{"id":20114,"date":"2023-05-05T02:12:53","date_gmt":"2023-05-05T02:12:53","guid":{"rendered":"http:\/\/johnhealth.blog\/ch\/?p=20114"},"modified":"2023-05-05T02:12:53","modified_gmt":"2023-05-05T02:12:53","slug":"%e3%80%8a%e6%b7%b1%e8%b0%88nmn%e7%b3%bb%e5%88%97-%e4%b8%a5%e9%87%8d%e7%89%b9%e6%ae%8a%e4%bc%a0%e6%9f%93%e6%80%a7%e8%82%ba%e7%82%8e3%e3%80%8b%e5%a4%a7%e5%8d%ab%c2%b7%e8%be%9b%e5%85%8b%e8%8e%b1-2","status":"publish","type":"post","link":"http:\/\/johnhealth.blog\/ch\/?p=20114","title":{"rendered":"\u300a\u6df1\u8c08NMN\u7cfb\u5217-\u4e25\u91cd\u7279\u6b8a\u4f20\u67d3\u6027\u80ba\u708e3\u300b\u5927\u536b\u00b7\u8f9b\u514b\u83b1\u5c14\u6559\u6388\u547c\u5401\u533b\u7597\u673a\u6784\u5f00\u53d1\u4ee5NMN\u4e3a\u4e3b\u7684\u65b0\u51a0\u4ecb\u5165\u624b\u6bb5"},"content":{"rendered":"<p>\u4ece\u4e0a\u4e00\u7bc7\u8bba\u6587\u4e2d\uff0c\u7f8e\u56fd\u7231\u8377\u534e\u5927\u5b66\u7684Brenner\u56e2\u961f\u57282020\u5e744\u6708\u7684\u7814\u7a76\u62a5\u544a\u4e2d\u6307\u51fa\uff0cNAD+\u5728\u65b0\u51a0\u75c5\u6bd2\u5165\u4fb5\u4eba\u4f53\u65f6\u53d1\u6325\u4e86\u91cd\u8981\u4f5c\u7528\u3002\u4eba\u4f53\u7684\u5148\u5929\u514d\u75ab\u7cfb\u7edf\u4f1a\u6d88\u8017\u5927\u91cfNAD+\u4ee5\u542f\u52a8\u9632\u5fa1\u673a\u5236\uff0c\u6291\u5236\u75c5\u6bd2\u590d\u5236\u3002Brenner\u56e2\u961f\u63d0\u51fa\u4e86\u591a\u79cd\u89e3\u51b3\u7b56\u7565\uff0c\u5176\u4e2d\u8865\u5145\u5916\u6e90\u6027NAD+\u88ab\u8ba4\u4e3a\u662f\u6700\u4e3a\u6709\u6548\u7684\u65b9\u6cd5\uff0c\u6709\u52a9\u65bc\u534f\u52a9\u5148\u5929\u514d\u75ab\u7cfb\u7edf\u5bf9\u6297\u65b0\u51a0\u75c5\u6bd2\u3002<\/p>\n<p>\u7531\u65bc\u6709\u8bc1\u636e\u663e\u793aNAD+\u6c34\u5e73\u4e0e\u65b0\u51a0\u80ba\u708e\u611f\u67d3\u5bc6\u5207\u76f8\u5173\uff0c\u800cNMN\u7b49\u6297\u8870\u8001\u7269\u8d28\u53ef\u6709\u52a9\u63d0\u9ad8NAD+\u6c34\u5e73\uff0c\u8fdb\u800c\u589e\u5f3a\u8eab\u4f53\u5bf9\u75c5\u6bd2\u7684\u62b5\u6297\u529b\u3002\u5927\u536b\u00b7\u8f9b\u514b\u83b1\u5c14\u6559\u6388 (Prof. David Sinclair) \u66f4\u65bc\u300aAging\u300b\u671f\u520a\u4e0a\u53d1\u8868\u8bba\u6587\u6307\u51fa\uff0c\u6297\u8870\u8001\u7269\u8d28\u53ef\u6210\u4e3a\u65b0\u51a0\u80ba\u708e\u6cbb\u7597\u7684\u4e00\u79cd\u65b9\u5411\u3002<\/p>\n<p>\u8fd9\u9879\u7814\u7a76\u4e0d\u4ec5\u4e0e\u524d\u4e24\u9879\u7814\u7a76\u76f8\u4e92\u4f50\u8bc1\uff0c\u66f4\u8ba9\u6211\u4eec\u66f4\u52a0\u6df1\u5165\u4e86\u89e3\u6297\u8870\u8001\u7269\u8d28\u4e0e\u65b0\u51a0\u80ba\u708e\u4e4b\u95f4\u7684\u5173\u7cfb\u3002\u73b0\u5728\uff0c\u4f60\u4e5f\u53ef\u4ee5\u900f\u8fc7\u8865\u5145\u6297\u8870\u8001\u7269\u8d28\uff0c\u4fdd\u62a4\u81ea\u5df1\u514d\u53d7\u75c5\u6bd2\u4fb5\u5bb3\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-20115\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/05\/\u6df1\u8c08NMN\u7cfb\u5217-\u80ba\u708e3.jpg\" alt=\"\" width=\"940\" height=\"788\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/05\/\u6df1\u8c08NMN\u7cfb\u5217-\u80ba\u708e3.jpg 940w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/05\/\u6df1\u8c08NMN\u7cfb\u5217-\u80ba\u708e3-300x251.jpg 300w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/05\/\u6df1\u8c08NMN\u7cfb\u5217-\u80ba\u708e3-768x644.jpg 768w\" sizes=\"auto, (max-width: 940px) 100vw, 940px\" \/><\/p>\n<p>\u5168\u6587\u8fde\u7ed3\uff1a<a href=\"http:\/\/johnhealth.blog\/ch\/?p=19503\">\u65b0\u51a0\u75c5\u6bd2\u4e0eNMN \uff08\u4ece\u9884\u9632\u5230\u6cbb\u6108\uff09\u5927\u6c47\u603b \u2013 John\u54e5\u8c08\u5065\u5eb7 (johnhealth.blog)<\/a><br \/>\nMueller AL, McNamara MS, Sinclair DA. Why does COVID-19 disproportionately affect older people? Aging (Albany NY). 