{"id":20309,"date":"2023-09-12T01:26:05","date_gmt":"2023-09-12T01:26:05","guid":{"rendered":"http:\/\/johnhealth.blog\/ch\/?p=20309"},"modified":"2023-09-12T01:31:23","modified_gmt":"2023-09-12T01:31:23","slug":"%e6%b8%85%e5%8d%8e%e5%a4%a7%e5%ad%a6%e6%9c%80%e6%96%b0%e7%a0%94%e7%a9%b6-nmn%e5%8f%af%e6%8a%91%e5%88%b6%e4%b8%89%e9%98%b4%e6%80%a7%e4%b9%b3%e8%85%ba%e7%99%8c%e7%94%9f%e9%95%bf%e5%92%8c%e8%bd%ac","status":"publish","type":"post","link":"http:\/\/johnhealth.blog\/ch\/?p=20309","title":{"rendered":"\u6e05\u534e\u5927\u5b66\u65b0\u7814\u7a76 2023 1.23\u53d1\u8868\u4e8eOncogene  | NMN\u53ef\u6291\u5236\u4e09\u9634\u6027\u4e73\u817a\u764c\u751f\u957f\u548c\u8f6c\u79fb"},"content":{"rendered":"<p>2020\u5e74\uff0c\u5168\u7403\u5973\u6027\u4e73\u817a\u764c\u65b0\u53d1\u75c5\u4f8b\u8fbe\u5230\u4e86226\u4e07\u4f8b\uff0c\u5df2\u7ecf\u8d85\u8fc7\u80ba\u764c\uff0c\u6210\u4e3a\u5168\u7403\u6700\u5e38\u89c1\u7684\u764c\u75c7[1]\u3002\u4e73\u817a\u764c\u6839\u636e\u96cc\u6fc0\u7d20\u53d7\u4f53(ER)\u3001\u5b55\u6fc0\u7d20\u53d7\u4f53(PR)\u548c\u4eba\u8868\u76ae\u751f\u957f\u56e0\u5b502 (HER2)\u7684\u4e0d\u540c\uff0c\u53ef\u5206\u4e3a\u591a\u79cd\u7c7b\u578b[2]\u3002\u4e0d\u540c\u7c7b\u578b\u7684\u4e73\u817a\u764c\u9700\u8981\u91c7\u7528\u4e0d\u540c\u7684\u6cbb\u7597\u65b9\u6cd5\uff0c\u4f8b\u5982ER\u9633\u6027\u7684\u4e73\u817a\u764c\u901a\u5e38\u4f1a\u7528\u5185\u5206\u6ccc\u6cbb\u7597\u6765\u6cbb\u7597\u3002<\/p>\n<p>\u5728\u6240\u6709\u4e73\u817a\u764c\u4e2d\uff0cER\u3001PR\u3001HER2\u5747\u4e3a\u9634\u6027\u7684\u4e09\u9634\u6027\u4e73\u817a\u764c(TNBC)\u6700\u4e3a\u96be\u6cbb\uff0c\u5360\u4e73\u817a\u764c\u75c5\u4f8b\u6570\u768415%\u3002\u7531\u4e8eER\u3001PR\u3001HER2\u53d7\u4f53\u5747\u4e3a\u9634\u6027\uff0c\u7f3a\u5c11\u6cbb\u7597\u5f31\u70b9\uff0c\u901a\u5e38\u7684\u6cbb\u7597\u65b9\u6cd5\u4e0d\u8d77\u6548\uff0c\u5316\u7597\u662f\u4e3a\u6570\u4e0d\u591a\u7684\u9009\u62e9\u4e4b\u4e00\u3002<!--more--><\/p>\n<p>\u76f8\u5bf9\u4e8e\u5176\u4ed6\u7c7b\u578b\u7684\u4e73\u817a\u764c\uff0cTNBC\u8f6c\u79fb\u7684\u53ef\u80fd\u6027\u66f4\u5927\uff0c\u6613\u4e8e\u65e9\u671f\u590d\u53d1\uff0c\u603b\u751f\u5b58\u671f\u8f83\u77ed\uff0c\u56e0\u6b64\u9700\u8981\u65b0\u7684\u6cbb\u7597\u65b9\u6cd5\u6765\u6cbb\u7597TNBC\u3002<\/p>\n<p>\u4e4b\u524d\u7684\u7814\u7a76\u8868\u660e\uff0cNAD+\u4ee3\u8c22\u4e0e\u764c\u75c7\u6709\u5173\uff0c\u5bf9\u80bf\u7624\u7684\u5f62\u6210\u548c\u8f6c\u79fb\u53d1\u6325\u5173\u952e\u4f5c\u7528[3]\u3002\u6b64\u5916\uff0cNAD+\u8fd8\u662fsirtuins\u548cPARPs\u7684\u5e95\u7269\uff0c\u5728\u4e0d\u540c\u7684\u7ec6\u80de\u548c\u7ec4\u7ec7\u73af\u5883\u4e2d\uff0csirtuins\u548cPARPs\u53ef\u4ee5\u53d1\u6325\u81f4\u764c\u6216\u6291\u764c\u4f5c\u7528\u3002<\/p>\n<p>\u4e3a\u4e86\u4e86\u89e3NAD+\u4ee3\u8c22\u5728TNBC\u4e2d\u7684\u4f5c\u7528\uff0c\u6e05\u534e\u5927\u5b66\u7f57\u6c38\u7ae0\u6559\u6388\u56e2\u961f\u8fdb\u884c\u4e86\u7814\u7a76\uff0c\u5e76\u5c06\u6210\u679c\u53d1\u8868\u5728\u9876\u5c16\u671f\u520a\u300a<strong><span style=\"color: #ff0000;\">Oncogene<\/span><\/strong>\u300b\u4e0a\u3002\u4ed6\u4eec\u53d1\u73b0\uff0cNMN\u53ef\u4ee5\u6291\u5236\u5c0f\u9f20TNBC\u80bf\u7624\u7684\u751f\u957f\u548c\u8f6c\u79fb\uff0c\u663e\u8457\u63d0\u9ad8\u5c0f\u9f20\u60a3\u764c\u540e\u7684\u751f\u5b58\u671f\uff0c\u6216\u8bb8\u662f\u6cbb\u7597\u4e73\u817a\u764c\u7684\u6f5c\u5728\u65b9\u6cd5\u3002<\/p>\n<p><strong><span style=\"color: #ff0000;\">NMN\u53ef\u4ee5\u5ef6\u7f13\u4e73\u817a\u764c\u7684\u751f\u957f\u548c\u6269\u6563<\/span><\/strong><\/p>\n<p><span style=\"color: #ff6600;\"><strong>\u5e76\u5ef6\u957f\u5c0f\u9f20\u7684\u751f\u5b58\u671f<\/strong><\/span><\/p>\n<p>\u4e3a\u4e86\u8bf1\u53d1\u4e09\u9634\u6027\u4e73\u817a\u764c\uff08TNBC\uff09\uff0c\u7814\u7a76\u4eba\u5458\u5728NCG\u5c0f\u9f20\u7684\u8179\u80a1\u6c9f\u4e73\u817a\u8102\u80aa\u57ab\u4e2d\u6ce8\u5c04\u4e86HCC1937\u764c\u7ec6\u80de\u3002\u968f\u540e\uff0c\u6bcf\u5929\u7ed9\u5c0f\u9f20\u6ce8\u5c04500mg\/kg\u7684NMN\uff0c48\u5929\u540e\u53d1\u73b0\uff0cNMN\u7ec4\u5c0f\u9f20\u7684\u80bf\u7624\u4f53\u79ef\u6bd4\u5bf9\u7167\u7ec4\u5c0f10%\u3002<\/p>\n<p>\u6b64\u5916\uff0cH&amp;E\u67d3\u8272\u663e\u793a\uff0cNMN\u7ec4\u5c0f\u9f20\u7684\u80ba\u90e8\u8f6c\u79fb\u9762\u79ef\u8f83\u5c0f\uff0c\u8fd9\u8868\u660eNMN\u53ef\u4ee5\u660e\u663e\u6291\u5236TNBC\u80bf\u7624\u7684\u751f\u957f\u548c\u8f6c\u79fb\u3002\u7814\u7a76\u4eba\u5458\u8fd8\u53d1\u73b0\uff0cNMN\u7ec4\u5c0f\u9f20\u7684\u5e73\u5747\u5bff\u547d\u5ef6\u957f\u4e8615%\uff0c\u8bf4\u660eNMN\u53ef\u4ee5\u901a\u8fc7\u6291\u5236\u764c\u7ec6\u80de\u7684\u589e\u6b96\uff0c\u63d0\u9ad8TNBC\u53d1\u75c5\u540e\u5c0f\u9f20\u7684\u751f\u5b58\u671f\u3002<\/p>\n<section>\n<section>\n<section><span style=\"color: #ff0000;\"><strong>NMN\u53ef\u4ee5\u6fc0\u6d3bSIRT1 \u6291\u5236\u764c\u7ec6\u80de\u8f6c\u79fb<\/strong><\/span>NMN\u662fNAD+\u7684\u524d\u4f53\uff0c\u53ef\u4ee5\u663e\u8457\u589e\u52a0NAD+\u6c34\u5e73\uff0c<span style=\"color: #0000ff;\">\u4ece\u800c\u6fc0\u6d3b\u957f\u5bff\u86cb\u767dSIRT1\u3002<strong>SIRT1\u8d1f\u8d23\u4fee\u590dDNA\u5e76\u6d88\u9664\u7ec6\u80de\u4e2d\u7684\u6d3b\u6027\u6c27\uff08ROS\uff09<\/strong><\/span>\uff0c\u56e0\u6b64\uff0c\u7814\u7a76\u56e2\u961f\u63a8\u6d4bNMN\u6297\u4e73\u817a\u764c\u7684\u76ca\u5904\u6e90\u81ea\u4e8e\u6fc0\u6d3bSIRT1\u3002\u901a\u8fc7\u68c0\u6d4b\u53d1\u73b0\uff0cTNBC\u80bf\u7624\u4e2d\u7684SIRT1\u6c34\u5e73\u8981\u4f4e\u4e8e\u6b63\u5e38\u4eba\u4e73\u817a\u4e0a\u76ae\u7ec6\u80de\uff0c\u8fd9\u8fdb\u4e00\u6b65\u652f\u6301\u4e86\u7814\u7a76\u4eba\u5458\u7684\u63a8\u6d4b\u3002\u4e3a\u4e86\u9a8c\u8bc1\u8fd9\u4e00\u5047\u8bbe\uff0c\u7814\u7a76\u4eba\u5458\u6572\u9664\u4e86SIRT1\u7684\u76f8\u5173\u57fa\u56e0\uff0c\u5e76\u53d1\u73b0\u7f3a\u5c11\u8fd9\u4e00\u86cb\u767d\u540e\uff0cNMN\u65e0\u6cd5\u6291\u5236TNBC\u7684\u8f6c\u79fb\u548c\u751f\u957f\uff0c\u8fd9\u8bf4\u660eNMN\u7684\u786e\u53ef\u4ee5\u901a\u8fc7\u6fc0\u6d3bSIRT1\u6765\u6291\u5236\u764c\u75c7\u8f6c\u79fb\u3002\u7814\u7a76\u4eba\u5458\u8fdb\u4e00\u6b65\u7814\u7a76\u4e86SIRT1\u6291\u5236\u80bf\u7624\u7684\u673a\u5236\uff0c\u5e76\u53d1\u73b0\u4e0eSIRT1\u51cf\u5c11p66Shc\u7684\u78f7\u9178\u5316\u548c\u4e59\u9170\u5316\u6709\u5173\u3002<\/p>\n<p><strong>\u603b\u7ed3\u6765\u770b<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<p>&nbsp;<\/p>\n<section>\u8fd9\u9879\u7814\u7a76\u53d1\u73b0\uff0c<strong>NMN\u53ef\u4ee5\u901a\u8fc7\u6fc0\u6d3bSIRT1\uff0c\u6291\u5236\u4e09\u9634\u6027\u4e73\u817a\u764c\u7684\u751f\u957f\u548c\u8f6c\u79fb\uff0c\u5ef6\u957f\u764c\u75c7\u60a3\u8005\u7684\u751f\u5b58\u671f<\/strong>\u3002\u6709\u8da3\u7684\u662f\uff0c\u5728\u4f53\u5916\u7814\u7a76\u4e2d\uff0c\u6dfb\u52a0NMN\u5e76\u4e0d\u4f1a\u5f71\u54cdHCC1937\u764c\u7ec6\u80de\u7684\u589e\u6b96\u3002\u7814\u7a76\u4eba\u5458\u8ba4\u4e3a\uff0cNMN\u8fd8\u53ef\u80fd\u589e\u5f3a\u514d\u75ab\u7ec6\u80de\u7684\u6297\u764c\u53cd\u5e94\uff0c\u4ece\u800c\u6291\u5236\u80bf\u7624\u751f\u957f\u3002\u65e9\u671f\u7814\u7a76\u53d1\u73b0\uff0c\u4f7f\u7528\u8f83\u4f4e\u5242\u91cf\uff08250\u6beb\u514b\/\u5343\u514b\/\u5929\uff09\u7684NMN\u5bf9\u80bf\u7624\u65e0\u5f71\u54cd\uff0c\u8fd9\u610f\u5473\u7740NMN\u7684\u6297\u764c\u6548\u679c\u4e0e\u5242\u91cf\u6709\u5173\u3002\u9700\u8981\u6ce8\u610f\u7684\u662f\uff0c\u4ee5\u4e0a\u7814\u7a76\u4ec5\u9488\u5bf9\u4e73\u817a\u764c\u8fdb\u884c\uff0c\u56e0\u6b64\u53ea\u80fd\u8bf4\u9ad8\u5242\u91cf\u7684NMN\u53ef\u80fd\u5177\u6709\u6291\u5236\u4e09\u9634\u6027\u4e73\u817a\u764c\u7684\u6f5c\u529b\u3002\u81f3\u4e8eNMN\u662f\u6297\u764c\u8fd8\u662f\u