{"id":20109,"date":"2023-05-05T01:55:01","date_gmt":"2023-05-05T01:55:01","guid":{"rendered":"http:\/\/johnhealth.blog\/ch\/?p=20109"},"modified":"2023-05-05T01:55:01","modified_gmt":"2023-05-05T01:55:01","slug":"%e3%80%90%e7%a7%91%e6%8a%80%e8%bf%9b%e5%b1%95%e3%80%91nmn-%e5%8f%af%e9%80%86%e8%bd%ac%e8%a1%b0%e8%80%81%e5%b0%8f%e9%bc%a0%e7%9a%84%e8%a1%80%e7%ae%a1%e5%8a%9f%e8%83%bd%e9%9a%9c%e7%a2%8d","status":"publish","type":"post","link":"http:\/\/johnhealth.blog\/ch\/?p=20109","title":{"rendered":"\u3010\u79d1\u6280\u8fdb\u5c55\u3011NMN \u53ef\u9006\u8f6c\u8870\u8001\u5c0f\u9f20\u7684\u8840\u7ba1\u529f\u80fd\u969c\u788d"},"content":{"rendered":"

\u996e\u7528\u542b\u6709\u70df\u9170\u80fa\u5355\u6838\u82f7\u9178 \uff08NMN\uff09 \u7684\u6c34\u7684\u8001\u5e74\u5c0f\u9f20\u6539\u5584\u4e86\u52a8\u8109\u529f\u80fd\uff0c\u8fd9\u5bf9\u9884\u9632\u5fc3\u8840\u7ba1\u75be\u75c5\u81f3\u5173\u91cd\u8981\u3002<\/p>\n

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ByBrett J. Weiss<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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Published:12:19 p.m. PST Jun 7, 2016| Updated:11:44 am PST Sep 22, 2020<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u5fc3\u8840\u7ba1\u75be\u75c5\u662f\u53d1\u8fbe\u56fd\u5bb6\u6b7b\u4ea1\u7684\u4e3b\u8981\u539f\u56e0\uff0c\u800c\u8001\u9f84\u5316\u662f\u5fc3\u8840\u7ba1\u75be\u75c5\u7684\u4e3b\u8981\u5371\u9669\u56e0\u7d20\u3002 \u7531\u4e8e\u5bf9\u8001\u5e74\u4eba\u6570\u91cf\u7684\u9884\u6d4b\u52302050\u5e74\u53ef\u80fd\u81f3\u5c11\u7ffb\u4e00\u500d<\/a>\uff0c\u4e0e\u5e74\u9f84\u76f8\u5173\u7684\u5fc3\u810f\u75c5\u73b0\u5728\u6bd4\u4ee5\u5f80\u4efb\u4f55\u65f6\u5019\u90fd\u66f4\u6210\u4e3a\u4e00\u4e2a\u95ee\u9898\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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NMN \u6539\u5584\u4e3b\u52a8\u8109<\/span><\/h3>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n
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\u8fd9\u4e9b\u63a5\u53d7 NMN \u7684\u8001\u5e74\u5c0f\u9f20\u4e5f\u8868\u73b0\u51fa\u4e0e\u66f4\u597d\u7684\u8840\u7ba1\u529f\u80fd\u76f8\u5173\u7684\u5206\u5b50\u6c34\u5e73\u7684\u6539\u5584\u3002 \u80f6\u539f\u86cb\u767d\uff08\u4e00\u79cd\u50f5\u786c\u7684\u6807\u5fd7\u7269\uff09\u6c34\u5e73\u964d\u4f4e\uff0c\u800c\u5f39\u6027\u86cb\u767d\uff08\u4e00\u79cd\u5f39\u6027\u7684\u6807\u5fd7\u7269\uff09\u6c34\u5e73\u5347\u9ad8\u5230\u4e0e\u5e74\u8f7b\u5c0f\u9f20\u76f8\u4f3c\u7684\u6c34\u5e73\u3002 \u8fd9\u4e9b\u7ed3\u679c\u8868\u660e\uff0cNMN\u5bfc\u81f4\u5bf9\u52a8\u8109\u58c1\u7ed3\u6784\u5f88\u91cd\u8981\u7684\u86cb\u767d\u8d28\u5b8c\u5168\u6216\u90e8\u5206\u6b63\u5e38\u5316\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u5168\u5929\u5728\u996e\u7528\u6c34\u4e2d\u52a0\u5165\u5c11\u91cf NMN \u7684\u8001\u5e74\u5c0f\u9f20\uff0c\u5176\u4e3b\u52a8\u8109\uff08\u5fc3\u808c\u7684\u8840\u7ba1\uff09\u7684\u50f5\u786c\u6062\u590d\u6b63\u5e38\uff0c\u8fd9\u8868\u660e\u5fc3\u810f\u5065\u5eb7\u5f97\u5230\u6539\u5584<\/a>\u3002 \u201c\u603b\u4e4b\uff0c\u8fd9\u4e9b\u89c2\u5bdf\u7ed3\u679c\u8868\u660e\uff0cNMN \u53ef\u4ee5\u9006\u8f6c\u5927\u5f39\u6027\u52a8\u8109\u968f\u7740\u5e74\u9f84\u7684\u589e\u957f\u800c\u53d8\u786c\uff0c\u90e8\u5206\u662f\u901a\u8fc7\u4f7f\u80f6\u539f\u86cb\u767d\u6b63\u5e38\u5316\u548c\u90e8\u5206\u4fdd\u7559\u52a8\u8109\u58c1\u4e2d\u7684\u5f39\u6027\u86cb\u767d\uff0c\u201dde Picciotto \u53ca\u5176\u540c\u4e8b\u603b\u7ed3\u9053\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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(de Picciotto et al., 2016 |<\/strong><\/a> Aging Cell<\/strong><\/em><\/a>\uff09<\/strong><\/a>NMN \u4f7f\u8001\u5e74\u5c0f\u9f20\u7684\u4e3b\u52a8\u8109\u5f39\u6027\u6062\u590d\u5230\u5e74\u8f7b\u7684\u6c34\u5e73<\/strong> \u3002 \u4e0e\u5e74\u8f7b\u5c0f\u9f20 \uff08YC\uff09 \u76f8\u6bd4\uff0c\u8001\u5e74\u5c0f\u9f20 \uff08OC\uff09 \u7684\u4e3b\u52a8\u8109\u50f5\u786c\u5ea6\u589e\u52a0\u3002 NMN \u5c06\u8001\u5e74\u5c0f\u9f20 \uff08ONMN\uff09 \u7684\u4e3b\u52a8\u8109\u50f5\u786c\u5ea6\u964d\u4f4e\u5230\u4e0e\u672a\u7ecf\u6cbb\u7597\u7684\u5e74\u8f7b\u5c0f\u9f20\u548c\u7528 NMN \uff08YNMN\uff09 \u6cbb\u7597\u7684\u5c0f\u9f20\u76f8\u5f53\u7684\u6c34\u5e73\u3002<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u540c\u6837\uff0c\u901a\u8fc7\u996e\u7528\u6c34\u6444\u5165 NMN \u7684\u8001\u5e74\u5c0f\u9f20\u7684\u4e3b\u52a8\u8109\u6269\u5f20\u4e5f\u6709\u6240\u6539\u5584\u3002 \u8fd9\u4e9b\u6539\u5584\u4e0e\u6269\u5f20\u6240\u9700\u7684 NO \u6062\u590d\u53ef\u7528\u6027\u548c\u51cf\u5c11\u6c27\u5316\u5e94\u6fc0\u6709\u5173\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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(de Picciotto et al., 2016 |<\/strong><\/a> Aging Cell<\/strong><\/em><\/a>\uff09<\/strong><\/a>NMN \u53ef\u6539\u5584\u8001\u5e74\u5c0f\u9f20\u7684\u4e3b\u52a8\u8109\u6269\u5f20<\/strong> \u3002 \u8001\u5e74\u5c0f\u9f20 \uff08OC\uff09 \u7684\u4e3b\u52a8\u8109\u6269\u5f20\u80fd\u529b\u964d\u4f4e\u5230\u5e74\u8f7b\u5c0f\u9f20 \uff08YC\uff09 \u6269\u5f20\u91cf\u7684\u4e00\u534a\u5de6\u53f3\u3002 NMN \u5c06\u8001\u5e74\u5c0f\u9f20 \uff08ONMN\uff09 \u7684\u4e3b\u52a8\u8109\u6269\u5f20\u6539\u5584\u5230\u4e0e\u672a\u7ecf\u6cbb\u7597\u7684\u5e74\u8f7b\u5c0f\u9f20\u548c\u7528 NMN \uff08YNMN\uff09 \u6cbb\u7597\u7684\u5c0f\u9f20\u76f8\u5f53\u7684\u6c34\u5e73\u3002<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u201c\u5728\u672c\u7814\u7a76\u4e2d\uff0c\u6211\u4eec\u8bc1\u660e\u53e3\u670d NMN \u8865\u5145\u5242\u53ef\u4ee5\u9006\u8f6c\u4e0e\u5e74\u9f84\u76f8\u5173\u7684\u5185\u76ae\u529f\u80fd\u969c\u788d\uff0c\u201dde Picciotto \u53ca\u5176\u540c\u4e8b\u8bf4\u3002 \u201c\u603b\u4f53\u800c\u8a00\uff0c\u6211\u4eec\u7684\u7814\u7a76\u7ed3\u679c\u63d0\u4f9b\u4e86\u7b2c\u4e00\u4e2a\u8bc1\u636e\uff0c\u652f\u6301 NMN \u8865\u5145\u5242<\/a>\u5728\u6cbb\u7597\u52a8\u8109\u8870\u8001\u65b9\u9762\u7684\u6f5c\u5728\u8f6c\u5316\u6f5c\u529b\uff0c\u201d\u79d1\u5b66\u5bb6\u5728\u4ed6\u4eec\u7684\u7814\u7a76\u4e2d\u8868\u793a\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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Story Source<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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  1. de Picciotto NE, Gano LB, Johnson LC, et al. Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice. Aging Cell. 2016; 15(3):522-530. doi:10.1111\/acel.12461<\/span><\/li>\n<\/ol>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n
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    Journal Reference<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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    1. GBD 2013 Mortality and Causes of Death Collaborators. Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2015; 385(9963):117-171. doi:10.1016\/S0140-6736(14)61682-2<\/li>\n
    2. Petsko GA. A seat at the table. Genome Biol. 2008; 9(12):113. doi:10.1186\/gb-2008-9-12-113<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n
