{"id":19967,"date":"2023-04-23T16:06:58","date_gmt":"2023-04-23T16:06:58","guid":{"rendered":"http:\/\/johnhealth.blog\/ch\/?p=19967"},"modified":"2023-04-23T16:06:58","modified_gmt":"2023-04-23T16:06:58","slug":"%e3%80%8a%e6%b7%b1%e8%b0%88nmn%e7%b3%bb%e5%88%97-%e4%b8%a5%e9%87%8d%e7%89%b9%e6%ae%8a%e4%bc%a0%e6%9f%93%e6%80%a7%e8%82%ba%e7%82%8e4%e3%80%8b%e9%ab%98nad%e6%b0%b4%e5%b9%b3%e5%8f%af%e6%8a%91%e5%88%b6","status":"publish","type":"post","link":"http:\/\/johnhealth.blog\/ch\/?p=19967","title":{"rendered":"\u300a\u6df1\u8c08NMN\u7cfb\u5217-\u4e25\u91cd\u7279\u6b8a\u4f20\u67d3\u6027\u80ba\u708e4\u300b\u9ad8NAD+\u6c34\u5e73\u53ef\u6291\u5236\u65b0\u51a0\u8bf1\u5bfc\u7684\u7ec6\u80de\u56e0\u5b50\u98ce\u66b4"},"content":{"rendered":"<p>\u4ece\u4e0a\u4e00\u7bc7\u8bba\u6587\u4e2d\uff0c\u5927\u536b\u00b7\u8f9b\u514b\u83b1\u5c14\u6559\u6388\u6307\u51fa\uff0cNMN\u4f5c\u4e3a\u6297\u8870\u8001\u7269\u8d28\u53ef\u4ee5\u6210\u4e3a\u4ecb\u5165\u65b0\u51a0\u80ba\u708e\u7684\u4e00\u79cd\u65b9\u5411\u3002\u8fd9\u7bc7\u6587\u7ae0\u63d0\u4f9b\u4e86\u66f4\u6df1\u5165\u7684\u4e86\u89e3\u6297\u8870\u8001\u7269\u8d28\u4e0e\u65b0\u51a0\u80ba\u708e\u4e4b\u95f4\u7684\u5173\u7cfb\uff0c\u5e76\u5efa\u8bae\u900f\u8fc7\u8865\u5145\u6297\u8870\u8001\u7269\u8d28\u6765\u4fdd\u62a4\u81ea\u5df1\u514d\u53d7\u75c5\u6bd2\u4fb5\u5bb3\u3002<\/p>\n<p>\u8f9b\u514b\u83b1\u5c14\u6559\u6388\u7684\u89c2\u70b9\u5f88\u5feb\u5c31\u5f97\u5230\u4e86\u56de\u5e94\uff0c2020\u5e747\u6708\uff0c\u51e0\u4f4d\u533b\u5b66\u4e13\u5bb6\u5728\u79d1\u7814\u671f\u520a\u300aMedical Hypotheses\u300b\u4e0a\uff0c\u6df1\u5165\u63a2\u8ba8\u4e86\u4f7f\u7528NAD+\u8865\u5145\u5242\u548cSIRT1\u6fc0\u6d3b\u5242\u4f5c\u4e3a\u65b0\u51a0\u80ba\u708e\u4ecb\u5165\u65b9\u5f0f\u7684\u53ef\u884c\u6027\u95ee\u9898\u3002<\/p>\n<p>\u4ed6\u4eec\u53d1\u73b0\u65b0\u51a0\u75c5\u6bd2\u5728\u611f\u67d3\u7ec6\u80de\u5f8c\uff0c\u4f1a\u63d0\u5347Adam17\u86cb\u767d\u7684\u8868\u8fbe\uff0c\u5f15\u53d1\u9ad8\u81f4\u547d\u6027\u7684\u7ec6\u80de\u56e0\u5b50\u98ce\u66b4\u3002\u800cNAD+\u6c34\u5e73\u5145\u6c9b\u7684\u6761\u4ef6\u4e0b\uff0c\u53ef\u4ee5\u901a\u8fc7\u6fc0\u6d3b\u957f\u5bff\u57fa\u56e0Sirt1\u6765\u6291\u5236Adam17\uff0c\u964d\u4f4e\u7ec6\u80de\u56e0\u5b50\u98ce\u66b4\u7684\u5f3a\u5ea6\u3002<\/p>\n<p>\u8fd9\u7bc7\u6587\u7ae0\u8bc1\u5b9e\u4e86NAD+\u53ef\u4ee5\u6291\u5236\u65b0\u51a0\u8bf1\u5bfc\u7684\u7ec6\u80de\u56e0\u5b50\u98ce\u66b4\uff0c\u4ece\u5168\u65b0\u7684\u89d2\u5ea6\u6765\u9610\u8ff0NAD+\u4e0e\u65b0\u51a0\u75c5\u6bd2\u7684\u5173