{"id":19977,"date":"2023-04-01T13:17:41","date_gmt":"2023-04-01T13:17:41","guid":{"rendered":"http:\/\/johnhealth.blog\/ch\/?p=19977"},"modified":"2023-04-01T13:39:41","modified_gmt":"2023-04-01T13:39:41","slug":"%e3%80%90%e7%a7%91%e6%8a%80%e8%bf%9b%e5%b1%95%e3%80%91nmn-%e5%b8%ae%e5%8a%a9%e5%b0%8f%e9%bc%a0%e9%80%86%e8%bd%ac%e9%a5%ae%e9%a3%9f%e5%92%8c%e5%b9%b4%e9%be%84%e8%af%b1%e5%8f%91%e7%9a%84%e7%b3%96","status":"publish","type":"post","link":"http:\/\/johnhealth.blog\/ch\/?p=19977","title":{"rendered":"\u3010\u79d1\u6280\u8fdb\u5c55\u3011NMN \u5e2e\u52a9\u5c0f\u9f20\u9006\u8f6c\u996e\u98df\u548c\u5e74\u9f84\u8bf1\u53d1\u7684\u7cd6\u5c3f\u75c5"},"content":{"rendered":"

\u79d1\u5b66\u5bb6\u4eec\u53d1\u73b0\uff0c\u7ed9\u7cd6\u5c3f\u75c5\u5c0f\u9f20\u670d\u7528 NMN \u53ef\u4ee5\u9006\u8f6c\u7cd6\u5c3f\u75c5\u7684\u75c7\u72b6\uff0c\u8be5\u65b9\u6cd5\u4e3a\u6f5c\u5728\u5e72\u9884 2 \u578b\u7cd6\u5c3f\u75c5\u63d0\u4f9b\u4e86\u91cd\u8981\u89c1\u89e3\u3002<\/p>\n

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By\u00a0swriter<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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Published:\u00a011:50 am PST Oct 12, 2011\u00a0| Updated:\u00a011:41 am PST Sep 22, 2020<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u8d85\u8fc73400\u4e07\u7f8e\u56fd\u4eba\u60a3\u6709\u7cd6\u5c3f\u75c5<\/a>\uff0c\u5176\u4e2d\u7ea690%\u81f395%\u60a3\u67092\u578b\u7cd6\u5c3f\u75c5\u3002 \u5728\u6211\u4eec\u73b0\u4ee3\u4e45\u5750\u4e0d\u52a8\u7684\u751f\u6d3b\u65b9\u5f0f\u4e2d\uff0c2 \u578b\u7cd6\u5c3f\u75c5\u5df2\u6210\u4e3a\u4e00\u79cd\u6d41\u884c\u75c5\uff0c\u8fd9\u53ef\u80fd\u662f\u7531\u4e8e\u9ad8\u70ed\u91cf\u996e\u98df\u538b\u5012\u4e86\u6211\u4eec\u7684\u65b0\u9648\u4ee3\u8c22\u9014\u5f84\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u4f4d\u4e8e\u5723\u8def\u6613\u65af\u7684\u534e\u76db\u987f\u5927\u5b66\u533b\u5b66\u9662\u7684\u7814\u7a76\u4eba\u5458\u901a\u8fc7\u7ed9\u5c0f\u9f20\u5582\u98df\u5929\u7136\u5316\u5408\u7269\u70df\u9170\u80fa\u5355\u6838\u82f7\u9178 \uff08NMN\uff09 <\/a>\u6765\u9006\u8f6c\u996e\u98df\u548c\u5e74\u9f84\u8bf1\u53d1\u7684\u7cd6\u5c3f\u75c5\u3002 \u8fd9\u7bc7\u53d1\u8868\u5728\u5b66\u672f\u671f\u520a \u300a\u7ec6\u80de\u4ee3\u8c22\u300b \uff08Cell Metabolism\uff09 <\/a>\u7684\u7814\u7a76\u8bba\u6587\u8868\u660e\uff0c\u5c06 NMN \u4f5c\u4e3a\u81b3\u98df\u8865\u5145\u5242<\/a>\u670d\u7528\u53ef\u80fd\u6709\u4e00\u5929\u4f1a\u6210\u4e3a 2 \u578b\u7cd6\u5c3f\u75c5\u7684\u4ecb\u5165\u6216\u9884\u9632\u63aa\u65bd\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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(Yoshino et al., 2011 |<\/strong><\/a> Cell Metabolism<\/strong><\/em><\/a>)<\/strong><\/a> NMN \u4ecb\u5165\u524d\u540e\u5973\u6027\uff08\u56fe B\uff09\u548c\u7537\u6027\uff08\u56fe E\uff09\u7684\u8840\u6d46\u80f0\u5c9b\u7d20\u6c34\u5e73\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u201c\u7ed9\u4e88 NMN \u540e\uff0c\u96cc\u6027\u7cd6\u5c3f\u75c5\u5c0f\u9f20\u7684\u8461\u8404\u7cd6\u8010\u53d7\u6027\u5b8c\u5168\u6062\u590d\u6b63\u5e38\uff0c\u201d\u5723\u8def\u6613\u65af\u534e\u76db\u987f\u5927\u5b66\u7684\u8d44\u6df1\u4f5c\u8005 Shin-ichiro Imai \u5728\u4e00\u4efd\u58f0\u660e\u4e2d\u8bf4\u3002 \u201c\u5728\u7537\u6027\u4e2d\uff0c\u4e0e\u5973\u6027\u76f8\u6bd4\uff0c\u6211\u4eec\u770b\u5230\u7684\u5f71\u54cd\u66f4\u8f7b\u5fae\uff0c\u4f46\u6211\u4eec\u4ecd\u7136\u770b\u5230\u4e86\u5f71\u54cd\u3002 \u8fd9\u4e9b\u90fd\u662f\u975e\u5e38\u4e86\u4e0d\u8d77\u7684\u7ed3\u679c\u3002 NMN \u6539\u5584\u4e86\u7cd6\u5c3f\u75c5\u75c7\u72b6\uff0c\u81f3\u5c11\u5728\u8001\u9f20\u8eab\u4e0a\u662f\u8fd9\u6837\u3002 \u201d<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u9ad8\u8102\u80aa\u996e\u98df\u548c\u8870\u8001\u4f1a\u635f\u5bb3\u4ea7\u751f\u70df\u9170\u80fa\u817a\u560c\u5464\u4e8c\u6838\u82f7\u9178 \uff08NAD+\uff09 \u7684\u4ee3\u8c22\u9014\u5f84\uff0cNAD+ \u662f\u4e00\u79cd\u5145\u5f53\u7ec6\u80de\u80fd\u91cf\u8d27\u5e01\u7684\u91cd\u8981\u5206\u5b50\u3002 NAD+ \u8fd8\u5728\u6fc0\u6d3b SIRT1 \u4e2d\u53d1\u6325\u4f5c\u7528\uff0cSIRT1 \u662f\u4e00\u79cd\u8c03\u8282\u7ec6\u80de\u5065\u5eb7\u3001\u4fdd\u62a4\u7ec6\u80de\u514d\u53d7\u75be\u75c5\u548c\u6076\u5316\u5f71\u54cd\u7684\u5206\u5b50\u3002 NAD+ \u6c34\u5e73\u964d\u4f4e\u4f1a\u5bfc\u81f4\u7cd6\u5c3f\u75c5\u7b49\u4ee3\u8c22\u75be\u75c5\u3002 \u7cd6\u5c3f\u75c5\u60a3\u8005\u7684\u75c7\u72b6\u4e4b\u4e00\u662f\u7cd6\u8010\u53d7\u6027\u4f4e\u4e0b\uff0c\u4ed6\u4eec\u7684\u8eab\u4f53\u65e0\u6cd5\u6709\u6548\u5730\u5c06\u8461\u8404\u7cd6\u4ece\u8840\u6db2\u4e2d\u8f6c\u79fb\u5230\u5668\u5b98\u548c\u7ec4\u7ec7\u4e2d\u4ee5\u4f9b\u4f7f\u7528\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u7814\u7a76\u4eba\u5458\u53d1\u73b0\uff0c\u9ad8\u8102\u80aa\u996e\u98df\u7684\u5e74\u8f7b\u5065\u5eb7\u5c0f\u9f20\u4f1a\u5728\u516d\u4e2a\u6708\u5185\u60a3\u4e0a\u7cd6\u5c3f\u75c5\u3002 \u4e0e\u6807\u51c6\u996e\u98df\u76f8\u6bd4\uff0c\u7cd6\u5c3f\u75c5\u5c0f\u9f20\u7684\u809d\u810f\u548c\u8102\u80aa\u7ec4\u7ec7\u4e2d\u7684 NAD+ \u6c34\u5e73\u663e\u8457\u4e0b\u964d\u3002 \u7136\u800c\uff0c\u5411\u5c0f\u9f20\u6ce8\u5c04 NMN\uff08NAD+ \u7684\u524d\u4f53\uff09\u53ef\u6062\u590d\u7ec4\u7ec7\u4e2d\u7684 NAD+ \u6c34\u5e73<\/a>\uff0c\u5e76\u4f7f\u7cd6\u5c3f\u75c5\u96cc\u6027\u5c0f\u9f20\u7684\u8461\u8404\u7cd6\u8010\u53d7\u6027\u53d7\u635f\u5b8c\u5168\u6b63\u5e38\u5316\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u201c\u6211\u5f88\u9ad8\u5174\u770b\u5230\u8fd9\u4e9b\u7ed3\u679c\uff0c\u56e0\u4e3a NMN \u7684\u4f5c\u7528\u6bd4\u5176\u4ed6\u5df2\u77e5\u5316\u5408\u7269\u6216\u5316\u5b66\u7269\u8d28\u5927\u5f97\u591a\uff0c\u201d\u5171\u540c\u7b2c\u4e00\u4f5c\u8005 Jun Yoshino \u8bf4\u3002 \u201c\u6b64\u5916\uff0c\u4eba\u4f53\u81ea\u7136\u4ea7\u751f NMN \u8fd9\u4e00\u4e8b\u5b9e\u6709\u671b\u5c06\u8fd9\u4e9b\u53d1\u73b0\u8f6c\u5316\u4e3a\u4eba\u7c7b\u3002\u201d<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u53d1\u751f 2 \u578b\u7cd6\u5c3f\u75c5\u7684\u53e6\u4e00\u4e2a\u5371\u9669\u56e0\u7d20\u662f\u8870\u8001\u3002 \u4e0e\u5e74\u8f7b\u5c0f\u9f20\u76f8\u6bd4\uff0c\u5e74\u8001\u5c0f\u9f20\u7684\u80f0\u817a\u3001\u8102\u80aa\u7ec4\u7ec7\u548c\u808c\u8089\u4e2d\u7684 NAD+ \u6c34\u5e73\u8f83\u4f4e\u3002 \u7814\u7a76\u5c0f\u7ec4\u53d1\u73b0\uff0c\u5927\u7ea6 15% \u7684\u5065\u5eb7\u8001\u5e74\u96c4\u6027\u5c0f\u9f20\u60a3\u4e0a\u4e86\u7cd6\u5c3f\u75c5\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u201c\u5f53\u6211\u4eec\u7ed9\u8fd9\u4e9b\u5e74\u957f\u7684\u7cd6\u5c3f\u75c5\u5c0f\u9f20\u6ce8\u5c04 NMN \u65f6\uff0c\u5b83\u4eec\u7684\u8461\u8404\u7cd6\u8010\u53d7\u6027\u5f97\u5230\u6539\u5584\uff0c\u5373\u4f7f\u5728\u6ce8\u5c04\u4e00\u6b21\u540e\u4e5f\u662f\u5982\u6b64\uff0c\u201d\u5171\u540c\u7b2c\u4e00\u4f5c\u8005 