{"id":2330,"date":"2017-07-30T15:29:41","date_gmt":"2017-07-30T19:29:41","guid":{"rendered":"http:\/\/www.deepthinkgohelper.com\/wp\/?p=2330"},"modified":"2022-05-25T14:38:43","modified_gmt":"2022-05-25T14:38:43","slug":"%e7%99%bd%e8%97%9c%e8%8a%a6%e9%86%87%e5%af%b9%e5%a4%a7%e9%bc%a0%e6%b5%b7%e9%a9%acca1%e5%8c%ba%e8%af%b1%e5%8f%91%e7%99%ab%e7%97%ab%e6%a0%b7%e6%b4%bb%e5%8a%a8%e7%9a%84%e6%8a%91%e5%88%b6%e4%bd%9c","status":"publish","type":"post","link":"http:\/\/johnhealth.blog\/ch\/?p=2330","title":{"rendered":"\u767d\u85dc\u82a6\u9187\u5bf9\u5927\u9f20\u6d77\u9a6cCA1\u533a\u8bf1\u53d1\u766b\u75eb\u6837\u6d3b\u52a8\u7684\u6291\u5236\u4f5c\u7528"},"content":{"rendered":"<p><span style=\"color: #000000;\"><strong>\u3010\u6458\u8981\u3011\uff1a<\/strong><\/span>\u76ee\u7684 \u672c\u7814\u7a76\u91c7\u7528\u6b63\u5e38\u5927\u9f20\u6d77\u9a6c\u8111\u7247\u704c\u6d41\u79bb\u5b50\u578b\u03b3-\u6c28\u57fa\u4e01\u9178\u53d7\u4f53\uff08GABAA\u53d7\u4f53\uff09\u62ee\u6297\u5242\u8377\u5305\u7261\u4e39\u78b1\uff08bicuculline\uff0cBic\uff09\u5f15\u8d77\u766b\u75eb\u6837\u6d3b\u52a8\uff1b\u4ee5\u53ca\u5e94\u7528\u8111\u7acb\u4f53\u5b9a\u4f4d\u6280\u672f\u5728\u5927\u9f20\u6d77\u9a6cCA3\u4e2d\u5fc3\u533a\u901a\u8fc7\u5fae\u91cf\u6ce8\u5c04\u6d77\u4eba\u8349\u9178\uff08Kainic acid\uff0cKA\uff09\u6765\u5efa\u7acb\u989e\u53f6\u766b\u75eb\uff08temporal lobe epilepsy\uff0cTLE\uff09\u5927\u9f20\u6a21\u578b\u3002\u91c7\u7528\u79bb\u4f53\u8111\u7247\u7ec6\u80de\u5916\u573a\u7535\u4f4d\u8bb0\u5f55\u65b9\u6cd5\u89c2\u6d4b\u4e0d\u540c\u6d53\u5ea6\u767d\u85dc\u82a6\u9187\uff08resveratrol, Res\uff09\u5bf9\u766b\u75eb\u5927\u9f20\u6d77\u9a6cCA1\u533a\u573a\u7535\u4f4d\u7684\u5f71\u54cd\uff0c\u4e3a\u4e34\u5e8a\u7814\u53d1\u6297\u766b\u75eb\u65b0\u836f\u63d0\u4f9b\u7406\u8bba\u4f9d\u636e\u3002 \u65b9\u6cd5 1\u6a21\u578b\u5efa\u7acb 1.1\u989e\u53f6\u766b\u75eb\u6a21\u578bWistar\u96c4\u6027\u5927\u9f20\uff0c\u4f53\u91cd200\uff5e240\u514b\uff0c\u6e05\u6d01\u7ea7\u3002\u5927\u9f20\u7ecf\u6c34\u5408\u6c2f\u919b\uff08350mg\/kg\uff09\u8179\u8154\u9ebb\u9189\u540e\uff0c\u56fa\u5b9a\u4e8e\u7acb\u4f53\u5b9a\u4f4d\u4eea\u4e0a\uff0c\u5728\u53f3\u4fa7\u6d77\u9a6cCA3\u4e2d\u5fc3\u533a\uff08AP:\u20134.0mm,ML:4.4mm, DV:3.8mm\uff09\u7528\u5fae\u91cf\u6ce8\u5c04\u9488\u6ce8\u51652.5\uff5e3\u03bcl