{"id":19976,"date":"2023-04-01T13:41:43","date_gmt":"2023-04-01T13:41:43","guid":{"rendered":"http:\/\/johnhealth.blog\/ch\/?p=19976"},"modified":"2023-04-03T04:00:57","modified_gmt":"2023-04-03T04:00:57","slug":"%e3%80%8a%e6%b7%b1%e8%b0%88nmn%e7%b3%bb%e5%88%97-%e7%b3%96%e5%b0%bf%e7%97%85-1%e3%80%8b-nmn-%e5%b8%ae%e5%8a%a9%e5%b0%8f%e9%bc%a0%e9%80%86%e8%bd%ac%e9%a5%ae%e9%a3%9f%e5%92%8c%e5%b9%b4%e9%be%84%e8%af%b1","status":"publish","type":"post","link":"http:\/\/johnhealth.blog\/ch\/?p=19976","title":{"rendered":"\u300a\u6df1\u8c08NMN\u7cfb\u5217-\u7cd6\u5c3f\u75c5-1\u300b NMN \u5e2e\u52a9\u5c0f\u9f20\u9006\u8f6c\u996e\u98df\u548c\u5e74\u9f84\u8bf1\u53d1\u7684\u7cd6\u5c3f\u75c5"},"content":{"rendered":"

\u56fd\u9645\u7cd6\u5c3f\u75c5\u8054\u76df\uff08International Diabetes Federation\uff0c\u7b80\u79f0IDF\uff09\u8868\u793a\uff0c2019\u5e74\u5168\u7403\u5927\u7ea6\u67094.63\u4ebf\u4f4d\u6210\u5e74\u4eba\uff0820~79\u5c81\uff09\u6709\u7cd6\u5c3f\u75c5\uff0c\u4f30\u8ba1\u5230\u4e862045\u5e74\u5c06\u4f1a\u4e0a\u5347\u81f37\u4ebf\u3002\u5176\u4e2d\uff0c65\u5c81\u4ee5\u4e0a\u7684\u65cf\u7fa4\u4e2d\uff0c\u67091\/5\u7684\u4eba\u60a3\u6709\u7cd6\u5c3f\u75c5\u3002\u5168\u7403\u53ef\u80fd\u8fd8\u67092.32\u4ebf\u7684\u7cd6\u5c3f\u75c5\u60a3\u8005\u8fd8\u672a\u88ab\u8bca\u65ad…\u5176\u4e2d\u7ea6 90% \u81f3 95% \u60a3\u6709 2 \u578b\u7cd6\u5c3f\u75c5\u3002<\/p>\n

\u6765\u81ea\u5723\u8def\u6613\u65af\u7684\u534e\u76db\u987f\u5927\u5b66\u533b\u5b66\u9662\u7684\u79d1\u7814\u56e2\u961f\u5728\u9876\u7ea7\u5b66\u672f\u671f\u520a\u300a\u7ec6\u80de\u4ee3\u8c22\u300b (Cell Metabolism)\u4e0a\u53d1\u8868\u7684\u8bba\u6587\u53d1\u73b0\uff0c\u5c06 NMN \u4f5c\u4e3a\u81b3\u98df\u8865\u5145\u5242\u670d\u7528\u53ef\u80fd\u6709\u4e00\u5929\u4f1a\u6210\u4e3a 2 \u578b\u7cd6\u5c3f\u75c5\u7684\u4ecb\u5165\u6216\u9884\u9632\u63aa\u65bd\u3002
\n\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0c\u9ad8\u8102\u80aa\u996e\u98df\u7684\u5e74\u8f7b\u5065\u5eb7\u5c0f\u9f20\u4f1a\u5728\u516d\u4e2a\u6708\u5185\u60a3\u4e0a\u7cd6\u5c3f\u75c5\u3002\u4e0e\u6807\u51c6\u996e\u98df\u76f8\u6bd4\uff0c\u7cd6\u5c3f\u75c5\u5c0f\u9f20\u7684\u809d\u810f\u548c\u8102\u80aa\u7ec4\u7ec7\u4e2d\u7684 NAD+ \u6c34\u5e73\u663e\u7740\u4e0b\u964d<\/span><\/strong>\u3002 \u7136\u800c\uff0c\u5411\u5c0f\u9f20\u6ce8\u5c04 NMN\uff08500mg\/kg\/\u5929\uff09\u8fde\u7eed7\u5929\uff0c\u53ef\u6062\u590d\u7ec4\u7ec7\u4e2d\u7684 NAD+ \u6c34\u5e73\uff0c\u5e76\u4f7f\u7cd6\u5c3f\u75c5\u96cc\u6027\u5c0f\u9f20\u7684\u8461\u8404\u7cd6\u8010\u53d7\u6027\u53d7\u635f\u5b8c\u5168\u6b63\u5e38\u5316\uff0c\u800c\u4e14\u96cc\u6027\u5c0f\u9f20\u7684\u80f0\u5c9b\u7d20\u8010\u53d7\u6027\u663e\u7740\u63d0\u9ad8\u3002<\/p>\n

