{"id":2097,"date":"2017-04-02T23:51:47","date_gmt":"2017-04-03T03:51:47","guid":{"rendered":"http:\/\/www.deepthinkgohelper.com\/wp\/?p=2097"},"modified":"2022-05-26T01:22:05","modified_gmt":"2022-05-26T01:22:05","slug":"%e8%91%a1%e8%90%84%e4%b8%ad%e7%99%bd%e8%97%9c%e8%8a%a6%e9%86%87%e5%af%b9%e8%82%bf%e7%98%a4%e9%98%b2%e6%b2%bb%e4%bd%9c%e7%94%a8%e7%9a%84%e7%a0%94%e7%a9%b6%e8%bf%9b%e5%b1%95","status":"publish","type":"post","link":"http:\/\/johnhealth.blog\/ch\/?p=2097","title":{"rendered":"\u8461\u8404\u4e2d\u767d\u85dc\u82a6\u9187\u5bf9\u80bf\u7624\u9632\u6cbb\u4f5c\u7528\u7684\u7814\u7a76\u8fdb\u5c55"},"content":{"rendered":"
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\u8461\u8404\u4e2d\u767d\u85dc\u82a6\u9187\u5bf9\u80bf\u7624\u9632\u6cbb\u4f5c\u7528\u7684\u7814\u7a76\u8fdb\u5c55<\/h1>\n

Published at: May 09, 2014 2013\u5e74\u7b2c33\u5377\u7b2c6\u671f<\/a><\/p>\n

\u5218\u8fdc\u9526 1<\/sup> <\/span>, \u6797\u4eb2\u5f55 1<\/sup> <\/span>, \u7f57\u975e\u541b 1\u00a0<\/sup><\/span><\/div>\n
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1<\/sup> \u4e2d\u5357\u6797\u4e1a\u79d1\u6280\u5927\u5b66\u98df\u54c1\u79d1\u5b66\u4e0e\u5de5\u7a0b\u5b66\u9662\u98df\u54c1\u8425\u517b\u4e0e\u5065\u5eb7\u7814\u7a76\u5ba4\uff0c\u957f\u6c99 410004<\/div>\n<\/div>\n
\u901a\u8baf\u4f5c\u8005<\/strong> \u975e\u541b \u7f57 Email: luofeijun@hotmail.com<\/div>\n
DOI:<\/strong> 10.3978\/j.issn.2095-6959.10.3978\/j.issn.2095-6959.<\/div>\n
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\u57fa\u91d1\uff1a<\/strong><\/p>\n

\u56fd\u5bb6\u81ea\u7136\u79d1\u5b66\u57fa\u91d1<\/span> 81071755<\/span><\/div>\n<\/div>\n<\/header>\n
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\u6458\u8981<\/h2>\n

\u767d\u85dc\u82a6\u9187\u662f\u4e00\u79cd\u5927\u91cf\u5b58\u5728\u4e8e\u8461\u8404\u4e2d\u7684\u591a\u915a\u5316\u5408\u7269\uff0c\u5177\u6709\u6297\u80bf\u7624\u3001\u6297\u5fc3\u8840\u7ba1\u75be\u75c5\u548c\u8c03\u8282\u514d\u75ab\u7b49\u4f5c\u7528\u3002\u6587\u7ae0\u603b\u7ed3\u4e86\u767d\u85dc\u82a6\u9187\u5bf9\u4e0d\u540c\u7c7b\u578b\u80bf\u7624\u7ec6\u80de\u7684\u6291\u5236\u4f5c\u7528\uff0c\u9610\u8ff0\u4e86\u5176\u4e3b\u8981\u901a\u8fc7\u6291\u5236\u764c\u7ec6\u80de\u7684\u589e\u6b96\u3001\u4fc3\u8fdb\u7ec6\u80de\u51cb\u4ea1\u3001\u964d\u4f4e\u80bf\u7624\u7ec6\u80de\u7684\u4fb5\u88ad\u80fd\u529b\u548c\u589e\u5f3a\u653e\u5c04\u6cbb\u7597\u654f\u611f\u6027\u7b49\u9014\u5f84\u6297\u764c\uff0c\u5e76\u4ece\u5206\u5b50\u6c34\u5e73\u9610\u660e\u5176\u4f5c\u7528\u7684\u5206\u5b50\u9776\u70b9\u53ca\u5206\u5b50\u673a\u5236\uff0c\u6700\u540e\u5bf9\u767d\u85dc\u82a6\u9187\u7684\u6297\u764c\u673a\u5236\u548c\u5176\u5bf9\u5065\u5eb7\u3001\u533b\u7597\u3001\u7ecf\u6d4e\u7684\u8d21\u732e\u4f5c\u4e86\u5c55\u671b\u3002<\/p>\n<\/div>\n

\u5173\u952e\u8bcd\uff1a<\/strong> \u767d\u85dc\u82a6\u9187\uff1b\u51cb\u4ea1\uff1b\u589e\u6b96\uff1b\u591a\u915a\u5316\u5408\u7269\uff1b\u6297\u80bf\u7624<\/a><\/span><\/div>\n
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Recent advance in the study on prevention and treatment for cancer by resveratrol in grape<\/h1>\n
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LIU Yuanjin 1<\/sup> <\/span>, LIN Qinlu 1<\/sup> <\/span>, LUO Feijun 1<\/sup><\/span><\/p>\n

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1<\/sup> Laboratory of Food Nutrient and Health, College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha 410004, China<\/div>\n<\/div>\n<\/div>\n
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Abstract<\/h2>\n

Resveratrol is a polyphenol compound, at high level in grapes in particular. Resveratrol can exert the effects of antitumor, anti-cardiovascular disease, regulation of immunity, etc. This article summarized the antitumor effect and the molecular targets of resveratrol and the underlying mechanisms, including inhibition of proliferation, promotion of apoptosis, decrease of invasion ability and enhancement of radiotherapy sensitivity for tumor cells. Furthermore, we provided an outlook regarding the beneficial effects of resveratrol on human health, medical care, and economy.<\/p>\n<\/div>\n

Keywords: <\/strong>resveratrol<\/a> <\/span>apoptosis<\/a> <\/span>proliferation<\/a> <\/span>polyphenol compound<\/a> <\/span>antitumor<\/a><\/span><\/div>\n
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\u767d\u85dc\u82a6\u9187\u662f\u4e00\u79cd\u5b58\u5728\u4e8e\u8461\u8404\u79d1\u3001\u84fc\u79d1\u7b49\u690d\u7269\u4e2d\u7684\u6297\u6bd2\u7d20\u3002\u5f88\u591a\u7814\u7a76[1-3]<\/sup>\u8868\u660e\uff0c\u767d\u85dc\u82a6\u9187\u5177\u6709\u6297\u5fc3\u8840\u7ba1\u75be\u75c5[1]<\/sup>\u3001\u6297\u80bf\u7624[2]<\/sup>\u3001\u5ef6\u7f13\u8870\u8001[3]<\/sup>\u7b49\u4f5c\u7528\u3002\u8461\u8404\u76ae\u548c\u8461\u8404\u7c7d\u4e2d\u542b\u6709\u4e30\u5bcc\u7684\u767d\u85dc\u82a6\u9187\uff0c\u5728\u8461\u8404\u9152\u7684\u917f\u5236\u8fc7\u7a0b\u4e2d\uff0c\u767d\u85dc\u82a6\u9187\u4f1a\u6162\u6162\u8fdb\u5165\u5230\u8461\u8404\u9152\u4e2d\uff0c\u56e0\u6b64\u7ecf\u5e38\u5927\u91cf\u996e\u7528\u7ea2\u9152\u7684\u6cd5\u56fd\u4eba\u56e0\u51a0\u5fc3\u75c5\u53d1\u75c5\u7387\u548c\u75c5\u6b7b\u7387\u7684\u6bd4\u4f8b\u5728\u4e00\u4e9b\u9ad8\u8102\u80aa\u3001\u9ad8\u80fd\u91cf\u996e\u98df\u56fd\u5bb6\u4e2d\u662f\u6700\u4f4e\u7684\u3002\u7b14\u8005\u4e3b\u8981\u4ece\u767d\u85dc\u82a6\u9187\u7684\u6297\u80bf\u7624\u4f5c\u7528\u5207\u5165\uff0c\u5206\u522b\u4ece\u767d\u85dc\u82a6\u9187\u4f5c\u7528\u4e8e\u4e0d\u540c\u7684\u9776\u57fa\u56e0\uff0c\u8c03\u8282\u76f8\u5173\u57fa\u56e0\u7684\u8868\u8fbe\u548c\u86cb\u767d\u8d28\u7684\u8f6c\u5f55\u4ee5\u5b9e\u73b0\u6291\u5236\u764c\u7ec6\u80de\u589e\u6b96\uff0c\u4fc3\u8fdb\u764c\u7ec6\u80de\u51cb\u4ea1\u548c\u6291\u5236\u764c\u7ec6\u80de\u8f6c\u79fb3\u4e2a\u65b9\u9762\u8bba\u8ff0\u5176\u6297\u80bf\u7624\u4f5c\u7528\u3002\u767d\u85dc\u82a6\u9187\u6297\u80bf\u7624\u7684\u529f\u6548\u53ef\u4ee5\u5e94\u7528\u5728\u4fdd\u5065\u54c1\u7684\u751f\u4ea7\u4e0a\uff0c\u901a\u8fc7\u7ecf\u5e38\u98df\u7528\u767d\u85dc\u82a6\u9187\u76f8\u5173\u7684\u4fdd\u5065\u54c1\uff0c\u964d\u4f4e\u4eba\u4eec\u7f79\u60a3\u764c\u75c7\u7684\u6982\u7387\uff0c\u6216\u8005\u4f5c\u4e3a\u80bf\u7624\u6cbb\u7597\u7684\u8f85\u52a9\u6027\u836f\u7269\u3002<\/p>\n

