{"id":20390,"date":"2023-11-04T18:55:47","date_gmt":"2023-11-04T18:55:47","guid":{"rendered":"http:\/\/johnhealth.blog\/ch\/?p=20390"},"modified":"2023-11-28T13:35:43","modified_gmt":"2023-11-28T13:35:43","slug":"%e6%9c%80%e8%bf%91%e4%b8%ad%e5%9b%bd%e7%a7%91%e5%ad%a6%e5%ae%b6%e5%8f%91%e7%8e%b0%e8%91%a1%e8%90%84%e7%b1%bd%e6%8f%90%e5%8f%96%e7%89%a9%e8%83%bd%e5%a2%9e%e5%bc%ba%e7%83%9f%e9%85%b0%e8%83%ba%e5%8d%95","status":"publish","type":"post","link":"http:\/\/johnhealth.blog\/ch\/?p=20390","title":{"rendered":"\u6700\u8fd1\u4e2d\u56fd\u79d1\u5b66\u5bb6\u53d1\u73b0\u8461\u8404\u7c7d\u63d0\u53d6\u7269\u80fd\u589e\u5f3a \u70df\u9170\u80fa\u5355\u6838\u82f7\u9178 \u6548\u80fd\uff0c\u4fdd\u62a4\u5c0f\u9f20\u89c6\u7f51\u819c\u7ec6\u80de\u514d\u53d7\u8870\u8001\u4fb5\u88ad\uff01"},"content":{"rendered":"<header class=\"entry-header\">\n<h1>\u8461\u8404\u7c7d \u4e0e \u70df\u9170\u80fa\u5355\u6838\u82f7\u9178 \u5bf9\u89c6\u529b\u7684\u4fdd\u62a4<\/h1>\n<h1 class=\"entry-title\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-20394\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/11\/image-30.png\" alt=\"\" width=\"794\" height=\"458\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/11\/image-30.png 794w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/11\/image-30-300x173.png 300w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/11\/image-30-768x443.png 768w\" sizes=\"auto, (max-width: 794px) 100vw, 794px\" \/><\/h1>\n<\/header>\n<div class=\"entry-content\">\n<pre class=\"wp-block-preformatted\">\u8fd9\u79cd\u4ee5\u6d46\u679c\u679c\u5b9e\u4e3a\u57fa\u7840\u63d0\u53d6\u7684\u5316\u5408\u7269<strong><span style=\"color: #ff0000;\">\u539f\u82b1\u9752\u7d20<\/span><\/strong>\u6709\u53ef\u80fd\u4f1a\u88ab\u7528\u6765\u5e2e\u52a9\u6570\u767e\u4e07\u60a3\u6709\u89c6\u7f51\u819c\u75be\u75c5\u7684\u4eba\uff0c\r\n\u5e76\u901a\u8fc7\u63d0\u9ad8\u4ed6\u4eec\u4f53\u5185NAD+\u7684\u6c34\u5e73\uff0c\u4fdd\u62a4\u8bb8\u591a\u4eba\u514d\u4e8e\u5931\u660e\u4e4b\u75db\u3002\r\n\r\n\u672c\u6587\u4eae\u70b9\uff1a\r\n\u8461\u8404\u7c7d\u63d0\u53d6\u7269\u4e2d\u6709\u4e00\u79cd\u53eb\u505a\u539f\u82b1\u9752\u7d20\u7684\u5316\u5408\u7269\uff0c\u5728\u89c6\u7f51\u819c\u7ec6\u80de\u4e2d\u5177\u6709\u6297\u8870\u8001\u7684\u4f5c\u7528\u3002\r\n\u8461\u8404\u7c7d\u539f\u82b1\u9752\u7d20\u63d0\u53d6\u7269(GSPE)\u901a\u8fc7\u6fc0\u6d3b\u9176NAMPT\u7684\u6c34\u5e73\uff0c\u751f\u6210\u70df\u9170\u80fa\u5355\u6838\u82f7\u9178, 