\u5168\u6587\u8fde\u7ed3\uff1a\u3010\u79d1\u6280\u8fdb\u5c55\u3011NMN \u5e2e\u52a9\u5c0f\u9f20\u9006\u8f6c\u996e\u98df\u548c\u5e74\u9f84\u8bf1\u53d1\u7684\u7cd6\u5c3f\u75c5 \u2013 John\u54e5\u8c08\u5065\u5eb7 (johnhealth.blog)<\/a><\/p>\n

\"\"
\nYoshino J, Mills KF, Yoon MJ, Imai S. Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice. Cell Metab. 2011 Oct 5;14(4):528-36. doi: 10.1016\/j.cmet.2011.08.014. PMID: 21982712; PMCID: PMC3204926.<\/p>\n

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\u56fd\u9645\u7cd6\u5c3f\u75c5\u8054\u76df\uff08International Diabetes Federation\uff0c\u7b80\u79f0IDF\uff09\u8868\u793a\uff0c2019\u5e74\u5168\u7403\u5927\u7ea6\u67094.63\u4ebf\u4f4d\u6210\u5e74\u4eba\uff0820~79\u5c81\uff09\u6709\u7cd6\u5c3f\u75c5\uff0c\u4f30\u8ba1\u5230\u4e862045\u5e74\u5c06\u4f1a\u4e0a\u5347\u81f37\u4ebf\u3002\u5176\u4e2d\uff0c65\u5c81\u4ee5\u4e0a\u7684\u65cf\u7fa4\u4e2d\uff0c\u67091\/5\u7684\u4eba\u60a3\u6709\u7cd6\u5c3f\u75c5\u3002\u5168\u7403\u53ef\u80fd\u8fd8\u67092.32\u4ebf\u7684\u7cd6\u5c3f\u75c5\u60a3\u8005\u8fd8\u672a\u88ab\u8bca\u65ad…\u5176\u4e2d\u7ea6 90% \u81f3 95% \u60a3\u6709 2 \u578b\u7cd6\u5c3f\u75c5\u3002 \u6765\u81ea\u5723\u8def\u6613\u65af\u7684\u534e\u76db\u987f\u5927\u5b66\u533b\u5b66\u9662\u7684\u79d1\u7814\u56e2\u961f\u5728\u9876\u7ea7\u5b66\u672f\u671f\u520a\u300a\u7ec6\u80de\u4ee3\u8c22\u300b (Cell Metabolism)\u4e0a\u53d1\u8868\u7684\u8bba\u6587\u53d1\u73b0\uff0c\u5c06 NMN \u4f5c\u4e3a\u81b3\u98df\u8865\u5145\u5242\u670d\u7528\u53ef\u80fd\u6709\u4e00\u5929\u4f1a\u6210\u4e3a 2 \u578b\u7cd6\u5c3f\u75c5\u7684\u4ecb\u5165\u6216\u9884\u9632\u63aa\u65bd\u3002 \u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0c\u9ad8\u8102\u80aa\u996e\u98df\u7684\u5e74\u8f7b\u5065\u5eb7\u5c0f\u9f20\u4f1a\u5728\u516d\u4e2a\u6708\u5185\u60a3\u4e0a\u7cd6\u5c3f\u75c5\u3002\u4e0e\u6807\u51c6\u996e\u98df\u76f8\u6bd4\uff0c\u7cd6\u5c3f\u75c5\u5c0f\u9f20\u7684\u809d\u810f\u548c\u8102\u80aa\u7ec4\u7ec7\u4e2d\u7684 NAD+ \u6c34\u5e73\u663e\u7740\u4e0b\u964d\u3002 \u7136\u800c\uff0c\u5411\u5c0f\u9f20\u6ce8\u5c04 NMN\uff08500mg\/kg\/\u5929\uff09\u8fde\u7eed7\u5929\uff0c\u53ef\u6062\u590d\u7ec4\u7ec7\u4e2d\u7684 NAD+ \u6c34\u5e73\uff0c\u5e76\u4f7f\u7cd6\u5c3f\u75c5\u96cc\u6027\u5c0f\u9f20\u7684\u8461\u8404\u7cd6\u8010\u53d7\u6027\u53d7\u635f\u5b8c\u5168\u6b63\u5e38\u5316\uff0c\u800c\u4e14\u96cc\u6027\u5c0f\u9f20\u7684\u80f0\u5c9b\u7d20\u8010\u53d7\u6027\u663e\u7740\u63d0\u9ad8\u3002 \u5168\u6587\u8fde\u7ed3\uff1a\u3010\u79d1\u6280\u8fdb\u5c55\u3011NMN \u5e2e\u52a9\u5c0f\u9f20\u9006\u8f6c\u996e\u98df\u548c\u5e74\u9f84\u8bf1\u53d1\u7684\u7cd6\u5c3f\u75c5 \u2013 John\u54e5\u8c08\u5065\u5eb7 (johnhealth.blog) Yoshino J, Mills KF, Yoon MJ, Imai S. Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice. Cell Metab. 2011 Oct 5;14(4):528-36. doi: 10.1016\/j.cmet.2011.08.014. PMID: […]<\/p>\n

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