{"id":20021,"date":"2023-04-06T02:08:18","date_gmt":"2023-04-06T02:08:18","guid":{"rendered":"http:\/\/johnhealth.blog\/ch\/?p=20021"},"modified":"2023-04-06T02:08:36","modified_gmt":"2023-04-06T02:08:36","slug":"%e3%80%90%e7%a7%91%e6%8a%80%e8%bf%9b%e5%b1%95%e3%80%91nmn-%e5%88%ba%e6%bf%80%e9%aa%a8%e9%ab%93%e5%b9%b2%e7%bb%86%e8%83%9e%e5%bd%a2%e6%88%90%e6%9b%b4%e5%a4%9a%e7%9a%84%e9%aa%a8%e9%aa%bc%e5%92%8c","status":"publish","type":"post","link":"http:\/\/johnhealth.blog\/ch\/?p=20021","title":{"rendered":"\u3010\u79d1\u6280\u8fdb\u5c55\u3011NMN \u523a\u6fc0\u9aa8\u9ad3\u5e72\u7ec6\u80de\u5f62\u6210\u66f4\u591a\u7684\u9aa8\u9abc\u548c\u66f4\u5c11\u7684\u8102\u80aa"},"content":{"rendered":"

\u7814\u7a76\u7ed3\u679c\u63ed\u793a\u4e86 NMN\u7684\u4ecb\u5165\u4e0e\u9aa8\u8d28\u758f\u677e\u75c7\u548c\u8870\u8001\u6cbb\u7597\u4e4b\u95f4\u7684\u6f5c\u5728\u8054\u7cfb\u3002<\/p>\n

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By\u00a0swriter Published:\u00a09:28 am PST Apr 25, 2019\u00a0| Updated:\u00a011:43 am PST Sep 22, 2020<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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206 \u5757\u9aa8\u5934\u652f\u6491\u7740\u4e00\u4e2a\u6210\u5e74\u4eba\u7684\u9aa8\u67b6\uff0c\u4fdd\u62a4\u6211\u4eec\u7684\u91cd\u8981\u5668\u5b98\uff0c\u652f\u6491\u6211\u4eec\u7684\u4f53\u91cd\uff0c\u5e76\u4f7f\u6211\u4eec\u7684\u6d3b\u52a8\u80fd\u529b\u5f97\u4ee5\u5b9e\u73b0\u3002 \u5728\u5668\u5b98\u7684\u521a\u6027\u8868\u5c42\u5185\u90e8\u662f\u8702\u7a9d\u72b6\u7684\u5b54\u3002 \u6211\u4eec\u7684\u9aa8\u7ec4\u7ec7\u4f1a\u5206\u89e3\u5e76\u4e0d\u65ad\u5f97\u5230\u8865\u5145\u3002 \u4f46\u968f\u7740\u5e74\u9f84\u7684\u589e\u957f\uff0c\u65b0\u9aa8\u7684\u5f62\u6210\u8ddf\u4e0d\u4e0a\u65e7\u9aa8\u7684\u53bb\u9664\u3002 \u5916\u5c42\u53d8\u8584\uff0c\u5c0f\u5b54\u53d8\u5927\u2014\u2014\u66fe\u7ecf\u575a\u56fa\u7684\u9aa8\u5934\u5f00\u59cb\u4ece\u91cc\u5230\u5916\u5206\u5d29\u79bb\u6790\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u4e2d\u5c71\u5927\u5b66\u7684\u79d1\u5b66\u5bb6\u53d1\u73b0\uff0c\u70df\u9170\u80fa\u5355\u6838\u82f7\u9178\uff08NMN\uff09<\/a>\u5206\u5b50\u53ef\u4ee5\u901a\u8fc7\u523a\u6fc0\u4e00\u7ec4\u5e72\u7ec6\u80de\u5206\u5316\u4e3a\u9aa8\u7ec6\u80de\u800c\u4e0d\u662f\u8102\u80aa\u6765\u4fc3\u8fdb\u5c0f\u9f20\u7684\u9aa8\u9abc\u751f\u6210\u3002 \u53d1\u8868\u5728\u5b66\u672f\u671f\u520a\u300a\u7ec6\u80de\u6b7b\u4ea1\u4e0e\u75be\u75c5\u300b\uff08Cell Death &Disease<\/em><\/a>\uff09<\/em><\/a>\u4e0a\u7684\u65b9\u6cd5\u63ed\u793a\u4e86 NMN \u662f\u4e00\u79cd\u65b0\u578b\u7684\u9aa8\u8d28\u758f\u677e\u75c7\u6f5c\u5728\u5e72\u9884\u63aa\u65bd\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u201c\u6211\u4eec\u7684\u7814\u7a76\u7ed3\u679c\u63ed\u793a\u4e86 NMN<\/a> \u4ecb\u5165\u4e0e\u9aa8\u8d28\u758f\u677e\u548c\u8870\u8001\u5c0f\u9f20\u6cbb\u7597\u4e4b\u95f4\u7684\u6f5c\u5728\u8054\u7cfb\uff0c\u201dSong\u53ca\u5176\u540c\u4e8b\u63d0\u51fa\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u9aa8\u9ad3\u5e72\u7ec6\u80de\u4ea7\u751f\u591a\u79cd\u7ec6\u80de\u7c7b\u578b<\/span><\/strong><\/p>\n

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NMN \u57f9\u517b\u7684\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSC\uff09 \u589e\u52a0\u66f4\u591a\u7684\u9aa8\u9abc\u548c\u66f4\u5c11\u7684\u8102\u80aa<\/span><\/strong><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u5728\u7ec6\u80de\u57f9\u517b\u7269\u548c\u6210\u5e74\u5c0f\u9f20\u4e2d\uff0c\u7814\u7a76\u5c0f\u7ec4\u53d1\u73b0 NMN \u6cbb\u7597\u6709\u6548\u5730\u4fc3\u8fdb\u4e86 MSC \u6269\u589e\uff0c\u5176\u4e2d\u5e72\u7ec6\u80de\u6570\u91cf\u589e\u52a0\u3002 \u5f53\u7814\u7a76\u4eba\u5458\u8fdb\u4e00\u6b65\u5c06 MSC \u8bf1\u5bfc\u6210\u4e24\u4e2a\u4e0d\u540c\u7684\u8c31\u7cfb\uff0c\u5373\u9aa8\u5f62\u6210\u7ec6\u80de\uff08bone-forming cell\uff09\u548c\u8102\u80aa\u5f62\u6210\u7ec6\u80de\uff08fat-forming cell\uff09\u65f6\uff0c\u4ed6\u4eec\u53d1\u73b0 NMN \u5bf9\u8fd9\u4e24\u4e2a\u8c31\u7cfb\u5177\u6709\u663e\u8457\u4e14\u72ec\u7279\u7684\u5f71\u54cd\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u867d\u7136\u7528NMN\u4ecb\u5165\u7684\u9aa8\u5f62\u6210\u7ec6\u80de\u7cfb\u4ea7\u751f\u4e86\u7ea650%\u7684\u6210\u9aa8\u7ec6\u80de\uff0c\u5373\u5f62\u6210\u65b0\u9aa8\u7684\u7ec6\u80de\uff0c\u4f46\u672a\u7ecf\u4ecb\u5165\u7684\u7ec6\u80de\u4ec5\u4ea7\u751f\u7ea630%\u3002 \u76f8\u6bd4\u4e4b\u4e0b\uff0c\u4e0e\u672a\u4ecb\u5165\u7684\u7ec6\u80de\u76f8\u6bd4\uff0c\u7528 NMN \u4ecb\u5165\u7684\u8102\u80aa\u5f62\u6210\u7ec6\u80de\u7cfb\u5f62\u6210\u8102\u80aa\u7684\u8102\u80aa\u7ec6\u80de\u6d53\u5ea6\u8f83\u4f4e\u3002 \u7ed3\u679c\u8868\u660e\uff0cNMN\u4fc3\u8fdb\u9aa8\u9abc\u751f\u6210\uff0c\u540c\u65f6\u963b\u788d\u8102\u80aa\u5f62\u6210\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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(Song et al., 2019 |<\/strong><\/a> Cell Death Dis.