1\u00a0 \u767d\u85dc\u82a6\u9187\u7684\u7406\u5316\u7279\u5f81<\/h3>\n

\u767d\u85dc\u82a6\u9187 (\u53cd\u5f0f-3,4,5-\u4e09\u7f9f\u57fa\u4e8c\u82ef\u4e59\u70ef\uff0cresveratrol)\u662f\u4e00\u79cd\u591a\u915a\u5316\u5408\u7269\uff0c\u5206\u5b50\u5f0f\u4e3aC14<\/sub>H12<\/sub>O3<\/sub>\uff0c\u76f8\u5bf9\u5206\u5b50\u8d28\u91cf\u4e3a228.25\u3002\u5e38\u6e29\u4e0b\u5448\u767d\u8272\u9488\u72b6\u6676\u4f53\uff0c\u96be\u6eb6\u4e8e\u6c34\uff0c\u80fd\u6eb6\u4e8e\u4e59\u9187\u3001\u4e59\u9178\u4e59\u916f\u548c\u4e19\u916e\u7b49\u6781\u6027\u5f3a\u7684\u6eb6\u5242\uff0c\u7194\u70b9\u5728256~257 \u2103\u4e4b\u95f4\uff0c261 \u2103\u5373\u5347\u534e\u3002\u767d\u85dc\u82a6\u9187\u5728\u7d2b\u8461\u8404\u4e2d\u7684\u542b\u91cf\u5c24\u4e3a\u4e30\u5bcc\uff0c\u6bcf\u514b\u65b0\u9c9c\u8461\u8404\u76ae\u4e2d\u5927\u7ea6\u542b\u767d\u85dc\u82a6\u918750~100 mg\uff1b\u8461\u8404\u7684\u5176\u4ed6\u76f8\u5173\u4ea7\u54c1\uff0c\u5982\u7ea2\u8461\u8404\u9152\u4e2d\u767d\u85dc\u82a6\u9187\u7684\u542b\u91cf\u4e3a1.5~3.0 mg\/L\uff0c\u5728\u767d\u8461\u8404\u9152\u4e2d\u4e5f\u6709\u5c11\u91cf\u7684\u767d\u85dc\u82a6\u9187\u3002\u4f46\u5e76\u4e0d\u662f\u6240\u6709\u7684\u8461\u8404\u9152\u4e2d\u90fd\u542b\u6709\u767d\u85dc\u82a6\u9187\uff0c\u52fe\u5151\u9152\u548c\u52a3\u8d28\u9152\u4e2d\u662f\u68c0\u6d4b\u4e0d\u5230\u7684\u3002\u8fc4\u4eca\u7684\u7814\u7a76[3-5]<\/sup>\u8868\u660e\uff0c\u767d\u85dc\u82a6\u9187\u5177\u6709\u6297\u6c27\u5316[3]<\/sup>\u3001\u6297\u708e\u75c7[4]<\/sup>\u3001\u514d\u75ab\u8c03\u8282[5]<\/sup>\u7b49\u591a\u79cd\u751f\u7269\u5b66\u529f\u80fd\uff0c\u5e76\u4e14\u5728\u80bf\u7624\u7684\u542f\u52a8\u3001\u53d1\u751f\u548c\u53d1\u5c553\u4e2a\u9636\u6bb5\u5747\u53d1\u6325\u5f3a\u5927\u7684\u6297\u80bf\u7624\u4f5c\u7528\u3002<\/p>\n

2\u00a0 \u767d\u85dc\u82a6\u9187\u7684\u6297\u80bf\u7624\u4f5c\u7528<\/h3>\n

\u76ee\u524d\u7684\u7814\u7a76[6]<\/sup>\u8868\u660e\u767d\u85dc\u82a6\u9187\u5728\u5bab\u9888\u764c\u3001\u809d\u764c\u3001\u7ed3\u80a0\u764c\u548c\u80c3\u764c\u7b49\u6076\u6027\u80bf\u7624\u7684\u6cbb\u7597\u548c\u9884\u9632\u65b9\u9762\u90fd\u6709\u7740\u79ef\u6781\u7684\u4f5c\u7528\u3002\u767d\u85dc\u82a6\u9187\u6297\u80bf\u7624\u4f5c\u7528\u4e3b\u8981\u4f53\u73b0\u5728\u6291\u5236\u764c\u7ec6\u80de\u589e\u6b96\u3001\u4fc3\u8fdb\u51cb\u4ea1\u3001\u8c03\u63a7\u8f6c\u79fb\u548c\u4fb5\u88ad\u65b9\u9762\uff08\u56fe1\uff09\u3002\u5728\u57fa\u56e0\u6c34\u5e73\u4e0a\uff0c\u767d\u85dc\u82a6\u9187\u4e3b\u8981\u5e72\u9884\u764c\u7ec6\u80de\u4e2d\u4e0e\u764c\u53d8\u7d27\u5bc6\u76f8\u5173\u7684\u4fe1\u53f7\u8f6c\u5bfc\u901a\u8def\uff0c\u8fdb\u800c\u4e0a\u8c03\u6216\u8005\u4e0b\u8c03\u764c\u53d8\u76f8\u5173\u57fa\u56e0\u7684\u8868\u8fbe\u6765\u6291\u5236\u764c\u7ec6\u80de\u7684\u589e\u6b96\u3001\u964d\u4f4e\u764c\u7ec6\u80de\u7684\u4fb5\u88ad\u8f6c\u79fb\u80fd\u529b\u6216\u4fc3\u8fdb\u764c\u7ec6\u80de\u7684\u51cb\u4ea1\u3002\u767d\u85dc\u82a6\u9187\u4e5f\u53ef\u4ee5\u901a\u8fc7\u5f71\u54cd\u8840\u7ba1\u7684\u5f62\u6210\u6765\u6291\u5236\u80bf\u7624\u7684\u5f62\u6210\u3002\u540c\u65f6\uff0c\u767d\u85dc\u82a6\u9187\u540c\u5176\u4ed6\u7269\u8d28\u5171\u540c\u4f5c\u7528\u4e8e\u764c\u7ec6\u80de\u65f6\u4ea7\u751f\u660e\u663e\u7684\u534f\u540c\u6548\u5e94\uff0c\u63d0\u9ad8\u6297\u80bf\u7624\u4f5c\u7528\u3002\u767d\u85dc\u82a6\u9187\u53ef\u4ee5\u589e\u5f3a\u59dc\u9ec4\u7d20\u5bf9\u6dcb\u5df4\u764c\u7ec6\u80de\u7684\u4fc3\u51cb\u4ea1\u4f5c\u7528[7]<\/sup>\uff1b\u4e5f\u53ef\u4ee5\u548c\u6842\u679d\u832f\u82d3\u6c64\u5171\u540c\u6291\u5236\u5bab\u9888\u764c\u7ec6\u80de\u7684\u8f6c\u79fb[8]<\/sup>\uff1b\u8fd8\u53ef\u4ee5\u63d0\u9ad8\u809d\u764c\u7ec6\u80de\u5bf9\u03b2\u5c04\u7ebf\u7684\u654f\u611f\u6027\uff0c\u4ece\u800c\u63d0\u9ad8\u5316\u7597\u6548\u679c[9]<\/sup>\u3002\u4f46\u662f\uff0c\u767d\u85dc\u82a6\u9187\u7684\u8fd9\u4e9b\u4f5c\u7528\u5c1a\u672a\u5728\u4eba\u7c7b\u8eab\u4e0a\u5f97\u5230\u8bc1\u5b9e\u3002\u52a8\u7269\u548c\u4eba\u7c7b\u5b9e\u9a8c[10-12]<\/sup>\u90fd\u8868\u660e\u4e86\u767d\u85dc\u82a6\u9187\u7ecf\u53e3\u670d\u7684\u751f\u7269\u6548\u7387\u8f83\u4f4e\uff1b\u8fd9\u53ef\u80fd\u4f1a\u5f71\u54cd\u767d\u85dc\u82a6\u9187\u8fbe\u5230\u7406\u60f3\u7684\u836f\u6548\u3002<\/p>\n

\"\"<\/p>\n

2.1\u00a0 \u9884\u9632\u764c\u75c7\u7684\u53d1\u751f<\/h4>\n

\u6c27\u5316\u635f\u4f24\u662f\u5bfc\u81f4\u57fa\u56e0\u7a81\u53d8\u5f15\u53d1\u764c\u75c7\u7684\u91cd\u8981\u9014\u5f84\u4e4b\u4e00\u3002\u6d3b\u6027\u6c27(ROS)\u7684\u4ea7\u751f\u5728\u63a8\u52a8\u80bf\u7624\u7684\u53d1\u751f\u4e0e\u53d1\u5c55\u4e2d\u6709\u7740\u91cd\u8981\u7684\u4f5c\u7528\u3002\u6b63\u5e38\u60c5\u51b5\u4e0b\uff0c\u7ec6\u80de\u5185\u5b58\u5728\u7740\u4e00\u5957\u5b8c\u5584\u7684\u6c27\u5316-\u6297\u6c27\u5316\u4f53\u7cfb\uff0c\u53ef\u5c06ROS\u7ef4\u6301\u5728\u4e00\u4e2a\u7a33\u5b9a\u7684\u8303\u56f4\u5185\u3002\u4f46\u662f\uff0c\u5f53\u5728\u7269\u7406\u3001\u5316\u5b66\u3001\u751f\u7269\u7b49\u56e0\u7d20\u7684\u5e72\u9884\u3001\u523a\u6fc0\u4e0b\uff0c\u8fd9\u79cd\u5e73\u8861\u88ab\u6253\u7834\uff0c\u5bfc\u81f4ROS\u751f\u6210\u5f02\u5e38\uff0c\u5728\u7ec6\u80de\u5185\u5bcc\u96c6\uff0c\u81f4\u4f7f\u7ec6\u80de\u53d1\u751f\u8f6c\u5316\uff0c\u5bfc\u81f4\u6076\u6027\u80bf\u7624\u7684\u53d1\u751f[13]<\/sup>\u3002\u9648\u5c0f\u5e73\u7b49[14]<\/sup>\u7684\u7814\u7a76\u8ba4\u4e3a\u767d\u85dc\u82a6\u9187\u53ef\u4ee5\u964d\u4f4e\u4eba\u975e\u5c0f\u7ec6\u80de\u80ba\u764cSPC-A-1\u7ec6\u80de\u5185ROS\u7684\u542b\u91cf\uff0c\u5e76\u80fd\u4e0a\u8c03\u8d85\u6c27\u5316\u7269\u6b67\u5316\u9176(SOD)\u6d3b\u6027\u5e76\u964d\u4f4e\u4e19\u4e8c\u919b(MAD)\u542b\u91cf\u3002\u4e00\u4e9b\u5176\u4ed6\u7684\u7269\u7406\u3001\u5316\u5b66\u523a\u6fc0\u4e5f\u80fd\u5f15\u8d77\u7ec6\u80de\u7684\u764c\u53d8\u3002\u6c7d\u8f66\u5c3e\u6c14\u3001\u88ab\u6c61\u67d3\u98df\u7269\u4e2d\u7684\u82ef\u5e76\u8298\u3001\u9999\u70df\u71c3\u70e7\u4ea7\u7269\u7b49\u90fd\u4f1a\u5bf9\u673a\u4f53\u9020\u6210\u4e00\u5b9a\u7684\u4f24\u5bb3\u3002\u4ed8\u62db\u5a23\u7b49[15]<\/sup>\u7528\u68c0\u6d4b\u57fa\u56e0\u7a81\u53d8\u7684\u65b9\u6cd5\u89c2\u5bdf\u767d\u85dc\u82a6\u9187\u7684\u6297\u7a81\u53d8\u4f5c\u7528\u3002\u7ed3\u679c\u663e\u793a\uff0c\u5728\u7532\u57fa\u78fa\u9178\u7532\u916f\u548c\u82ef\u5e76\u8298\u4f5c\u7528\u4e0b\uff0c\u7a81\u53d8\u83cc\u843d\u5927\u91cf\u589e\u52a0\uff0c\u52a0\u767d\u85dc\u82a6\u9187\u540e\u53ef\u4ee5\u663e\u8457\u964d\u4f4e\u7a81\u53d8\u83cc\u843d\u6570\u76ee\u3002\u52a8\u7269\u5b9e\u9a8c[10]<\/sup>\u663e\u793a\uff0c\u6ce8\u5c04\u73af\u78f7\u9170\u80fa(cyclophosphamide\uff0cCTX)\u81f4\u5c0f\u9f20\u9aa8\u9ad3\u55dc\u591a\u67d3\u7ea2\u7ec6\u80de\u5fae\u6838\u5927\u91cf\u589e\u591a\uff0c\u4f46\u9884\u5148\u704c\u5582\u767d\u85dc\u82a6\u9187\u53ef\u4f7fCTX\u8bf1\u53d1\u7684\u5fae\u6838\u7387\u663e\u8457\u4e0b\u964d\uff0c\u7ec6\u80de\u67d3\u8272\u4f53\u5f97\u5230\u4e00\u5b9a\u7a0b\u5ea6\u7684\u4fdd\u62a4\u3002\u4ed8\u62db\u5a23\u7b49[15]<\/sup>\u7684\u7814\u7a76\u5206\u522b\u4ece\u7ec6\u83cc\u6c34\u5e73\u548c\u4f53\u5185\u6c34\u5e73\u8bc1\u5b9e\u4e86\u767d\u85dc\u82a6\u9187\u5728\u764c\u59cb\u53d1\u9636\u6bb5\u7684\u9884\u9632\u4f5c\u7528\u3002<\/p>\n