KA\uff080.4\u03bcg\/\u03bcl\uff09\uff0c\u6ce8\u5c0415min\uff0c\u7559\u948810min\uff0c\u672f\u540e\u7f1d\u5408\u5934\u76ae\u3002\u5927\u9f20\u6025\u6027\u53d1\u4f5c\u7b49\u7ea7\u53c2\u7167Racine\u6807\u51c6\u5206\u7ea7\uff0c\u8fbe\u5230\u2163\u7ea7\u53ca\u4ee5\u4e0a\u89c6\u4e3a\u5efa\u6a21\u6210\u529f\uff0c\u6a21\u578b\u5927\u9f20\u5728\u624b\u672f\u540e2\uff5e4\u5468\u8fdb\u884c\u7ec6\u80de\u5916\u573a\u7535\u4f4d\u8bb0\u5f55\u3002 1.2\u6025\u6027\u766b\u75eb\u6837\u6d3b\u52a8\u6b63\u5e38\u5927\u9f20\u79bb\u4f53\u6d77\u9a6c\u8111\u7247\u704c\u6d41GABAA\u53d7\u4f53\u62ee\u6297\u5242Bic\uff0830\u03bcmol\/L\uff09\u4ee5\u5f15\u8d77\u766b\u75eb\u6837\u6d3b\u52a8\u3002 2\u79bb\u4f53\u8111\u7247\u5236\u5907\u5927\u9f20\u75282%\u620a\u5df4\u6bd4\u59a5\u94a0\u9ebb\u9189\u540e\u8fc5\u901f\u65ad\u5934\u53d6\u8111\uff0c\u7f6e\u4e8e\u6301\u7eed\u7ed9\u4e8895%O2\u548c5%CO2\u6df7\u5408\u6c14\u76844\u2103\u4eba\u5de5\u8111\u810a\u6db2\uff08artificial cerebrospinal fluid,ACSF\uff09\u4e2d\u3002\u5f85\u8111\u7ec4\u7ec7\u51b7\u5374\u540e\u6cbf\u6d77\u9a6c\u69fd\u7ea4\u7ef4\u8d70\u5411\u5207\u6210400\u03bcm\u539a\u7684\u8111\u7247\uff0c\u5e76\u5c06\u5176\u79fb\u81f3\u542bACSF\uff0830\u00b12\u2103\uff09\u7684\u5b75\u80b2\u69fd\u4e2d\uff0c\u6301\u7eed\u901a\u5165\u6df7\u5408\u6c14\uff0c\u5b75\u80b21\uff5e2h\u3002 3\u573a\u7535\u4f4d\u8bb0\u5f55\u5c06\u5b75\u80b2\u7684\u8111\u7247\u79fb\u81f3\u8bb0\u5f55\u69fd\uff0c\u6301\u7eed\u704c\u6d4195%O2\u548c5%CO2\u6df7\u5408\u6c14\u9971\u548c\u7684ACSF\uff0c\u704c\u6d41\u901f\u5ea62ml\/min\uff0c\u6e29\u5ea632\u2103\u3002\u523a\u6fc0\u6d77\u9a6c\u8f90\u5c04\u5c42Schaffer\u4fa7\u652f\u901a\u8def\uff0c\u5728CA1\u533a\u9525\u4f53\u7ec6\u80de\u5c42\u8bb0\u5f55\u7fa4\u5cf0\u7535\u4f4d\uff08population spike, PS\uff09\u3002 4\u7edf\u8ba1\u5b66\u5206\u6790\u91c7\u7528SPSS13.0\u7edf\u8ba1\u8f6f\u4ef6\u5206\u6790\u3002\u5b9e\u9a8c\u7ed3\u679c\u4ee5x\u00b1SEM\u8868\u793a\uff0c\u7ec4\u95f4\u5747\u6570\u7528t\u68c0\u9a8c\u8fdb\u884c\u6bd4\u8f83\uff0cP 0.05\u5177\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\u3002 \u7ed3\u679c 1. Res\u5bf9\u6b63\u5e38\u5927\u9f20\u6d77\u9a6cCA1\u533aPS\u7684\u5f71\u54cd\u7535\u523a\u6fc0\u79bb\u4f53\u6d77\u9a6c\u8111\u7247Schaffer\u4fa7\u652f\uff0c\u5728CA1\u533a\u9525\u4f53\u7ec6\u80de\u5c42\u901a\u5e38\u53ef\u8bb0\u5f55\u5230\u5355\u4e2aPS\uff0c\u5728\u704c\u6d41\u6b63\u5e38\u8111\u7247\u7684ACSF\u4e2d\u5206\u522b\u52a0\u5165\u4f4e\u3001\u4e2d\u548c\u9ad8\u5242\u91cf\u7684Res\uff08\u5206\u522b\u4e3a5\u03bcmol\/L\u300115\u03bcmol\/L\u548c50\u03bcmol\/L\uff09\uff0c\u5f53\u542b\u6709\u76f8\u5e94\u6d53\u5ea6Res\u7684ACSF\u704c\u6d41\u8111\u7247\u540e\uff0c\u8bb0\u5f55\u7684PS\u5e45\u5ea6\u5747\u65e0\u660e\u663e\u53d8\u5316\uff08n=8, P\ufe650.05\uff09\u3002 