{"id":20020,"date":"2023-07-09T13:05:53","date_gmt":"2023-07-09T13:05:53","guid":{"rendered":"http:\/\/johnhealth.blog\/ch\/?p=20020"},"modified":"2023-07-13T01:45:57","modified_gmt":"2023-07-13T01:45:57","slug":"%e3%80%8a%e6%b7%b1%e8%b0%88nmn%e7%b3%bb%e5%88%97-%e9%aa%a8%e8%b4%a8%e7%96%8f%e6%9d%be%e3%80%8b1-nmn-%e5%88%ba%e6%bf%80%e9%aa%a8%e9%ab%93%e5%b9%b2%e7%bb%86%e8%83%9e%e5%bd%a2%e6%88%90%e6%9b%b4%e5%a4%9a","status":"publish","type":"post","link":"http:\/\/johnhealth.blog\/ch\/?p=20020","title":{"rendered":"\u300a\u6df1\u8c08NMN\u7cfb\u5217-\u9aa8\u8d28\u758f\u677e\u300b1 NMN \u523a\u6fc0\u9aa8\u9ad3\u5e72\u7ec6\u80de\u5f62\u6210\u66f4\u591a\u7684\u9aa8\u9abc\u548c\u66f4\u5c11\u7684\u8102\u80aa"},"content":{"rendered":"<p>\u9aa8\u8d28\u758f\u677e\u75c7\u662f\u8001\u5316\u8fc7\u7a0b\u4e2d\u7684\u9690\u5f62\u6740\u624b\uff0c\u5728\u4e0d\u77e5\u4e0d\u89c9\u4e2d\u5c31\u4f1a\u8ba9\u6211\u4eec\u6210\u4e3a\u9aa8\u6298\u7684\u9ad8\u98ce\u9669\u65cf\u7fa4\uff0c\u800c\u8dcc\u5012\u66f4\u662f\u9020\u6210\u9acb\u90e8\u9aa8\u6298\u800c\u5931\u80fd\u7684\u6700\u5927\u5f71\u54cd\u3002<\/p>\n<p>\u53d1\u8868\u5728\u5b66\u672f\u671f\u520a\u300a\u7ec6\u80de\u6b7b\u4ea1\u4e0e\u75be\u75c5\u300b( Cell Death &amp; Disease)\u4e0a\u7684\u8bba\u6587\u53d1\u73b0\uff0cNMN\u53ef\u4ee5\u901a\u8fc7\u523a\u6fc0\u4e00\u7ec4\u5e72\u7ec6\u80de\u5206\u5316\u4e3a\u6210\u9aa8\u7ec6\u80de\uff0c\u800c\u4e0d\u662f\u8102\u80aa\uff0c\u5e76\u4ee5\u6b64\u6765\u4fc3\u8fdb\u5c0f\u9f20\u7684\u9aa8\u9abc\u751f\u6210\u3002<\/p>\n<p>\u9aa8\u9ad3\u4e2d\u7684\u95f4\u8d28\u5e72\u7ec6\u80de(MSC) \u662f\u591a\u529f\u80fd\u5e72\u7ec6\u80de\u7684\u50a8\u5b58\u5e93\uff0c\u53ef\u4ee5\u5206\u5316\u6210\u591a\u79cd\u7ec6\u80de\u7c7b\u578b\uff0c\u5305\u62ec\u9aa8\u9abc\u4e36\u8f6f\u9aa8\u548c\u8102\u80aa\u3002 \u5e72\u7ec6\u80de\u5728\u9aa8\u7ec4\u7ec7\u5185\u4fdd\u6301\u5e73\u8861\u3002 \u7136\u800c\uff0c\u5f53\u9aa8\u9ad3 MSC \u5f02\u5e38\u5206\u5316\u4e3a\u8102\u80aa\u800c\u4e0d\u662f\u9aa8\u7ec4\u7ec7\u65f6\uff0c\u5b83\u4f1a\u635f\u5bb3\u9aa8\u9abc\u7684\u5f62\u6210\uff0c\u5bfc\u81f4\u9aa8\u9abc\u8001\u5316\u548c\u9aa8\u8d28\u758f\u677e\u75c7\u3002<\/p>\n<p>\u7814\u7a76\u53d1\u73b0\uff0cNMN \u6709\u6548\u5730\u4fc3\u8fdb\u4e86 MSC \u6269\u589e\uff0c\u5176\u4e2d\u5e72\u7ec6\u80de\u6570\u91cf\u589e\u52a0\u3002 \u5f53\u7814\u7a76\u4eba\u5458\u8fdb\u4e00\u6b65\u5c06 MSC \u8bf1\u5bfc\u6210\u4e24\u4e2a\u4e0d\u540c\u7684\u8c31\u7cfb\uff0c\u5373\u9aa8\u9abc\u5f62\u6210\u7ec6\u80de(bone\u0002forming cell)\u548c\u8102\u80aa\u5f62\u6210\u7ec6\u80de(fat-forming