\u65b0\u751f\u8840\u7ba1\u662f\u80bf\u7624\u53d1\u751f\u7684\u5fc5\u8981\u73af\u8282\u3002\u674e\u4e1c\u5347[16]<\/sup>\u8ba4\u4e3a\u767d\u9ece\u82a6\u9187\u5728\u4f53\u5916\u80fd\u660e\u663e\u6291\u5236\u5185\u76ae\u7ec6\u80de\u7ba1\u72b6\u7ed3\u6784\u7684\u5f62\u6210\uff0c\u8868\u660e\u767d\u9ece\u82a6\u9187\u5177\u6709\u660e\u663e\u6297\u8840\u7ba1\u65b0\u751f\u6548\u5e94\u3002\u80be\u7d20-\u8840\u7ba1\u7d27\u5f20\u7d20\u7cfb\u7edf(renin-angiotensin system\uff0cRAS)\u662f\u5b58\u5728\u4e8e\u8bb8\u591a\u7ec4\u7ec7\u4e2d\u7684\u4e00\u4e2a\u5faa\u73af\u7684\u5185\u5206\u6ccc\u7cfb\u7edf\uff0c\u5176\u529f\u80fd\u4e3b\u8981\u662f\u8c03\u8282\u673a\u4f53\u7684\u8840\u538b\u548c\u6c34\u7535\u89e3\u8d28\u5e73\u8861[17]<\/sup>\u3002\u5c40\u90e8RAS\u5b58\u5728\u4e8e\u673a\u4f53\u5fc3\u8840\u7ba1\u7cfb\u7edf\u5185\u5916\u53c2\u4e0e\u673a\u4f53\u591a\u79cd\u751f\u7406\u53ca\u75c5\u7406\u6027\u6d3b\u52a8\uff0c\u5982\u708e\u75c7\u3001\u7ea4\u7ef4\u5316\u3001\u7ec6\u80de\u589e\u6b96\u53ca\u51cb\u4ea1\u7b49\u3002\u8840\u7ba1\u7d27\u5f20\u7d20II(Ang II)\u662fRAs\u7684\u4e3b\u8981\u6548\u5e94\u80bd\uff0c\u5b83\u6709\u4e24\u79cd\u7279\u5f02\u6027\u53d7\u4f53\uff1a\u8840\u7ba1\u7d27\u5f20\u7d20I\u578b(AT1R)\u548cII\u578b\u53d7\u4f53(AT2R)[18]<\/sup>\u3002Ang II\u5177\u6709\u6709\u4e1d\u5206\u88c2\u539f\u6d3b\u6027\uff0c\u53ef\u4fc3\u8fdb\u591a\u79cd\u7ec6\u80de\u5206\u88c2\uff0c\u540c\u65f6\u53ef\u589e\u5f3a\u7ec6\u80de\u5bf9\u751f\u957f\u56e0\u5b50\u7684\u654f\u611f\u6027\uff0c\u4fc3\u8fdb\u7ec6\u80de\u7684\u751f\u957f\u7e41\u6b96\u5e76\u6291\u5236\u5176\u51cb\u4ea1[19-20]<\/sup>\u3002Ang II\u80fd\u4fc3\u8fdb\u5927\u9f20\u8840\u7ba1\u5e73\u6ed1\u808c\u7ec6\u80de\u3001\u5fc3\u810f\u6210\u7ea4\u7ef4\u7ec6\u80de\u3001\u5fc3\u808c\u7ec6\u80de\u53ca\u80be\u5c0f\u7403\u7cfb\u819c\u7ec6\u80de\u751f\u957f\uff0c\u662f\u4e00\u79cd\u4fc3\u7ec6\u80de\u751f\u957f\u56e0\u5b50\uff0c\u5176\u8c03\u8282\u7ec6\u80de\u751f\u957f\u7684\u673a\u5236\u4e0e\u8f6c\u5316\u751f\u957f\u56e0\u5b50\u03b2(transforming growth factor \u03b2\uff0cTGF-\u03b2)\u3001\u8840\u5c0f\u677f\u884d\u751f\u751f\u957f\u56e0\u5b50(platelet derived growth factor\uff0cPDGF)\u3001\u80f0\u5c9b\u7d20\u6837\u751f\u957f\u56e0\u5b50(insulin like growth factor\uff0c IGF)\u7684\u4f5c\u7528\u6709\u5173\u3002AT1R\u80fd\u6291\u5236\u751f\u957f\u56e0\u5b50\u5728\u6076\u6027\u9ed1\u7d20\u7624\u7684\u8868\u8fbe\uff0c\u963b\u6b62\u6bdb\u7ec6\u8840\u7ba1\u7684\u5f62\u6210\uff0c\u767d\u9ece\u82a6\u9187\u5bf9\u6076\u6027\u9ed1\u7d20\u7624\u8840\u7ba1\u65b0\u751f\u7684\u6291\u5236\u6548\u5e94\u53ef\u80fd\u662f\u901a\u8fc7\u4e0b\u8c03AT1R\u5b9e\u73b0\u7684[16]<\/sup>\u3002<\/p>\n

\u73af\u6c27\u5316\u9176(cyclooxygenase\uff0cCOX)\u53c8\u79f0\u524d\u5217\u817a\u7d20\u5185\u6c27\u5316\u9176\u8fd8\u539f\u9176\uff0c\u662f\u4e00\u79cd\u53cc\u529f\u80fd\u9176\uff0c\u5177\u6709COX\u548c\u8fc7\u6c27\u5316\u6c22\u9176\u6d3b\u6027\uff0c\u662f\u50ac\u5316\u82b1\u751f\u56db\u70ef\u9178\u8f6c\u5316\u4e3a\u524d\u5217\u817a\u7d20\u7684\u5173\u952e\u9176\u3002COX\u6709\u4e24\u79cd\u5f02\u6784\u4f53\uff1aCOX1\u548cCOX2\u3002COX\u80fd\u6d3b\u5316\u81f4\u764c\u7269\uff0c\u7834\u574f\u9057\u4f20\u7269\u8d28\uff0c\u4fc3\u8fdb\u764c\u53d8\u3002COX2\u5728\u50ac\u5316\u82b1\u751f\u56db\u70ef\u9178\u751f\u6210\u524d\u5217\u817a\u7d20\u65f6\u4f1a\u4ea7\u751f\u81ea\u7531\u57fa\u3002\u6e38\u79bb\u7684\u81ea\u7531\u57fa\u4f1a\u5bf9\u751f\u547d\u5927\u5206\u5b50\u53d1\u8d77\u653b\u51fb\uff0c\u81f4\u4f7fDNA\u7b49\u53d7\u5230\u635f\u4f24\u3002\u7531\u4e8e\u767d\u85dc\u82a6\u9187\u5177\u6709\u8fd8\u539f\u6027\uff0c\u56e0\u6b64\u53ef\u4ee5\u8d77\u5230\u4fdd\u62a4\u7684\u4f5c\u7528\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u6709\u7814\u7a76[21]<\/sup>\u8868\u660e\uff1a\u767d\u85dc\u82a6\u9187\u80fd\u901a\u8fc7\u963b\u788d\u6838\u8f6c\u5f55\u56e0\u5b50NF-\u03baB\u7684\u6d3b\u5316\u6765\u6291\u5236COX\u7684\u8868\u8fbe\u8fdb\u800c\u6291\u5236COX\u7684\u73af\u6c27\u5408\u9176\u6d3b\u6027\u548c\u6c22\u8fc7\u6c27\u5316\u7269\u9176\u6d3b\u6027\u800c\u5728\u80bf\u7624\u53d1\u751f\u9636\u6bb5\u8d77\u6291\u5236\u4f5c\u7528\u3002<\/p>\n

