{"id":20007,"date":"2023-04-01T14:57:39","date_gmt":"2023-04-01T14:57:39","guid":{"rendered":"http:\/\/johnhealth.blog\/ch\/?p=20007"},"modified":"2023-04-01T14:58:22","modified_gmt":"2023-04-01T14:58:22","slug":"%e3%80%90%e7%a7%91%e6%8a%80%e6%96%87%e7%8c%ae%e3%80%91nmn%e5%8f%af%e6%94%b9%e5%96%84%e8%84%91%e7%9b%b8%e5%85%b3%e8%a1%80%e7%ae%a1%e7%bb%86%e8%83%9e%e5%af%b9%e5%8e%8b%e5%8a%9b%e7%9a%84%e5%8f%8d","status":"publish","type":"post","link":"http:\/\/johnhealth.blog\/ch\/?p=20007","title":{"rendered":"\u3010\u79d1\u6280\u6587\u732e\u3011NMN\u53ef\u6539\u5584\u8111\u76f8\u5173\u8840\u7ba1\u7ec6\u80de\u5bf9\u538b\u529b\u7684\u53cd\u5e94"},"content":{"rendered":"

NMN \u6cbb\u7597\u53ef\u63d0\u9ad8\u5927\u8111\u76f8\u5173\u8840\u7ba1\u7ec6\u80de\u7684\u5b58\u6d3b\u7387\uff0c\u5e76\u9632\u6b62\u7cd6\u5c3f\u75c5\u7b49\u4ee3\u8c22\u75be\u75c5\u4e2d\u7684\u6709\u5bb3\u538b\u529b\u3002<\/p>\n

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By\u00a0Brett J. Weiss<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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Published:\u00a03:20 p.m. PST Dec 26, 2020\u00a0| Updated:\u00a01:01 p.m. PST Sep 29, 2021<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u7cd6\u5c3f\u75c5\u75c5\u4f8b\u5728\u5168\u7403\u8303\u56f4\u5185\u7ee7\u7eed\u6025\u5267\u4e0a\u5347\u3002 \u8fd9\u4e9b\u60a3\u8005\u66f4\u5bb9\u6613\u4e2d\u98ce\uff0c\u51fa\u8840\u6027\u4e2d\u98ce\u7684\u98ce\u9669\u589e\u52a0 50%\u2014\u2014\u5927\u8111\u4e2d\u7684\u8840\u7ba1\u7834\u88c2\u3002 \u8fd9\u88ab\u8ba4\u4e3a\u662f\u7531\u7cd6\u5c3f\u75c5\u53d1\u5c55\u8fc7\u7a0b\u4e2d\u8111\u76f8\u5173\u8840\u7ba1\u7ec6\u80de\uff08\u5185\u76ae\u7ec6\u80de\uff09\u529f\u80fd\u969c\u788d\u5f15\u8d77\u7684\u3002 \u5c3d\u7ba1\u79d1\u5b66\u5bb6\u4eec\u77e5\u9053\u8fd9\u79cd\u5206\u89e3\u662f\u7531\u6709\u5bb3\u6c27\u79bb\u5b50\uff08\u6c27\u5316\u5e94\u6fc0\uff09\u5f15\u8d77\u7684\u708e\u75c7\u548c\u7ec6\u80de\u538b\u529b\u5f15\u8d77\u7684\uff0c\u4f46\u5982\u4f55\u6cbb\u7597\u8fd9\u79cd\u60c5\u51b5\u4ecd\u7136\u96be\u4ee5\u6349\u6478\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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Luo \u53ca\u5176\u540c\u4e8b\u5728\u5b66\u672f\u671f\u520a \u300aFEBS Open Bio\u300b \u4e0a\u53d1\u8868\u4e86\u4e00\u7bc7\u8bba\u6587\uff0c\u63d0\u4f9b\u4e86\u8865\u5145\u70df\u9170\u80fa\u5355\u6838\u82f7\u9178 \uff08NMN\uff09<\/a> \u53ef\u4ee5\u4fdd\u62a4\u5c0f\u9f20\u5927\u8111\u76f8\u5173\u5185\u76ae\u7ec6\u80de\u514d\u53d7\u6c27\u5316\u5e94\u6fc0\u548c\u529f\u80fd\u8870\u9000\u7684\u8bc1\u636e<\/a>\u3002 \u8be5\u7814\u7a76\u8868\u660e\uff0c\u5411\u5c0f\u9f20\u5185\u76ae\u7ec6\u80de\u8865\u5145 NMN \u8fd8\u53ef\u4ee5\u51cf\u5c11\u7ec6\u80de\u6b7b\u4ea1\u5e76\u6539\u5584\u7ec6\u80de\u7684\u80fd\u91cf\u5de5\u5382\u2014\u2014\u7c92\u7ebf\u4f53\u7684\u529f\u80fd\u3002 \u8fd9\u4e9b\u53d1\u73b0\u53ef\u4ee5\u8f6c\u5316\u4e3a\u9884\u9632\u7cd6\u5c3f\u75c5\u60a3\u8005\u7684\u8111\u5185\u76ae\u7ec6\u80de\u5206\u89e3\u548c\u6700\u7ec8\u7684\u51fa\u8840\u6027\u4e2d\u98ce\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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NMN \u6539\u5584\u6c27\u5316\u5e94\u6fc0\u540e\u8111\u8840\u7ba1\u7ec6\u80de\u7684\u6d3b\u529b<\/p>\n