4fc3\u764c\uff0c\u4ecd\u5b58\u5728\u4e89\u8bae\u3002\u6b63\u5982\u5f00\u5934\u6240\u8ff0\uff0c\u5728\u4e0d\u540c\u7684\u7ec6\u80de\u548c\u7ec4\u7ec7\u4e2d\uff0cNMN\u7684\u4f5c\u7528\u4e5f\u662f\u4e0d\u540c\u7684\u3002\u6839\u636e\u76ee\u524d\u5df2\u6709\u7684\u8bc1\u636e\uff0c\u764c\u75c7\u60a3\u8005\u6700\u597d\u4e0d\u8981\u4f7f\u7528NMN\u3002\u8981\u60f3\u771f\u6b63\u5c06NMN\u7528\u4e8e\u6cbb\u7597\u4eba\u7c7b\u4e09\u9634\u6027\u4e73\u817a\u764c\uff0c\u9700\u8981\u8fdb\u884c\u66f4\u591a\u3001\u66f4\u9ad8\u6c34\u5e73\u7684\u4e34\u5e8a\u7814\u7a76\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36690678\/\" target=\"_blank\" rel=\"noopener\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-large wp-image-20310\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/09\/20230123-\u4e73\u817a\u764c-1024x906.png\" alt=\"\" width=\"900\" height=\"796\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/09\/20230123-\u4e73\u817a\u764c-1024x906.png 1024w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/09\/20230123-\u4e73\u817a\u764c-300x265.png 300w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/09\/20230123-\u4e73\u817a\u764c-768x679.png 768w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/09\/20230123-\u4e73\u817a\u764c.png 1038w\" sizes=\"auto, (max-width: 900px) 100vw, 900px\" \/><\/a><\/p>\n<p><strong>\u53c2\u8003\u6587\u732e<\/strong><\/p>\n<section><em>[1]\u00a0Sung, Hyuna et al. \u201cGlobal Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries.\u201d\u00a0CA: a cancer journal for cliniciansvol. 71,3 (2021): 209-249. doi:10.3322\/caac.21660<\/em><em>[2] Harbeck, Nadia, and Michael Gnant. \u201cBreast cancer.\u201d\u00a0Lancet (London, England)\u00a0vol. 389,10074 (2017): 1134-1150. doi:10.1016\/S0140-6736(16)31891-8<\/em><em>[3] Xie, Na et al. \u201cNAD+\u00a0metabolism: pathophysiologic mechanisms and therapeutic potential.\u201d\u00a0Signal transduction and targeted therapy\u00a0vol. 5,1 227. 7 Oct. 2020, doi:10.1038\/s41392-020-00311-7<\/em><\/p>\n<p><em>[4] Jiang, Yi et al. \u201cNAD+\u00a0supplementation limits triple-negative breast cancer metastasis via SIRT1-P66Shc signaling.\u201d\u00a0Oncogene, 10.1038\/s41388-023-02592-y. 23 Jan. 2023, doi:10.1038\/s41388-023-02592-y<\/em><\/p>\n<\/section>\n<p>&nbsp;<\/p>\n<\/section>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<div class=\"pvc_clear\"><\/div>\n<p id=\"pvc_stats_20309\" class=\"pvc_stats all  \" 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