{"id":19987,"date":"2023-04-05T04:02:30","date_gmt":"2023-04-05T04:02:30","guid":{"rendered":"http:\/\/johnhealth.blog\/ch\/?p=19987"},"modified":"2023-04-05T04:02:30","modified_gmt":"2023-04-05T04:02:30","slug":"%e3%80%8a%e6%b7%b1%e8%b0%88nmn%e7%b3%bb%e5%88%97-%e7%b3%96%e5%b0%bf%e7%97%85-3%e3%80%8b-%e7%a5%9e%e7%bb%8f%e7%a7%91%e5%ad%a6%e5%ae%b6%e6%81%a2%e5%a4%8d%e7%b3%96%e5%b0%bf%e7%97%85%e5%a4%a7%e9%bc%a0","status":"publish","type":"post","link":"http:\/\/johnhealth.blog\/ch\/?p=19987","title":{"rendered":"\u300a\u6df1\u8c08NMN\u7cfb\u5217-\u7cd6\u5c3f\u75c5-3\u300b \u795e\u7ecf\u79d1\u5b66\u5bb6\u6062\u590d\u7cd6\u5c3f\u75c5\u5927\u9f20\u7684\u8bb0\u5fc6\u7f3a\u9677\u548c\u8111\u7ec6\u80de\u635f\u5931"},"content":{"rendered":"<p>\u7f8e\u56fd\u9a6c\u91cc\u5170\u5927\u5b66\u533b\u5b66\u9662\u7684\u79d1\u7814\u56e2\u961f\u53d1\u73b0\u7cd6\u5c3f\u75c5\u60a3\u8005\u7684\u5927\u8111\u7ecf\u5e38\u56e0NAD+\u6c34\u5e73\u964d\u4f4e\u800c\u53d1\u751f\u53d8\u5316\uff0c\u9020\u6210\u7f79\u60a3\u963f\u6ecb\u6d77\u9ed8\u75c7\u7684\u751f\u7269\u6807\u5fd7\u3002\u670d\u7528NMN\u5f8c\uff0c\u7cd6\u5c3f\u75c5\u5c0f\u9f20\u6d77\u9a6c\u56de(\u638c\u7ba1\u7a7a\u95f4\u5b66\u4e60\u548c\u8bb0\u5fc6\u7684\u80fd\u529b\u7684\u8111\u533a)\u7684\u80fd\u91cf\u538b\u529b\u548c\u7c92\u7ebf\u4f53\u7684\u5de5\u4f5c\u91cf\u90fd\u5f97\u5230\u7f13\u89e3\uff0c\u800c\u4e14 SIRT1 \u6c34\u5e73\u5728\u63a5\u53d7 NMN \u5f8c\u6062\u590d\u5230\u4e0e\u975e\u7cd6\u5c3f\u75c5\u5927\u9f20\u76f8\u540c\u7684\u6c34\u5e73!<\/p>\n<p>\u672c\u7814\u7a76\u7684\u7ed3\u679c\u8868\u660e\uff0cNMN \u53ef\u9632\u6b62\u7cd6\u5c3f\u75c5\u5f15\u8d77\u7684 NAD+ \u6c34\u5e73\u4e0b\u964d\uff0c\u4f7f SIRT1 \u86cb\u767d\u6c34\u5e73\u6b63\u5e38\u5316\uff0c\u5e76\u6539\u5584\u7531 NAD+ \u4ecb\u5bfc\u7684\u7c92\u7ebf\u4f53\u529f\u80fd\u7b49\u4e0b\u6e38\u6d3b\u52a8\uff0c\u4ee5\u4fdd\u62a4\u795e\u7ecf\u5143\u514d\u53d7\u7cd6\u5c3f\u75c5\u5f15\u8d77\u7684\u795e\u7ecf\u5143\u9000\u5316\u3002 \u8fd9\u9879\u7814\u7a76\u8868\u660e\uff0c\u9884\u9632\u7cd6\u5c3f\u75c5\u5f15\u8d77\u7684 NAD+ \u8017\u7aed\u7684\u836f\u7269\u548c\u6fc0\u6d3b SIRT1 \u7684\u5206\u5b50\u53ef\u80fd\u5bf9\u7cd6\u5c3f\u75c5\u5927\u8111\u7684\u6076\u5316\u6709\u5e2e\u52a9\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-19995\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/04\/\u7cd6\u5c3f\u75c53.jpg\" alt=\"\" width=\"536\" height=\"528\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/04\/\u7cd6\u5c3f\u75c53.jpg 536w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/04\/\u7cd6\u5c3f\u75c53-300x296.jpg 300w\" sizes=\"auto, (max-width: 536px) 100vw, 536px\" \/><\/p>\n<p>\u5168\u6587\u8fde\u7ed3\uff1a<a href=\"http:\/\/johnhealth.blog\/ch\/?p=19988\">\u3010\u79d1\u6280\u6587\u732e\u3011\u795e\u7ecf\u79d1\u5b66\u5bb6\u6062\u590d\u7cd6\u5c3f\u75c5\u5927\u9f20\u7684\u8bb0\u5fc6\u7f3a\u9677\u548c\u8111\u7ec6\u80de\u635f\u5931 \u2013 John\u54e5\u8c08\u5065\u5eb7 (johnhealth.blog)<\/a><\/p>\n<p>Chandrasekaran K, Choi J, Arvas MI, Salimian M, Singh S, Xu S, Gullapalli RP, Kristian T, Russell JW. Nicotinamide Mononucleotide Administration Prevents Experimental Diabetes-Induced Cognitive Impairment and Loss of Hippocampal Neurons. Int J Mol Sci. 2020 May 26;21(11):3756. DOI: 10.3390\/ijms21113756. PMID: 32466541; PMCID: PMC7313029.