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\u5728\u4ed6\u4eec\u7684\u5b9e\u9a8c\u4e2d\uff0c\u7814\u7a76\u5c0f\u7ec4\u53d1\u73b0 NMN \u53ef\u4ee5\u4fdd\u62a4\u5728\u7528\u6c27\u5316\u5e94\u6fc0\u8bf1\u5bfc\u5206\u5b50\u8fc7\u6c27\u5316\u6c22\u5904\u7406\u7684\u5b9e\u9a8c\u5ba4\u57f9\u517b\u76bf\u4e2d\u57f9\u517b\u7684\u5c0f\u9f20\u5185\u76ae\u7ec6\u80de\u3002 \u7528\u8fc7\u6c27\u5316\u6c22\u5904\u7406 12\u300124 \u548c 48 \u5c0f\u65f6\u5bfc\u81f4\u7ec6\u80de\u5b58\u6d3b\u7387\u9010\u6e10\u964d\u4f4e\u3002 \u66f4\u91cd\u8981\u7684\u662f\uff0c\u989d\u5916\u589e\u52a0NMN\u8865\u5145\u6d53\u5ea6\uff08300\u81f3500 \u03bcM\uff09\u6709\u52a9\u4e8e\u63d0\u9ad8\u7ec6\u80de\u589e\u6b96\u7387\u3002 \u8fd9\u4e9b\u7ed3\u679c\u8868\u660e\uff0cNMN \u53ef\u4ee5\u9006\u8f6c\u6c27\u5316\u5e94\u6fc0\u5bf9\u5927\u8111\u5185\u76ae\u7ec6\u80de\u7684\u4e0d\u5229\u5f71\u54cd\uff0c\u8fd9\u79cd\u4e0d\u5229\u5f71\u54cd\u662f\u7531\u7cd6\u5c3f\u75c5\u7b49\u4ee3\u8c22\u7d0a\u4e71\u5f15\u8d77\u7684\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\uff08Deng et al.\uff0c 2020 |<\/a> FEBS Open Bio<\/em><\/a>\uff09<\/a> NMN \u6cbb\u7597\u53ef\u4fdd\u62a4\u8111\u5185\u76ae\u7ec6\u80de\u514d\u53d7\u6709\u5bb3\u7684\u6c27\u5316\u5e94\u6fc0\u3002 <\/strong> \uff08A\uff09 \u663e\u793a\u589e\u52a0\u6d53\u5ea6\u7684\u6c27\u5316\u5e94\u6fc0\u8bf1\u5bfc\u8fc7\u6c27\u5316\u6c22\u5904\u7406 12\u300124 \u548c 48 \u5c0f\u65f6\u5bfc\u81f4\u9010\u6e10\u51cf\u5c11\u3002 \uff08C\uff09 \u663e\u793a\u7528 NMN \u5904\u7406\u7ec6\u80de\u53ef\u633d\u6551\u9ad8\u8fbe 300 \u81f3 500 \u03bcM \u6d53\u5ea6\u7684\u7ec6\u80de\u5b58\u6d3b\u3002<\/p>\n

