{"id":20165,"date":"2023-05-13T13:33:16","date_gmt":"2023-05-13T13:33:16","guid":{"rendered":"http:\/\/johnhealth.blog\/ch\/?p=20165"},"modified":"2023-05-13T13:33:16","modified_gmt":"2023-05-13T13:33:16","slug":"%e5%af%bc%e8%87%b4%e7%a5%9e%e7%bb%8f%e9%80%80%e8%a1%8c%e6%80%a7%e7%96%be%e7%97%85%ef%bc%88ndd%ef%bc%89%e7%9a%84%e5%9b%a0%e7%b4%a0-%e8%a1%a5%e5%85%85nmn%e5%8f%af%e9%99%8d%e4%bd%8e%e7%a5%9e%e7%bb%8f","status":"publish","type":"post","link":"http:\/\/johnhealth.blog\/ch\/?p=20165","title":{"rendered":"\u5bfc\u81f4\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\uff08NDD\uff09\u7684\u56e0\u7d20, \u8865\u5145NMN\u53ef\u964d\u4f4e\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\uff08NDD\uff09\u98ce\u9669"},"content":{"rendered":"<p>\u4e16\u754c\u536b\u751f\u7ec4\u7ec7\u9884\u6d4b\uff0c\u52302040\u5e74\uff0c\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\uff08Neurodegenerative Disease, NDD\uff09\u5c06\u4f1a\u53d6\u4ee3\u764c\u75c7\uff0c\u6210\u4e3a\u4eba\u7c7b\u7b2c\u4e8c\u5927\u81f4\u6b7b\u75be\u75c5\u3002\u7136\u800c\u76ee\u524d\u4e16\u754c\u8303\u56f4\u5185\u8fd8\u6ca1\u6709\u4efb\u4f55\u4e00\u79cd\u836f\u7269\u80fd\u591f\u6709\u6548\u6cbb\u7597NDD\u3002<br \/>\nNDD\u662f\u4e00\u7c7b\u53d1\u751f\u5728\u795e\u7ecf\u7cfb\u7edf\u4e2d\uff0c\u9020\u6210\u795e\u7ecf\u5143\u53ca\u5176\u9644\u5c5e\u6811\u7a81\u4e36\u8f74\u7a81\u548c\u7a81\u89e6\uff0c\u4ee5\u53ca\u904d\u5e03\u795e\u7ecf\u7cfb\u7edf\u7684\u80f6\u8d28\u7ec6\u80de\u53d1\u751f\u635f\u4f24\u6216\u8005\u529f\u80fd\u5931\u5e38\u7684\u75be\u75c5\uff0c\u5176\u4e2d\u5178\u578b\u7684\u75be\u75c5\u5305\u62ec\u963f\u5c14\u5179\u6d77\u9ed8\u75c5\u4e36\u5e15\u91d1\u68ee\u75c5\u4e36\u808c\u8089\u840e\u7f29\u6027\u4fa7\u7d22\u786c\u5316\u75c7\u7b49\u3002<\/p>\n<h3><strong><span style=\"color: #ff6600;\">\u5bfc\u81f4\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\uff08NDD\uff09\u7684\u56e0\u7d20<\/span><\/strong><\/h3>\n<p>\u9057\u4f20\u548c\u57fa\u56e0\u6539\u53d8\u662f\u5f88\u591aNDD\u7684\u5371\u9669\u56e0\u7d20\uff0c\u7269\u7406\u4e36\u5316\u5b66\u548c\u751f\u7269\u523a\u6fc0\uff08\u5982\u5916\u4f24\u4e36\u6740\u866b\u5242\u548c\u611f\u67d3\uff09\u4e5f\u4f1a\u63d0\u9ad8NDD\u7684\u53d1\u75c5\u7387\u3002\u9664\u6b64\u4ee5\u5916\uff0c\u76ee\u524d\u4e0eNDD\u6700\u5177\u5173\u8054\u7684\u5c31\u662f\u5e74\u9f84\u4e86\u3002\u65f6\u4ee3\u7684\u53d1\u5c55\u548c\u79d1\u6280\u7684\u8fdb\u6b65\uff0c\u4f7f\u5f97\u5168\u7403\u4e0d\u53ef\u907f\u514d\u8fdb\u5165\u8001\u9f84\u5316\u72b6\u6001\uff0cNDD\u7684\u5371\u5bb3\u4e5f\u9010\u6e10\u51f8\u663e\u3002\u4eba\u7c7b\u7684\u5e73\u5747\u5bff\u547d\u4ece\u4e0d\u523040\u5c81\u5230\u73b0\u5728\u768470\u5c81\u4ee5\u4e0a\uff0c\u53ea\u7528\u4e86\u77ed\u77ed200\u5e74\u7684\u65f6\u95f4\uff0c\u8fd9\u8ba9200\u5e74\u524d\u7f55\u89c1\u7684\u75be\u75c5\u5982\u764c\u75c7\u548c\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u53d6\u4ee3\u4f17\u591a\u6d41\u884c\u75c5\u6210\u4e3a\u75be\u75c5\u821e\u53f0\u7684\u4e2d\u5fc3\u3002<\/p>\n<p>\u6240\u4ee5\uff0c<strong><span style=\"color: #ff0000;\">\u8870\u8001\u662f\u9020\u6210\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u9ad8\u53d1\u7684\u9ad8\u5371\u56e0\u7d20\u3002<\/span><\/strong><!