\u7ec6\u80de\u8272\u7d20P450\u9176(CYP450)\u662f\u4e00\u7c7b\u57fa\u56e0\u8d85\u5bb6\u65cf\u9176\u7cfb\u3002\u5176\u529f\u80fd\u662f\u50ac\u5316\u5916\u6765\u5316\u5408\u7269\u8fdb\u5165\u4f53\u5185\u7684\u7b2c\u4e00\u9636\u6bb5\u6c27\u5316\u53cd\u5e94\uff0c\u5bf9\u4e8e\u5316\u5b66\u81f4\u764c\u7269\u6765\u8bf4\uff0c\u5373\u628a\u65e0\u6d3b\u6027\u7684\u524d\u81f4\u764c\u7269\u6fc0\u6d3b\u8f6c\u53d8\u4e3a\u7535\u5b50\u5316\u5408\u7269\uff0c\u4eb2\u7535\u5b50\u5316\u5408\u7269\u53ef\u653b\u51fb\u7ec6\u80de\u5185\u7684\u751f\u7269\u5927\u5206\u5b50\uff0c\u4e0eDNA\u6216\u86cb\u767d\u8d28\u5f62\u6210\u52a0\u5408\u7269\uff0c\u6700\u7ec8\u5f15\u8d77\u539f\u764c\u57fa\u56e0\u548c\u6291\u764c\u57fa\u56e0\u7684\u6539\u53d8\uff0c\u4ece\u800c\u5bfc\u81f4\u7ec6\u80de\u764c\u53d8\u3002\u82b3\u9999\u70c3\u53d7\u4f53(aryl hydrocarbon receptor\uff0cAhR\uff09\u662f\u57fa\u672c\u87ba\u65cb-\u73af-\u87ba\u65cb\u8f6c\u5f55\u56e0\u5b50\u5bb6\u65cf\u4e2d\u7684\u4e00\u4e2a\u6210\u5458\u3002AhR\u7684\u751f\u7406\u5b66\u914d\u4f53\u672a\u77e5\uff0c\u4f46\u4ed6\u4f1a\u7ed3\u5408\u4e00\u4e9b\u5929\u7136\u690d\u7269\u9ec4\u916e\u7c7b\u5316\u5408\u7269\u3001\u591a\u915a\u7c7b\u4e0e\u5432\u54da\u7c7b\u7b49\u5916\u6e90\u914d\u4f53\uff0c\u4eba\u9020\u7684\u591a\u73af\u82b3\u70c3\u4ee5\u53ca\u4e8c\u6076\u82f1\u6837\u7269\u8d28\u540c\u6837\u5982\u6b64\u3002AhR\u662f\u4e00\u79cd\u901a\u5e38\u60c5\u51b5\u4e0b\u65e0\u6d3b\u6027\u800c\u4e0e\u4e00\u4e9b\u5171\u5206\u5b50\u4f34\u4fa3\u80de\u8d28\u6eb6\u80f6\u7ed3\u5408\u7684\u8f6c\u5f55\u56e0\u5b50\u3002\u4e00\u65e6\u914d\u4f53\u7ed3\u5408\u52302,3,7,8-\u56db\u6c2f\u4e8c\u82ef\u4e8c\u6c27\u8291\uff08TCDD\uff09\u7b49\u5316\u5b66\u7269\u8d28\u4e0a\u65f6\uff0c\u5206\u5b50\u4f34\u4fa3\u79bb\u89e3\u5e76\u5bfc\u81f4AhR\u8f6c\u79fb\u5230\u7ec6\u80de\u6838\u4e2d\u5e76\u4e0e\u82b3\u9999\u70c3\u53d7\u4f53\u6838\u8f6c\u8fd0\u4f53(aryl hydrocarbon receptor nuclear translocator\uff0cARNT)\u4e8c\u805a\u5316\uff0c\u81f4\u4f7f\u57fa\u56e0\u8f6c\u5f55\u4ea7\u751f\u6539\u53d8\u3002CPY\u5728\u8fd9\u4e2a\u8fc7\u7a0b\u4e2d\u88ab\u6fc0\u6d3b\uff0c\u8bf1\u53d1\u4e0b\u4e00\u6b65\u7684\u7ec6\u80de\u764c\u53d8\u3002\u767d\u85dc\u82a6\u9187\u80fd\u901a\u8fc7\u62ee\u6297AhR\u6765\u6291\u5236CYP1A1\u548c CYP1B1\u7684\u8868\u8fbe\uff0c\u4ece\u800c\u53d1\u6325\u5176\u6297\u764c\u548c\u9632\u764c\u6d3b\u6027\u3002<\/p>\n

2.2\u00a0 \u6291\u5236\u764c\u7ec6\u80de\u7684\u589e\u6b96<\/h4>\n

\u4e0d\u540c\u6d53\u5ea6\u7684\u767d\u85dc\u82a6\u9187\u5bf9\u4e0d\u540c\u79cd\u7c7b\u7684\u764c\u7ec6\u80de\u4f1a\u4ea7\u751f\u4e0d\u540c\u7a0b\u5ea6\u7684\u6291\u5236\u4f5c\u7528\u3002\u5f53\u767d\u85dc\u82a6\u9187\u7684\u6d53\u5ea6\u572850~100 \u03bcmol\/L\u8303\u56f4\u5185\u65f6\uff0c\u5176\u5bf9HeLa\u7ec6\u80de\u7684\u6291\u5236\u4f5c\u7528\u4e0e\u65f6\u95f4\u548c\u5242\u91cf\u5448\u6b63\u76f8\u5173\u3002\u5f53\u767d\u85dc\u82a6\u9187\u4f4e\u5242\u91cf\u4f5c\u7528\u4e8eHeLa\u7ec6\u80de\u65f6\uff0c\u6291\u5236\u4f5c\u7528\u968f\u7740\u65f6\u95f4\u7684\u5ef6\u957f\u800c\u6e10\u6e10\u660e\u663e\uff0c\u800c\u8f83\u9ad8\u6d53\u5ea6\u7684\u767d\u85dc\u82a6\u9187\u572812 h\u4e4b\u5185\u5bf9Hela\u7ec6\u80de\u7684\u589e\u6b96\u5373\u4ea7\u751f\u660e\u663e\u7684\u6291\u5236\u4f5c\u7528\u3002\u767d\u85dc\u82a6\u9187\u5728100~400 \u03bcmol\/L\u8303\u56f4\u5185\u5bf9\u7ed3\u76f4\u80a0\u764c\u7ec6\u80deSW480\u4e5f\u4ea7\u751f\u660e\u663e\u7684\u6291\u5236\u4f5c\u7528\uff0c\u5e76\u5448\u65f6\u95f4\u548c\u5242\u91cf\u4f9d\u8d56\u6027\u3002\u800c\u767d\u85dc\u82a6\u9187\u5bf9\u76f4\u7ed3\u80a0\u764c\u7684\u53e6\u5916\u4e00\u79cd\u7ec6\u80de\u682aHCT-116\u5728400 \u03bcmol\/L\u624d\u4ea7\u751f\u660e\u663e\u7684\u6291\u5236\u4f5c\u7528\u3002<\/p>\n

\u767d\u85dc\u82a6\u9187\u6291\u5236\u764c\u7ec6\u80de\u7684\u589e\u6b96\u4e3b\u8981\u662f\u901a\u8fc7\u6291\u5236\u80bf\u7624\u7ec6\u80de\u5185DNA\u7684\u5408\u6210\u3001\u963b\u6ede\u7ec6\u80de\u5468\u671f\u3001\u6291\u5236\u7aef\u7c92\u9176\u6d3b\u6027\u548c\u5e72\u9884\u7ec6\u80de\u589e\u6b96\u76f8\u5173\u7684\u4fe1\u53f7\u8f6c\u5bfc\u901a\u8def[22]<\/sup>\u3002\u7ec6\u80de\u5468\u671f\u5206\u4e3a\u95f4\u671f\u548c\u5206\u88c2\u671f\uff0c\u95f4\u671f\u53c8\u5206\u4e3aG1<\/sub>\uff0cS\u548cG2<\/sub>\u4e09\u4e2a\u65f6\u671f\u3002G1<\/sub>\u671f\u4ece\u6709\u4e1d\u5206\u88c2\u5230DNA\u590d\u5236\u524d\u7684\u4e00\u6bb5\u65f6\u671f\uff0c\u53c8\u79f0\u5408\u6210\u524d\u671f\uff0c\u6b64\u671f\u4e3b\u8981\u5408\u6210RNA\u548c\u6838\u7cd6\u4f53\uff0c\u4e3a\u4e0b\u9636\u6bb5S\u671f\u7684DNA\u590d\u5236\u505a\u597d\u7269\u8d28\u548c\u80fd\u91cf\u7684\u51c6\u5907\u3002S\u671f\u5373DNA\u7684\u5408\u6210\u671f\u3002G2<\/sub>\u662fDNA\u5408\u6210\u540e\u671f\uff0c\u662f\u6709\u4e1d\u5206\u88c2\u7684\u51c6\u5907\u671f\uff0c\u7136\u540e\u8fdb\u5165M\u671f\u3002\u90e8\u5206\u7ec6\u80de\u5728\u5206\u88c2\u7ed3\u675f\u4e4b\u540e\u4fbf\u8fdb\u5165G0<\/sub>\u671f\uff0c\u6682\u65f6\u505c\u6b62\u5206\u88c2\u3002\u767d\u85dc\u82a6\u9187\u53ef\u4ee5\u901a\u8fc7\u963b\u6edeS\u671f\u548c\u51cf\u5c11G0<\/sub>\/G1<\/sub>\u671f\u7684\u767e\u5206\u7387\u6765\u6291\u5236\u764c\u7ec6\u80de\uff0c\u4e14\u4e0d\u540c\u7684\u7ec6\u80de\u88ab\u963b\u6ede\u5728\u4e0d\u540c\u7684\u671f\u95f4\u3002Ahmad\u7b49[23]<\/sup>\u62a5\u9053\u4eba\u8868\u76ae\u764cA431\u5728\u767d\u85dc\u82a6\u9187\u4f5c\u7528\u540e\u505c\u6ede\u5728\u7ec6\u80de\u7684G1<\/sub>\u671f\uff0c\u4e0d\u80fd\u5b8c\u6210\u4eceG1<\/sub>\u671f\u81f3S\u671f\u7684\u8f6c\u5316\uff0c\u5e76\u4e14\u662f\u4e0d\u53ef\u9006\u7684\u3002\u6731\u632f\u52e4\u7b49[24]<\/sup>\u4ee5HeLa\u7ec6\u80de\u505a\u4f53\u5916\u5b9e\u9a8c\u8bc1\u660e\u767d\u85dc\u82a6\u9187\u80fd\u6291\u5236HeLa\u7ec6\u80de\u589e\u6b96\u5e76\u963b\u65adHeLa\u7ec6\u80de\u7531S\u671f\u5411G2<\/sub>\u671f\u8f6c\u53d8\u3002\u5468\u671f\u7d20(cyclins)\u3001\u5468\u671f\u7d20\u4f9d\u8d56\u6027\u86cb\u767d\u6fc0\u9176(cyclins depend kinase\uff0cCDK)\u3001\u5468\u671f\u7d20\u4f9d\u8d56\u6027\u86cb\u767d\u6fc0\u9176\u6291\u5236\u56e0\u5b50(CKD inhibitor\uff0cCKI)\u548c\u5468\u671f\u7d20\u4f9d\u8d56\u6027\u86cb\u767d\u6fc0\u9176\u8c03\u63a7\u56e0\u5b50\u7b49\u76f4\u63a5\u6216\u8005\u95f4\u63a5\u5730\u8c03\u63a7\u7ec6\u80de\u5468\u671f\u3002\u5f53cyclins\u4e0eCDK\u7684\u86cb\u767d\u8d28\u4ea7\u7269\u5f62\u6210\u6709\u6d3b\u6027\u7684\u86cb\u767d\u6fc0\u9176\u590d\u5408\u4f53\u65f6\uff0c\u53ef\u4f7f\u591a\u79cd\u86cb\u767d\u5e95\u7269\u78f7\u9178\u5316\u4ece\u800c\u9a71\u52a8\u4e86\u7ec6\u80de\u5728\u5404\u4e2a\u7ec6\u80de\u5468\u671f\u7684\u8f6c\u6362\u3002P21\u4e3aCDI\u7684\u5bb6\u65cf\u6210\u5458\uff0c\u6291\u5236cyclinD1\u7684\u6d3b\u6027\uff0c\u4f7f\u7ec6\u80de\u5468\u671f\u53d7\u963b\u3002\u767d\u85dc\u82a6\u9187\u80fd\u660e\u663e\u4e0b\u8c03CyclinD1\u7684\u8868\u8fbe\u6c34\u5e73\uff0c\u540c\u65f6\u4e0a\u8c03P21\u86cb\u767d\u7684\u8868\u8fbe\u6c34\u5e73[16]<\/sup>\u3002\u767d\u85dc\u82a6\u9187\u53ef\u80fd\u662f\u901a\u8fc7\u963b\u6edeCDK\u4e0ecyclins\u7684\u7ed3\u5408\uff0c\u4f7f\u86cb\u767d\u5e95\u7269\u78f7\u9178\u5316\u53d7\u963b\uff0c\u4ee5\u5b9e\u73b0\u963b\u6ede\u7ec6\u80de\u5468\u671f[25]<\/sup>(\u56fe2)\u3002\u8fd1\u671f\uff0c\u6709\u7814\u7a76[26]<\/sup>\u6307\u51fa\uff0c\u767d\u85dc\u82a6\u9187\u963b\u6ede\u7ec6\u80de\u5468\u671f\u53ef\u80fd\u4e0e\u5176\u6291\u5236\u62d3\u6251\u5f02\u6784\u91762\u7684\u6d3b\u6027\u6709\u5173\u3002<\/p>\n

