{"id":20123,"date":"2023-05-17T01:10:09","date_gmt":"2023-05-17T01:10:09","guid":{"rendered":"http:\/\/johnhealth.blog\/ch\/?p=20123"},"modified":"2023-05-17T01:10:09","modified_gmt":"2023-05-17T01:10:09","slug":"%e3%80%8a%e6%b7%b1%e8%b0%88nmn%e7%b3%bb%e5%88%97-%e4%b8%a5%e9%87%8d%e7%89%b9%e6%ae%8a%e4%bc%a0%e6%9f%93%e6%80%a7%ef%bc%99%e3%80%8b-nmn%e9%80%9a%e8%bf%87%e5%87%8f%e5%b0%91dna%e6%8d%9f%e4%bc%a4%e6%9d%a5","status":"publish","type":"post","link":"http:\/\/johnhealth.blog\/ch\/?p=20123","title":{"rendered":"\u300a\u6df1\u8c08NMN\u7cfb\u5217-\u4e25\u91cd\u7279\u6b8a\u4f20\u67d3\u6027\uff19\u300b NMN\u901a\u8fc7\u51cf\u5c11DNA\u635f\u4f24\u6765\u9884\u9632\u65b0\u51a0"},"content":{"rendered":"<p>\u5728\u4eba\u4f53\u4e34\u5e8a\u8bd5\u9a8c\u4e0a\uff0c\u6709\u597d\u51e0\u4e2a\u7ed3\u679c\u53d1\u73b0NMN\u7b49NAD+\u7684\u524d\u4f53\u7269\u8d28\u5728\u4eba\u4f53\u4e2d\u53ef\u4ee5\u52a0\u901f\u65b0\u51a0\u60a3\u8005\u7684\u5eb7\u590d\u4e36\u6cbb\u7597\u65b0\u51a0\u91cd\u75c7\uff0c\u4e5f\u53ef\u4ee5\u6cbb\u7597\u4e00\u4e9b\u65b0\u51a0\u5f15\u53d1\u7684\u5e76\u53d1\u75c7\uff0c\u8bc1\u5b9e\u4e86\u6b64\u524d\u79d1\u5b66\u5bb6\u7684\u731c\u6d4b\u3002<br \/>\n\u6240\u4ee5\uff0c\u5317\u4eac\u751f\u79d1\u6240\u7684\u7814\u7a76\u4eba\u5458\u5728\u8870\u8001\u9886\u57df\u9876\u5c16\u671f\u520a\u300aAging Cell\u300b\u4e0a\u53d1\u8868\u6587\u7ae0\uff0c\u4ed6\u53d1\u73b0200mg\/kg\u7684NMN\u53ef\u4ee5\u6291\u5236\u65b0\u51a0\u75c5\u6bd2\u611f\u67d3\u3002<\/p>\n<p>\u4ed6\u4eec\u53d1\u73b0NMN\u662f\u901a\u8fc7\u51cf\u5c11DNA\u7684\u635f\u4f24\u6765\u963b\u6b62ACE2\u53d7\u4f53\u7684\u79ef\u7d2f\uff0c\u800cACE2\u53d7\u4f53\u6b63\u662f\u65b0\u51a0\u75c5\u6bd2\u611f\u67d3\u7ec6\u80de\u7684\u201c\u94a5\u5319\u201d\uff0c\u6ca1\u4e86\u8fd9\u628a\u201c\u94a5\u5319\u201d\uff0c\u65b0\u51a0\u75c5\u6bd2\u81ea\u7136\u96be\u4ee5\u4e0b\u624b\u3002<br \/>\n\u8fd9\u9879\u7814\u7a76\u4eceDNA\u635f\u4f24\u7684\u89d2\u5ea6\u5f88\u597d\u5730\u89e3\u91ca\u4e86\u4e3a\u4ec0\u9ebd\u8001\u5e74\u4eba\u662f\u65b0\u51a0\u6613\u611f\u4eba\u7fa4\uff0c\u7f8e\u4e2d\u4e0d\u8db3\u7684\u662f\uff0c\u8fd9\u9879\u7814\u7a76\u8fd8\u5c40\u9650\u65bc\u8001\u9f20\u4e0a\uff0c\u82e5\u80fd\u5728\u4eba\u4f53\u4e34\u5e8a\u4e0a\u5f97\u5230\u9a8c\u8bc1\uff0c\u610f\u4e49\u5c06\u4f1a\u975e\u5e38\u91cd\u5927\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-20124\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/05\/\u6df1\u8c08NMN\u7cfb\u5217-\u80ba\u708e9.jpg\" alt=\"\" width=\"940\" height=\"788\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/05\/\u6df1\u8c08NMN\u7cfb\u5217-\u80ba\u708e9.jpg 940w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/05\/\u6df1\u8c08NMN\u7cfb\u5217-\u80ba\u708e9-300x251.jpg 300w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/05\/\u6df1\u8c08NMN\u7cfb\u5217-\u80ba\u708e9-768x644.jpg 768w\" sizes=\"auto, (max-width: 940px) 100vw, 940px\" \/><\/p>\n<p>\u5168\u6587\u8fde\u7ed3\uff1a<a href=\"http:\/\/johnhealth.blog\/ch\/?p=396\">NMN\u53ef\u4ee5\u5e2e\u52a9\u5bf9\u6297COVID-19\u5417 \u2013 John\u54e5\u8c08\u5065\u5eb7 (johnhealth.blog)<\/a><\/p>\n<p>Jin, R., Niu, C., Wu, F., Zhou, S., Han, T., Zhang, Z., Li, E., Zhang, X., Xu, S., Wang, J., Tian, S., Chen, W., Ye, Q., Cao, C., &amp; Cheng, L. (2022). DNA damage contributes to age-associated differences in SARS-CoV-2 infection. 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(2022). DNA damage contributes to age-associated differences in SARS-CoV-2 infection. 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