{"id":202,"date":"2022-02-26T19:13:28","date_gmt":"2022-02-26T19:13:28","guid":{"rendered":"http:\/\/choosebiz.me\/?p=202"},"modified":"2022-05-27T03:07:47","modified_gmt":"2022-05-27T03:07:47","slug":"%e6%a2%85%e5%a5%a5%e8%af%8a%e6%89%80%e7%a0%94%e7%a9%b6%e8%a1%a8%e6%98%8e%e8%84%8a%e9%ab%93%e7%a5%9e%e7%bb%8f%e4%be%9d%e8%b5%96%e6%96%bc-nad","status":"publish","type":"post","link":"http:\/\/johnhealth.blog\/ch\/?p=202","title":{"rendered":"\u6885\u5965\u8bca\u6240\u7814\u7a76\u8868\u660e\u810a\u9ad3\u795e\u7ecf\u4f9d\u8d56\u65bc NAD+"},"content":{"rendered":"

\u5728\u5c0f\u9f20\u4e2d\uff0c\u9ad8\u8102\u80aa\u996e\u98df\u4f1a\u5bfc\u81f4\u79f0\u4e3a\u9ad3\u9798\u7684\u4f20\u5bfc\u6027\u795e\u7ecf\u6d82\u5c42\u964d\u89e3\uff0c\u4f46\u5b83\u4eec\u53ef\u4ee5\u901a\u8fc7\u524d\u4f53 NMN \u6062\u590d NAD+ \u6c34\u5e73\u6765\u518d\u751f\u3002<\/p>\n

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By\u00a0Jonathan D. Grinstein, Ph.D.\u00a0Published:\u00a010:46 am PST Oct 11, 2021\u00a0| Updated:\u00a01:53 p.m. PST Oct 15, 2021<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u91cd\u5927\u4eae\u70b9<\/h3>\n

\u25cf\u00a0\u9ad8\u8102\u80aa\u996e\u98df\u4f1a\u964d\u4f4e\u5c0f\u9f20\u7684 NAD+ \u6c34\u5e73\uff0c\u4ece\u800c\u5bf9\u4ea7\u751f\u9ad3\u9798\u7684\u7ec6\u80de\uff08\u79f0\u4e3a\u5be1\u7a81\u80f6\u8d28\u7ec6\u80de\uff09\u7684\u5b58\u6d3b\u548c\u529f\u80fd\u4ea7\u751f\u4e0d\u5229\u5f71\u54cd\u3002<\/p>\n

\u25cf\u00a0\u901a\u8fc7\u9057\u4f20\u6216\u57fa\u65bc\u836f\u7269\u7684\u64cd\u4f5c\u706d\u6d3b CD38\uff08\u4e00\u79cd NAD+ \u6d88\u8017\u9176\uff09\u53ef\u63d0\u9ad8\u5be1\u7a81\u80f6\u8d28\u7ec6\u80de\u7684\u5b58\u6d3b\u7387\u3002<\/p>\n