--more--><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-20166\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/05\/NDD.jpg\" alt=\"\" width=\"761\" height=\"495\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/05\/NDD.jpg 761w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/05\/NDD-300x195.jpg 300w\" sizes=\"auto, (max-width: 761px) 100vw, 761px\" \/><\/p>\n<h3><strong><span style=\"color: #ff6600;\">\u8865\u5145NMN\u53ef\u964d\u4f4e\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\uff08NDD\uff09\u98ce\u9669<\/span><\/strong><\/h3>\n<p>\u8bf8\u591a\u79d1\u7814\u8bc1\u5b9e\uff0c\u8865\u5145NMN\u80fd\u6709\u6548\u63d0\u5347\u968f\u5e74\u9f84\u589e\u957f\u800c\u51cf\u5c11\u7684NAD+\u6c34\u5e73\uff0c\u4fdd\u8bc1\u7ebf\u7c92\u4f53\u529f\u80fd\uff0c\u6fc0\u6d3b\u6297\u8870\u8001\u86cb\u767dSIRT\uff0c\u53ca\u65f6\u4fee\u590d\u53d7\u635f\u7ec6\u80de\uff0c\u8fbe\u5230\u6297\u8870\u8001\u529f\u6548\u3002<br \/>\n\u5728\u5927\u591a\u6570NDD\u4e2d\uff0c\u6c27\u5316\u5e94\u6fc0\u4e0e\u795e\u7ecf\u5143\u7ec6\u80de\u6b7b\u4ea1\u6709\u5173\u3002\u7ebf\u7c92\u4f53\u662f\u6d3b\u6027\u6c27\u4ea7\u751f\u7684\u573a\u6240\uff0c\u8fc7\u591a\u7684\u6d3b\u6027\u6c27\u4f1a\u7834\u574f\u7ebf\u7c92\u4f53\uff0c\u4f46\u662f\uff0c\u7ebf\u7c92\u4f53\u4e2d\u542b\u6709\u6297\u6c27\u5316\u5242\u8d85\u6c27\u5316\u7269\u6b67\u5316\u91762\uff08SOD2\uff09\uff0c\u53ef\u4ee5\u51cf\u5c11\u6d3b\u6027\u6c27\u542b\u91cf\u3002\u8865\u5145NMN\u80fd\u589e\u52a0SOD2\u542b\u91cf\uff0c\u51cf\u8f7b\u6c27\u5316\u5e94\u6fc0\u5e76\u51cf\u5c11\u795e\u7ecf\u75c5\u53d8\u3002<\/p>\n<p>\u54fa\u4e73\u52a8\u7269\u4e2d\u7684\u6297\u8870\u8001\u86cb\u767dSIRT\u53ef\u4ee5\u901a\u8fc7\u8131\u4e59\u9170\u4f5c\u7528\u8c03\u8282\u86cb\u767d\u8d28\u7684\u6d3b\u6027\uff0c\u4f53\u5185\u5916\u7814\u7a76\u8868\u660e\u6fc0\u6d3bSIRT\u80fd\u62b5\u6297\u795e\u7ecf\u529f\u80fd\u9000\u5316\u3002\u5176\u4e2dSIRT3\u4f4d\u65bc\u7ebf\u7c92\u4f53\u5185\uff0c\u5b83\u7684\u9776\u6807\u86cb\u767d\u4e4b\u4e00\u5c31\u662fSOD2\u3002\u800cSIRT\u53d1\u6325\u6d3b\u6027\u9700\u8981NAD+\u4f5c\u4e3a\u5e95\u7269\uff0cNMN\uff08\u70df\u9170\u80fa\u5355\u6838\u82f7\u9178\uff09\u4f5c\u4e3aNAD+\u7684\u524d\u4f53\u53ef\u4ee5\u6fc0\u6d3bSIRT\u3002\u6240\u4ee5\u8865\u5145NMN\u53ef\u901a\u8fc7\u6fc0\u6d3bSIRT\u53d1\u6325\u795e\u7ecf\u4fdd\u62a4\u529f\u80fd\u3002<\/p>\n<p>\u5927\u591a\u6570NDD\u6f5c\u4f0f\u671f\u5f88\u957f\uff0c\u751a\u81f3\u80fd\u8d85\u8fc720\u5e74\uff0c\u800c\u4eba\u7c7b\u795e\u7ecf\u7cfb\u7edf\u51e0\u4e4e\u4e0d\u53ef\u518d\u751f\uff0c\u75c5\u60c5\u7684\u52a0\u91cd\u662f\u4e0d\u53ef\u9006\u7684\u3002\u56e0\u6b64\u901a\u8fc7\u8865\u5145NMN\u964d\u4f4e\u8fd9\u4e9b\u75be\u75c5\u7684\u60a3\u75c5\u98ce\u9669\u662f\u975e\u5e38\u6709\u5fc5\u8981\u7684\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-large wp-image-18581\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/08\/nmn-14-1536x809-1-1024x539.jpg\" alt=\"\" width=\"900\" height=\"474\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/08\/nmn-14-1536x809-1-1024x539.jpg 1024w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/08\/nmn-14-1536x809-1-300x158.jpg 