\"\"<\/p>\n

2.3\u00a0 \u6291\u5236\u764c\u7ec6\u80de\u7684\u4fb5\u88ad\u4e0e\u8f6c\u79fb<\/h4>\n

\u764c\u7ec6\u80de\u7684\u8f6c\u79fb\u662f\u591a\u6570\u6076\u6027\u80bf\u7624\u8fdb\u4e00\u6b65\u53d1\u5c55\u7684\u4e3b\u8981\u9014\u5f84\uff0c\u4e5f\u662f\u6cbb\u7597\u764c\u75c7\u7684\u6700\u5927\u96be\u9898\u3002\u4e00\u79cd\u80fd\u591f\u6709\u6548\u6291\u5236\u764c\u7ec6\u80de\u8f6c\u79fb\u7684\u836f\u7269\u5bf9\u4e8e\u6cbb\u7597\u80bf\u7624\u5c06\u662f\u5f88\u5927\u7684\u7a81\u7834\u3002\u767d\u85dc\u82a6\u9187\u9664\u4e86\u53ef\u4ee5\u6291\u5236\u764c\u7ec6\u80de\u7684\u589e\u6b96\uff0c\u8fd8\u53ef\u4ee5\u6291\u5236\u764c\u7ec6\u80de\u7684\u4fb5\u88ad\u3002\u7528\u767d\u85dc\u82a6\u9187\u4f5c\u7528\u4e8e\u4e24\u682a\u4e0d\u540c\u4fb5\u88ad\u80fd\u529b\u7684\u4e73\u764c\u7ec6\u80de\uff0c\u4fb5\u88ad\u80fd\u529b\u5f3a\u7684\u7ec6\u80de\u682a\u6bd4\u4fb5\u88ad\u80fd\u529b\u5dee\u7684\u7ec6\u80de\u682a\u53d7\u5230\u7684\u6291\u5236\u4f5c\u7528\u66f4\u660e\u663e[22]<\/sup>\u3002\u8fd9\u8bf4\u660e\u767d\u85dc\u82a6\u9187\u5bf9\u764c\u7ec6\u80de\u7684\u4fb5\u88ad\u80fd\u529b\u786e\u5b9e\u6709\u4e00\u5b9a\u7684\u5f71\u54cd\u3002\u767d\u85dc\u82a6\u9187\u6291\u5236\u764c\u7ec6\u80de\u4fb5\u88ad\u4e3b\u8981\u6709\u4ee5\u4e0b3\u4e2a\u65b9\u9762\uff1a\u7b2c\u4e00\uff0c\u767d\u85dc\u82a6\u9187\u80fd\u591f\u660e\u663e\u6291\u5236\u5bab\u9888\u764c\u7ec6\u80de\u57fa\u8d28\u91d1\u5c5e\u86cb\u767d\u9176-2\u57fa\u56e0(MMP-2)\u53ca\u7ec6\u80de\u57fa\u8d28\u91d1\u5c5e\u86cb\u767d\u9176-9\u57fa\u56e0(MMP-9)\u7684\u8868\u8fbe\u6c34\u5e73\u53ca\u76f8\u5173\u9176\u7684\u6d3b\u6027\uff0c\u63d0\u9ad8\u57fa\u8d28\u91d1\u5c5e\u86cb\u767d\u9176\u7ec4\u7ec7\u6291\u5236\u5242-1\u57fa\u56e0(matrix metalloproteinases tissue inhibitors-1\uff0cTIMP-1)\u53ca\u57fa\u8d28\u91d1\u5c5e\u86cb\u767d\u9176\u7ec4\u7ec7\u6291\u5236\u5242-2\u57fa\u56e0(matrix metalloproteinases tissue inhibitors-2\uff0cTIMP-2)\u7684\u8868\u8fbe\u6c34\u5e73\u53ca\u5176\u76f8\u5173\u9176\u7684\u6d3b\u6027\uff0c\u964d\u4f4eMMP\/TIMP\u503c\uff0c\u6291\u5236\u5bab\u9888\u764c\u4fb5\u88ad\u3002\u7b2c\u4e8c\uff0c\u767d\u85dc\u82a6\u9187\u80fd\u591f\u6291\u5236\u94be\u6c2f\u534f\u540c\u8f6c\u8fd0\u5b50\u57fa\u56e0-1(potassium chloride synergy transporter gene-1\uff0cKCC-1)\u53ca\u86cb\u767d\u7684\u8868\u8fbe\u6c34\u5e73\uff0cKCC-1\u80fd\u7ef4\u6301\u80bf\u7624\u7ec6\u80de\u81ea\u7a33\u72b6\u6001\u3002\u767d\u85dc\u82a6\u9187\u53ef\u901a\u8fc7\u7834\u574f\u5bab\u9888\u764c\u7ec6\u80de\u7684\u81ea\u7a33\u72b6\u6001\uff0c\u6291\u5236\u80bf\u7624\u7ec6\u80de\u7684\u4fb5\u88ad\u3002\u7b2c\u4e09\uff0c\u764c\u7ec6\u80de\u7684\u8f6c\u79fb\u9996\u5148\u662f\u764c\u7ec6\u80de\u4ece\u539f\u53d1\u7076\u7684\u8131\u843d\u8fdb\u800c\u4fb5\u88ad\u5468\u8fb9\u7684\u7ec4\u7ec7\u3002\u767d\u85dc\u82a6\u9187\u80fd\u591f\u8c03\u8282\u03b2\u8fde\u63a5\u7d20(\u03b2-cat)\u5728\u7ec6\u80de\u4e2d\u7684\u8868\u8fbe\uff0c\u4f7f\u7ec6\u80de\u9ecf\u9644\u5728\u4e00\u8d77\uff0c\u63a7\u5236\u4e86\u764c\u7ec6\u80de\u7684\u8f6c\u79fb[27]<\/sup>\u3002<\/p>\n

2.4\u00a0 \u4fc3\u8fdb\u764c\u7ec6\u80de\u7684\u51cb\u4ea1<\/h4>\n

\u7ec6\u80de\u51cb\u4ea1\u662f\u6307\u673a\u4f53\u4e3a\u4e86\u7ef4\u6301\u5185\u73af\u5883\u7a33\u5b9a\uff0c\u7531\u57fa\u56e0\u63a7\u5236\u7684\u7ec6\u80de\u81ea\u4e3b\u6709\u5e8f\u7684\u6b7b\u4ea1\u3002\u767d\u85dc\u82a6\u9187\u8bf1\u4f7f\u80bf\u7624\u7ec6\u80de\u51cb\u4ea1\u6d89\u53ca\u7684\u8f6c\u5f55\u56e0\u5b50\u3001\u86cb\u767d\u8d28\u7b49\u9519\u7efc\u590d\u6742\u3002\u5176\u4e2dcaspases\u662f\u4e00\u7ec4\u4e0e\u7ec6\u80de\u51cb\u4ea1\u5bc6\u5207\u76f8\u5173\u7684\u534a\u80f1\u6c28\u9178\u86cb\u767d\u9176\u3002Nakagawa\u7b49[28]<\/sup>\u62a5\u9053\u9ad8\u5242\u91cf\u767d\u85dc\u82a6\u9187(\u226544 \u03bcmol\/L)\u53ef\u589e\u52a0\u4eba\u4e73\u817a\u764c\u7ec6\u80de\u682aKPL-I\uff0cMCF-7(\u96cc\u6fc0\u7d20\u53d7\u4f53\u9633\u6027)\u53caMKL-F(\u96cc\u6fc0\u7d20\u53d7\u4f53\u9634\u6027)\u7684\u4fc3\u51cb\u4ea1\u57fa\u56e0(Bax)\u53ca\u4fc3\u51cb\u4ea1\u86cb\u767d\u7684\u8868\u8fbe\uff0c\u540c\u65f6\u51cf\u5c11\u6297\u51cb\u4ea1\u57fa\u56e0(Bcl-xl)\u7684\u8868\u8fbe\uff0c\u6fc0\u6d3bcaspase-3\uff0c\u5bfc\u81f4\u7ec6\u80de\u51cb\u4ea1\u3002\u53e6\u6709\u7814\u7a76[29]<\/sup>\u53d1\u73b0\uff1a\u767d\u85dc\u82a6\u9187\u53ef\u4ee5\u6291\u5236MCF-7\u7ec6\u80de\u7684\u6d3b\u6027\uff0c\u5e76\u4e146-\u78f7\u9178\u679c\u7cd6\u6fc0\u9176\u662f\u91cd\u8981\u8c03\u63a7\u9176\u3002\u8fd9\u4e0e\u767d\u85dc\u82a6\u9187\u8c03\u8282\u4ee3\u8c22\u75be\u75c5\u6709\u7740\u7d27\u5bc6\u7684\u8054\u7cfb\u3002<\/p>\n