\u25cf\u00a0\u4f7f\u7528 NAD+ \u524d\u4f53 NMN \u6062\u590d NAD+ \u6c34\u5e73\u53ef\u9632\u6b62\u5be1\u7a81\u80f6\u8d28\u7ec6\u80de\u4e22\u5931\u5e76\u4fc3\u8fdb\u9ad3\u9798\u4fee\u590d\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u5bf9\u65bc\u6709\u610f\u8bc6\u548c\u6f5c\u610f\u8bc6\u7684\u4efb\u52a1\uff0c\u4ece\u62e5\u62b1\u5230\u547c\u5438\uff0c\u6211\u4eec\u7684\u795e\u7ecf\u7cfb\u7edf\u9700\u8981\u4ee5\u95ea\u7535\u822c\u7684\u901f\u5ea6\u53d1\u9001\u7535\u4fe1\u53f7\u3002 \u4e3a\u4e86\u5b9e\u73b0\u7c7b\u4f3c\u751f\u7269\u5149\u7ea4\u7684\u4f20\u8f93\uff0c\u6211\u4eec\u79f0\u4e3a\u795e\u7ecf\u5143\u7684\u795e\u7ecf\u7ec6\u80de\u5728\u9ad3\u9798\u4e2d\u7edd\u7f18\u2014\u2014\u9ad3\u9798\u662f\u4e00\u79cd\u7528\u65bc\u5feb\u901f\u795e\u7ecf\u901a\u8baf\u7684\u5bfc\u7535\u8986\u76d6\u7269\u3002 \u4f46\u662f\u5f53\u9ad3\u9798\u88ab\u7834\u574f\u65f6\uff0c\u968f\u7740\u5e74\u9f84\u7684\u589e\u957f\u4e36\u67d0\u4e9b\u9057\u4f20\u75be\u75c5\uff08\u5982\u591a\u53d1\u6027\u786c\u5316\u75c7\uff09\u548c\u65b0\u9648\u4ee3\u8c22\u4e0d\u826f\u800c\u53d1\u751f\uff0c\u6211\u4eec\u5c31\u5bb9\u6613\u53d7\u5230\u6c38\u4e45\u6027\u810a\u9ad3\u548c\u8111\u635f\u4f24\u7684\u5f71\u54cd\u3002 \u56e0\u6b64\uff0c\u6240\u6709\u7684\u901f\u98df\u548c\u4e0d\u8fd0\u52a8\u4e0d\u4ec5\u4e0d\u5229\u65bc\u60a8\u7684\u65b0\u9648\u4ee3\u8c22\uff1b \u5b83\u4f1a\u7834\u574f\u9ad3\u9798\u6d82\u5c42\uff0c\u4ece\u800c\u4e25\u91cd\u524a\u5f31\u65e5\u5e38\u751f\u6d3b\u4e2d\u5fc5\u4e0d\u53ef\u5c11\u7684\u795e\u7ecf\u4fe1\u53f7\u3002<\/p>\n

\u53d1\u8868\u5728\u5b66\u672f\u671f\u520a\u300a\u795e\u7ecf\u79d1\u5b66\u300b(The Journal of Neuroscience)\u4e0a\u7684\u6885\u5965\u8bca\u6240\u7684\u7814\u7a76\u8868\u660e\uff0c\u767d\u8d28\uff08\u9ad3\u9798\u5305\u88f9\u7684\u795e\u7ecf\u6295\u5c04\u7a7f\u8fc7\u5927\u8111\u548c\u810a\u9ad3\u7684\u5730\u65b9\uff09\u4f1a\u56e0\u9ad8\u8102\u80aa\u6d88\u8017\u800c\u53d7\u635f<\/a>\u3002 \u8fd9\u662f\u901a\u8fc7\u7834\u574f\u4e00\u79cd\u79f0\u4e3a\u70df\u9170\u80fa\u817a\u560c\u5464\u4e8c\u6838\u82f7\u9178 (NAD+) \u7684\u91cd\u8981\u4ee3\u8c22\u8f85\u9176\u7684\u6c34\u5e73\u800c\u53d1\u751f\u7684\uff0c\u5bfc\u81f4\u5c06\u9ad3\u78f7\u8102\u6dfb\u52a0\u5230\u795e\u7ecf\u5143\u7684\u7ec6\u80de\u2500\u2500\u5373\u79f0\u4e3a\u5be1\u7a81\u80f6\u8d28\u7ec6\u80de\u7684\u795e\u7ecf\u7cfb\u7edf\u7ec6\u80de\u4e27\u5931\u3002 \u4f46\u662f\u901a\u8fc7\u963b\u6b62 NAD+ \u7684\u6d88\u8017\u6216\u8865\u5145\u524d\u4f53\u70df\u9170\u80fa\u5355\u6838\u82f7\u9178 (NMN) \u6765\u589e\u52a0 NAD+ \u6c34\u5e73\uff0c\u53ef\u4ee5\u51cf\u8f7b\u5be1\u7a81\u80f6\u8d28\u7ec6\u80de\u7684\u635f\u5931\u5e76\u4fc3\u8fdb\u9ad3\u9798\u518d\u751f\u3002<\/p>\n