300w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/08\/nmn-14-1536x809-1-768x405.jpg 768w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/08\/nmn-14-1536x809-1.jpg 1536w\" sizes=\"auto, (max-width: 900px) 100vw, 900px\" \/><\/p>\n<div class=\"pvc_clear\"><\/div>\n<p id=\"pvc_stats_20165\" class=\"pvc_stats all  \" data-element-id=\"20165\" style=\"\"><i class=\"pvc-stats-icon medium\" aria-hidden=\"true\"><svg aria-hidden=\"true\" focusable=\"false\" data-prefix=\"far\" data-icon=\"chart-bar\" role=\"img\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\" class=\"svg-inline--fa fa-chart-bar fa-w-16 fa-2x\"><path fill=\"currentColor\" d=\"M396.8 352h22.4c6.4 0 12.8-6.4 12.8-12.8V108.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v230.4c0 6.4 6.4 12.8 12.8 12.8zm-192 0h22.4c6.4 0 12.8-6.4 12.8-12.8V140.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v198.4c0 6.4 6.4 12.8 12.8 12.8zm96 0h22.4c6.4 0 12.8-6.4 12.8-12.8V204.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v134.4c0 6.4 6.4 12.8 12.8 12.8zM496 400H48V80c0-8.84-7.16-16-16-16H16C7.16 64 0 71.16 0 80v336c0 17.67 14.33 32 32 32h464c8.84 0 16-7.16 16-16v-16c0-8.84-7.16-16-16-16zm-387.2-48h22.4c6.4 0 12.8-6.4 12.8-12.8v-70.4c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v70.4c0 6.4 6.4 12.8 12.8 12.8z\" class=\"\"><\/path><\/svg><\/i> <img loading=\"lazy\" decoding=\"async\" width=\"16\" height=\"16\" alt=\"Loading\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/plugins\/page-views-count\/ajax-loader-2x.gif\" border=0 \/><\/p>\n<div class=\"pvc_clear\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u4e16\u754c\u536b\u751f\u7ec4\u7ec7\u9884\u6d4b\uff0c\u52302040\u5e74\uff0c\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\uff08Neurodegenerative Disease, NDD\uff09\u5c06\u4f1a\u53d6\u4ee3\u764c\u75c7\uff0c\u6210\u4e3a\u4eba\u7c7b\u7b2c\u4e8c\u5927\u81f4\u6b7b\u75be\u75c5\u3002\u7136\u800c\u76ee\u524d\u4e16\u754c\u8303\u56f4\u5185\u8fd8\u6ca1\u6709\u4efb\u4f55\u4e00\u79cd\u836f\u7269\u80fd\u591f\u6709\u6548\u6cbb\u7597NDD\u3002 NDD\u662f\u4e00\u7c7b\u53d1\u751f\u5728\u795e\u7ecf\u7cfb\u7edf\u4e2d\uff0c\u9020\u6210\u795e\u7ecf\u5143\u53ca\u5176\u9644\u5c5e\u6811\u7a81\u4e36\u8f74\u7a81\u548c\u7a81\u89e6\uff0c\u4ee5\u53ca\u904d\u5e03\u795e\u7ecf\u7cfb\u7edf\u7684\u80f6\u8d28\u7ec6\u80de\u53d1\u751f\u635f\u4f24\u6216\u8005\u529f\u80fd\u5931\u5e38\u7684\u75be\u75c5\uff0c\u5176\u4e2d\u5178\u578b\u7684\u75be\u75c5\u5305\u62ec\u963f\u5c14\u5179\u6d77\u9ed8\u75c5\u4e36\u5e15\u91d1\u68ee\u75c5\u4e36\u808c\u8089\u840e\u7f29\u6027\u4fa7\u7d22\u786c\u5316\u75c7\u7b49\u3002 \u5bfc\u81f4\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\uff08NDD\uff09\u7684\u56e0\u7d20 \u9057\u4f20\u548c\u57fa\u56e0\u6539\u53d8\u662f\u5f88\u591aNDD\u7684\u5371\u9669\u56e0\u7d20\uff0c\u7269\u7406\u4e36\u5316\u5b66\u548c\u751f\u7269\u523a\u6fc0\uff08\u5982\u5916\u4f24\u4e36\u6740\u866b\u5242\u548c\u611f\u67d3\uff09\u4e5f\u4f1a\u63d0\u9ad8NDD\u7684\u53d1\u75c5\u7387\u3002\u9664\u6b64\u4ee5\u5916\uff0c\u76ee\u524d\u4e0eNDD\u6700\u5177\u5173\u8054\u7684\u5c31\u662f\u5e74\u9f84\u4e86\u3002\u65f6\u4ee3\u7684\u53d1\u5c55\u548c\u79d1\u6280\u7684\u8fdb\u6b65\uff0c\u4f7f\u5f97\u5168\u7403\u4e0d\u53ef\u907f\u514d\u8fdb\u5165\u8001\u9f84\u5316\u72b6\u6001\uff0cNDD\u7684\u5371\u5bb3\u4e5f\u9010\u6e10\u51f8\u663e\u3002\u4eba\u7c7b\u7684\u5e73\u5747\u5bff\u547d\u4ece\u4e0d\u523040\u5c81\u5230\u73b0\u5728\u768470\u5c81\u4ee5\u4e0a\uff0c\u53ea\u7528\u4e86\u77ed\u77ed200\u5e74\u7684\u65f6\u95f4\uff0c\u8fd9\u8ba9200\u5e74\u524d\u7f55\u89c1\u7684\u75be\u75c5\u5982\u764c\u75c7\u548c\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u53d6\u4ee3\u4f17\u591a\u6d41\u884c\u75c5\u6210\u4e3a\u75be\u75c5\u821e\u53f0\u7684\u4e2d\u5fc3\u3002 \u6240\u4ee5\uff0c\u8870\u8001\u662f\u9020\u6210\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u9ad8\u53d1\u7684\u9ad8\u5371\u56e0\u7d20\u3002<\/p>\n<div class=\"pvc_clear\"><\/div>\n<p id=\"pvc_stats_20165\" class=\"pvc_stats all  \" data-element-id=\"20165\" style=\"\"><i class=\"pvc-stats-icon medium\" aria-hidden=\"true\"><svg aria-hidden=\"true\" focusable=\"false\" data-prefix=\"far\" data-icon=\"chart-bar\" role=\"img\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\" class=\"svg-inline--fa fa-chart-bar fa-w-16 fa-2x\"><path fill=\"currentColor\" d=\"M396.8 352h22.4c6.4 0 12.8-6.4 12.8-12.8V108.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v230.4c0 6.4 6.4 12.8 12.8 12.8zm-192 0h22.4c6.4 0 12.8-6.4 12.8-12.8V140.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v198.4c0 6.4 6.4 12.8 12.8 12.8zm96 0h22.4c6.4 0 12.8-6.4 12.8-12.8V204.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v134.4c0 6.4 6.4 12.8 12.8 12.8zM496 400H48V80c0-8.84-7.16-16-16-16H16C7.16 64 0 71.16 0 80v336c0 17.67 14.33 32 32 32h464c8.84 0 16-7.16 16-16v-16c0-8.84-7.16-16-16-16zm-387.2-48h22.4c6.4 0 12.8-6.4 12.8-12.8v-70.4c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v70.4c0 6.4 6.4 12.8 12.8 12.8z\" class=\"\"><\/path><\/svg><\/i> <img loading=\"lazy\" decoding=\"async\" width=\"16\" height=\"16\" alt=\"Loading\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/plugins\/page-views-count\/ajax-loader-2x.gif\" border=0 \/><\/p>\n<div class=\"pvc_clear\"><\/div>\n","protected":false},"author":1,"featured_media":20167,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[409,172],"tags":[778,289],"class_list":["post-20165","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-nad","category-nmn-","tag-ndd","tag-289"],"aioseo_notices":[],"_links":{"self":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts\/20165","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=20165"}],"version-history":[{"count":1,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts\/20165\/revisions"}],"predecessor-version":[{"id":20168,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts\/20165\/revisions\/20168"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/media\/20167"}],"wp:attachment":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=20165"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=20165"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=20165"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}