\u767d\u85dc\u82a6\u9187\u53ef\u901a\u8fc7\u7ebf\u7c92\u4f53\u819c\u7684\u53bb\u6781\u5316\u53cd\u5e94\uff0c\u5bfc\u81f4caspase-9\uff0ccaspase-2\uff0ccaspase-3\u548ccaspase-6\u7684\u9176\u539f\u88ab\u6fc0\u6d3b\u3002\u6700\u5148\u88ab\u6fc0\u6d3b\u7684\u662fcaspase-9\uff0c\u7136\u540e\u6fc0\u6d3b\u4e0b\u6e38\u7684caspase\u7ea7\u8054\u53cd\u5e94\uff0c\u4fc3\u8fdb\u548c\u653e\u5927\u51cb\u4ea1\u901a\u8def\uff0c\u4ece\u800c\u52a0\u901f\u80bf\u7624\u7ec6\u80de\u7684\u51cb\u4ea1[30]<\/sup>\u3002\u9664\u6b64\u4e4b\u5916\uff0cBcl-2\u86cb\u767d\u5bb6\u65cf\u5728\u7ec6\u80de\u51cb\u4ea1\u8fc7\u7a0b\u4e2d\u4e5f\u8d77\u7740\u975e\u5e38\u91cd\u8981\u7684\u4f5c\u7528\u3002Bcl-2\u5bb6\u65cf\u6210\u5458\u5206\u4e3a\u6297\u51cb\u4ea1\u86cb\u767d(Bcl-2\uff0cBcl-xl)\u7b49\u548c\u4fc3\u51cb\u4ea1\u86cb\u767d(Bax\uff0cBad)\u3002Bcl-2\u53ef\u4ee5\u6291\u5236\u7ebf\u7c92\u4f53\u9014\u5f84\u7684\u7ec6\u80de\u51cb\u4ea1\u3002\u767d\u85dc\u82a6\u9187\u53ef\u4e0b\u8c03Bcl-2\u7684\u8868\u8fbe\uff0c\u4fc3\u8fdb\u764c\u7ec6\u80de\u51cb\u4ea1(\u56fe3)\u3002<\/p>\n

\"\"<\/p>\n

\u80bf\u7624\u574f\u6b7b\u56e0\u5b50(tumor necrosis factor\uff0cTNF)\u53ca\u5176\u8d85\u5bb6\u65cf\u6210\u5458\u53ef\u4ee5\u8bf1\u5bfc\u80bf\u7624\u7ec6\u80de\u51cb\u4ea1\u3002\u80bf\u7624\u574f\u6b7b\u56e0\u5b50\u76f8\u5173\u51cb\u4ea1\u8bf1\u5bfc\u914d\u4f53(TNF-related apoptosis-inducing ligand\uff0cTRAIL)\u6709\u4e24\u79cd\u6b7b\u4ea1\u53d7\u4f53(death receptor\uff0cDR)\uff1aDR4\u548cDR5\u3002DR4\u4e0e DR5\u662fI\u578b\u819c\u86cb\u767d\uff0c\u4e0eTRAIL\u7ed3\u5408\u540e\uff0c\u901a\u8fc7\u7ec6\u80de\u5185\u4fe1\u53f7\u8f6c\u5bfc\uff0c\u6d3b\u5316\u7ebf\u7c92\u4f53\u4f9d\u8d56\u6027\u548c\u975e\u4f9d\u8d56\u6027\u9014\u5f84\u8bf1\u5bfc\u80bf\u7624\u7ec6\u80de\u53d1\u751f\u51cb\u4ea1\uff0c\u4ece\u800c\u6740\u4f24\u80bf\u7624\u7ec6\u80de\u3002\u767d\u85dc\u82a6\u9187\u81ea\u8eab\u4e0d\u4ec5\u5177\u6709\u6291\u5236\u764c\u7ec6\u80de\u589e\u6b96\u5e76\u4fc3\u8fdb\u764c\u7ec6\u80de\u51cb\u4ea1\u7684\u529f\u80fd\uff0c\u8fd8\u80fd\u63d0\u9ad8\u764c\u7ec6\u80de\u5bf9TRAIL\u7684\u654f\u611f\u6027[31]<\/sup>\u3002\u653e\u5c04\u6cbb\u7597\u548c\u5316\u5b66\u6cbb\u7597\u836f\u7269\u4e0d\u4ec5\u672c\u8eab\u8bf1\u5bfc\u80bf\u7624\u7ec6\u80de\u51cb\u4ea1\uff0c\u800c\u4e14\u53ef\u4ee5\u901a\u8fc7\u5f15\u53d1DNA\u635f\u4f24\uff0c\u4e0a\u8c03DR4\uff0cDR5\u57fa\u56e0\u8868\u8fbe\u6c34\u5e73\uff0c\u4ece\u800c\u653e\u5927TRAIL\u51cb\u4ea1\u901a\u8def\uff0c\u589e\u5f3a\u80bf\u7624\u7ec6\u80de\u5bf9TRAIL\u7684\u654f\u611f\u6027[32-36]<\/sup>\u3002\u9648\u6d0b\u7b49[31]<\/sup>\u53d1\u73b0TRAIL\u5e76\u4e0d\u76f4\u63a5\u5f71\u54cdDR4\uff0cDR5\u5728\u80bf\u7624\u7ec6\u80de\u4e2d\u7684\u8868\u8fbe\uff0c\u4f46\u662f\u767d\u85dc\u82a6\u9187\u80fd\u591f\u589e\u52a0 DR4\uff0cDR5\u5728\u4e73\u817a\u764cMDA-MB-231\u7ec6\u80de\u8868\u9762\u7684\u8868\u8fbe\uff0c\u653e\u5927TRAIL\u8bf1\u5bfc\u7684\u51cb\u4ea1\u4fe1\u53f7\uff0c\u4ece\u800c\u589e\u5f3a\u4e86TRAIL\u8bf1\u5bfc\u51cb\u4ea1\u7684\u6548\u5e94\u3002\u540c\u6837\uff0cDelmas\u7b49[32]<\/sup>\u7684\u7814\u7a76\u4e5f\u8868\u660e\u767d\u85dc\u82a6\u9187\u4f5c\u7528\u4e8e\u5927\u80a0\u764c\u7ec6\u80de\u540e\uff0c\u5e76\u6ca1\u6709\u589e\u52a0\u80bf\u7624\u7ec6\u80de\u8868\u9762\u6b7b\u4ea1\u53d7\u4f53\u7684\u6570\u91cf\uff0c\u4f46\u5374\u5f15\u8d77\u4e86CD95\u7684\u91cd\u65b0\u5206\u5e03\uff0c\u9003\u907fBc1-2\u4ecb\u5bfc\u7684\u6291\u5236\u4f5c\u7528\uff0c\u8bf1\u5bfc\u80bf\u7624\u7ec6\u80de\u51cb\u4ea1\u3002Fas-Fas-L\u662f\u767d\u85dc\u82a6\u9187\u8bf1\u5bfc\u80bf\u7624\u7ec6\u80de\u51cb\u4ea1\u7684\u53c8\u4e00\u6761\u9014\u5f84\u3002Fas\u53c8\u79f0APO-1\u6216 CD95\uff0c\u662f\u6b7b\u4ea1\u53d7\u4f53\u5bb6\u65cf\u7684\u91cd\u8981\u6210\u5458\u3002Fas-Fas-L\u8bf1\u5bfc\u7684\u7ec6\u80de\u51cb\u4ea1\u4e0d\u4f9d\u8d56\u4e8e\u9499\u79bb\u5b50\uff0c\u800c\u662f\u6fc0\u6d3bcaspase-8\u8bf1\u5bfc\u7ec6\u80de\u51cb\u4ea1\u3002<\/p>\n

NF-\u03baB\u662f\u4e00\u4e2a\u591a\u6548\u8f6c\u5f55\u56e0\u5b50\uff0c\u5728\u6b63\u5e38\u7ec6\u80de\u4e2d\u4e0e\u7279\u6b8a\u7684\u6291\u5236\u86cb\u767d( inhibitors of the NF-\u03baB\uff0cI\u03baB)\u7ed3\u5408\u800c\u5448\u73b0\u9759\u606f\u72b6\u6001\u5e76\u53ea\u5206\u5e03\u5728\u80de\u6d46\u4e2d\u3002\u7ec6\u80de\u53d7\u5230\u4e00\u5b9a\u7684\u523a\u6fc0\u540eI\u03baB\u88ab\u5206\u89e3\uff0cNF-\u03baB\u88ab\u6fc0\u6d3b\u91ca\u653e\u5e76\u8f6c\u79fb\u81f3\u6838\u5185\uff0c\u5728\u6838\u5185\u4e0e\u9776\u57fa\u56e0\u542f\u52a8\u5b50\u7684\u7279\u5f02\u6027\u533a\u57df\u7ed3\u5408\uff0c\u6fc0\u6d3b\u7279\u5b9a\u57fa\u56e0\u7684\u8868\u8fbe\u3002\u6797\u6d2a[33]<\/sup>\u7684\u7814\u7a76\u8868\u660e\u767d\u85dc\u82a6\u9187\u53ef\u4ee5\u6291\u5236NF-\u03baB\u7684\u8868\u8fbe\u3002p53\u662f\u4e00\u79cd\u80bf\u7624\u6291\u5236\u57fa\u56e0\uff0c50%\u4ee5\u4e0a\u6076\u6027\u80bf\u7624\u4f1a\u51fa\u73b0\u8be5\u57fa\u56e0\u7684\u7a81\u53d8\u3002P53\u86cb\u767d\u4e3b\u8981\u5206\u5e03\u4e8e\u7ec6\u80de\u6838\u6d46\uff0c\u80fd\u4e0eDNA\u7279\u5f02\u7ed3\u5408\uff0c\u5176\u6d3b\u6027\u53d7\u78f7\u9178\u5316\u3001\u4e59\u9170\u5316\u3001\u7532\u57fa\u5316\u3001\u6cdb\u7d20\u5316\u7b49\u7ffb\u8bd1\u540e\u4fee\u9970\u8c03\u63a7\u3002P53\u86cb\u767d\u901a\u8fc7Bax\/Bcl-2\uff0cFas\/Apol\u7b49\u86cb\u767d\u5b8c\u6210\u5bf9\u7ec6\u80de\u51cb\u4ea1\u7684\u8c03\u63a7\u4f5c\u7528\u3002\u767d\u85dc\u82a6\u9187\u53ef\u4ee5\u4e0a\u8c03p53\u7684\u8868\u8fbe\u4fc3\u8fdb\u764c\u7ec6\u80de\u7684\u51cb\u4ea1\u3002<\/p>\n