cell)\u65f6\uff0c\u4ed6\u4eec\u53d1\u73b0 NMN \u4ecb\u5165\u7684\u9aa8\u9abc\u5f62\u6210\u7ec6\u80de\u7cfb(bone\u0002forming cell)\u4ea7\u751f\u4e86\u7ea6 50% \u7684\u6210\u9aa8\u7ec6\u80de\uff0c\u4ee3\u8868NMN\u4fc3\u8fdb\u9aa8\u9abc\u751f\u6210\uff0c\u540c\u65f6\u963b\u788d\u8102\u80aa\u5f62\u6210\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-20029\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/04\/316113739_515737990575676_2251041653408437365_n.jpg\" alt=\"\" width=\"541\" height=\"614\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/04\/316113739_515737990575676_2251041653408437365_n.jpg 541w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/04\/316113739_515737990575676_2251041653408437365_n-264x300.jpg 264w\" sizes=\"auto, (max-width: 541px) 100vw, 541px\" \/><\/p>\n<p>\u5168\u6587\u8fde\u7ed3\uff1a<a href=\"http:\/\/johnhealth.blog\/ch\/?p=20021\">\u3010\u79d1\u6280\u8fdb\u5c55\u3011NMN \u523a\u6fc0\u9aa8\u9ad3\u5e72\u7ec6\u80de\u5f62\u6210\u66f4\u591a\u7684\u9aa8\u9abc\u548c\u66f4\u5c11\u7684\u8102\u80aa \u2013 John\u54e5\u8c08\u5065\u5eb7 (johnhealth.blog)<\/a><\/p>\n<p>Song J, Li J, Yang F, et al. Nicotinamide mononucleotide promotes osteogenesis and reduces adipogenesis by regulating mesenchymal stromal cells via the SIRT1 pathway in aged bone marrow. Cell Death Dis. 2019;10(5):336. Published 2019 Apr 18. doi:10.1038\/s41419-019-1569-2.<\/p>\n<div class=\"pvc_clear\"><\/div>\n<p id=\"pvc_stats_20020\" class=\"pvc_stats all  \" data-element-id=\"20020\" style=\"\"><i class=\"pvc-stats-icon medium\" aria-hidden=\"true\"><svg aria-hidden=\"true\" focusable=\"false\" data-prefix=\"far\" data-icon=\"chart-bar\" role=\"img\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\" class=\"svg-inline--fa fa-chart-bar fa-w-16 fa-2x\"><path fill=\"currentColor\" d=\"M396.8 352h22.4c6.4 0 12.8-6.4 12.8-12.8V108.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v230.4c0 6.4 6.4 12.8 12.8 12.8zm-192 0h22.4c6.4 0 12.8-6.4 12.8-12.8V140.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v198.4c0 6.4 6.4 12.8 12.8 12.8zm96 0h22.4c6.4 0 12.8-6.4 12.8-12.8V204.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v134.4c0 6.4 6.4 12.8 12.8 12.8zM496 400H48V80c0-8.84-7.16-16-16-16H16C7.16 64 0 71.16 0 80v336c0 17.67 14.33 32 32 32h464c8.84 0 16-7.16 16-16v-16c0-8.84-7.16-16-16-16zm-387.2-48h22.4c6.4 0 12.8-6.4 12.8-12.8v-70.4c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v70.4c0 6.4 6.4 12.8 12.8 12.8z\" class=\"\"><\/path><\/svg><\/i> <img