\u201c\u8fd9\u4e9b\u53d1\u73b0\u6307\u51fa\u4e86\u4e00\u79cd\u65b0\u7684\u4ee3\u8c22\u9776\u5411\u7b56\u7565\uff0c\u65e8\u5728\u6539\u5584\u591a\u53d1\u6027\u786c\u5316\u75c7\u548c\u5176\u4ed6\u9ad3\u9798\u5b8c\u6574\u6027\u5173\u952e\u95ee\u9898\u7684\u75be\u75c5\u7684\u8fdb\u7a0b\uff0c\u201d\u4f5c\u8005\u8bf4\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u996e\u98df\u548c NAD+ \u4e0e\u591a\u53d1\u6027\u786c\u5316\u75c7\u7684\u76f8\u5173\u6027<\/span><\/h3>\n

\u897f\u5f0f\u996e\u98df\u4f1a\u7834\u574f\u79f0\u4e3a\u5be1\u7a81\u80f6\u8d28\u7ec6\u80de\u7684\u9ad3\u9798\u7ec6\u80de\u548c\u79f0\u4e3a\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u7684\u652f\u6301\u7ec6\u80de\u3002 \u80a5\u80d6\u662f\u591a\u53d1\u6027\u786c\u5316\u75c7\u7684\u53d1\u5c55\u4e36\u8fdb\u7a0b\u548c\u5bfc\u81f4\u6b8b\u75be\u7684\u5173\u952e\u98ce\u9669\u56e0\u7d20\uff0c\u591a\u53d1\u6027\u786c\u5316\u75c7\u662f\u4e00\u79cd\u514d\u75ab\u7cfb\u7edf\u4fb5\u8680\u9ad3\u9798\u7684\u75be\u75c5\uff0c\u7834\u574f\u4e86\u5927\u8111\u548c\u8eab\u4f53\u4e4b\u95f4\u7684\u4ea4\u6d41\u3002<\/p>\n

CD38\u00a0\u662f\u795e\u7ecf\u7cfb\u7edf\u4e2d\u4e3b\u8981\u7684 NAD+ \u6d88\u8017\u9176<\/a>\uff0c\u5728\u591a\u53d1\u6027\u786c\u5316\u75c7\u6a21\u578b\u4e2d\u6c34\u5e73\u5347\u9ad8\u3002 \u6539\u53d8\u7684 NAD+ \u4ee3\u8c22\u4e0e\u9ad8\u8102\u80aa\u6d88\u8017\u548c\u591a\u53d1\u6027\u786c\u5316\u75c7\u6709\u5173\u3002 \u6b64\u5916\uff0c\u6700\u8fd1\u7684\u51e0\u9879\u7814\u7a76\u63a2\u7d22\u4e86\u8865\u5145 NAD+ \u524d\u4f53\u6216\u79f0\u4e3a\u9ec4\u916e\u7c7b\u5316\u5408\u7269\u7684\u690d\u7269\u884d\u751f\u5316\u5408\u7269\uff0c\u8fd9\u4e9b\u5316\u5408\u7269\u5df2\u77e5\u53ef\u6291\u5236 NAD+ \u6d88\u8017\u9176\u963b\u788d\u9ad3\u9798\u4fee\u590d\u548c\u795e\u7ecf\u4fdd\u62a4\u3002 \u4f8b\u5982\uff0cNAD+ \u524d\u4f53\u8865\u5145\u5242\u5728\u5404\u79cd\u795e\u7ecf\u75be\u75c5\u6a21\u578b\uff08\u5982\u4e2d\u98ce\u548c\u4ea8\u5ef7\u987f\u821e\u8e48\u75c7\uff09\u4e2d\u5177\u6709\u6cbb\u7597\u6027\u9ad3\u9798\u518d\u751f\u4f5c\u7528\u3002<\/p>\n

CD38 \u6c89\u9ed8\u7684\u5c0f\u9f20\u62b5\u6297\u9ad8\u8102\u80aa\u996e\u98df\u5f15\u8d77\u7684\u5be1\u7a81\u80f6\u8d28\u7ec6\u80de\u4e22\u5931<\/p>\n