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\/>\n<\/strong><\/p>\n<p>\u89c6\u7f51\u819c\u7684\u8272\u7d20\u5c42\u6216\u89c6\u7f51\u819c\u8272\u7d20\u4e0a\u76ae(RPE)\u4f4d\u4e8e\u795e\u7ecf\u611f\u89c9\u89c6\u7f51\u819c\u7684\u5916\u9762\uff0c\u5b83\u4eec\u5728\u90a3\u91cc\u6ecb\u517b\u89c6\u7f51\u819c\u7684\u89c6\u89c9\u795e\u7ecf\u7ec6\u80de\u3002RPE\u529f\u80fd\u969c\u788d\u88ab\u8ba4\u4e3a\u662f\u5bfc\u81f4\u7cd6\u5c3f\u75c5\u89c6\u7f51\u819c\u75c5\u53d8(DR)\u3001\u89c6\u7f51\u819c\u8272\u7d20\u53d8\u6027(RP)\u3001\u8001\u5e74\u6027\u9ec4\u6591\u53d8\u6027(AMD)\u7b49\u591a\u79cd\u9000\u884c\u6027\u773c\u75c5\u53d1\u751f\u7684\u5173\u952e\u56e0\u7d20\u3002RPE\u7ec6\u80de\u7684\u8870\u8001\u635f\u5bb3\u4e86\u5b83\u9002\u5f53\u5206\u6ccc\u4fc3\u8fdb\u773c\u775b\u4e2d\u611f\u89c9\u7ec6\u80de\u548c\u7ef4\u6301\u8840\u7ba1\u5065\u5eb7\u7684\u7ec6\u80de\u56e0\u5b50\u7684\u80fd\u529b\u3002<\/p>\n<p><strong><span style=\"color: #ff6600;\">\u8461\u8404\u7c7d\u63d0\u53d6\u7269\u4fdd\u62a4\u7ec6\u80de\u5065\u5eb7<\/span><br \/>\n<\/strong><\/p>\n<p>\u8461\u8404\u7c7d\u539f\u82b1\u9752\u7d20\u662f\u4ece\u6574\u4e2a\u8461\u8404\u7c7d\u4e2d\u63d0\u53d6\u7684\uff0c\u5177\u6709\u6297\u6c27\u5316\u3001\u6297\u708e\u3001\u6297\u8870\u8001\u7684\u7279\u6027\u3002\u8fd9\u79cd\u4ee5\u6c34\u679c\u4e3a\u57fa\u7840\u7684\u5316\u5408\u7269\u5df2\u88ab\u8bc1\u660e\u53ef\u4ee5\u589e\u52a0NAMPT\u7684\u6c34\u5e73\uff0c\u5b83\u5bf9\u901a\u8fc7\u70df\u9170\u80fa\u5355\u6838\u82f7\u9178\u6765\u7ef4\u6301\u5fc5\u9700\u7684\u3001\u4e0e\u5e74\u9f84\u76f8\u5173\u7684\u5206\u5b50\uff0c\u70df\u9170\u80fa\u817a\u560c\u5464\u4e8c\u6838\u82f7\u9178(NAD+)\u7684\u6c34\u5e73\u81f3\u5173\u91cd\u8981\u3002NAD+\u542b\u91cf\u968f\u5e74\u9f84\u7684\u4e0b\u964d\u4e0e\u5065\u5eb7\u3001\u5bff\u547d\u548c\u5e74\u9f84\u76f8\u5173\u6027\u7684\u9000\u884c\u6027\u75be\u75c5\u53d1\u751f\u5bc6\u5207\u76f8\u5173\u3002\u5728\u89c6\u7f51\u819c\u9000\u884c\u6027\u75be\u75c5\u4e2d\uff0cNAMPT\u7684\u8868\u8fbe\u4e0eNAD+\u7684\u542b\u91cf\u4e00\u81f4\uff0c\u4e14\u4e0e\u5065\u5eb7\u7684\u5bf9\u7167\u7ec4\u76f8\u6bd4\u53d1\u75c5\u7387\u964d\u4f4e\u3002<\/p>\n<p>\u56e0\u6b64\uff0c\u6211\u4eec\u6709\u7406\u7531\u76f8\u4fe1NAD+\u4ee3\u8c22\u9014\u5f84\u7684\u5173\u952e\u8c03\u63a7\u56e0\u5b50NAMPT\u4e0e\u89c6\u7f51\u819c\u9000\u884c\u6027\u75be\u75c5\u6709\u5173\u3002\u4f46\u539f\u82b1\u9752\u7d20\u4fc3\u8fdbNAMPT\u7684\u6f5c\u5728\u4fdd\u62a4\u4f5c\u7528\u662f\u5426\u4e5f\u9002\u7528\u4e8e\u51cf\u7f13\u89c6\u7f51\u819c\u7ec6\u80de\u7684\u8870\u8001\uff0c\u4e4b\u524d\u8fd8\u6ca1\u6709\u7814\u7a76\u8bba\u6587\u62a5\u544a\u8fc7\u3002<\/p>\n<p><strong><span style=\"color: #ff6600;\">\u539f\u82b1\u9752\u7d20\u51cf\u7f13\u89c6\u7f51\u819c\u7ec6\u80de\u8870\u8001<\/span><br 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class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-20393\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/11\/image-31.png\" alt=\"\" width=\"569\" height=\"162\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/11\/image-31.png 569w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/11\/image-31-300x85.png 300w\" sizes=\"auto, (max-width: 569px) 100vw, 