2.5\u00a0 \u63d0\u9ad8\u764c\u7ec6\u80de\u7684\u653e\u5c04\u654f\u611f\u6027<\/h4>\n

\u5b9e\u4f53\u7624\u7ec6\u80de\u56e0\u5176\u751f\u957f\u8fc7\u5feb\uff0c\u5bfc\u81f4\u764c\u7ec6\u80de\u7ec4\u7ec7\u7ecf\u5e38\u5904\u4e8e\u4e00\u79cd\u4f4e\u6c27\u7684\u72b6\u6001\uff0c\u56e0\u6b64\uff0c\u4e4f\u6c27\u7ec6\u80de\u7684\u5b58\u5728\u4f7f\u5f97\u653e\u5c04\u6cbb\u7597\u7684\u6548\u679c\u4e0d\u5c3d\u4eba\u610f[37]<\/sup>\u3002\u653e\u5c04\u589e\u654f\u5242\u80fd\u63d0\u9ad8\u80bf\u7624\u7ec6\u80de\u5bf9\u653e\u5c04\u7ebf\u7684\u654f\u611f\u6027\uff0c\u4ece\u800c\u964d\u4f4e\u5c04\u7ebf\u5242\u91cf\u7684\u4f7f\u7528\uff0c\u51cf\u5c11\u764c\u7ec6\u80de\u5468\u8fb9\u5065\u5eb7\u7ec6\u80de\u53d7\u9ad8\u5242\u91cf\u8f90\u5c04\u7684\u4f24\u5bb3\uff0c\u51cf\u8f7b\u60a3\u8005\u7684\u75db\u82e6\uff0c\u63d0\u9ad8\u7597\u6548\u3002\u7814\u7a76[38]<\/sup>\u8868\u660e\uff0c\u7528\u4e0d\u540c\u4f4e\u5242\u91cf\u7684\u767d\u85dc\u82a6\u9187\u9884\u5904\u7406\u53ef\u4ee5\u63d0\u9ad8\u5bab\u9888\u764c\u7ec6\u80de\u7684\u653e\u5c04\u654f\u611f\u6027\uff0c\u5176\u653e\u5c04\u589e\u654f\u6548\u679c\u968f\u7740\u767d\u85dc\u82a6\u9187\u5242\u91cf\u589e\u5927\u800c\u589e\u52a0\uff0c\u540c\u65f6\u767d\u85dc\u82a6\u9187\u5bf9\u6b63\u5e38\u7ec6\u80de\u6ca1\u6709\u660e\u663e\u7684\u6bd2\u526f\u4f5c\u7528\uff0c\u6545\u767d\u85dc\u82a6\u9187\u63d0\u9ad8\u764c\u7ec6\u80de\u7684\u653e\u5c04\u654f\u611f\u6027\u5c06\u4f1a\u5927\u5927\u6539\u5584\u653e\u5c04\u6cbb\u7597\u7684\u7597\u6548\u3002Fang\u7b49[39]<\/sup>\u7684\u7814\u7a76\u8868\u660e\uff0c\u767d\u85dc\u82a6\u9187\u53ef\u4ee5\u4f5c\u4e3a\u9ed1\u8272\u7d20\u7624\u653e\u5c04\u6cbb\u7597\u7684\u589e\u654f\u5242\u3002<\/p>\n

2.6\u00a0 \u534f\u540c\u5176\u4ed6\u7269\u8d28\u6291\u5236\u80bf\u7624\u7ec6\u80de<\/h4>\n

\u767d\u85dc\u82a6\u9187\u672c\u8eab\u5177\u6709\u6291\u5236\u80bf\u7624\u7684\u529f\u6548\uff0c\u4e0d\u4ec5\u5982\u6b64\uff0c\u5f53\u5b83\u548c\u5176\u4ed6\u4e00\u4e9b\u6709\u6297\u80bf\u7624\u4f5c\u7528\u7684\u7269\u8d28\u5171\u540c\u4f5c\u7528\u4e8e\u764c\u7ec6\u80de\u65f6\uff0c\u53ef\u4ee5\u964d\u4f4e\u4e24\u8005\u7684\u7528\u91cf\uff0c\u8fd8\u53ef\u4ee5\u63d0\u9ad8\u4f5c\u7528\u6548\u679c\u3002\u8463\u5fb7\u521a[8]<\/sup>\u7684\u7814\u7a76\u8868\u660e\u767d\u85dc\u82a6\u9187\u548c\u6842\u679d\u832f\u82d3\u6c64\u5171\u540c\u4f5c\u7528\uff0c\u5728\u4ea7\u751f\u540c\u7b49\u7597\u6548\u7684\u540c\u65f6\uff0c\u53ef\u4ee5\u964d\u4f4e\u5f7c\u6b64\u7684\u7528\u836f\u6d53\u5ea6\uff0c\u8fbe\u5230\u8f83\u6ee1\u610f\u7684\u836f\u7269\u6cbb\u7597\u5bab\u9888\u764c\u4fb5\u88ad\u8f6c\u79fb\u7684\u6548\u679c\u3002\u4f4e\u6d53\u5ea6\u7684\u6842\u679d\u832f\u82d3\u6c64\u4e0e\u767d\u85dc\u82a6\u9187\u8054\u5408\u5e94\u7528\u540e\u4ea6\u80fd\u591f\u660e\u663e\u964d\u4f4eMMP-2\/TIMP-l\uff0cMMP-9\/TIMP-2\u503c\uff0c\u6062\u590d\u57fa\u8d28\u91d1\u5c5e\u86cb\u767d\u9176\u53ca\u5176\u7ec4\u7ec7\u6291\u5236\u5242\u4e4b\u95f4\u7684\u5e73\u8861\u72b6\u6001\uff0c\u964d\u4f4e\u57fa\u8d28\u91d1\u5c5e\u86cb\u767d\u9176\u5bf9\u7ec6\u80de\u5916\u57fa\u8d28\u7684\u964d\u89e3\u80fd\u529b\uff0c\u6709\u6548\u6291\u5236\u5bab\u9888\u764c\u7ec6\u80de\u7684\u4fb5\u88ad\u8f6c\u79fb\u3002<\/p>\n

\u767d\u85dc\u82a6\u9187\u548c\u59dc\u9ec4\u7d20\u4e5f\u5b58\u5728\u7740\u534f\u540c\u4f5c\u7528\u3002HSP90\u662f\u5728\u5404\u79cd\u7ec6\u80de\u4e2d\u5e7f\u6cdb\u8868\u8fbe\u7684\u4e00\u79cd\u70ed\u4f11\u514b\u86cb\u767d\uff0c\u5b83\u6709\u591a\u79cd\u5ba2\u6237\u86cb\u767d\uff0c\u8fd9\u4e9b\u5ba2\u6237\u86cb\u767d\u5927\u591a\u53c2\u4e0e\u7ec4\u6210\u80bf\u7624\u7ec6\u80de\u4e2d\u591a\u4e2a\u4fe1\u53f7\u8f6c\u5bfc\u901a\u8def[40]<\/sup>\u3002\u76ee\u524d\u5df2\u8bc1\u5b9e\u8fd9\u4e9b\u5ba2\u6237\u86cb\u767d\u4e2d\u6709\u4e00\u90e8\u5206\u4e0e\u80bf\u7624\u7684\u53d1\u751f\u4e0e\u53d1\u5c55\u6709\u5173\u7cfb[41]<\/sup>\u3002HSP70\u4e5f\u662f\u5728\u5404\u79cd\u7ec6\u80de\u4e2d\u5e7f\u6cdb\u5b58\u5728\u7684\u4e00\u79cd\u70ed\u4f11\u514b\u86cb\u767d\u3002Guo\u7b49[42]<\/sup>\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff1a\u5728\u767d\u8840\u75c5\u7ec6\u80de\u4e2d\uff0cHSP70\u80fd\u4e0e\u51cb\u4ea1\u86cb\u767dBax\u7ed3\u5408\uff0c\u6291\u5236\u540e\u8005\u7684\u6784\u578b\u6539\u53d8\u548c\u7ebf\u7c92\u4f53\u5b9a\u4f4d\uff0c\u963b\u6b62\u7ebf\u7c92\u4f53\u91ca\u653e\u4fc3\u51cb\u4ea1\u5206\u5b50\uff0c\u4ece\u800c\u6291\u5236\u7ebf\u7c92\u4f53\u9014\u5f84\u7684\u51cb\u4ea1\u3002Hsp70\u8fd8\u80fd\u901a\u8fc7\u7ed3\u5408\u51cb\u4ea1\u8bf1\u5bfc\u56e0\u5b50\u800c\u963b\u6b62\u975e\u4f9d\u8d56caspase\u9014\u5f84\u7684\u51cb\u4ea1[43]<\/sup>\u3002\u59dc\u9ec4\u7d20\u53ef\u4ee5\u4fc3\u8fdbHSP90\u7684\u4e59\u9170\u5316\uff0c\u964d\u4f4eHSP90\u5206\u5b50\u4f34\u4fa3\u7684\u529f\u80fd\uff0c\u4fc3\u8fdb\u764c\u7ec6\u80de\u7684\u51cb\u4ea1\u3002\u4f46\u662f\u5728\u59dc\u9ec4\u7d20\u53d1\u6325\u964d\u4f4eHSP90\u5206\u5b50\u4f34\u4fa3\u4f5c\u7528\u7684\u540c\u65f6\u53c8\u4fc3\u8fdb\u4e86HSP70\u8868\u8fbe\u3002\u767d\u85dc\u82a6\u9187\u80fd\u591f\u540c\u65f6\u6291\u5236HSP90\u4e0eHSP70\u7684\u8868\u8fbe\uff0c\u4fc3\u8fdb\u764c\u7ec6\u80de\u7684\u51cb\u4ea1\u3002\u5f53\u767d\u85dc\u82a6\u9187\u4e0e\u59dc\u9ec4\u7d20\u540c\u65f6\u4f7f\u7528\u65f6\uff0c\u767d\u85dc\u82a6\u9187\u53ef\u4ee5\u62ee\u6297\u59dc\u9ec4\u7d20\u5bf9HSP70\u7684\u8bf1\u5bfc[7]<\/sup>\u3002\u53e6\u6709\u7814\u7a76[44]<\/sup>\u53d1\u73b0\uff0c\u767d\u85dc\u82a6\u9187\u548c\u59dc\u9ec4\u7d20\u534f\u540c\u4f5c\u7528\u4e0b\u8c03\u7ec6\u80de\u51cb\u4ea1\u6291\u5236\u86cb\u767d\u548csurvivin\u7684\u8868\u8fbe\uff0c\u4fc3\u8fdb\u809d\u764c\u7ec6\u80de\u7684\u51cb\u4ea1\u3002<\/p>\n