<\/p>\n<div class=\"pvc_clear\"><\/div>\n<p id=\"pvc_stats_19987\" class=\"pvc_stats all  \" data-element-id=\"19987\" style=\"\"><i class=\"pvc-stats-icon medium\" aria-hidden=\"true\"><svg aria-hidden=\"true\" focusable=\"false\" data-prefix=\"far\" data-icon=\"chart-bar\" role=\"img\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\" class=\"svg-inline--fa fa-chart-bar fa-w-16 fa-2x\"><path fill=\"currentColor\" d=\"M396.8 352h22.4c6.4 0 12.8-6.4 12.8-12.8V108.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v230.4c0 6.4 6.4 12.8 12.8 12.8zm-192 0h22.4c6.4 0 12.8-6.4 12.8-12.8V140.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v198.4c0 6.4 6.4 12.8 12.8 12.8zm96 0h22.4c6.4 0 12.8-6.4 12.8-12.8V204.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v134.4c0 6.4 6.4 12.8 12.8 12.8zM496 400H48V80c0-8.84-7.16-16-16-16H16C7.16 64 0 71.16 0 80v336c0 17.67 14.33 32 32 32h464c8.84 0 16-7.16 16-16v-16c0-8.84-7.16-16-16-16zm-387.2-48h22.4c6.4 0 12.8-6.4 12.8-12.8v-70.4c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v70.4c0 6.4 6.4 12.8 12.8 12.8z\" class=\"\"><\/path><\/svg><\/i> <img loading=\"lazy\" decoding=\"async\" width=\"16\" height=\"16\" alt=\"Loading\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/plugins\/page-views-count\/ajax-loader-2x.gif\" border=0 \/><\/p>\n<div class=\"pvc_clear\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u7f8e\u56fd\u9a6c\u91cc\u5170\u5927\u5b66\u533b\u5b66\u9662\u7684\u79d1\u7814\u56e2\u961f\u53d1\u73b0\u7cd6\u5c3f\u75c5\u60a3\u8005\u7684\u5927\u8111\u7ecf\u5e38\u56e0NAD+\u6c34\u5e73\u964d\u4f4e\u800c\u53d1\u751f\u53d8\u5316\uff0c\u9020\u6210\u7f79\u60a3\u963f\u6ecb\u6d77\u9ed8\u75c7\u7684\u751f\u7269\u6807\u5fd7\u3002\u670d\u7528NMN\u5f8c\uff0c\u7cd6\u5c3f\u75c5\u5c0f\u9f20\u6d77\u9a6c\u56de(\u638c\u7ba1\u7a7a\u95f4\u5b66\u4e60\u548c\u8bb0\u5fc6\u7684\u80fd\u529b\u7684\u8111\u533a)\u7684\u80fd\u91cf\u538b\u529b\u548c\u7c92\u7ebf\u4f53\u7684\u5de5\u4f5c\u91cf\u90fd\u5f97\u5230\u7f13\u89e3\uff0c\u800c\u4e14 SIRT1 \u6c34\u5e73\u5728\u63a5\u53d7 NMN \u5f8c\u6062\u590d\u5230\u4e0e\u975e\u7cd6\u5c3f\u75c5\u5927\u9f20\u76f8\u540c\u7684\u6c34\u5e73! \u672c\u7814\u7a76\u7684\u7ed3\u679c\u8868\u660e\uff0cNMN \u53ef\u9632\u6b62\u7cd6\u5c3f\u75c5\u5f15\u8d77\u7684 NAD+ \u6c34\u5e73\u4e0b\u964d\uff0c\u4f7f SIRT1 \u86cb\u767d\u6c34\u5e73\u6b63\u5e38\u5316\uff0c\u5e76\u6539\u5584\u7531 NAD+ \u4ecb\u5bfc\u7684\u7c92\u7ebf\u4f53\u529f\u80fd\u7b49\u4e0b\u6e38\u6d3b\u52a8\uff0c\u4ee5\u4fdd\u62a4\u795e\u7ecf\u5143\u514d\u53d7\u7cd6\u5c3f\u75c5\u5f15\u8d77\u7684\u795e\u7ecf\u5143\u9000\u5316\u3002 \u8fd9\u9879\u7814\u7a76\u8868\u660e\uff0c\u9884\u9632\u7cd6\u5c3f\u75c5\u5f15\u8d77\u7684 NAD+ \u8017\u7aed\u7684\u836f\u7269\u548c\u6fc0\u6d3b