NMN \u589e\u5f3a\u6c27\u5316\u5e94\u6fc0\u540e\u7684\u7c92\u7ebf\u4f53\u5065\u5eb7<\/span><\/strong><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u4e3a\u4e86\u786e\u5b9a NMN \u8bf1\u5bfc\u7684\u7ec6\u80de\u5b58\u6d3b\u589e\u5f3a\u662f\u5426\u6765\u81ea\u7c92\u7ebf\u4f53\u5065\u5eb7\u7684\u6539\u5584\uff0c\u79d1\u5b66\u5bb6\u4eec\u68c0\u67e5\u4e86\u7c92\u7ebf\u4f53\u819c\u7684\u7ed3\u6784\u5b8c\u6574\u6027\u3002 \u5728\u6709\u5bb3\u7684\u8fc7\u6c27\u5316\u6c22\u5904\u7406\u540e\uff0c\u4ed6\u4eec\u53d1\u73b0\u7c92\u7ebf\u4f53\u819c\u7684\u6e17\u900f\u6027\u66f4\u9ad8\uff0c\u8868\u660e\u7ed3\u6784\u5b8c\u6574\u6027\u964d\u4f4e\u3002 \u5728\u8fc7\u6c27\u5316\u6c22\u5904\u7406\u4e2d\u6dfb\u52a0 NMN \u53ef\u6062\u590d\u7c92\u7ebf\u4f53\u819c\u7535\u4f4d\uff0c\u8868\u660e\u7c92\u7ebf\u4f53\u5df2\u6062\u590d\u5065\u5eb7\u3002 \u8fd9\u4e9b\u7ed3\u679c\u8868\u660e\uff0cNMN\u901a\u8fc7\u6539\u5584\u7c92\u7ebf\u4f53\u819c\u7684\u5b8c\u6574\u6027\u548c\u5065\u5eb7\u6765\u589e\u52a0\u6c27\u5316\u5e94\u6fc0\u4e0b\u7684\u7ec6\u80de\u5b58\u6d3b\u7387\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\uff08Deng et al.\uff0c 2020 |<\/a> FEBS Open Bio<\/em><\/a>\uff09<\/a> NMN \u53ef\u9632\u6b62\u6c27\u5316\u5e94\u6fc0\u8bf1\u5bfc\u7684\u7ebf\u7c92\u4f53\u635f\u4f24<\/strong>\u3002 \u7ea2\u8272\u4e0e\u7eff\u8272\u8367\u5149\u7684\u6bd4\u7387\u8868\u660e\u7c92\u7ebf\u4f53\u819c\u901a\u900f\u6027\u2014\u2014\u79bb\u5b50\u7a7f\u8fc7\u7ebf\u7c92\u4f53\u819c\u7684\u80fd\u529b\u3002 \u8f83\u9ad8\u7684\u6bd4\u7387\u4ee3\u8868\u8f83\u4f4e\u7684\u819c\u6e17\u900f\u6027\uff0c\u8868\u660e\u7ed3\u6784\u5b8c\u6574\u6027\u8f83\u9ad8\u3002 \u5728\u8fd9\u4e2a\u5b9e\u9a8c\u4e2d\uff0cNMN \u5728\u7528\u8fc7\u6c27\u5316\u6c22\uff08\u4e00\u79cd\u5f15\u53d1\u6c27\u5316\u5e94\u6fc0\u7684\u5206\u5b50\uff09\u5904\u7406\u7ec6\u80de\u540e\u6062\u590d\u4e86\u7c92\u7ebf\u4f53\u819c\u7684\u7ed3\u6784\u5b8c\u6574\u6027\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u9610\u660e NMN \u5bf9\u7ec6\u80de\u901a\u8def\u7684\u5f71\u54cd<\/p>\n

