u80fd\u5bf9\u4e8e\u767d\u85dc\u82a6\u9187\u7684\u6d3b\u6027\u5f88\u91cd\u8981\uff0c\u767d\u85dc\u82a6\u9187\u53ef\u80fd \u534f\u8c03\u8c03\u63a7\u591a\u79cd\u9014\u5f84\u53d1\u6325\u836f\u7406\u6548\u5e94 [72-74] \u3002<\/p>\n<h2>2.4 \u767d\u85dc\u82a6\u9187\u4e0e\u766b\u75eb\u548c\u6291\u90c1\u75c7<\/h2>\n<p>\u766b\u75eb\u662f\u4e00\u79cd\u7531\u8111\u75c5\u53d8\u9020\u6210\u7684\u8111\u7ec6\u80de\u7a81\u7136\u5f02\u5e38\u7684 \u8fc7\u5ea6\u653e\u7535\u5f15\u53d1\u7684\u8111\u529f\u80fd\u5931\u8c03\u75be\u75c5\u3002\u766b\u75eb\u53d1\u4f5c\u65f6\u6613\u5f15 \u8d77\u6d77\u9a6c\u533a\u9f7f\u72b6\u56de\u795e\u7ecf\u5143\u548c\u690e\u4f53\u795e\u7ecf\u5143\u9000\u884c\u6027\u53d8\u5316\uff0c \u8fdb\u800c\u5bfc\u81f4\u5b66\u4e60\u548c\u8bb0\u5fc6\u969c\u788d\uff0c\u8bf1\u53d1\u6301\u7eed\u6027\u7684\u8ba4\u77e5\u529f\u80fd \u7d0a\u4e71\u3002\u9664\u4e86\u63a7\u5236\u795e\u7ecf\u5143\u7a81\u53d1\u6027\u5f02\u5e38\u653e\u7535\uff0c\u9488\u5bf9\u795e\u7ecf\u5143\u7684\u4fdd\u62a4\u4e5f\u53ef\u80fd\u662f\u6cbb\u7597\u766b\u75eb\u7684\u7406\u60f3\u65b9\u6cd5 [75-78] \u3002\u5728\u63a2 \u8ba8\u767d\u85dc\u82a6\u9187\u5bf9\u5927\u9f20\u6d77\u9a6c\u795e\u7ecf\u5174\u594b\u6027\u7a81\u89e6\u4f20\u9012\u5f71\u54cd\u7684 \u4f53\u5916\u5b9e\u9a8c\u4e2d\uff0c\u53d1\u73b0\u767d\u85dc\u82a6\u9187\u53ef\u80fd\u901a\u8fc7\u591a\u79cd\u673a\u5236\u53d1\u6325 \u795e\u7ecf\u4fdd\u62a4\u4f5c\u7528 \uff1a<\/p>\n<ul>\n<li>(1) \u6291\u5236\u95e8\u63a7\u94be\u79bb\u5b50\u7535\u6d41 \uff1b<\/li>\n<li>(2) \u6291\u5236 \u6d77\u9a6c CA1 \u533a\u795e\u7ecf\u5143\u7ec6\u80de\u7535\u5174\u594b\u6027 \uff1b<\/li>\n<li>(3) \u901a\u8fc7\u6291\u5236\u7a81 \u89e6\u540e\u8c37\u6c28\u9178\u53d7\u4f53\u963b\u788d\u5174\u594b\u6027\u7a81\u89e6\u4f20\u9012 [57,59,79] \uff0c\u63d0\u793a \u767d\u85dc\u82a6\u9187\u6297\u766b\u75eb\u6548\u5e94\u53ef\u80fd\u6709\u6297\u6c27\u5316\u548c\u6291\u5236\u795e\u7ecf\u5143\u5174 \u594b\u6027\u7b49\u591a\u79cd\u673a\u5236\u7684\u53c2\u4e0e\u3002<\/li>\n<\/ul>\n<p>\u53e6\u6709\u7814\u7a76\u663e\u793a , \u766b\u75eb\u80fd\u6fc0 \u6d3b\u96f7\u5e15\u9709\u7d20\u54fa\u4e73\u52a8\u7269\u9776\u70b9 (mammalian target of rapamycin, mTOR)\uff0c\u63d0\u9ad8 NF-\u03baB \u6d3b\u6027\uff0c\u4fc3\u8fdb\u708e\u75c7\u56e0\u5b50\u3001 \u4e00\u6c27\u5316\u6c2e\u5408\u9176 (nitricoxide synthase, NOS)\u3001\u73af\u6c27\u5408 \u9176 -2 (cyclooxygenase2, COX2)\u3001IL-2 \u7684\u8868\u8fbe\u3002\u8fdb\u4e00 \u6b65\u7814\u7a76\u53d1\u73b0\uff0c\u767d\u85dc\u82a6\u9187\u901a\u8fc7\u6fc0\u6d3b mTOR \u901a\u8def\u663e\u8457\u6291 \u5236 NF-\u03baB \u7684\u6d3b\u6027\u4ee5\u53ca\u708e\u75c7\u5206\u5b50\u7684\u4ea7\u751f\uff0c\u540c\u65f6\u4e5f\u8bc1\u5b9e \u4e86\u767d\u85dc\u82a6\u9187\u5bf9 mTOR \u4fe1\u53f7\u7684\u6291\u5236\u5f88\u5927\u7a0b\u5ea6\u4e0a\u662f\u56e0\u4e3a \u817a\u82f7\u9178\u6d3b\u5316\u86cb\u767d\u6fc0\u9176 (adenosine monophosphate activated kinase, AMPK) \u7684\u6d3b\u5316\uff0c\u63d0\u793a\u4e86\u767d\u85dc\u82a6\u9187\u53ef\u901a \u8fc7\u6fc0\u6d3b AMPK\/mTOR \u4fe1\u53f7\u901a\u8def\u6765\u6291\u5236\u708e\u75c7\u53cd\u5e94\uff0c \u4ece\u800c\u53d1\u6325\u6297\u766b\u75eb\u4f5c\u7528 [80] \u3002 \u6291\u90c1\u75c7\u662f\u4e00\u79cd\u4ee5\u60c5\u611f\u75c5\u6001\u53d8\u5316\u4e3a\u4e3b\u8981\u75c7\u72b6\u7684\u7cbe \u795e\u75c5\uff0c\u5176\u53d1\u75c5\u673a\u5236\u88ab\u8ba4\u4e3a\u4e0e\u8111\u5185\u5355\u80fa\u7c7b\u795e\u7ecf\u9012\u8d28\u5931 \u8c03\u6709\u5173\uff0c\u7279\u522b\u662f\u53bb\u7532\u80be\u4e0a\u817a\u7d20 (norepinephrine, NE) \u548c 5- \u7f9f\u8272\u80fa (5-hydroxy tryptamine, 5-HT) [81-82] \u3002\u901a \u8fc7\u80c3\u7ba1\u704c\u6ce8\u98df\u6cd5\u7ed9\u4e88\u6291\u90c1\u6a21\u578b\u5c0f\u9f20\u767d\u85dc\u82a6\u9187 (20\u3001 40\u300180 mg\/kg)\uff0c\u89c2\u5bdf\u5230\u767d\u85dc\u82a6\u9187\u5bf9\u8fd0\u52a8\u6ca1\u6709\u5f71\u54cd\uff0c \u4f46\u80fd\u51cf\u5c11\u6291\u90c1\u75c7\u5c0f\u9f20\u7684\u4e0d\u7a33\u5b9a\u65f6\u95f4\uff0c\u5e76\u5448\u5242\u91cf\u4f9d\u8d56 \u6027\u5730\u6fc0\u6d3b\u5355\u80fa\u6c27\u5316\u9176 A (monoamine oxidase-A, MAO-A) \u7684\u6d3b\u6027\uff0c\u7531\u6b64\u63d0\u51fa\u767d\u85dc\u82a6\u9187\u7684\u6297\u6291\u90c1\u6d3b\u6027\u53ef\u80fd\u4e0e 