SIRT1 \u7684\u5206\u5b50\u53ef\u80fd\u5bf9\u7cd6\u5c3f\u75c5\u5927\u8111\u7684\u6076\u5316\u6709\u5e2e\u52a9\u3002 \u5168\u6587\u8fde\u7ed3\uff1a\u3010\u79d1\u6280\u6587\u732e\u3011\u795e\u7ecf\u79d1\u5b66\u5bb6\u6062\u590d\u7cd6\u5c3f\u75c5\u5927\u9f20\u7684\u8bb0\u5fc6\u7f3a\u9677\u548c\u8111\u7ec6\u80de\u635f\u5931 \u2013 John\u54e5\u8c08\u5065\u5eb7 (johnhealth.blog) Chandrasekaran K, Choi J, Arvas MI, Salimian M, Singh S, Xu S, Gullapalli RP, Kristian T, Russell JW. Nicotinamide Mononucleotide Administration Prevents Experimental Diabetes-Induced Cognitive Impairment and Loss of Hippocampal Neurons. Int J Mol Sci. 2020 May 26;21(11):3756. [&hellip;]<\/p>\n<div class=\"pvc_clear\"><\/div>\n<p id=\"pvc_stats_19987\" class=\"pvc_stats all  \" data-element-id=\"19987\" style=\"\"><i class=\"pvc-stats-icon medium\" aria-hidden=\"true\"><svg aria-hidden=\"true\" focusable=\"false\" data-prefix=\"far\" data-icon=\"chart-bar\" role=\"img\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\" class=\"svg-inline--fa fa-chart-bar fa-w-16 fa-2x\"><path fill=\"currentColor\" d=\"M396.8 352h22.4c6.4 0 12.8-6.4 12.8-12.8V108.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v230.4c0 6.4 6.4 12.8 12.8 12.8zm-192 0h22.4c6.4 0 12.8-6.4 12.8-12.8V140.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v198.4c0 6.4 6.4 12.8 12.8 12.8zm96 0h22.4c6.4 0 12.8-6.4 12.8-12.8V204.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v134.4c0 6.4 6.4 12.8 12.8 12.8zM496 400H48V80c0-8.84-7.16-16-16-16H16C7.16 64 0 71.16 0 80v336c0 17.67 14.33 32 32 32h464c8.84 0 16-7.16 16-16v-16c0-8.84-7.16-16-16-16zm-387.2-48h22.4c6.4 0 12.8-6.4 12.8-12.8v-70.4c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v70.4c0 6.4 6.4 12.8 12.8 12.8z\" class=\"\"><\/path><\/svg><\/i> <img loading=\"lazy\" decoding=\"async\" width=\"16\" height=\"16\" alt=\"Loading\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/plugins\/page-views-count\/ajax-loader-2x.gif\" border=0 \/><\/p>\n<div class=\"pvc_clear\"><\/div>\n","protected":false},"author":1,"featured_media":19995,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[172,734],"tags":[728,33],"class_list":["post-19987","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-nmn-","category-nmn","tag-nmn","tag-33"],"aioseo_notices":[],"_links":{"self":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts\/19987","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=19987"}],"version-history":[{"count":2,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts\/19987\/revisions"}],"predecessor-version":[{"id":19996,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts\/19987\/revisions\/19996"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/media\/19995"}],"wp:attachment":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=19987"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=19987"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=19987"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}