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\u4e3a\u4e86\u9610\u660e NMN \u5982\u4f55\u4ece\u6c27\u5316\u5e94\u6fc0\u7684\u6bd2\u6027\u4f5c\u7528\u4e2d\u62ef\u6551\u7ec6\u80de\uff0c\u7814\u7a76\u4eba\u5458\u68c0\u67e5\u4e86\u86cb\u767d\u8d28 NF-\u0138B \u548c NAMPT \u7684\u6c34\u5e73\uff0c\u56e0\u4e3a\u5b83\u4eec\u7684\u6c34\u5e73\u4f1a\u968f\u7740\u708e\u75c7\u548c\u75be\u75c5\u800c\u6ce2\u52a8\u3002 NF-\u0138B \u662f\u4e00\u79cd\u86cb\u767d\u8d28\u590d\u5408\u7269\uff0c\u53ef\u534f\u8c03\u514d\u75ab\u53cd\u5e94\u4ee5\u53ca\u7ec6\u80de\u5bf9\u6c27\u5316\u5e94\u6fc0<\/a>\u7684\u53cd\u5e94\uff0c\u800cNAMPT\u662f\u7ec6\u80de\u4e2d\u7684\u4e00\u79cd\u9176\uff0c\u53ef\u4ece\u70df\u9170\u80fa\u5408\u6210NMN\u3002 Luo\u548c\u540c\u4e8b\u5728\u8fc7\u6c27\u5316\u6c22\u5904\u7406\u540e\u53d1\u73b0\uff0cNMN\u589e\u52a0\u4e86NAMPT\u6c34\u5e73\u5e76\u964d\u4f4e\u4e86NF-\u0138B\u6c34\u5e73\u3002 NAMPT \u548c NF-\u0138B \u6c34\u5e73\u7684\u53d8\u5316\u8868\u660e NMN \u6cbb\u7597\u5206\u522b\u6539\u5584\u4e86 NAD+ \u751f\u7269\u5408\u6210\u548c\u51cf\u5c11\u708e\u75c7\u3002 \u8fd9\u79cd\u89c1\u89e3\u53ef\u4ee5\u5e2e\u52a9\u7814\u7a76\u4eba\u5458\u4e86\u89e3 NMN \u53d1\u6325\u4f5c\u7528\u7684\u7ec6\u80de\u673a\u5236\uff0c\u4ece\u800c\u4e3a\u9776\u5411\u8fd9\u4e9b\u7ec6\u80de\u9014\u5f84\u5236\u5b9a\u66f4\u597d\u7684\u75be\u75c5\u4ecb\u5165\u65b9\u6cd5\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\uff08Deng et al.\uff0c 2020 |<\/a> FEBS Open Bio<\/em><\/a>\uff09<\/a> NMN \u5bf9\u5c0f\u9f20\u8111\u5185\u76ae\u7ec6\u80de\u7684\u5904\u7406\u5bfc\u81f4\u6c27\u5316\u5e94\u6fc0\u5bf9 NAMPT \u548c NF-KB \u7684\u5f71\u54cd\u9006\u8f6c<\/strong> \u3002 \u5de6\u56fe\u663e\u793a\u5f15\u8d77\u6c27\u5316\u5e94\u6fc0\u7684\u8fc7\u6c27\u5316\u6c22\u5904\u7406\u5bfc\u81f4NAMPT\u6c34\u5e73\u964d\u4f4e\uff0c\u800cNMN\u9006\u8f6c\u4e86\u8fd9\u4e9b\u5f71\u54cd\u3002 \u53f3\u56fe\u8868\u660e\uff0c\u8fc7\u6c27\u5316\u6c22\u5904\u7406\u4fc3\u8fdb\u4e86 NF-KB \u6c34\u5e73\u7684\u663e\u8457\u589e\u52a0\uff0c\u800c\u6dfb\u52a0 NMN \u5219\u9006\u8f6c\u4e86\u8fd9\u79cd\u6548\u679c\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u201c\u603b\u4e4b\uff0c\u6211\u4eec\u7684\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0cNMN \u80fd\u591f\u901a\u8fc7\u8c03\u8282\u9176 NAMPT \u548c NF-\u0138B p65 \u4fe1\u53f7\u901a\u8def\u6765\u4fdd\u62a4 H2O2 \u635f\u4f24\u7684 bEnd.3 \u7ec6\u80de\u514d\u4e8e\u51cb\u4ea1\uff0c\u201d\u4f5c\u8005\u5728\u4ed6\u4eec\u7684\u5b66\u672f\u8bba\u6587\u4e2d\u63d0\u5230\u4e86NMN\u5bf9\u8111\u5185\u76ae\u7ec6\u80de\u8fc7\u6c27\u5316\u6c22\u6cbb\u7597\u7684\u5f71\u54cd\u3002<\/p>\n