569px\" \/><figcaption>\u8461\u8404\u7c7d\u539f\u82b1\u9752\u7d20\u63d0\u53d6\u7269(GSPE)\u53ef\u4ee5\u4fdd\u62a4\u8870\u8001\u5c0f\u9f20\u7684\u89c6\u7f51\u819c\u7ec6\u80de\u5c4f\u969c\u3002\u8870\u8001\u663e\u8457\u964d\u4f4e\u4e86\u7ec6\u80de\u5c4f\u969c\u86cb\u767dZO1(\u7ea2\u8272)\u7684\u6c34\u5e73\uff0c\u8fd9\u8868\u660e\u4e86\u7ec6\u80de\u7684\u5b8c\u6574\u6027\u3002GSPE\u53ef\u663e\u8457\u63d0\u9ad8\u8001\u5316\u89c6\u7f51\u819c\u8272\u7d20\u4e0a\u76ae(RPE)\u7ec6\u80de\u4e2dZO1\u6c34\u5e73\u3002<\/figcaption><\/figure>\n<\/div>\n<p>&nbsp;<\/p>\n<p><strong><span style=\"color: #ff6600;\">\u8461\u8404\u7c7d\u539f\u82b1\u9752\u7d20\u63d0\u53d6\u7269\u901a\u8fc7NMN\u63d0\u9ad8NAD+\u6c34\u5e73<\/span><br 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class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-20392\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/11\/image-32.png\" alt=\"\" width=\"524\" height=\"648\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/11\/image-32.png 524w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/11\/image-32-243x300.png 243w\" sizes=\"auto, (max-width: 524px) 100vw, 524px\" \/><figcaption>(Wan et al.\uff0c 2021 | Journal of\u708e\u75c7\u7814\u7a76)\u8461\u8404\u7c7d\u539f\u82b1\u9752\u7d20\u63d0\u53d6\u7269(GSPE)\u8c03\u8282\u8001\u5316RPE\u7ec6\u80de\u4e2dNAD+\u6c34\u5e73\u548c\u7ec6\u80de\u8870\u8001\u3002(A) 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class=\"wp-block-quote\"><p>\u201c\u8fd9\u9879\u7814\u7a76\u7684\u7ed3\u679c\u5f3a\u8c03\u4e86\u7b5b\u9009\u66f4\u591a\u6297\u8870\u8001\u5929\u7136\u63d0\u53d6\u7269\u7684\u91cd\u8981\u6027\uff0c\u5e76\u5c06\u6709\u52a9\u4e8e\u6211\u4eec\u66f4\u597d\u5730\u7406\u89e3\u5b83\u4eec\u5bf9\u4e0e\u8870\u8001\u76f8\u5173\u7684\u9000\u884c\u6027\u75be\u75c5\u7684\u5f71\u54cd\uff0c\u201d\u4f5c\u8005\u63d0\u51fa\u3002<\/p><\/blockquote>\n<p>\u8be5\u7814\u7a76\u4e2d\u4e00\u4e2a\u666e\u904d\u5b58\u5728\u7684\u95ee\u9898\u4e0e\u5982\u4f55\u9009\u62e9\u6700\u4f73\u7684\u4fc3\u8fdbNAD+\u4ea7\u751f\u7684\u65b9\u6cd5\u6709\u5173\uff1a\u662f\u901a\u8fc7\u4ea7\u751fNAD+\u548c\u4ee3\u8c22\u4e2d\u95f4\u4f53\u7684\u9176\u6216\u6fc0\u6d3b\u5242\u5462\uff0c\u8fd8\u662f\u76f4\u63a5\u8865\u5145\u8fd9\u4e9b\u9176\u7684\u524d\u4f53\u7269\u8d28\uff1f\u7ed3\u5408\u4e24\u79cdNAD+\u4fc3\u8fdb\u7b56\u7565\u53ef\u80fd\u6709\u6700\u6709\u6548\u7684\u6548\u679c\uff0c\u56e0\u4e3a\u6211\u4eec\u4ecd\u5728\u7814\u7a76\u7ec6\u80de\u5728\u5438\u6536\u8fd9\u4e9b\u5206\u5b50\u65f6\u6709\u4f55\u5f02\u540c\u3002<\/p>\n<p>\u4f8b\u5982\uff0c\u6211\u4eec\u77e5\u9053\u54fa\u4e73\u52a8\u7269\u7684\u80c3\u80a0\u9053\u4e2d\u6709\u70df\u9170\u80fa\u5355\u6838\u82f7\u9178\u7684\u53d7\u4f53\uff0c\u76f4\u63a5\u8865\u5145\u70df\u9170\u80fa\u5355\u6838\u82f7\u9178\u4f1a\u6709\u5f88\u597d\u7684\u6548\u679c\u3002\u800c\u5176\u4ed6\u7c7b\u578b\u7684\u7ec6\u80de\u53