Kathryn Mills \u8bf4\u3002 \u201c\u6211\u4eec\u8fd8\u7ed9\u5e74\u957f\u7684\u5065\u5eb7\u8001\u9f20\u6ce8\u5c04NMN\uff0c\u53d1\u73b0\u5b83\u4eec\u6ca1\u6709\u53d7\u5230\u4e0d\u5229\u5f71\u54cd\u3002 \u5f88\u9ad8\u5174\u77e5\u9053\u5373\u4f7f\u8001\u9f20\u6ca1\u6709\u7cd6\u5c3f\u75c5\uff0c\u7ed9\u4e88 NMN \u4e5f\u4e0d\u4f1a\u4f24\u5bb3\u5b83\u4eec\u3002 \u201d<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u7cd6\u5c3f\u75c5\u4e0d\u4ec5\u4ee5\u5065\u5eb7\u4e3a\u4ee3\u4ef7\uff0c\u5b83\u786e\u5b9e\u6709\u4e00\u4e2a\u4ef7\u683c\u6807\u7b7e\u3002 2017\u5e74\uff0c\u8bca\u65ad\u7cd6\u5c3f\u75c5\u7684\u603b\u4f30\u8ba1\u6210\u672c\u4e3a3270\u4ebf\u7f8e\u5143<\/a>\uff0c\u5176\u4e2d\u5305\u62ec2370\u4ebf\u7f8e\u5143\u7684\u76f4\u63a5\u533b\u7597\u6210\u672c\u548c900\u4ebf\u7f8e\u5143\u7684\u751f\u4ea7\u529b\u4e0b\u964d\u3002 \u6839\u636e\u7f8e\u56fd\u75be\u75c5\u63a7\u5236\u4e0e\u9884\u9632\u4e2d\u5fc3\uff08CDC\uff09\u7684\u6570\u636e\uff0c\u79d1\u5b66\u5bb6\u9884\u6d4b<\/a>\uff0c\u52302030\u5e74\uff0c\u7f8e\u56fd\u7cd6\u5c3f\u75c5\u60a3\u8005\u4eba\u6570\u5c06\u8d85\u8fc75490\u4e07\uff0c\u4e0e\u7cd6\u5c3f\u75c5\u76f8\u5173\u7684\u8d39\u7528\u5c06\u8d85\u8fc76220\u4ebf\u7f8e\u5143\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u968f\u7740\u7cd6\u5c3f\u75c5\u7684\u6d41\u884c\u548c\u6211\u4eec\u7ecf\u6d4e\u8d1f\u62c5\u7684\u589e\u52a0\uff0c\u8be5\u56e2\u961f\u8fc8\u51fa\u4e86\u7b2c\u4e00\u6b65\uff0c\u786e\u5b9a NMN \u5bf9 2 \u578b\u7cd6\u5c3f\u75c5\u7684\u6f5c\u5728\u6cbb\u7597\u7279\u6027\u3002 \u5728\u8fd9\u9879\u7814\u7a76\u4e4b\u540e\uff0cImai \u5728 2016 \u5e74\u8868\u660e\uff0c\u957f\u671f\u53e3\u670d NMN \u8865\u5145\u5242\u53ef\u5ef6\u957f\u5c0f\u9f20\u7684\u5065\u5eb7\u5bff\u547d<\/a>\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u73b0\u5728\uff0c2020\u5e74\u516c\u5e03\u7684\u7b2c\u4e00\u4e2aNMN\u4eba\u4f53\u8bd5\u9a8c<\/a>\uff0c\u4eca\u4e95\u4e5f\u53c2\u4e0e\u5176\u4e2d\uff0c\u8868\u660eNMN\u5bf9\u4eba\u7c7b\u662f\u5b89\u5168\u7684\u3002 \u968f\u7740\u4e0eNMN\u76f8\u5173\u7684\u4e34\u5e8a\u7814\u7a76\u6570\u91cf\u7684\u589e\u957f\uff0c\u79d1\u5b66\u5bb6\u4eec\u5c06\u5f88\u5feb\u5f97\u5230NMN\u6cbb\u7597\u6f5c\u529b\u7684\u7b54\u6848\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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Yoshino J, Mills KF, Yoon MJ, Imai S. Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice. Cell Metab. 2011; 14(4):528-536. doi:10.1016\/j.cmet.2011.08.014<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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https:\/\/www.nmn.com\/news\/nmn-helps-reverse-diet-and-age-induced-diabetes-mice<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u79d1\u5b66\u5bb6\u4eec\u53d1\u73b0\uff0c\u7ed9\u7cd6\u5c3f\u75c5\u5c0f\u9f20\u670d\u7528 NMN \u53ef\u4ee5\u9006\u8f6c\u7cd6\u5c3f\u75c5\u7684\u75c7\u72b6\uff0c\u8be5\u65b9\u6cd5\u4e3a\u6f5c\u5728\u5e72\u9884 2 \u578b\u7cd6\u5c3f\u75c5\u63d0\u4f9b\u4e86\u91cd\u8981\u89c1\u89e3\u3002 By\u00a0swriter Published:\u00a011:50 am PST Oct 12, 2011\u00a0| Updated:\u00a011:41 am PST Sep 22, 2020 \u8d85\u8fc73400\u4e07\u7f8e\u56fd\u4eba\u60a3\u6709\u7cd6\u5c3f\u75c5\uff0c\u5176\u4e2d\u7ea690%\u81f395%\u60a3\u67092\u578b\u7cd6\u5c3f\u75c5\u3002 \u5728\u6211\u4eec\u73b0\u4ee3\u4e45\u5750\u4e0d\u52a8\u7684\u751f\u6d3b\u65b9\u5f0f\u4e2d\uff0c2 \u578b\u7cd6\u5c3f\u75c5\u5df2\u6210\u4e3a\u4e00\u79cd\u6d41\u884c\u75c5\uff0c\u8fd9\u53ef\u80fd\u662f\u7531\u4e8e\u9ad8\u70ed\u91cf\u996e\u98df\u538b\u5012\u4e86\u6211\u4eec\u7684\u65b0\u9648\u4ee3\u8c22\u9014\u5f84\u3002 \u4f4d\u4e8e\u5723\u8def\u6613\u65af\u7684\u534e\u76db\u987f\u5927\u5b66\u533b\u5b66\u9662\u7684\u7814\u7a76\u4eba\u5458\u901a\u8fc7\u7ed9\u5c0f\u9f20\u5582\u98df\u5929\u7136\u5316\u5408\u7269\u70df\u9170\u80fa\u5355\u6838\u82f7\u9178 \uff08NMN\uff09 \u6765\u9006\u8f6c\u996e\u98df\u548c\u5e74\u9f84\u8bf1\u53d1\u7684\u7cd6\u5c3f\u75c5\u3002 \u8fd9\u7bc7\u53d1\u8868\u5728\u5b66\u672f\u671f\u520a \u300a\u7ec6\u80de\u4ee3\u8c22\u300b \uff08Cell Metabolism\uff09 \u7684\u7814\u7a76\u8bba\u6587\u8868\u660e\uff0c\u5c06 NMN \u4f5c\u4e3a\u81b3\u98df\u8865\u5145\u5242\u670d\u7528\u53ef\u80fd\u6709\u4e00\u5929\u4f1a\u6210\u4e3a 2 \u578b\u7cd6\u5c3f\u75c5\u7684\u4ecb\u5165\u6216\u9884\u9632\u63aa\u65bd\u3002<\/p>\n

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