\u5728\u8fd9\u9879\u7814\u7a76\u4e2d\uff0cLangley\u548c\u6885\u5965\u8bca\u6240\u7684\u540c\u4e8b\u5c06\u996e\u98df\u4e36\u9ad3\u78f7\u8102\u548c NAD+ \u8054\u7ed3\u5728\u4e00\u8d77\u3002 \u4ed6\u4eec\u53d1\u73b0\uff0c\u5728\u6162\u6027\u9ad8\u8102\u80aa\u6d88\u8017\u4e36\u8131\u9ad3\u9798\u635f\u4f24\u548c\u6d3b\u52a8\u6027\u591a\u53d1\u6027\u786c\u5316\u6837\u75c5\u53d8\uff08\u810a\u9ad3\u548c\u5927\u8111\u4e2d\u7684\u635f\u4f24\u6216\u75a4\u75d5\uff08\u786c\u5316\uff09\u533a\u57df\uff09\u5f8c\uff0c\u5c0f\u9f20\u810a\u9ad3\u4e2d CD38 \u7684\u6c34\u5e73\u5347\u9ad8\uff0cNAD+\u7684 \u6c34\u5e73\u964d\u4f4e\u3002 \u4f46\u662f\uff0c\u57fa\u56e0\u6216\u6cbb\u7597\u5931\u53bb\u6d3b\u6027\u7684 CD38\u7684\u5c0f\u9f20\uff0c\u5728\u9ad8\u8102\u80aa\u8bf1\u5bfc\u7684 NAD+ \u8017\u7aed\u548c\u5be1\u7a81\u80f6\u8d28\u7ec6\u80de\u4e22\u5931\u65b9\u9762\u5f97\u5230\u4e86\u663e\u7740\u7684\u4fdd\u62a4\u3002<\/p>\n

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\u6291\u5236 CD38 \u53ef\u963b\u6b62\u9ad8\u8102\u80aa\u996e\u98df\u8bf1\u5bfc\u7684\u5be1\u7a81\u80f6\u8d28\u7ec6\u80de\u4e22\u5931\u5e76\u4fc3\u8fdb\u9ad3\u9798\u4fee\u590d\u3002\u00a0\uff08\u5de6\u4e0a\uff09\u4e0e\u91c7\u7528\u5e38\u89c4\u996e\u98df (RD) \u7684\u975e\u8f6c\u57fa\u56e0\u5c0f\u9f20\u7684 NAD+ \u6c34\u5e73\u76f8\u6bd4\uff0c\u91c7\u7528\u9ad8\u8102\u80aa\u996e\u98df (HFD) \u7684\u5c0f\u9f20\u7684\u810a\u9ad3 NAD+ \u6c34\u5e73\u663e\u7740\u964d\u4f4e\u3002 \u5f53 CD38 \u88ab\u57fa\u56e0\u6c89\u9ed8 (CD38ci) \u65f6\uff0c\u65e0\u8bba\u996e\u98df\u5982\u4f55\uff0c\u5c0f\u9f20\u7684 NAD+ \u6c34\u5e73\u90fd\u4f1a\u589e\u52a0\u3002 \uff08\u53f3\u4e0a\uff09\u5be1\u7a81\u80f6\u8d28\u7ec6\u80de\u8c31\u7cfb\u7684\u7ec6\u80de\u6761\u5f62\u56fe\uff1a\u65e9\u671f\uff08PDGFR\u03b1\uff0c\u7ea2\u8272\uff09\u4e36\u4e2d\u671f\uff08Olig2\uff0c\u9752\u8272\uff09\u548c\u6210\u719f\u5be1\u7a81\u80f6\u8d28\u7ec6\u80de\u6807\u8bb0\u7269\uff08ASPA\uff0c\u7eff\u8272\uff09\u3002 CD38 \u6291\u5236\u5c0f\u9f20\u6062\u590d\u88ab\u9ad8\u8102\u80aa\u996e\u98df\u7834\u574f\u7684\u5be1\u7a81\u80f6\u8d28\u7ec6\u80de\u6c34\u5e73\u3002 \uff08\u5e95\u884c\uff09CD38 \u6291\u5236\u5242 78c \u53ef\u6539\u5584\u810a\u9ad3\u5316\u5b66\u8bf1\u5bfc\u8131\u9ad3\u9798 (LL) \u5f8c\u7684\u9ad3\u9798\u518d\u751f\u548c\u9ad3\u9798\u7ed3\u5408\u86cb\u767d (MBP) \u6c34\u5e73\u3002<\/p>\n