<\/strong><\/em><\/a> \uff09<\/strong><\/a> NMN \u6269\u589e\u7684\u9aa8\u9ad3\u5e72\u7ec6\u80de\u589e\u5f3a\u4e86\u6210\u9aa8\u4f5c\u7528\uff0c\u4f46\u964d\u4f4e\u4e86\u8102\u80aa\u751f\u6210\u80fd\u529b\u3002 <\/strong>\u4e0e\u5bf9\u7167\u7ec4\uff08B\u3001D\uff09\u4e2d\u7684~30% \u76f8\u6bd4\uff0c\u5728\u7528 NMN \u5904\u7406\u7684\u57f9\u517b\u7269\u4e2d\u57f9\u517b\u7684\u9aa8\u9ad3\u5e72\u7ec6\u80de\u4ea7\u751f\u663e\u8457\u66f4\u591a\u7684\u6210\u9aa8\u7ec6\u80de\uff08~50% Alizarin R+ colonies\uff09\u3002 \u6b64\u5916\uff0c\u5728\u6d53\u5ea6\u5927\u4e8e 0.25 \u03bcM \uff08E\uff09 \u7684 NMN \u5904\u7406\u7684\u7ec6\u80de\u4e2d\uff0c\u8102\u80aa\u7ec6\u80de\u5206\u5316\u663e\u8457\u51cf\u5c11\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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NMN \u9006\u8f6c\u5c0f\u9f20\u4e0e\u5e74\u9f84\u76f8\u5173\u7684\u9aa8\u8d28\u6d41\u5931<\/span><\/strong><\/p>\n

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(Song et al., 2019 |<\/strong><\/a> Cell Death Dis.<\/strong><\/em><\/a> \uff09<\/strong><\/a> NMN \u589e\u52a0\u8001\u5e74\u5c0f\u9f20\u7684\u6210\u9aa8\u4f5c\u7528\u3002 NMN \u4ecb\u5165\u7684\u8001\u5e74\u5c0f\u9f20\u5bfc\u81f4\u9aa8\u5c0f\u6881\u6570\u91cf \uff08I\uff09\u3001\u539a\u5ea6 \uff08J\uff09 \u548c\u9aa8\u8fde\u63a5\u5bc6\u5ea6 \uff08L\uff09 \u589e\u52a0\u2014\u2014\u6240\u6709\u8fd9\u4e9b\u8ff9\u8c61\u90fd\u8868\u660e\u9aa8\u5f62\u6210\u589e\u52a0\u3002 \u4e00\u81f4\u5730\uff0cNMN \u4ecb\u5165\u4e5f\u964d\u4f4e\u4e86\u5c0f\u6881\u95f4\u8ddd \uff08K\uff09\u3002 <\/strong><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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(Song et al., 2019 |<\/strong><\/a> Cell Death Dis.<\/strong><\/em><\/a> \uff09<\/strong><\/a> NMN \u5728\u7167\u5c04\u4e0b\u589e\u52a0\u6210\u5e74\u5c0f\u9f20\u7684\u6210\u9aa8\u3002 <\/strong>\u4ee3\u8868\u6027\u7684\u03bcCT\u56fe\u50cf\u663e\u793a\u6765\u81ea\u80a1\u9aa8\u5f62\u800c\u4e0a\u5b66\u7684\u9aa8\u5c0f\u6881\u3002 \u7167\u5c04\u540e\uff0c\u672a\u7ecf\u6cbb\u7597\u7684\u6210\u5e74\u5c0f\u9f20\u5c0f\u6881\u6570\u91cf\u3001\u539a\u5ea6\u548c\u9aa8\u8fde\u63a5\u5bc6\u5ea6\u51cf\u5c11\uff0c\u5c0f\u6881\u95f4\u8ddd\u589e\u52a0\u3002 \u91cd\u8981\u7684\u662f\uff0cNMN \u4ecb\u5165\u9006\u8f6c\u4e86\u7167\u5c04\u540e\u9aa8\u5c0f\u6881\u7684\u8fd9\u4e9b\u53d8\u5316\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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(Song et al., 2019 |<\/strong><\/a> Cell Death Dis.