2. Res\u5bf9\u5927\u9f20\u6d77\u9a6cCA1\u533a\u8bf1\u53d1\u766b\u75eb\u6837\u653e\u7535\u7684\u5f71\u54cd\u5927\u9f20\u6d77\u9a6cCA1\u533a\u766b\u75eb\u6837\u653e\u7535\u7684\u5f62\u6210\u53ef\u901a\u8fc7\u8111\u7247\u6025\u6027\u704c\u6d41\u542bBic\u7684ACSF\u6216\u5728\u4f53\u6d77\u9a6c\u8111\u533a\u6ce8\u5c04KA\u8bf1\u53d1TLE\u3002\u704c\u6d41\u542bBic\uff0830\u03bcmol\/L\uff09\u7684ACSF20min\u540e\uff0c\u8bb0\u5f55\u5230\u7684\u573a\u7535\u4f4d\u4e3a\u591a\u4e2aPS\u7684\u75eb\u6837\u7535\u4f4d\uff0c\u518d\u5206\u522b\u704c\u6d41\u6dfb\u52a0\u4f4e\u3001\u4e2d\u5242\u91cfRes\uff085\u300115\u03bcmol\/L\uff09\u7684ACSF\u540e\uff0c\u524d4\u4e2aPS\u5e45\u5ea6\u5747\u65e0\u660e\u663e\u53d8\u5316\uff08\u5206\u522b\u4e3an=8, P\ufe650.05\uff1bn=8, P\ufe650.05\uff09\uff1b\u704c\u6d41\u6dfb\u52a0\u9ad8\u5242\u91cfRes\uff0850\u03bcmol\/L\uff09\u7684ACSF\u540e\uff0c\u524d4\u4e2aPS\u5e45\u5ea6\u5747\u51fa\u73b0\u663e\u8457\u6027\u964d\u4f4e\uff0c\uff08n=8, P\ufe640.01\uff09\uff0c\u5e76\u4e14PS\u6570\u76ee\u4e5f\u660e\u663e\u51cf\u5c11\uff0c\u4e3a\u704c\u6d41\u524d\u768482.02\u00b11.3%\uff08n=8, P\ufe640.01\uff09\u3002\u5728TLE\u6a21\u578b\u5927\u9f20\u6d77\u9a6c\u8111\u7247\u4e0a\u8bb0\u5f55\u5230\u7684\u573a\u7535\u4f4d\u4e3a\u591a\u4e2aPS\u7684\u75eb\u6837\u7535\u4f4d\uff0c\u5206\u522b\u704c\u6d41\u542b\u4f4e\u3001\u4e2d\u5242\u91cfRes\uff085\u300115\u03bcmol\/L\uff09\u7684ACSF\u540e\uff0c\u524d4\u4e2aPS\u5e45\u5ea6\u5747\u65e0\u660e\u663e\u53d8\u5316\uff08\u5206\u522b\u4e3an=6, P\ufe650.05\uff1bn=6, P\ufe650.05\uff09\uff1b\u704c\u6d41\u542b\u9ad8\u5242\u91cfRes\uff0850\u03bcmol\/L\uff09\u7684ACSF\u540e\uff0c\u524d4\u4e2aPS\u5e45\u5ea6\u5747\u51fa\u73b0\u663e\u8457\u6027\u964d\u4f4e\uff08n=6, P\ufe640.01\uff09\uff0cPS\u6570\u76ee\u4e5f\u660e\u663e\u51cf\u5c11\uff0c\u4e3a\u704c\u6d41\u524d\u768484.58\u00b12.4%\uff08n=6, P\ufe640.01\uff09\u3002 \u7ed3\u8bba 1.\u4f4e\u3001\u4e2d\u3001\u9ad8\u5242\u91cf\u7684Res (5\u03bcmol\/L,15\u03bcmol\/L\u548c50\u03bcmol\/L)\u5bf9\u6b63\u5e38\u5927\u9f20\u6d77\u9a6cCA1\u533a\u7684PS\u6ca1\u6709\u660e\u663e\u7684\u5f71\u54cd\u3002 2.