{"id":20031,"date":"2023-07-13T01:45:19","date_gmt":"2023-07-13T01:45:19","guid":{"rendered":"http:\/\/johnhealth.blog\/ch\/?p=20031"},"modified":"2023-07-13T01:45:19","modified_gmt":"2023-07-13T01:45:19","slug":"%e3%80%8a%e6%b7%b1%e8%b0%88nmn%e7%b3%bb%e5%88%97-%e9%aa%a8%e8%b4%a8%e7%96%8f%e6%9d%be%e3%80%8b%ef%bc%92-nmn-%e4%bd%bf%e9%aa%a8%e7%bb%84%e7%bb%87%e5%b9%b2%e7%bb%86%e8%83%9e%e6%81%a2%e5%a4%8d%e6%b4%bb","status":"publish","type":"post","link":"http:\/\/johnhealth.blog\/ch\/?p=20031","title":{"rendered":"\u300a\u6df1\u8c08NMN\u7cfb\u5217-\u9aa8\u8d28\u758f\u677e\u300b\uff12 NMN \u4f7f\u9aa8\u7ec4\u7ec7\u5e72\u7ec6\u80de\u6062\u590d\u6d3b\u529b"},"content":{"rendered":"<p>\u9aa8\u8d28\u758f\u677e\u75c7\u6240\u5bfc\u81f4\u7684\u9aa8\u6298\uff0c\u4e0d\u4f46\u4f1a\u5e26\u6765\u751f\u6d3b\u54c1\u8d28\u4e0b\u964d\u4e36\u7f79\u75c5\u7387\u4e0a\u5347\u4e36\u6b7b\u4ea1\u7387\u589e\u52a0\u53ca\u533b\u7597\u8017\u7528\u589e\u52a0\u7b49\u5f8c\u679c\u4e4b\u5916\uff0c\u8fd8\u53ef\u80fd\u9020\u6210\u4e0b\u5217\u5f71\u54cd\uff1a<\/p>\n<ul>\n<li>1.\u9aa8\u677e\u6027\u9aa8\u6298\u5f8c\u9020\u6210\u75bc\u75db\u53ca\u5931\u80fd\u7684\u9650\u5236\u3002<\/li>\n<li>2.\u9aa8\u677e\u6027\u4e8c\u6b21\u9aa8\u6298\u98ce\u9669\u5927\u589e\u3002<\/li>\n<li>3.\u9aa8\u8d28\u758f\u677e\u75c7\u4e0e\u808c\u5c11\u75c7\u5e38\u5e38\u662f\u5171\u75c5\u53d1\u751f\uff0c\u4e24\u8005\u7686\u662f\u5f15\u8d77\u8001\u5e74\u4eba\u8dcc\u5012\u7684\u91cd\u8981\u5371\u9669\u56e0\u5b50\u4e4b\u4e00\uff0c\u800c\u8dcc\u5012\u66f4\u662f\u9020\u6210\u9acb\u90e8\u9aa8\u6298\u7684\u4e3b\u56e0\u3002<\/li>\n<\/ul>\n<p><!--more--><\/p>\n<p>\u53d1\u8868\u5728\u5b66\u672f\u671f\u520a\u300a\u8870\u8001\u7ec6\u80de\u300b(Aging Cell)\u4e0a\u7684\u8bba\u6587\u53d1\u73b0\uff0c\u63a5\u53d7\u5316\u7597\u548c\u6c27\u5316\u5e94\u6fc0\u7684\u9aa8\u968f\u95f4\u8d28\u5e72\u7ec6\u80de (BMSCs) \u5728\u63a5\u53d7 NMN \u4ecb\u5165\u5f8c\uff0c\u8868\u73b0\u51fa\u589e\u5f3a\u7684\u5e72\u7ec6\u80de\u7279\u6027\u3002<br \/>\n\u800c\u4e14\u7814\u7a76\u7ed3\u679c\u663e\u793a NMN \u4f1a\u4e0e DNA \u7ed3\u5408\uff0c\u53ef\u4ee5\u4f7f\u57fa\u56e0\u8868\u8fbe\u8c31\u6062\u590d\u6d3b\u529b\u3002<\/p>\n<p>\u95f4\u8d28\u5e72\u7ec6\u80de (BMSCs) \u7684\u5e72\u7ec6\u80de\u7279\u6027\u4e0b\u964d\uff0c\u662f\u7531\u65bc\u5e72\u7ec6\u80de\u5728\u901a\u8fc7\u7ec6\u80de\u5468\u671f\u8fdb\u5c55\u5230\u6210\u719f\u4e3a\u6210\u9aa8\u7ec6\u80de\u65f6\u7684\u7a81\u53d8\u79ef\u7d2f\u3002\u56e0\u6b64\u7814\u7a76\u7684\u65b9\u5411\u662f\u5bfb\u627e\u7ef4\u6301BMSCs\u7684\u5e72\u7ec6\u80de\u7279\u6027\u7684\u65b9\u6cd5\u3002<\/p>\n<p>\u7814\u7a76\u4eba\u5458\u53d1\u73b0\u7528 