5-HT \u548c NE \u80fd\u6d3b\u52a8\u6709\u5173\u3002\u7528\u767d\u85dc\u82a6\u9187\u5904\u7406\u957f\u671f\u5904\u4e8e \u538b\u529b\u72b6\u6001\u4e0b\u7684\u5927\u9f20\uff0c\u53d1\u73b0\u5927\u9f20\u989d\u76ae\u8d28\u3001\u6d77\u9a6c\u533a\u3001\u4e0b \u4e18\u8111\u533a 5-HT \u6c34\u5e73\u663e\u8457\u4e0a\u5347\uff0c\u989d\u76ae\u8d28\u3001\u7eb9\u72b6\u4f53 NE \u548c\u591a\u5df4\u80fa\u6c34\u5e73\u63d0\u9ad8\uff0c\u6291\u5236\u4e86\u5927\u8111 4 \u533a\u57df\uff0c\u7279\u522b\u5728\u989d \u76ae\u8d28\u3001\u6d77\u9a6c\u533a MAO-A \u7684\u6d3b\u6027\uff0c\u800c\u5bf9 MAO-B \u5219\u6ca1 \u6709\u5f71\u54cd\uff0c\u8868\u660e\u767d\u85dc\u82a6\u9187\u8c03\u8282\u8111\u5185\u5355\u80fa\u7c7b\u9012\u8d28\u7684\u5e73\u8861 \u53ef\u80fd\u662f\u5176\u6297\u6291\u90c1\u6548\u5e94\u7684\u4e3b\u8981\u673a\u5236\u4e4b\u4e00 [83-84] \u3002<\/p>\n<h2>2.5 \u767d\u85dc\u82a6\u9187\u7684\u6297\u8870\u8001\u6548\u5e94<\/h2>\n<p>\u795e\u7ecf\u7cfb\u7edf\u662f\u767d\u85dc\u82a6\u9187\u53d1\u6325\u6297\u8870\u8001\u6548\u5e94\u7684\u91cd\u8981\u4f5c \u7528\u73af\u8282\u3002\u8870\u8001\u662f\u4e00\u5207\u751f\u547d\u7531\u9057\u4f20\u56e0\u7d20\u548c\u5185\u5916\u73af\u5883\u4e92 \u76f8\u4f5c\u7528\u4e0b\u7684\u751f\u7269\u8fc7\u7a0b\uff0c\u662f\u673a\u4f53\u529f\u80fd\u9000\u884c\u6027\u4e0b\u964d\u53ca\u7d0a \u4e71\u7684\u7efc\u5408\u53d8\u5316\u3002\u70ed\u91cf\u9650\u5236\u548c Sirtuins \u6d3b\u6027\u589e\u52a0\u80fd \u5ef6\u957f\u6709\u673a\u4f53\uff0c\u5982\u9175\u6bcd\u3001\u8815\u866b\u3001\u679c\u8747\u3001\u54fa\u4e73\u52a8\u7269\u7684\u5bff \u547d [85-86] \uff0c\u8fd1\u5e74\u6765\u6709\u5b66\u8005\u8bc1\u5b9e\u4e86\u767d\u85dc\u82a6\u9187\u53ef\u90e8\u5206\u6a21\u62df \u70ed\u91cf\u9650\u5236\u7684\u6297\u8870\u8001\u6548\u5e94\u3002\u6b64\u5916\uff0c\u53d1\u73b0\u767d\u85dc\u82a6\u9187\u53ef\u7ade \u4e89\u6027\u6291\u5236 cAMP \u78f7\u9178\u4e8c\u916f\u9176\uff0c\u6fc0\u6d3b cAMP \u6548\u5e94\u86cb\u767d\uff0c\u5f15\u8d77 Ca 2+ \u5185\u6d41\u589e\u52a0\u8fdb\u800c\u6fc0\u6d3b CamKK\u03b2-AMPK \u9014\u5f84\uff0c \u5bfc\u81f4\u8f85\u9176\u2160\u53ca Sirt1 \u6d3b\u6027\u589e\u52a0\uff0c\u8fdb\u800c\u6539\u5584\u5e74\u9f84\u76f8\u5173 \u4ee3\u8c22\u8868\u578b [87] \u3002\u7528\u767d\u85dc\u82a6\u9187\u5582\u517b\u9c7c\u7c7b\u540e\uff0c\u5bf9\u540e\u5929\u5b66\u4e60 \u80fd\u529b\u6709\u663e\u8457\u7684\u7ef4\u62a4\u4f5c\u7528\uff0c\u5e76\u53ef\u9884\u9632\u4e0e\u5e74\u9f84\u76f8\u5173\u7684\u8111 \u529f\u80fd\u9000\u884c\u6027\u75be\u75c5\u3002<\/p>\n<p>\u767d\u85dc\u82a6\u9187\u5e72\u9884\u53ef\u51cf\u5c11\u5e74\u9f84\u4f9d\u8d56\u7684 \u6c27\u5316\u751f\u7269\u6807\u5fd7\u7269\u7684\u5806\u79ef\uff0c\u8fdb\u4e00\u6b65\u8868\u660e\u767d\u85dc\u82a6\u9187\u5177\u6709 \u6297\u8111\u529f\u80fd\u8870\u8001\u7684\u4f5c\u7528\uff0c\u4f46\u4e5f\u4e0d\u80fd\u6392\u9664\u767d\u85dc\u82a6\u9187\u662f\u901a \u8fc7\u5bf9\u795e\u7ecf\u7cfb\u7edf\u7684\u4fdd\u62a4\u4f5c\u7528\u95f4\u63a5\u5bfc\u81f4\u751f\u7269\u4f53\u5bff\u547d\u7684 \u5ef6\u957f [88-89] \u3002<\/p>\n<p>\u66f4\u4ee4\u4eba\u5174\u594b\u7684\u662f\uff0c<span style=\"color: #ff0000;\">\u767d\u85dc\u82a6\u9187\u5728\u4f53\u5916\u5bf9\u7aef \u7c92\u9176\u6d3b\u6027\u5177\u6709\u79ef\u6781\u6548\u5e94<\/span>\uff0c\u8fd9\u5bf9\u4e8e\u767d\u85dc\u82a6\u9187\u6297\u8870\u8001\u673a \u5236\u7684\u7814\u7a76\u5177\u6709\u91cd\u8981\u7684\u6307\u5bfc\u610f\u4e49\uff0c\u56e0\u4e3a\u7aef\u7c92\u9176\u529f\u80fd\u969c \u788d\u4e0e\u8870\u8001\u5bc6\u5207\u76f8\u5173\uff0c<span style=\"color: #ff00ff;\"><strong>\u7aef\u7c92\u7f29\u77ed\u4f1a\u4fc3\u8fdb\u7ec6\u80de\u8870\u8001\u6216\u51cb \u4ea1<\/strong><\/span>\u3002\u7531\u4e8e\u53d1\u73b0 Sirt1 \u53c2\u4e0e\u7aef\u7c92\u7684\u4fee\u590d\uff0c\u63d0\u793a\u767d\u85dc\u82a6 \u9187\u53ef\u80fd\u901a\u8fc7\u6fc0\u6d3b Sirt1 \u6765\u8c03\u8282\u7aef\u7c92\u9176\u6d3b\u6027 [90-93] \u3002\u8fd9 \u4e9b\u90fd\u4e3a\u6297\u8870\u8001\u836f\u7269\u7684\u5f00\u53d1\u63d0\u4f9b\u4e86\u91cd\u8981\u7684\u5b9e\u9a8c\u4f9d\u636e\u3002<\/p>\n<h1>3 \u7ed3\u8bed<\/h1>\n<p>\u7efc\u4e0a\u6240\u8ff0\uff0c\u767d\u85dc\u82a6\u9187\u5728\u795e\u7ecf\u7cfb\u7edf\u3001\u5fc3\u8840\u7ba1\u3001 \u80bf\u7624\u7b49\u91cd\u8981\u75be\u75c5\u4e2d\u5448\u73b0\u51fa\u5e7f\u6cdb\u7684\u751f\u7269\u6d3b\u6027\uff0c\u56e0\u800c \u53d7\u5230\u5e7f\u6cdb\u91cd\u89c6\u3002\u5728\u591a\u79cd\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u52a8\u7269\u6a21\u578b\u4e2d\uff0c \u767d\u85dc\u82a6\u9187\u5747\u663e\u793a\u8f83\u597d\u7684\u795e\u7ecf\u4fdd\u62a4\u4f5c\u7528\u3002\u867d\u7136\u6297\u6c27 \u5316\u662f\u767d\u85dc\u82a6\u9187\u795e\u7ecf\u4fdd\u62a4\u6548\u5e94\u7684\u4e3b\u8981\u673a\u5236\uff0c\u4f46\u4e5f\u6709 \u5176\u4ed6\u673a\u5236\u53c2\u4e0e\uff0c\u5305\u62ec\u6297\u708e\u3001\u6297\u7ec6\u80de\u51cb\u4ea1\u4ee5\u53ca\u5bf9\u7ec6 \u80de\u4fe1\u53f7\u8f6c\u5bfc\u901a\u8def\u7684\u8c03\u8282\u7b49\u3002\u56e0\u6b64\uff0c\u5bf9\u767d\u85dc\u82a6\u9187\u795e \u7ecf\u4fdd\u62a4\u4f5c\u7528\u7684\u6df1\u5165\u7814\u7a76\u53ef\u80fd\u4e3a\u9884\u9632\u548c\u6cbb\u7597\u795e\u7ecf\u7cfb \u7edf\u75be\u75c5\u63d0\u4f9b\u65b9\u6848\u3002<\/p>\n<p>\u7136\u800c\uff0c\u5c31\u767d\u85dc\u82a6\u9187\u5bf9\u795e\u7ecf\u7cfb\u7edf \u7684\u4f5c\u7528\u800c\u8a00\uff0c\u73b0\u6709\u7684\u7814\u7a76\u7ed3\u679c\u8fd8\u5b58\u5728\u660e\u663e\u7684\u4e0d\u8db3 \uff1a<\/p>\n<p>(1) \u73b0\u6709\u7814\u7a76\u5de5\u4f5c\u96c6\u4e2d\u5728\u5f62\u6001\u5b66\u3001\u751f\u7269\u5316\u5b66\u548c\u5206\u5b50 \u751f\u7269\u5b66\u6c34\u5e73\uff0c\u7f3a\u4e4f\u767d\u85dc\u82a6\u9187\u5bf9\u4e8e\u5927\u8111\u7684\u751f\u7406\u529f\u80fd\uff0c \u7279\u522b\u662f\u5728\u4f53\u795e\u7ecf\u7535\u6d3b\u52a8\u7684\u5b9e\u9a8c\u8bc1\u636e \uff1b<\/p>\n<p>(2) \u867d\u5df2\u8bc1\u660e \u5305\u62ec\u6297\u6c27\u5316\u4f5c\u7528\u7b49\u591a\u79cd\u673a\u5236\u53c2\u4e0e\u767d\u85dc\u82a6\u9187\u7684\u795e\u7ecf \u4fdd\u62a4\u4f5c\u7528\uff0c\u4f46\u5176\u76f8\u5e94\u7684\u4f5c\u7528\u9776\u70b9\u548c\u786e\u5207\u7684\u4f5c\u7528\u673a \u5236\u5c1a\u4e0d\u660e\u786e \uff1b<\/p>\n<p>(3) \u867d\u7136\u767d\u85dc\u82a6\u9187\u5728\u81ea\u7136\u754c\u5e7f\u6cdb\u5b58\u5728\uff0c \u5e76\u4f5c\u4e3a\u98df\u7269\u88ab\u4eba\u7c7b\u957f\u671f\u98df\u7528\uff0c\u652f\u6301\u5176\u5177\u6709\u8f83\u4f4e\u6bd2 \u6027\u3001\u8010\u53d7\u6027\u548c\u5b89\u5168\u7684\u7279\u6027\uff0c\u4f46\u66f4\u6df1\u5165\u7684\u6bd2\u6027\u7814\u7a76 \u5bf9\u5176\u4f5c\u4e3a\u6cbb\u7597\u836f\u7269\u4ecd\u662f\u5fc5\u9700\u7684\uff0c\u5982\u5927\u5242\u91cf (3 g\/kg\/d) \u767d\u85dc\u82a6\u9187\u53ef\u5bfc\u81f4\u5927\u9f20\u56e0\u80be\u6bd2\u6027\u800c\u6b7b\u4ea1 [94] \u3002\u767d\u85dc\u82a6 \u9187\u8f83\u4f4e\u7684\u751f\u7269\u5229\u7528\u5ea6\u4e5f\u53ef\u80fd\u662f\u5f71\u54cd\u5176\u5e94\u7528\u7684\u56e0\u7d20 \u4e4b\u4e00 [95] \uff0c\u4f46\u5242\u578b\u6539\u826f\u53ef\u6709\u6548\u6539\u5584\u8fd9\u4e2a\u95ee\u9898\u3002\u6700\u65b0 \u7684\u4e00\u9879\u7814\u7a76\u62a5\u9053\uff0c\u5065\u5eb7\u4eba\u6bcf\u65e5\u670d\u7528 40 mg \u6539\u826f\u5242 \u578b\u7684\u53cd\u5f0f\u767d\u85dc\u82a6\u9187\uff0c\u53ef\u6709\u6548\u63d0\u5347\u8840\u836f\u6d53\u5ea6\u5230 0.1~6 \u00b5M[96] \u3002\u56e0\u6b64\uff0c\u968f\u7740\u767d\u85dc\u82a6\u9187\u5bf9\u795e\u7ecf\u7cfb\u7edf\u7684\u6574\u4f53\u5f71 \u54cd\u53ca\u5206\u5b50\u673a\u5236\u7684\u9010\u6b65\u9610\u660e\uff0c\u5176\u4f5c\u4e3a\u795e\u7ecf\u7cfb\u7edf\u836f\u7269 \u5e94\u7528\u7684\u524d\u666f\u5c06\u66f4\u6e05\u6670\u3002<\/p>\n<p>\u6458\u81ea\uff1a<a href=\"http:\/\/www.lifescience.net.cn\/news\/upload\/20136566.pdf\" target=\"_blank\" rel=\"noopener\">\u00a0http:\/\/www.lifescience.net.cn<\/a><\/p>\n<div class=\"pvc_clear\"><\/div>\n<p id=\"pvc_stats_2388\" class=\"pvc_stats all  \" data-element-id=\"2388\" style=\"\"><i class=\"pvc-stats-icon medium\" aria-hidden=\"true\"><svg aria-hidden=\"true\" focusable=\"false\" data-prefix=\"far\" data-icon=\"chart-bar\" role=\"img\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\" class=\"svg-inline--fa fa-chart-bar fa-w-16 fa-2x\"><path fill=\"currentColor\" d=\"M396.8 352h22.4c6.4 0 12.8-6.4 12.8-12.8V108.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v230.4c0 6.4 6.4 12.8 12.8 12.8zm-192 0h22.4c6.4 0 12.8-6.4 12.8-12.8V140.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v198.4c0 6.4 6.4 12.8 12.8 12.8zm96 0h22.4c6.4 0 12.8-6.4 12.8-12.8V204.