\u7cfb\u3002\u73b0\u5728\uff0c\u60a8\u4e5f\u53ef\u4ee5\u901a\u8fc7\u8865\u5145NMN\u6765\u63d0\u5347\u4f53\u5185\u7684NAD+\uff0c\u8ba9\u8eab\u4f53\u66f4\u5f3a\u5927\uff0c\u62b5\u5fa1\u75c5\u6bd2\u4fb5\u5bb3\uff01<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-19968\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/04\/\u6df1\u8c08NMN\u7cfb\u5217-\u80ba\u708e4.jpg\" alt=\"\" width=\"940\" height=\"788\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/04\/\u6df1\u8c08NMN\u7cfb\u5217-\u80ba\u708e4.jpg 940w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/04\/\u6df1\u8c08NMN\u7cfb\u5217-\u80ba\u708e4-300x251.jpg 300w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/04\/\u6df1\u8c08NMN\u7cfb\u5217-\u80ba\u708e4-768x644.jpg 768w\" sizes=\"auto, (max-width: 940px) 100vw, 940px\" \/><\/p>\n<p>\u5168\u6587\u8fde\u7ed3\uff1a<a href=\"http:\/\/johnhealth.blog\/ch\/?p=19503\">\u65b0\u51a0\u75c5\u6bd2\u4e0eNMN \uff08\u4ece\u9884\u9632\u5230\u6cbb\u6108\uff09\u5927\u6c47\u603b \u2013 John\u54e5\u8c08\u5065\u5eb7 (johnhealth.blog)<\/a><\/p>\n<p>R. Miller, A.R. Wentzel, G.A. Richards., COVID-19: NAD+ deficiency may predispose the aged, obese and type2 diabetics to mortality through its effect on SIRT1 activity.,<br \/>\nMedical Hypotheses., Volume 144, 2020, 110044., ISSN 0306-9877., https:\/\/doi.org\/10.1016\/j.mehy.2020.110044.<\/p>\n<div class=\"pvc_clear\"><\/div>\n<p id=\"pvc_stats_19967\" class=\"pvc_stats all  \" data-element-id=\"19967\" style=\"\"><i class=\"pvc-stats-icon medium\" aria-hidden=\"true\"><svg aria-hidden=\"true\" focusable=\"false\" data-prefix=\"far\" data-icon=\"chart-bar\" role=\"img\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\" class=\"svg-inline--fa fa-chart-bar fa-w-16 fa-2x\"><path fill=\"currentColor\" d=\"M396.8 352h22.4c6.4 0 12.8-6.4 12.8-12.8V108.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v230.4c0 6.4 6.4 12.8 12.8 12.8zm-192 0h22.4c6.4 0 12.8-6.4 12.8-12.8V140.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v198.4c0 6.4 6.4 12.8 12.8 12.8zm96 0h22.4c6.4 0 12.8-6.4 12.8-12.8V204.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v134.4c0 6.4 6.4 12.8 12.8 12.8zM496 400H48V80c0-8.84-7.16-16-16-16H16C7.16 64 0 71.16 0 80v336c0 17.67 14.33 32 32 32h464c8.84 0 16-7.16 16-16v-16c0-8.84-7.16-16-16-16zm-387.2-48h22.4c6.4 0 12.8-6.4 12.8-12.8v-70.4c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v70.4c0 6.4 6.4 12.8 12.8 12.8z\" class=\"\"><\/path><\/svg><\/i> <img