NAD+ \u548c NMN \u5728\u8102\u80aa\u9971\u548c\u57f9\u517b\u7269\u4e2d\u6062\u590d\u5be1\u7a81\u80f6\u8d28\u7ec6\u80de\u5206\u5316<\/p>\n

\u4e3a\u4e86\u68c0\u67e5\u8865\u5145 NAD+ \u6c34\u5e73\u5bf9\u795e\u7ecf\u7cfb\u7edf\u7684\u5f71\u54cd\uff0cLangley \u53ca\u5176\u540c\u4e8b\u63a5\u4e0b\u6765\u7528 NAD+ \u6216 NMN \u8865\u5145\u5be1\u7a81\u80f6\u8d28\u7ec6\u80de\u57f9\u517b\u7269\u3002 \u867d\u7136\u5355\u72ec\u4f7f\u7528\u9971\u548c\u8102\u80aa\u4f1a\u964d\u4f4e\u5173\u952e\u5be1\u7a81\u80f6\u8d28\u7ec6\u80de\u548c\u9ad3\u9798\u86cb\u767d\u7684\u6c34\u5e73\uff0c\u4f46\u4e0e NAD+ \u6216 NMN \u5171\u540c\u5904\u7406\u5c06\u8fd9\u4e9b\u6c34\u5e73\u6062\u590d\u5230\u672a\u5904\u7406\u7ec6\u80de\u7684\u6c34\u5e73\u3002 \u8fd9\u4e9b\u53d1\u73b0\u8868\u660e\uff0c\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u7684 CD38 \u7684\u589e\u52a0\u4ee5\u53ca\u76f8\u5173\u7684 NAD+ \u6c34\u5e73\u7684\u6d88\u8017\uff0c\u53ef\u80fd\u901a\u8fc7\u708e\u75c7\u548c\u6c27\u5316\u5e94\u6fc0\uff0c\u95f4\u63a5\u5bfc\u81f4\u5be1\u7a81\u80f6\u8d28\u7ec6\u80de\u7684\u5065\u5eb7\u548c\u9ad3\u9798\u7684\u518d\u751f\u53d7\u635f\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u8865\u5145NAD+\u5bf9\u9971\u548c\u8102\u80aa\u66b4\u9732\u7684\u5be1\u7a81\u80f6\u8d28\u7ec6\u80de\u9ad3\u9798\u86cb\u767d\u7684\u76f4\u63a5\u5f71\u54cd\u3002\u00a0\u66b4\u9732\u65bc\u57f9\u517b\u76bf\u4e2d\u9971\u548c\u8102\u80aa\u68d5\u6988\u9178\u916f (PA) \u7684\u5be1\u7a81\u80f6\u8d28\u7ec6\u80de\u964d\u4f4e\u4e86\u5173\u952e\u5be1\u7a81\u80f6\u8d28\u7ec6\u80de\u548c\u9ad3\u9798\u86cb\u767d PLP\uff08\u5de6\uff09\u548c MBP\uff08\u53f3\uff09\u7684\u6c34\u5e73\u3002 \u8865\u5145 NMN \u4f7f PLP \u548c MBP \u7684\u6c34\u5e73\u6062\u590d\u5230\u672a\u5904\u7406\u7684\u5be1\u7a81\u80f6\u8d28\u7ec6\u80de\u7684\u6c34\u5e73\u3002 NMN \u7684\u4f5c\u7528\u88ab SIRT1 \u6291\u5236\u5242\u963b\u65ad\uff0cSIRT1 \u662f\u4e00\u79cd\u4f9d\u8d56\u65bc NAD+ \u7684\u9176\uff0c\u5bf9\u7ec6\u80de\u5065\u5eb7\u548c\u5b58\u6d3b\u81f3\u5173\u91cd\u8981\uff0c\u79f0\u4e3a EX527\u3002<\/p>\n