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v134.4c0 6.4 6.4 12.8 12.8 12.8zM496 400H48V80c0-8.84-7.16-16-16-16H16C7.16 64 0 71.16 0 80v336c0 17.67 14.33 32 32 32h464c8.84 0 16-7.16 16-16v-16c0-8.84-7.16-16-16-16zm-387.2-48h22.4c6.4 0 12.8-6.4 12.8-12.8v-70.4c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v70.4c0 6.4 6.4 12.8 12.8 12.8z\" class=\"\"><\/path><\/svg><\/i> <img loading=\"lazy\" decoding=\"async\" width=\"16\" height=\"16\" alt=\"Loading\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/plugins\/page-views-count\/ajax-loader-2x.gif\" border=0 \/><\/p>\n<div class=\"pvc_clear\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u767d\u85dc\u82a6\u9187\u662f\u67d0\u4e9b\u79cd\u5b50\u7c7b\u690d\u7269 (spermatophytes)\uff0c \u5728\u62b5\u6297\u75c5\u539f\u83cc\u3001\u635f\u4f24\u7b49\u4fb5\u88ad\u65f6\u4ea7\u751f\u7684\u690d\u7269\u6297\u6bd2\u7d20 (phytoalexin)\uff0c\u5e7f\u6cdb\u5b58\u5728\u4e8e\u8461\u8404\u79d1\u3001\u767e\u5408\u79d1\u3001\u8c46\u79d1\u3001 \u84fc\u79d1\u3001\u4f1e\u5f62\u79d1\u7b49 70 \u591a\u79cd\u690d\u7269\u4e2d\uff0c\u5176\u4e2d\u5305\u62ec\u85dc\u82a6\u3001 \u864e\u4ed7\u548c\u89c9\u660e\u7b49\u836f\u7528\u690d\u7269\uff0c\u4ee5\u53ca\u82b1\u751f\u3001\u8349\u8393\u53ca\u8461\u8404\u7b49 \u98df\u7269\u3002\u767d\u85dc\u82a6\u9187\u5f15\u8d77\u79d1\u5b66\u5bb6\u7684\u5173\u6ce8\u6e90\u4e8e\u4e00\u9879\u6d41\u884c\u75c5 \u5b66\u8c03\u67e5\u4e2d\u53d1\u73b0\u7684\u201cThe French Paradox\u201d\u73b0\u8c61\uff0c\u5373\u6cd5 \u56fd\u4eba\u867d\u7136\u6444\u5165\u9ad8\u8102\u3001\u9ad8\u80c6\u56fa\u9187\u996e\u98df\uff0c\u4f46\u5fc3\u8840\u7ba1\u75be\u75c5 \u53d1\u75c5\u7387\u5374\u5f88\u4f4e\uff0c\u4e00\u822c\u8ba4\u4e3a\u8fd9\u4e0e\u6cd5\u56fd\u4eba\u7ecf\u5e38\u996e\u7528\u8461\u8404 \u9152\u6709\u5173 [1] \u3002\u968f\u7740\u5bf9\u767d\u85dc\u82a6\u9187\u7814\u7a76\u7684\u6df1\u5165\uff0c\u53d1\u73b0\u6b64\u5316 \u5408\u7269\u5177\u6709\u975e\u5e38\u5e7f\u6cdb\u7684\u751f\u7269\u6d3b\u6027\uff0c\u5982\u6297\u80bf\u7624\u3001\u6297\u5fc3\u8840 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