loading=\"lazy\" decoding=\"async\" width=\"16\" height=\"16\" alt=\"Loading\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/plugins\/page-views-count\/ajax-loader-2x.gif\" border=0 \/><\/p>\n<div class=\"pvc_clear\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u4ece\u4e0a\u4e00\u7bc7\u8bba\u6587\u4e2d\uff0c\u5927\u536b\u00b7\u8f9b\u514b\u83b1\u5c14\u6559\u6388\u6307\u51fa\uff0cNMN\u4f5c\u4e3a\u6297\u8870\u8001\u7269\u8d28\u53ef\u4ee5\u6210\u4e3a\u4ecb\u5165\u65b0\u51a0\u80ba\u708e\u7684\u4e00\u79cd\u65b9\u5411\u3002\u8fd9\u7bc7\u6587\u7ae0\u63d0\u4f9b\u4e86\u66f4\u6df1\u5165\u7684\u4e86\u89e3\u6297\u8870\u8001\u7269\u8d28\u4e0e\u65b0\u51a0\u80ba\u708e\u4e4b\u95f4\u7684\u5173\u7cfb\uff0c\u5e76\u5efa\u8bae\u900f\u8fc7\u8865\u5145\u6297\u8870\u8001\u7269\u8d28\u6765\u4fdd\u62a4\u81ea\u5df1\u514d\u53d7\u75c5\u6bd2\u4fb5\u5bb3\u3002 \u8f9b\u514b\u83b1\u5c14\u6559\u6388\u7684\u89c2\u70b9\u5f88\u5feb\u5c31\u5f97\u5230\u4e86\u56de\u5e94\uff0c2020\u5e747\u6708\uff0c\u51e0\u4f4d\u533b\u5b66\u4e13\u5bb6\u5728\u79d1\u7814\u671f\u520a\u300aMedical Hypotheses\u300b\u4e0a\uff0c\u6df1\u5165\u63a2\u8ba8\u4e86\u4f7f\u7528NAD+\u8865\u5145\u5242\u548cSIRT1\u6fc0\u6d3b\u5242\u4f5c\u4e3a\u65b0\u51a0\u80ba\u708e\u4ecb\u5165\u65b9\u5f0f\u7684\u53ef\u884c\u6027\u95ee\u9898\u3002 \u4ed6\u4eec\u53d1\u73b0\u65b0\u51a0\u75c5\u6bd2\u5728\u611f\u67d3\u7ec6\u80de\u5f8c\uff0c\u4f1a\u63d0\u5347Adam17\u86cb\u767d\u7684\u8868\u8fbe\uff0c\u5f15\u53d1\u9ad8\u81f4\u547d\u6027\u7684\u7ec6\u80de\u56e0\u5b50\u98ce\u66b4\u3002\u800cNAD+\u6c34\u5e73\u5145\u6c9b\u7684\u6761\u4ef6\u4e0b\uff0c\u53ef\u4ee5\u901a\u8fc7\u6fc0\u6d3b\u957f\u5bff\u57fa\u56e0Sirt1\u6765\u6291\u5236Adam17\uff0c\u964d\u4f4e\u7ec6\u80de\u56e0\u5b50\u98ce\u66b4\u7684\u5f3a\u5ea6\u3002 \u8fd9\u7bc7\u6587\u7ae0\u8bc1\u5b9e\u4e86NAD+\u53ef\u4ee5\u6291\u5236\u65b0\u51a0\u8bf1\u5bfc\u7684\u7ec6\u80de\u56e0\u5b50\u98ce\u66b4\uff0c\u4ece\u5168\u65b0\u7684\u89d2\u5ea6\u6765\u9610\u8ff0NAD+\u4e0e\u65b0\u51a0\u75c5\u6bd2\u7684\u5173\u7cfb\u3002\u73b0\u5728\uff0c\u60a8\u4e5f\u53ef\u4ee5\u901a\u8fc7\u8865\u5145NMN\u6765\u63d0\u5347\u4f53\u5185\u7684NAD+\uff0c\u8ba9\u8eab\u4f53\u66f4\u5f3a\u5927\uff0c\u62b5\u5fa1\u75c5\u6bd2\u4fb5\u5bb3\uff01 \u5168\u6587\u8fde\u7ed3\uff1a\u65b0\u51a0\u75c5\u6bd2\u4e0eNMN \uff08\u4ece\u9884\u9632\u5230\u6cbb\u6108\uff09\u5927\u6c47\u603b \u2013 John\u54e5\u8c08\u5065\u5eb7 (johnhealth.blog) R. Miller, A.R. Wentzel, G.A. Richards., COVID-19: NAD+ deficiency may predispose the aged, obese and type2 diabetics to mortality through its effect on SIRT1 activity., Medical Hypotheses., Volume 144, 2020, 110044., ISSN 0306-9877., https:\/\/doi.org\/10.1016\/j.mehy.2020.110044.