\u8111\u8840\u7ba1\u7814\u7a76\u7684\u672a\u6765\u65b9\u5411<\/span><\/p>\n

\u8be5\u7814\u7a76\u6307\u51fa\u4e86\u6539\u5584\u8111\u8840\u7ba1\u5b8c\u6574\u6027\u4ee5\u5e94\u5bf9\u7cd6\u5c3f\u75c5\u7b49\u4ee3\u8c22\u7d0a\u4e71\u5f15\u8d77\u7684\u6c27\u5316\u5e94\u6fc0\u7684\u76ee\u6807\u3002 \u5982\u679c\u8fd9\u4e9b\u53d1\u73b0\u8f6c\u5316\u4e3a\u4eba\u7c7b\uff0c<\/span>NMN \u8865\u5145\u5242 <\/span>\u53ef\u80fd\u4f1a\u6539\u5584\u4ee3\u8c22\u7d0a\u4e71\u60a3\u8005\u7684<\/span>\u8111\u8840\u7ba1\u529f\u80fd<\/a>\u3002<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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Deng, X., Liang, X., Yang, H., Huang, Z., Huang, X., Liang, C., Kuang, Y., Qin, Y., Lin, F. and Luo, Z. (2020),\u00a0Nicotinamide mononucleotide (NMN) protects bEnd.3 cells against H<\/strong>2O2\u2010induced damage via NAMPT and the NF\u2010<\/strong>\u03baB p65 signalling pathway<\/strong>. FEBS Open Bio. Accepted Author Manuscript. DOI:\u00a010.1002\/2211-5463.13067<\/a><\/p>\n

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https:\/\/www.nmn.com\/news\/nmn-blood-brain-barrier-cell-response-stress<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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NMN \u6cbb\u7597\u53ef\u63d0\u9ad8\u5927\u8111\u76f8\u5173\u8840\u7ba1\u7ec6\u80de\u7684\u5b58\u6d3b\u7387\uff0c\u5e76\u9632\u6b62\u7cd6\u5c3f\u75c5\u7b49\u4ee3\u8c22\u75be\u75c5\u4e2d\u7684\u6709\u5bb3\u538b\u529b\u3002 By\u00a0Brett J. Weiss Published:\u00a03:20 p.m. PST Dec 26, 2020\u00a0| Updated:\u00a01:01 p.m. PST Sep 29, 2021   \u7cd6\u5c3f\u75c5\u75c5\u4f8b\u5728\u5168\u7403\u8303\u56f4\u5185\u7ee7\u7eed\u6025\u5267\u4e0a\u5347\u3002 \u8fd9\u4e9b\u60a3\u8005\u66f4\u5bb9\u6613\u4e2d\u98ce\uff0c\u51fa\u8840\u6027\u4e2d\u98ce\u7684\u98ce\u9669\u589e\u52a0 50%\u2014\u2014\u5927\u8111\u4e2d\u7684\u8840\u7ba1\u7834\u88c2\u3002 \u8fd9\u88ab\u8ba4\u4e3a\u662f\u7531\u7cd6\u5c3f\u75c5\u53d1\u5c55\u8fc7\u7a0b\u4e2d\u8111\u76f8\u5173\u8840\u7ba1\u7ec6\u80de\uff08\u5185\u76ae\u7ec6\u80de\uff09\u529f\u80fd\u969c\u788d\u5f15\u8d77\u7684\u3002 \u5c3d\u7ba1\u79d1\u5b66\u5bb6\u4eec\u77e5\u9053\u8fd9\u79cd\u5206\u89e3\u662f\u7531\u6709\u5bb3\u6c27\u79bb\u5b50\uff08\u6c27\u5316\u5e94\u6fc0\uff09\u5f15\u8d77\u7684\u708e\u75c7\u548c\u7ec6\u80de\u538b\u529b\u5f15\u8d77\u7684\uff0c\u4f46\u5982\u4f55\u6cbb\u7597\u8fd9\u79cd\u60c5\u51b5\u4ecd\u7136\u96be\u4ee5\u6349\u6478\u3002<\/p>\n

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