\u201c\u6211\u4eec\u7684\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0c\u9ad8\u8102\u80aa\u996e\u98df\u4f1a\u635f\u5bb3\u5be1\u7a81\u80f6\u8d28\u7ec6\u80de\u7684\u5b58\u6d3b\u548c\u5206\u5316\u2026\u2026\u7531 NAD+ \u6d88\u8017\u9176 CD38 \u4ecb\u5bfc\uff0c\u5e76\u5f3a\u8c03 CD38 \u6291\u5236\u5242\u662f\u6539\u5584\u9ad3\u9798\u518d\u751f\u7684\u6f5c\u5728\u6cbb\u7597\u5019\u9009\u7269\uff0c\u201dLangley\u53ca\u5176\u540c\u4e8b\u8bf4\u3002<\/p>\n

\u4ed6\u4eec\u8fd8\u8868\u793a\uff0c\u8fd9\u4e9b\u7814\u7a76\u662f\u672a\u6765\u7814\u7a76\u7684\u57fa\u7840\uff0c\u4ee5\u9610\u660e\u996e\u98df\u5728\u53d1\u80b2\u548c\u8870\u8001\u8fc7\u7a0b\u4e2d\u5bf9\u5be1\u7a81\u80f6\u8d28\u7ec6\u80de\u7684\u4f5c\u7528\u3002<\/p>\n

\u8fd9\u4e9b\u53d1\u73b0\u5171\u540c\u6307\u51fa\u4e86\u9776\u5411 CD38 \u4ee5\u6539\u5584\u591a\u53d1\u6027\u786c\u5316\u75c7\u548c\u5176\u4ed6\u8131\u9ad3\u9798\u75be\u75c5\u7684\u7ed3\u679c\u7684\u6f5c\u5728\u8f6c\u5316\u4ef7\u503c\u3002<\/p>\n

\u4f5c\u8005\u63d0\u51fa\uff0c\u201c\u6211\u4eec\u63d0\u51fa\u7684\u7814\u7a76\u7ed3\u679c\u5e94\u8be5\u6fc0\u53d1\u8fdb\u4e00\u6b65\u7814\u7a76\uff0c\u4ee5\u51cf\u8f7b\u9ad8\u8102\u80aa\u996e\u98df\u5bf9\u5be1\u7a81\u80f6\u8d28\u7ec6\u80de\u7684\u8d1f\u9762\u5f71\u54cd\uff0c\u4ee5\u53ca\u5728\u767d\u8d28\u635f\u4f24\u7684\u80cc\u666f\u4e0b\uff0c\u8fd9\u53ef\u80fd\u5305\u62ec\u996e\u98df\u6444\u5165 NAD+ \u524d\u4f53\u4e36\u7ed9\u4e88 CD38 \u6291\u5236\u5242\u6216\u8fd0\u52a8\u76f8\u5173\u7684\u5eb7\u590d\u7b56\u7565\u3002\u201d<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u7531\u6444\u5165\u9ad8\u8102\u80aa\u996e\u98df\u5f15\u53d1\u7684\u4ee3\u8c22\u7d0a\u4e71\u901a\u8fc7\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u76f8\u5173\u7684\u95f4\u63a5 NAD+ \u4f9d\u8d56\u6027\u673a\u5236\u4fc3\u8fdb\u5be1\u7a81\u80f6\u8d28\u7ec6\u80de\u4e22\u5931\u5e76\u635f\u5bb3\u9ad3\u9798\u518d\u751f\u3002\u00a0\u9759\u606f\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u901a\u5e38\u6709\u52a9\u65bc\u5728\u5fc5\u8981\u65f6\u4e3a\u5be1\u7a81\u80f6\u8d28\u7ec6\u80de\u5206\u5316\u548c\u4fee\u590d\u63d0\u4f9b\u652f\u6301\u73af\u5883\u3002 \u9ad8\u8102\u80aa\u996e\u98df (HFD) \u548c\u6eb6\u8840\u5375\u78f7\u8102 (LL) \u4f1a\u589e\u52a0\u53cd\u5e94\u6027\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u4e2d CD38 \u7684\u8868\u8fbe\uff0c\u4ece\u800c\u6d88\u8017 NAD+ \u6c34\u5e73\u3002 NAD+ \u7684\u51cf\u5c11\u4f1a\u89e6\u53d1\u5be1\u7a81\u80f6\u8d28\u7ec6\u80de\u8c31\u7cfb\u7ec6\u80de\u7684\u5206\u5316\u548c\u5b58\u6d3b\u53d7\u635f\u3002 CD38 \u6291\u5236\u5242 78c \u6291\u5236\u5bf9\u5be1\u7a81\u80f6\u8d28\u7ec6\u80de\u7684\u4e0d\u5229\u5f71\u54cd\u5e76\u6539\u5584\u9ad3\u9798\u4fee\u590d\u3002<\/p>\n