<\/p>\n<div class=\"pvc_clear\"><\/div>\n<p id=\"pvc_stats_19967\" class=\"pvc_stats all  \" data-element-id=\"19967\" style=\"\"><i class=\"pvc-stats-icon medium\" aria-hidden=\"true\"><svg aria-hidden=\"true\" focusable=\"false\" data-prefix=\"far\" data-icon=\"chart-bar\" role=\"img\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\" class=\"svg-inline--fa fa-chart-bar fa-w-16 fa-2x\"><path fill=\"currentColor\" d=\"M396.8 352h22.4c6.4 0 12.8-6.4 12.8-12.8V108.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v230.4c0 6.4 6.4 12.8 12.8 12.8zm-192 0h22.4c6.4 0 12.8-6.4 12.8-12.8V140.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v198.4c0 6.4 6.4 12.8 12.8 12.8zm96 0h22.4c6.4 0 12.8-6.4 12.8-12.8V204.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v134.4c0 6.4 6.4 12.8 12.8 12.8zM496 400H48V80c0-8.84-7.16-16-16-16H16C7.16 64 0 71.16 0 80v336c0 17.67 14.33 32 32 32h464c8.84 0 16-7.16 16-16v-16c0-8.84-7.16-16-16-16zm-387.2-48h22.4c6.4 0 12.8-6.4 12.8-12.8v-70.4c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v70.4c0 6.4 6.4 12.8 12.8 12.8z\" class=\"\"><\/path><\/svg><\/i> <img loading=\"lazy\" decoding=\"async\" width=\"16\" height=\"16\" alt=\"Loading\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/plugins\/page-views-count\/ajax-loader-2x.gif\" border=0 \/><\/p>\n<div class=\"pvc_clear\"><\/div>\n","protected":false},"author":1,"featured_media":19968,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[172,734],"tags":[728,245,474],"class_list":["post-19967","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-nmn-","category-nmn","tag-nmn","tag-245","tag-474"],"aioseo_notices":[],"_links":{"self":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts\/19967","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=19967"}],"version-history":[{"count":1,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts\/19967\/revisions"}],"predecessor-version":[{"id":19969,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts\/19967\/revisions\/19969"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/media\/19968"}],"wp:attachment":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=19967"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=19967"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=19967"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}