loading=\"lazy\" decoding=\"async\" width=\"16\" height=\"16\" alt=\"Loading\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/plugins\/page-views-count\/ajax-loader-2x.gif\" border=0 \/><\/p>\n<div class=\"pvc_clear\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u9aa8\u8d28\u758f\u677e\u75c7\u662f\u8001\u5316\u8fc7\u7a0b\u4e2d\u7684\u9690\u5f62\u6740\u624b\uff0c\u5728\u4e0d\u77e5\u4e0d\u89c9\u4e2d\u5c31\u4f1a\u8ba9\u6211\u4eec\u6210\u4e3a\u9aa8\u6298\u7684\u9ad8\u98ce\u9669\u65cf\u7fa4\uff0c\u800c\u8dcc\u5012\u66f4\u662f\u9020\u6210\u9acb\u90e8\u9aa8\u6298\u800c\u5931\u80fd\u7684\u6700\u5927\u5f71\u54cd\u3002 \u53d1\u8868\u5728\u5b66\u672f\u671f\u520a\u300a\u7ec6\u80de\u6b7b\u4ea1\u4e0e\u75be\u75c5\u300b( Cell Death &amp; Disease)\u4e0a\u7684\u8bba\u6587\u53d1\u73b0\uff0cNMN\u53ef\u4ee5\u901a\u8fc7\u523a\u6fc0\u4e00\u7ec4\u5e72\u7ec6\u80de\u5206\u5316\u4e3a\u6210\u9aa8\u7ec6\u80de\uff0c\u800c\u4e0d\u662f\u8102\u80aa\uff0c\u5e76\u4ee5\u6b64\u6765\u4fc3\u8fdb\u5c0f\u9f20\u7684\u9aa8\u9abc\u751f\u6210\u3002 \u9aa8\u9ad3\u4e2d\u7684\u95f4\u8d28\u5e72\u7ec6\u80de(MSC) \u662f\u591a\u529f\u80fd\u5e72\u7ec6\u80de\u7684\u50a8\u5b58\u5e93\uff0c\u53ef\u4ee5\u5206\u5316\u6210\u591a\u79cd\u7ec6\u80de\u7c7b\u578b\uff0c\u5305\u62ec\u9aa8\u9abc\u4e36\u8f6f\u9aa8\u548c\u8102\u80aa\u3002 \u5e72\u7ec6\u80de\u5728\u9aa8\u7ec4\u7ec7\u5185\u4fdd\u6301\u5e73\u8861\u3002 \u7136\u800c\uff0c\u5f53\u9aa8\u9ad3 MSC \u5f02\u5e38\u5206\u5316\u4e3a\u8102\u80aa\u800c\u4e0d\u662f\u9aa8\u7ec4\u7ec7\u65f6\uff0c\u5b83\u4f1a\u635f\u5bb3\u9aa8\u9abc\u7684\u5f62\u6210\uff0c\u5bfc\u81f4\u9aa8\u9abc\u8001\u5316\u548c\u9aa8\u8d28\u758f\u677e\u75c7\u3002 \u7814\u7a76\u53d1\u73b0\uff0cNMN \u6709\u6548\u5730\u4fc3\u8fdb\u4e86 MSC \u6269\u589e\uff0c\u5176\u4e2d\u5e72\u7ec6\u80de\u6570\u91cf\u589e\u52a0\u3002 \u5f53\u7814\u7a76\u4eba\u5458\u8fdb\u4e00\u6b65\u5c06 MSC \u8bf1\u5bfc\u6210\u4e24\u4e2a\u4e0d\u540c\u7684\u8c31\u7cfb\uff0c\u5373\u9aa8\u9abc\u5f62\u6210\u7ec6\u80de(bone\u0002forming cell)\u548c\u8102\u80aa\u5f62\u6210\u7ec6\u80de(fat-forming cell)\u65f6\uff0c\u4ed6\u4eec\u53d1\u73b0 NMN \u4ecb\u5165\u7684\u9aa8\u9abc\u5f62\u6210\u7ec6\u80de\u7cfb(bone\u0002forming cell)\u4ea7\u751f\u4e86\u7ea6 50% \u7684\u6210\u9aa8\u7ec6\u80de\uff0c\u4ee3\u8868NMN\u4fc3\u8fdb\u9aa8\u9abc\u751f\u6210\uff0c\u540c\u65f6\u963b\u788d\u8102\u80aa\u5f62\u6210\u3002 \u5168\u6587\u8fde\u7ed3\uff1a\u3010\u79d1\u6280\u8fdb\u5c55\u3011NMN \u523a\u6fc0\u9aa8\u9ad3\u5e72\u7ec6\u80de\u5f62\u6210\u66f4\u591a\u7684\u9aa8\u9abc\u548c\u66f4\u5c11\u7684\u8102\u80aa \u2013 John\u54e5\u8c08\u5065\u5eb7 (johnhealth.blog) Song