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      https:\/\/www.nmn.com\/news\/taking-nmn-reverses-vascular-dysfunction-from-aging-in-mice<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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      \u996e\u7528\u542b\u6709\u70df\u9170\u80fa\u5355\u6838\u82f7\u9178 \uff08NMN\uff09 \u7684\u6c34\u7684\u8001\u5e74\u5c0f\u9f20\u6539\u5584\u4e86\u52a8\u8109\u529f\u80fd\uff0c\u8fd9\u5bf9\u9884\u9632\u5fc3\u8840\u7ba1\u75be\u75c5\u81f3\u5173\u91cd\u8981\u3002 ByBrett J. Weiss Published:12:19 p.m. PST Jun 7, 2016| Updated:11:44 am PST Sep 22, 2020 \u5fc3\u8840\u7ba1\u75be\u75c5\u662f\u53d1\u8fbe\u56fd\u5bb6\u6b7b\u4ea1\u7684\u4e3b\u8981\u539f\u56e0\uff0c\u800c\u8001\u9f84\u5316\u662f\u5fc3\u8840\u7ba1\u75be\u75c5\u7684\u4e3b\u8981\u5371\u9669\u56e0\u7d20\u3002 \u7531\u4e8e\u5bf9\u8001\u5e74\u4eba\u6570\u91cf\u7684\u9884\u6d4b\u52302050\u5e74\u53ef\u80fd\u81f3\u5c11\u7ffb\u4e00\u500d\uff0c\u4e0e\u5e74\u9f84\u76f8\u5173\u7684\u5fc3\u810f\u75c5\u73b0\u5728\u6bd4\u4ee5\u5f80\u4efb\u4f55\u65f6\u5019\u90fd\u66f4\u6210\u4e3a\u4e00\u4e2a\u95ee\u9898\u3002 \u79d1\u7f57\u62c9\u591a\u5927\u5b66\u7684\u79d1\u5b66\u5bb6\u5728\u5b66\u672f\u671f\u520a\u300aAging Cell\u300b \u4e0a\u53d1\u8868\u4e86\u4e00\u9879\u7814\u7a76\uff0c\u8bc1\u660eNMN\u53ef\u4ee5\u9006\u8f6c\u5c0f\u9f20\u7684\u8840\u7ba1\u529f\u80fd\u969c\u788d\u3002 NMN \u53ef\u63d0\u9ad8\u7ec6\u80de\u4e2d\u70df\u9170\u80fa\u817a\u560c\u5464\u4e8c\u6838\u82f7\u9178 \uff08NAD+\uff09 \u7684\u6c34\u5e73\u3002 NAD+ \u6c34\u5e73\u968f\u7740\u5e74\u9f84\u7684\u589e\u957f\u800c\u4e0b\u964d\uff0c\u79d1\u5b66\u5bb6\u8ba4\u4e3a\u8fd9\u4e0e\u5fc3\u8840\u7ba1\u75be\u75c5\u7b49\u591a\u79cd\u4e0e\u5e74\u9f84\u6709\u5173\u7684\u75be\u75c5\u7684\u53d1\u75c5\u6709\u5173\u3002 \u8fd9\u4e9b\u7ed3\u679c\u8868\u660e NMN \u4f5c\u4e3a\u4e00\u79cd\u6f5c\u5728\u7684\u6cbb\u7597\u65b9\u6cd5\u53ef\u4ee5\u964d\u4f4e\u4eba\u4eec\u60a3\u5fc3\u8840\u7ba1\u75be\u75c5\u7684\u98ce\u9669\u3002   \u4ec0\u4e48\u662f\u8840\u7ba1\u529f\u80fd\u969c\u788d\uff1f   \u8840\u7ba1\u529f\u80fd\u969c\u788d\u901a\u5e38\u4e0e\u8840\u7ba1\u50f5\u786c\u548c\u6269\u5f20\u8f83\u5dee\u6709\u5173\uff0c\u5373\u8840\u7ba1\u6269\u5927\u4ee5\u4fbf\u53ef\u4ee5\u6cf5\u51fa\u66f4\u591a\u7684\u8840\u6db2\u3002 \u968f\u7740\u5e74\u9f84\u7684\u589e\u957f\uff0c\u80f6\u539f\u86cb\u767d\uff08\u4e00\u79cd\u63d0\u4f9b\u7ec4\u7ec7\u7ed3\u6784\u5b8c\u6574\u6027\u7684\u86cb\u767d\u8d28\uff09\u7684\u6c34\u5e73\u4f1a\u589e\u52a0\uff0c\u800c\u5f39\u6027\u86cb\u767d\uff08\u4e00\u79cd\u8d4b\u4e88\u7ec4\u7ec7\u5f39\u6027\u7684\u86cb\u767d\u8d28\uff09\u7684\u6c34\u5e73\u4f1a\u4e0b\u964d\u3002 \u8fd9\u79cd\u968f\u7740\u5e74\u9f84\u589e\u957f\u800c\u53d1\u751f\u7684\u50f5\u786c\u901a\u5e38\u4f1a\u5bfc\u81f4\u5fc3\u8840\u7ba1\u75be\u75c5\u3002 \u6cbf\u7740\u8fd9\u4e9b\u601d\u8def\uff0c\u8001\u5e74\u4eba\u5fc3\u8840\u7ba1\u75be\u75c5\u7684\u4e24\u4e2a\u5173\u952e\u9884\u6d4b\u56e0\u7d20\u662f\u8840\u7ba1\u529f\u80fd\u969c\u788d\uff0c\u901a\u8fc7\u8840\u7ba1\u6269\u5f20\u7684\u80fd\u529b\u548c\u5b83\u4eec\u53d8\u5f97\u591a\u4e48\u50f5\u786c\u6765\u8bc4\u4f30\u3002 \u901a\u5e38\uff0c\u968f\u7740\u5e74\u9f84\u7684\u589e\u957f\uff0c\u8840\u7ba1\u53d8\u5f97\u66f4\u52a0\u50f5\u786c\u5e76\u4e14\u66f4\u96be\u6269\u5f20\u3002   NMN \u6539\u5584\u4e3b\u52a8\u8109 \u79d1\u7f57\u62c9\u591a\u5927\u5b66\u535a\u5c14\u5fb7\u5206\u6821\u7684\u7814\u7a76\u5c0f\u7ec4\u60f3\u4e86\u89e3\u7528 NMN \u63d0\u9ad8 NAD+ \u6c34\u5e73\u662f\u5426\u80fd\u6539\u5584\u8001\u5e74\u5c0f\u9f20\u4e3b\u52a8\u8109\uff08\u5fc3\u810f\u4e2d\u7684\u5927\u8840\u7ba1\uff09\u7684\u529f\u80fd\u3002 \u4e3a\u6b64\uff0c\u4ed6\u4eec\u7ed9\u5e74\u8f7b\u548c\u5e74\u8001\u7684\u8001\u9f20\u559d\u6c34\u4e0e\u559dNMN\u6c34 \u8fdb\u884c\u6bd4\u8f83\uff0c\u5e76\u5c06\u5b83\u4eec\u4e0e\u6765\u81ea\u4e24\u4e2a\u5e74\u9f84\u7ec4\u7684\u672a\u4ecb\u5165\u5c0f\u9f20\u8fdb\u884c\u6bd4\u8f83\u3002   \u8fd9\u4e9b\u63a5\u53d7 NMN \u7684\u8001\u5e74\u5c0f\u9f20\u4e5f\u8868\u73b0\u51fa\u4e0e\u66f4\u597d\u7684\u8840\u7ba1\u529f\u80fd\u76f8\u5173\u7684\u5206\u5b50\u6c34\u5e73\u7684\u6539\u5584\u3002 \u80f6\u539f\u86cb\u767d\uff08\u4e00\u79cd\u50f5\u786c\u7684\u6807\u5fd7\u7269\uff09\u6c34\u5e73\u964d\u4f4e\uff0c\u800c\u5f39\u6027\u86cb\u767d\uff08\u4e00\u79cd\u5f39\u6027\u7684\u6807\u5fd7\u7269\uff09\u6c34\u5e73\u5347\u9ad8\u5230\u4e0e\u5e74\u8f7b\u5c0f\u9f20\u76f8\u4f3c\u7684\u6c34\u5e73\u3002 \u8fd9\u4e9b\u7ed3\u679c\u8868\u660e\uff0cNMN\u5bfc\u81f4\u5bf9\u52a8\u8109\u58c1\u7ed3\u6784\u5f88\u91cd\u8981\u7684\u86cb\u767d\u8d28\u5b8c\u5168\u6216\u90e8\u5206\u6b63\u5e38\u5316\u3002   \u5168\u5929\u5728\u996e\u7528\u6c34\u4e2d\u52a0\u5165\u5c11\u91cf NMN \u7684\u8001\u5e74\u5c0f\u9f20\uff0c\u5176\u4e3b\u52a8\u8109\uff08\u5fc3\u808c\u7684\u8840\u7ba1\uff09\u7684\u50f5\u786c\u6062\u590d\u6b63\u5e38\uff0c\u8fd9\u8868\u660e\u5fc3\u810f\u5065\u5eb7\u5f97\u5230\u6539\u5584\u3002 […]<\/p>\n

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