\u767d\u85dc\u82a6\u9187\u589e\u5f3a\u6076\u6027\u80f6\u8d28\u7624\u7ec6\u80de\u5bf9\u66ff\u83ab\u5511\u80fa\u836f\u7269\u654f\u611f\u6027\u4e5f\u503c\u5f97\u5173\u6ce8\u3002\u6076\u6027\u80f6\u8d28\u7624\u5185O6-\u7532\u57fa\u9e1f\u560c\u5464-DNA\u7532\u57fa\u8f6c\u79fb\u9176(O6-methyl guanine-DNA methyltransferase\uff0cMGMT)\u7684\u4f5c\u7528\uff0c\u9ad8\u8fbe\u4e00\u534a\u7684\u60a3\u8005\u5bf9\u66ff\u83ab\u5511\u80fa\u5316\u7597\u5e76\u4e0d\u654f\u611f\u3002\u6797\u6d2a[33]<\/sup>\u8ba4\u4e3a\uff0c\u6076\u6027\u80f6\u8d28\u7624T98G\u7ec6\u80de\u5bf9\u66ff\u83ab\u5511\u80fa\u836f\u7269\u7684\u4e0d\u654f\u611f\u6027\u4e00\u65b9\u9762\u662f\u56e0\u4e3a\u7624\u7ec6\u80de\u5185MGMT\u86cb\u767d\u672c\u8eab\u7684\u8868\u8fbe\uff1b\u53e6\u4e00\u65b9\u9762\u7531\u4e8e\u66ff\u83ab\u5511\u80fa\u80fd\u901a\u8fc7\u4e0a\u8c03NF-\u03baB\u8868\u8fbe\u6765\u8bf1\u5bfc\u7624\u7ec6\u80de\u751f\u6210\u66f4\u591a\u7684MGMT\u3002\u800c\u767d\u85dc\u82a6\u9187\u5219\u80fd\u591f\u901a\u8fc7\u6d3b\u5316\u7684Notch-1\u4fe1\u53f7\u963b\u65ad\u7624\u7ec6\u80de\u5185MGMT\u7684\u8868\u8fbe\uff0c\u5e76\u901a\u8fc7NF-\u03baB\uff0cp53\u9014\u5f84\u63d0\u9ad8\u6076\u6027\u80f6\u8d28\u7624\u7ec6\u80de\u5bf9\u66ff\u83ab\u5511\u80fa\u7684\u836f\u7269\u654f\u611f\u6027\uff0c\u4fc3\u4f7f\u6076\u6027\u80f6\u8d28\u7624\u7ec6\u80de\u51cb\u4ea1\u3002Aires\u7b49[45]<\/sup>\u8ba4\u4e3a\uff0c\u767d\u85dc\u82a6\u9187\u7ecf\u53e3\u670d\u751f\u7269\u5229\u7528\u7387\u5f88\u4f4e\uff0c\u4f46\u662f\uff0c\u5176\u5728\u751f\u7269\u4f53\u5185\u7684\u5404\u79cd\u4ee3\u8c22\u4ea7\u7269\u4e4b\u95f4\u53ef\u4ee5\u4ea7\u751f\u4e00\u4e2a\u534f\u540c\u7684\u4f5c\u7528\uff0c\u5171\u540c\u53d1\u6325\u4fc3\u8fdb\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u7ec6\u80de\u7684\u51cb\u4ea1\u3002\u66f4\u52a0\u6709\u8da3\u7684\u662f\uff0c\u767d\u85dc\u82a6\u9187\u8fd8\u53ef\u4ee5\u4fc3\u8fdb\u4e09\u6c27\u5316\u4e8c\u7837\u5728\u4f53\u5185\u7684\u89e3\u6bd2\u8fc7\u7a0b\uff0c\u964d\u4f4e\u673a\u4f53\u5bf9\u4e09\u6c27\u5316\u4e8c\u7837\u7684\u6c27\u5316\u5e94\u6fc0\u53cd\u5e94[46]<\/sup>\u3002<\/p>\n

3\u00a0 \u603b\u7ed3\u4e0e\u5c55\u671b<\/h3>\n

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\n

\u53c2\u8003\u6587\u732e<\/h4>\n
    \n
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  5. Dom\u00ednguez B, Pardo BG, Noia M, et al. Microarray analysis of the inflammatory and immune responses in head kidney turbot leucocytes treated with resveratrol[J]. Int Immunopharmacol, 2013, 15(3): 588-596.<\/li>\n
  6. \u4e25\u5cfb, \u5434\u6653\u59dd,\u00a0 \u5b59\u6167\u71d5, \u7b49. \u4f4e\u6c27\u6761\u4ef6\u4e0b\u767d\u85dc\u82a6\u9187\u5bf9HepG2\u7ec6\u80de\u589e\u6b96\u53ca\u81ea\u566c\u7684\u8c03\u8282\u4f5c\u7528\u53ca\u521d\u6b65\u673a\u5236[J]. \u4e2d\u56fd\u79d1\u5b66, 2011, 41(6): 456-461.
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    \u6587\u7ae0\u6765\u81ea\uff1a<\/a>\u4e34\u5e8a\u4e0e\u75c5\u7406\u6742\u5fd7<\/p>\n

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    \u8461\u8404\u4e2d\u767d\u85dc\u82a6\u9187\u5bf9\u80bf\u7624\u9632\u6cbb\u4f5c\u7528\u7684\u7814\u7a76\u8fdb\u5c55 Published at: May 09, 2014 2013\u5e74\u7b2c33\u5377\u7b2c6\u671f \u5218\u8fdc\u9526 1 , \u6797\u4eb2\u5f55 1 , \u7f57\u975e\u541b 1\u00a0 1 \u4e2d\u5357\u6797\u4e1a\u79d1\u6280\u5927\u5b66\u98df\u54c1\u79d1\u5b66\u4e0e\u5de5\u7a0b\u5b66\u9662\u98df\u54c1\u8425\u517b\u4e0e\u5065\u5eb7\u7814\u7a76\u5ba4\uff0c\u957f\u6c99 410004 \u901a\u8baf\u4f5c\u8005 \u975e\u541b \u7f57 Email: luofeijun@hotmail.com DOI: 10.3978\/j.issn.2095-6959.10.3978\/j.issn.2095-6959. \u57fa\u91d1\uff1a \u56fd\u5bb6\u81ea\u7136\u79d1\u5b66\u57fa\u91d1 81071755 \u6458\u8981 \u767d\u85dc\u82a6\u9187\u662f\u4e00\u79cd\u5927\u91cf\u5b58\u5728\u4e8e\u8461\u8404\u4e2d\u7684\u591a\u915a\u5316\u5408\u7269\uff0c\u5177\u6709\u6297\u80bf\u7624\u3001\u6297\u5fc3\u8840\u7ba1\u75be\u75c5\u548c\u8c03\u8282\u514d\u75ab\u7b49\u4f5c\u7528\u3002\u6587\u7ae0\u603b\u7ed3\u4e86\u767d\u85dc\u82a6\u9187\u5bf9\u4e0d\u540c\u7c7b\u578b\u80bf\u7624\u7ec6\u80de\u7684\u6291\u5236\u4f5c\u7528\uff0c\u9610\u8ff0\u4e86\u5176\u4e3b\u8981\u901a\u8fc7\u6291\u5236\u764c\u7ec6\u80de\u7684\u589e\u6b96\u3001\u4fc3\u8fdb\u7ec6\u80de\u51cb\u4ea1\u3001\u964d\u4f4e\u80bf\u7624\u7ec6\u80de\u7684\u4fb5\u88ad\u80fd\u529b\u548c\u589e\u5f3a\u653e\u5c04\u6cbb\u7597\u654f\u611f\u6027\u7b49\u9014\u5f84\u6297\u764c\uff0c\u5e76\u4ece\u5206\u5b50\u6c34\u5e73\u9610\u660e\u5176\u4f5c\u7528\u7684\u5206\u5b50\u9776\u70b9\u53ca\u5206\u5b50\u673a\u5236\uff0c\u6700\u540e\u5bf9\u767d\u85dc\u82a6\u9187\u7684\u6297\u764c\u673a\u5236\u548c\u5176\u5bf9\u5065\u5eb7\u3001\u533b\u7597\u3001\u7ecf\u6d4e\u7684\u8d21\u732e\u4f5c\u4e86\u5c55\u671b\u3002 \u5173\u952e\u8bcd\uff1a \u767d\u85dc\u82a6\u9187\uff1b\u51cb\u4ea1\uff1b\u589e\u6b96\uff1b\u591a\u915a\u5316\u5408\u7269\uff1b\u6297\u80bf\u7624 Recent advance in the study on prevention and treatment for cancer by resveratrol in grape LIU Yuanjin 1 , LIN Qinlu 1 , LUO Feijun 1 1 Laboratory […]<\/p>\n

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