2020 May 29;12(10):9959-9981. doi: 10.18632\/aging.103344. Epub 2020 May 29. PMID: 32470948; PMCID: PMC7288963.<\/p>\n<div class=\"pvc_clear\"><\/div>\n<p id=\"pvc_stats_20114\" class=\"pvc_stats all  \" data-element-id=\"20114\" style=\"\"><i class=\"pvc-stats-icon medium\" aria-hidden=\"true\"><svg aria-hidden=\"true\" focusable=\"false\" data-prefix=\"far\" data-icon=\"chart-bar\" role=\"img\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\" class=\"svg-inline--fa fa-chart-bar fa-w-16 fa-2x\"><path fill=\"currentColor\" d=\"M396.8 352h22.4c6.4 0 12.8-6.4 12.8-12.8V108.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v230.4c0 6.4 6.4 12.8 12.8 12.8zm-192 0h22.4c6.4 0 12.8-6.4 12.8-12.8V140.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v198.4c0 6.4 6.4 12.8 12.8 12.8zm96 0h22.4c6.4 0 12.8-6.4 12.8-12.8V204.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v134.4c0 6.4 6.4 12.8 12.8 12.8zM496 400H48V80c0-8.84-7.16-16-16-16H16C7.16 64 0 71.16 0 80v336c0 17.67 14.33 32 32 32h464c8.84 0 16-7.16 16-16v-16c0-8.84-7.16-16-16-16zm-387.2-48h22.4c6.4 0 12.8-6.4 12.8-12.8v-70.4c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v70.4c0 6.4 6.4 12.8 12.8 12.8z\" class=\"\"><\/path><\/svg><\/i> <img loading=\"lazy\" decoding=\"async\" width=\"16\" height=\"16\" alt=\"Loading\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/plugins\/page-views-count\/ajax-loader-2x.gif\" border=0 \/><\/p>\n<div class=\"pvc_clear\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u4ece\u4e0a\u4e00\u7bc7\u8bba\u6587\u4e2d\uff0c\u7f8e\u56fd\u7231\u8377\u534e\u5927\u5b66\u7684Brenner\u56e2\u961f\u57282020\u5e744\u6708\u7684\u7814\u7a76\u62a5\u544a\u4e2d\u6307\u51fa\uff0cNAD+\u5728\u65b0\u51a0\u75c5\u6bd2\u5165\u4fb5\u4eba\u4f53\u65f6\u53d1\u6325\u4e86\u91cd\u8981\u4f5c\u7528\u3002\u4eba\u4f53\u7684\u5148\u5929\u514d\u75ab\u7cfb\u7edf\u4f1a\u6d88\u8017\u5927\u91cfNAD+\u4ee5\u542f\u52a8\u9632\u5fa1\u673a\u5236\uff0c\u6291\u5236\u75c5\u6bd2\u590d\u5236\u3002Brenner\u56e2\u961f\u63d0\u51fa\u4e86\u591a\u79cd\u89e3\u51b3\u7b56\u7565\uff0c\u5176\u4e2d\u8865\u5145\u5916\u6e90\u6027NAD+\u88ab\u8ba4\u4e3a\u662f\u6700\u4e3a\u6709\u6548\u7684\u65b9\u6cd5\uff0c\u6709\u52a9\u65bc\u534f\u52a9\u5148\u5929\u514d\u75ab\u7cfb\u7edf\u5bf9\u6297\u65b0\u51a0\u75c5\u6bd2\u3002 \u7531\u65bc\u6709\u8bc1\u636e\u663e\u793aNAD+\u6c34\u5e73\u4e0e\u65b0\u51a0\u80ba\u708e\u611f\u67d3\u5bc6\u5207\u76f8\u5173\uff0c\u800cNMN\u7b49\u6297\u8870\u8001\u7269\u8d28\u53ef\u6709\u52a9\u63d0\u9ad8NAD+\u6c34\u5e73\uff0c\u8fdb\u800c\u589e\u5f3a\u8eab\u4f53\u5bf9\u75c5\u6bd2\u7684\u62b5\u6297\u529b\u3002\u5927\u536b\u00b7\u8f9b\u514b\u83b1\u5c14\u6559\u6388 (Prof. David Sinclair) \u66f4\u65bc\u300aAging\u300b\u671f\u520a\u4e0a\u53d1\u8868\u8bba\u6587\u6307\u51fa\uff0c\u6297\u8870\u8001\u7269\u8d28\u53ef\u6210\u4e3a\u65b0\u51a0\u80ba\u708e\u6cbb\u7597\u7684\u4e00\u79cd\u65b9\u5411\u3002 \u8fd9\u9879\u7814\u7a76\u4e0d\u4ec5\u4e0e\u524d\u4e24\u9879\u7814\u7a76\u76f8\u4e92\u4f50\u8bc1\uff0c\u66f4\u8ba9\u6211\u4eec\u66f4\u52a0\u6df1\u5165\u4e86\u89e3\u6297\u8870\u8001\u7269\u8d28\u4e0e\u65b0\u51a0\u80ba\u708e\u4e4b\u95f4\u7684\u5173\u7cfb\u3002\u73b0\u5728\uff0c\u4f60\u4e5f\u53ef\u4ee5\u900f\u8fc7\u8865\u5145\u6297\u8870\u8001\u7269\u8d28\uff0c\u4fdd\u62a4\u81ea\u5df1\u514d\u53d7\u75c5\u6bd2\u4fb5\u5bb3\u3002 \u5168\u6587\u8fde\u7ed3\uff1a\u65b0\u51a0\u75c5\u6bd2\u4e0eNMN \uff08\u4ece\u9884\u9632\u5230\u6cbb\u6108\uff09\u5927\u6c47\u603b \u2013 John\u54e5\u8c08\u5065\u5eb7 (johnhealth.blog) Mueller AL, McNamara MS, Sinclair DA. Why does COVID-19 disproportionately affect older people? Aging (Albany NY). 2020 May 29;12(10):9959-9981. doi: 10.18632\/aging.103344. Epub 2020 May 29. PMID: 32470948; PMCID: PMC7288963.<\/p>\n<div class=\"pvc_clear\"><\/div>\n<p id=\"pvc_stats_20114\" class=\"pvc_stats all  \" data-element-id=\"20114\" style=\"\"><i class=\"pvc-stats-icon medium\" aria-hidden=\"true\"><svg aria-hidden=\"true\" focusable=\"false\" data-prefix=\"far\" data-icon=\"chart-bar\" role=\"img\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\" class=\"svg-inline--fa fa-chart-bar fa-w-16 fa-2x\"><path fill=\"currentColor\" d=\"M396.8 352h22.4c6.4 0 12.8-6.4 12.8-12.8V108.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v230.4c0 6.4 6.4 12.8 12.8 12.8zm-192 0h22.4c6.4 0 12.8-6.4 12.8-12.8V140.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v198.4c0 6.4 6.4 12.8 12.8 12.8zm96 0h22.4c6.4 0 12.8-6.4 12.8-12.8V204.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v134.4c0 6.4 6.4 12.8 12.8 12.8zM496 400H48V80c0-8.84-7.16-16-16-16H16C7.16 64 0 71.16 0 80v336c0 17.67 14.33 32 32 32h464c8.84 0 16-7.16 16-16v-16c0-8.84-7.16-16-16-16zm-387.2-48h22.4c6.4 0 12.8-6.4 12.8-12.8v-70.4c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v70.4c0 6.4 6.4 12.8 12.8 12.8z\" class=\"\"><\/path><\/svg><\/i> <img loading=\"lazy\" decoding=\"async\" width=\"16\" height=\"16\" alt=\"Loading\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/plugins\/page-views-count\/ajax-loader-2x.gif\" border=0 \/><\/p>\n<div class=\"pvc_clear\"><\/div>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[191,172,734],"tags":[246,321,728],"class_list":["post-20114","post","type-post","status-publish","format-standard","hentry","category-covid-19","category-nmn-","category-nmn","tag-covid19","tag-321","tag-nmn"],"aioseo_notices":[],"_links":{"self":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts\/20114","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=20114"}],"version-history":[{"count":1,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts\/20114\/revisions"}],"predecessor-version":[{"id":20116,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts\/20114\/revisions\/20116"}],"wp:attachment":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=20114"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=20114"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=20114"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}