J, Li J, Yang F, et al. Nicotinamide mononucleotide promotes osteogenesis and reduces adipogenesis by regulating mesenchymal stromal cells via the SIRT1 pathway in aged bone marrow. Cell [&hellip;]<\/p>\n<div class=\"pvc_clear\"><\/div>\n<p id=\"pvc_stats_20020\" class=\"pvc_stats all  \" data-element-id=\"20020\" style=\"\"><i class=\"pvc-stats-icon medium\" aria-hidden=\"true\"><svg aria-hidden=\"true\" focusable=\"false\" data-prefix=\"far\" data-icon=\"chart-bar\" role=\"img\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\" class=\"svg-inline--fa fa-chart-bar fa-w-16 fa-2x\"><path fill=\"currentColor\" d=\"M396.8 352h22.4c6.4 0 12.8-6.4 12.8-12.8V108.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v230.4c0 6.4 6.4 12.8 12.8 12.8zm-192 0h22.4c6.4 0 12.8-6.4 12.8-12.8V140.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v198.4c0 6.4 6.4 12.8 12.8 12.8zm96 0h22.4c6.4 0 12.8-6.4 12.8-12.8V204.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v134.4c0 6.4 6.4 12.8 12.8 12.8zM496 400H48V80c0-8.84-7.16-16-16-16H16C7.16 64 0 71.16 0 80v336c0 17.67 14.33 32 32 32h464c8.84 0 16-7.16 16-16v-16c0-8.84-7.16-16-16-16zm-387.2-48h22.4c6.4 0 12.8-6.4 12.8-12.8v-70.4c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v70.4c0 6.4 6.4 12.8 12.8 12.8z\" class=\"\"><\/path><\/svg><\/i> <img loading=\"lazy\" decoding=\"async\" width=\"16\" height=\"16\" alt=\"Loading\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/plugins\/page-views-count\/ajax-loader-2x.gif\" border=0 \/><\/p>\n<div class=\"pvc_clear\"><\/div>\n","protected":false},"author":1,"featured_media":20029,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[172,734],"tags":[687,728,87,755],"class_list":["post-20020","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-nmn-","category-nmn","tag-687","tag-nmn","tag-87","tag-755"],"aioseo_notices":[],"_links":{"self":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts\/20020","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=20020"}],"version-history":[{"count":1,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts\/20020\/revisions"}],"predecessor-version":[{"id":20030,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts\/20020\/revisions\/20030"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/media\/20029"}],"wp:attachment":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=20020"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=20020"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=20020"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}