\u53c2\u8003\u6587\u732e:\u00a0Langley MR, Choi CI, Peclat TR, Guo Y, Simon W, Yoon H, Kleppe L, Lucchinetti CF, Chini CCS, Chini EN, Scarisbrick IA. Critical Role of Astrocyte NAD+ Glycohydrolase in Myelin Injury and Regeneration. J Neurosci. 2021 Sep 7:JN-RM-2264-20. doi: 10.1523\/JNEUROSCI.2264-20.2021. Epub ahead of print. PMID: 34493542.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u6587\u7ae0\u4f86\u6e90:https:\/\/www.nmn.com\/news\/mayo-clinic-spinal-cord-nerve-projection-health-nad<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u5728\u5c0f\u9f20\u4e2d\uff0c\u9ad8\u8102\u80aa\u996e\u98df\u4f1a\u5bfc\u81f4\u79f0\u4e3a\u9ad3\u9798\u7684\u4f20\u5bfc\u6027\u795e\u7ecf\u6d82\u5c42\u964d\u89e3\uff0c\u4f46\u5b83\u4eec\u53ef\u4ee5\u901a\u8fc7\u524d\u4f53 NMN \u6062\u590d NAD+ \u6c34\u5e73\u6765\u518d\u751f\u3002 By\u00a0Jonathan D. Grinstein, Ph.D.\u00a0Published:\u00a010:46 am PST Oct 11, 2021\u00a0| Updated:\u00a01:53 p.m. PST Oct 15, 2021   \u91cd\u5927\u4eae\u70b9 \u25cf\u00a0\u9ad8\u8102\u80aa\u996e\u98df\u4f1a\u964d\u4f4e\u5c0f\u9f20\u7684 NAD+ \u6c34\u5e73\uff0c\u4ece\u800c\u5bf9\u4ea7\u751f\u9ad3\u9798\u7684\u7ec6\u80de\uff08\u79f0\u4e3a\u5be1\u7a81\u80f6\u8d28\u7ec6\u80de\uff09\u7684\u5b58\u6d3b\u548c\u529f\u80fd\u4ea7\u751f\u4e0d\u5229\u5f71\u54cd\u3002 \u25cf\u00a0\u901a\u8fc7\u9057\u4f20\u6216\u57fa\u65bc\u836f\u7269\u7684\u64cd\u4f5c\u706d\u6d3b CD38\uff08\u4e00\u79cd NAD+ \u6d88\u8017\u9176\uff09\u53ef\u63d0\u9ad8\u5be1\u7a81\u80f6\u8d28\u7ec6\u80de\u7684\u5b58\u6d3b\u7387\u3002 \u25cf\u00a0\u4f7f\u7528 NAD+ \u524d\u4f53 NMN \u6062\u590d NAD+ \u6c34\u5e73\u53ef\u9632\u6b62\u5be1\u7a81\u80f6\u8d28\u7ec6\u80de\u4e22\u5931\u5e76\u4fc3\u8fdb\u9ad3\u9798\u4fee\u590d\u3002<\/p>\n

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