\u4f4e\u3001\u4e2d\u5242\u91cf\u7684Res (5\u03bcmol\/L\u548c15\u03bcmol\/L)\u7684\u5bf9\u5927\u9f20\u6d77\u9a6cCA1\u533a\u8bf1\u53d1\u7684\u766b\u75eb\u6837\u653e\u7535\u6d3b\u52a8\u6ca1\u6709\u660e\u663e\u7684\u5f71\u54cd\uff0c\u800c\u9ad8\u5242\u91cf\u7684Res (50\u03bcmol\/L)\u5bf9\u5927\u9f20\u6d77\u9a6cCA1\u533a\u8bf1\u53d1\u7684\u766b\u75eb\u6837\u653e\u7535\u6d3b\u52a8\u6709\u90e8\u5206\u6291\u5236\u4f5c\u7528\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-17250\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2017\/07\/Screenshot-998.png\" alt=\"\" width=\"1920\" height=\"1080\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2017\/07\/Screenshot-998.png 1920w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2017\/07\/Screenshot-998-300x169.png 300w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2017\/07\/Screenshot-998-1024x576.png 1024w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2017\/07\/Screenshot-998-768x432.png 768w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2017\/07\/Screenshot-998-1536x864.png 1536w\" sizes=\"auto, (max-width: 1920px) 100vw, 1920px\" \/><\/p>\n<p>\u8be6\u60c5\u8bf7\u67e5\u9605\uff1a<a href=\"http:\/\/cdmd.cnki.com.cn\/Article\/CDMD-10366-1012468732.htm\" target=\"_blank\" rel=\"noopener\">http:\/\/cdmd.cnki.com.cn\/Article\/CDMD-10366-1012468732.htm<\/a><\/p>\n<p>&nbsp;<\/p>\n<div class=\"pvc_clear\"><\/div>\n<p id=\"pvc_stats_2330\" class=\"pvc_stats all  \" data-element-id=\"2330\" style=\"\"><i class=\"pvc-stats-icon medium\" aria-hidden=\"true\"><svg aria-hidden=\"true\" focusable=\"false\" data-prefix=\"far\" data-icon=\"chart-bar\" role=\"img\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\" class=\"svg-inline--fa fa-chart-bar fa-w-16 fa-2x\"><path 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Res\u5bf9\u5927\u9f20\u6d77\u9a6cCA1\u533a\u8bf1\u53d1\u766b\u75eb\u6837\u653e\u7535\u7684\u5f71\u54cd\u5927\u9f20\u6d77\u9a6cCA1\u533a\u766b\u75eb\u6837\u653e\u7535\u7684\u5f62\u6210\u53ef\u901a\u8fc7\u8111\u7247\u6025\u6027\u704c\u6d41\u542bBic\u7684ACSF\u6216\u5728\u4f53\u6d77\u9a6c\u8111\u533a\u6ce8\u5c04KA\u8bf1\u53d1TLE\u3002\u704c\u6d41\u542bBic\uff0830\u03bcmol\/L\uff09\u7684ACSF20min\u540e\uff0c\u8bb0\u5f55\u5230\u7684\u573a\u7535\u4f4d\u4e3a\u591a\u4e2aPS\u7684\u75eb\u6837\u7535\u4f4d\uff0c\u518d\u5206\u522b\u704c\u6d41\u6dfb\u52a0\u4f4e\u3001\u4e2d\u5242\u91cfRes\uff085\u300115\u03bcmol\/L\uff09\u7684ACSF\u540e\uff0c\u524d4\u4e2aPS\u5e45\u5ea6\u5747\u65e0\u660e\u663e\u53d8\u5316\uff08\u5206\u522b\u4e3an=8, P\ufe650.05\uff1bn=8, P\ufe650.05\uff09\uff1b\u704c\u6d41\u6dfb\u52a0\u9ad8\u5242\u91cfRes\uff0850\u03bcmol\/L\uff09\u7684ACSF\u540e\uff0c\u524d4\u4e2aPS\u5e45\u5ea6\u5747\u51fa\u73b0\u663e\u8457\u6027\u964d\u4f4e\uff0c\uff08n=8, 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