ef\u80fd\u66f4\u9002\u5408\u63a5\u53d7NAMPT\u6fc0\u6d3b\u5242\uff0c\u50cf\u5728\u672c\u7814\u7a76\u4e2d\u63d0\u51fa\u7684\u3002\u603b\u4e4b\uff0c\u8fd9\u4e9b\u7b56\u7565\u53ef\u80fd\u7ed9\u6211\u4eec\u63d0\u4f9b\u4e86\u6539\u5584\u5065\u5eb7\u548c\u5ef6\u957f\u5bff\u547d\u7684\u6700\u4f73\u65b9\u6cd5\uff0c\u540c\u65f6\u4e0e\u5e74\u9f84\u76f8\u5173\u75be\u75c5\u4f5c\u6597\u4e89\uff0c\u8fd9\u5c06\u5bf9\u4e2a\u4eba\u548c\u793e\u4f1a\u4ea7\u751f\u91cd\u5927\u5f71\u54cd\u3002<\/p>\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-20391\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/11\/image-33.png\" alt=\"\" width=\"561\" height=\"600\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/11\/image-33.png 561w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/11\/image-33-281x300.png 281w\" sizes=\"auto, (max-width: 561px) 100vw, 561px\" \/><figcaption>\u8461\u8404\u7c7d\u539f\u82b1\u9752\u7d20\u63d0\u53d6\u7269(GSPE)\u662f\u4e00\u79cd\u6f5c\u5728\u7684\u9000\u884c\u6027\u89c6\u7f51\u819c\u75be\u75c5\u7684\u6cbb\u7597\u65b9\u6cd5\u3002GSPE\u663e\u8457\u4e0a\u8c03\u8001\u5316\u89c6\u7f51\u819c\u8272\u7d20\u4e0a\u76ae(RPE)\u7ec6\u80deNAMPT\u7684\u8868\u8fbe\uff0c\u4ece\u800c\u4fc3\u8fdbNAD+\u7684\u4ea7\u751f\u3002\u6539\u5584\u7ec6\u80de\u8870\u8001\u72b6\u6001\u548c\u964d\u4f4eSASP\u6c34\u5e73\u5bf9\u9884\u9632\u89c6\u7f51\u819c\u9000\u884c\u6027\u75be\u75c5\u5177\u6709\u91cd\u8981\u4f5c\u7528\u3002<\/figcaption><\/figure>\n<\/div>\n<p><strong>\u8d44\u6599\u6765\u6e90\uff1a<\/strong><\/p>\n<p><em>Wan W, Zhu W, Wu Y, Long Y, Liu H, Wan W, Wan G, Yu J.\u00a0<strong>Grape Seed Proanthocyanidin Extract Moderated Retinal Pigment Epithelium Cellular Senescence Through NAMPT\/SIRT1\/NLRP3 Pathway<\/strong>. J Inflamm Res. 2021 Jul 12;14:3129-3143. Doi:\u00a010.2147\/JIR.S306456. PMID: 34285539; PMCID: PMC8286255.<\/em><\/p>\n<\/div>\n<p><!--more--><\/p>\n<p><!--more--><\/p>\n<div class=\"pvc_clear\"><\/div>\n<p id=\"pvc_stats_20390\" class=\"pvc_stats all  \" data-element-id=\"20390\" style=\"\"><i class=\"pvc-stats-icon medium\" aria-hidden=\"true\"><svg aria-hidden=\"true\" focusable=\"false\" data-prefix=\"far\" data-icon=\"chart-bar\" role=\"img\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\" class=\"svg-inline--fa fa-chart-bar fa-w-16 fa-2x\"><path fill=\"currentColor\" d=\"M396.8 352h22.4c6.4 0 12.8-6.4 12.8-12.8V108.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v230.4c0 6.4 6.4 12.8 12.8 12.8zm-192 0h22.4c6.4 0 12.8-6.4 12.8-12.8V140.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v198.4c0 6.4 6.4 12.8 12.8 12.8zm96 0h22.4c6.4 0 12.8-6.4 12.8-12.8V204.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v134.4c0 6.4 6.4 12.8 12.8 12.8zM496 400H48V80c0-8.84-7.16-16-16-16H16C7.16 64 0 71.16 0 80v336c0 17.67 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