NMN\u63d0\u9ad8 NAD+ \u6c34\u5e73\u5f8c\uff0c\u53ef\u4ee5\u8ba9NMN\u4e0e\u957f\u5bff\u57fa\u56e0SIRT1\u86cb\u767d\u7ed3\u5408\uff0c\u6fc0\u6d3b\u9aa8\u9abc\u518d\u751f\uff08\u6210\u9aa8\uff09\u7684\u57fa\u56e0\u3002\u5e76\u4e14\u901a\u8fc7\u523a\u6fc0\u6210\u9aa8\u4f5c\u7528\uff0cNMN\u53ef\u9632\u6b62\u9aa8\u8d28\u758f\u677e\u75c7\u7684\u53d1\u5c55\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-20032\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/04\/agingcell.jpg\" alt=\"\" width=\"591\" height=\"544\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/04\/agingcell.jpg 591w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/04\/agingcell-300x276.jpg 300w\" sizes=\"auto, (max-width: 591px) 100vw, 591px\" \/><\/p>\n<p>\u5168\u6587\u8fde\u7ed3\uff1a<a href=\"http:\/\/johnhealth.blog\/ch\/?p=185\">\u3010NMN\u79d1\u6280\u8fdb\u5c55\u3011NMN \u4f7f\u9aa8\u7ec4\u7ec7\u5e72\u7ec6\u80de\u6062\u590d\u6d3b\u529b \u2013 John\u54e5\u8c08\u5065\u5eb7 (johnhealth.blog)<\/a><\/p>\n<p>M, Xing L, Zhang L, Liu F, Wang S, Xie Y, Wang J, Jiang H, Guo J, Li X, Wang J, Sui L, Li C, Liu D, Liu Z. NAP1L2 drives mesenchymal stem cell senescence and suppresses osteogenic<br \/>\ndifferentiation. Aging Cell. 2022 Jan 15:e13551. doi: 10.1111\/acel.13551. Epub ahead of print. PMID: 35032339.<\/p>\n<div class=\"pvc_clear\"><\/div>\n<p id=\"pvc_stats_20031\" class=\"pvc_stats all  \" data-element-id=\"20031\" style=\"\"><i class=\"pvc-stats-icon medium\" aria-hidden=\"true\"><svg aria-hidden=\"true\" focusable=\"false\" data-prefix=\"far\" data-icon=\"chart-bar\" role=\"img\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\" class=\"svg-inline--fa fa-chart-bar fa-w-16 fa-2x\"><path fill=\"currentColor\" d=\"M396.8 352h22.4c6.4 0 12.8-6.4 12.8-12.8V108.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v230.4c0 6.4 6.4 12.8 12.8 12.8zm-192 0h22.4c6.4 0 12.8-6.4 12.8-12.8V140.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v198.4c0 6.4 6.4 12.8 12.8 12.8zm96 0h22.4c6.4 0 12.8-6.4 12.8-12.8V204.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v134.4c0 6.4 6.4 12.8 12.8 12.8zM496 400H48V80c0-8.84-7.16-16-16-16H16C7.16 64 0 71.16 0 80v336c0 17.67 14.33 32 32 32h464c8.84 0 16-7.16 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