<\/strong><\/em><\/a> \uff09<\/strong><\/a> NMN \u51cf\u5c11\u7167\u5c04\u4e0b\u6210\u5e74\u5c0f\u9f20\u7684\u8102\u80aa\u751f\u6210\u3002 <\/strong>\u4e0e\u672a\u6cbb\u7597\u7684\u5c0f\u9f20\u76f8\u6bd4\uff0c\u5728\u66b4\u9732\u4e8e\u8f90\u5c04\u540e\u7528 NMN \u4ecb\u5165\u7684\u5c0f\u9f20\uff08\u53f3\uff09\u7684\u8102\u80aa\u5f62\u6210\u7ec4\u7ec7\uff08\u67d3\u6210\u7ea2\u8272\uff09\u660e\u663e\u51cf\u5c11\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u201c\u6211\u4eec\u7684\u7814\u7a76\u8868\u660e\uff0cNMN \u589e\u5f3a\u4e86\u8001\u5e74\u548c\u53d7\u8fc7\u8f90\u5c04\u5c0f\u9f20\u9aa8\u8c31\u7cfb\u7684\u9aa8-\u8102\u80aa\u5e73\u8861\uff0c\u8fd9\u8868\u660e NMN \u662f\u633d\u6551\u8870\u8001\u8fc7\u7a0b\u4e2d\u9aa8\u8d28\u6d41\u5931\u7684\u4e00\u79cd\u6709\u4ef7\u503c\u7684\u65b9\u6cd5\uff0c\u201d\u4f5c\u8005\u6307\u51fa\u3002 \u201c\u6211\u4eec\u7684\u7814\u7a76\u5c06 NMN \u786e\u7acb\u4e3a\u4e00\u79cd\u6709\u524d\u666f\u7684\u6f5c\u5728\u7597\u6cd5\uff0c\u53ef\u7528\u4e8e MSCs \u6269\u5f20\u548c\u8001\u5e74 MSCs \u7684\u6062\u590d\u3002\u201d<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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Song J, Li J, Yang F, et al. Nicotinamide mononucleotide promotes osteogenesis and reduces adipogenesis by regulating mesenchymal stromal cells via the SIRT1 pathway in aged bone marrow. Cell Death Dis. 2019; 10(5):336. Published 2019 Apr 18. doi:10.1038\/s41419-019-1569-2<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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https:\/\/www.nmn.com\/news\/nmn-stimulates-bone-marrow-stem-cells<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u7814\u7a76\u7ed3\u679c\u63ed\u793a\u4e86 NMN\u7684\u4ecb\u5165\u4e0e\u9aa8\u8d28\u758f\u677e\u75c7\u548c\u8870\u8001\u6cbb\u7597\u4e4b\u95f4\u7684\u6f5c\u5728\u8054\u7cfb\u3002 By\u00a0swriter Published:\u00a09:28 am PST Apr 25, 2019\u00a0| Updated:\u00a011:43 am PST Sep 22, 2020 206 \u5757\u9aa8\u5934\u652f\u6491\u7740\u4e00\u4e2a\u6210\u5e74\u4eba\u7684\u9aa8\u67b6\uff0c\u4fdd\u62a4\u6211\u4eec\u7684\u91cd\u8981\u5668\u5b98\uff0c\u652f\u6491\u6211\u4eec\u7684\u4f53\u91cd\uff0c\u5e76\u4f7f\u6211\u4eec\u7684\u6d3b\u52a8\u80fd\u529b\u5f97\u4ee5\u5b9e\u73b0\u3002 \u5728\u5668\u5b98\u7684\u521a\u6027\u8868\u5c42\u5185\u90e8\u662f\u8702\u7a9d\u72b6\u7684\u5b54\u3002 \u6211\u4eec\u7684\u9aa8\u7ec4\u7ec7\u4f1a\u5206\u89e3\u5e76\u4e0d\u65ad\u5f97\u5230\u8865\u5145\u3002 \u4f46\u968f\u7740\u5e74\u9f84\u7684\u589e\u957f\uff0c\u65b0\u9aa8\u7684\u5f62\u6210\u8ddf\u4e0d\u4e0a\u65e7\u9aa8\u7684\u53bb\u9664\u3002 \u5916\u5c42\u53d8\u8584\uff0c\u5c0f\u5b54\u53d8\u5927\u2014\u2014\u66fe\u7ecf\u575a\u56fa\u7684\u9aa8\u5934\u5f00\u59cb\u4ece\u91cc\u5230\u5916\u5206\u5d29\u79bb\u6790\u3002<\/p>\n

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