{"id":19953,"date":"2023-04-19T02:48:28","date_gmt":"2023-04-19T02:48:28","guid":{"rendered":"http:\/\/johnhealth.blog\/ch\/?p=19953"},"modified":"2023-04-22T13:10:03","modified_gmt":"2023-04-22T13:10:03","slug":"%e3%80%8a%e6%b7%b1%e8%b0%88nmn%e7%b3%bb%e5%88%97-%e4%b8%a5%e9%87%8d%e7%89%b9%e6%ae%8a%e4%bc%a0%e6%9f%93%e6%80%a7%e8%82%ba%e7%82%8e2%e3%80%8b-nad%e6%98%af%e5%85%8d%e7%96%ab%e7%b3%bb%e7%bb%9f%e6%88%98","status":"publish","type":"post","link":"http:\/\/johnhealth.blog\/ch\/?p=19953","title":{"rendered":"\u300a\u6df1\u8c08NMN\u7cfb\u5217-\u4e25\u91cd\u7279\u6b8a\u4f20\u67d3\u6027\u80ba\u708e2\u300b- NAD+\u662f\u514d\u75ab\u7cfb\u7edf\u6218\u80dc\u65b0\u51a0\u7684\u5173\u952e"},"content":{"rendered":"<p>\u4ece\u4e0a\u4e00\u7bc7\u9884\u5370\u672c\u8bba\u6587\u4e2d\uff0c\u4f0a\u6717\u4f0a\u65af\u6cd5\u7f55\u533b\u79d1\u5927\u5b66\u7684Khanahmd\u56e2\u961f\u53d1\u73b0\u4eba\u4f53\u5185NAD+\u7684\u635f\u8017\u53ef\u80fd\u662f\u65b0\u51a0\u80ba\u708e\u75c7\u72b6\u7684\u6839\u6e90\u3002\u56e0\u4e3a\u65b0\u51a0\u75c5\u6bd2\u611f\u67d3\u4f1a\u4f7f\u80ba\u90e8\u7ec6\u80de\u751f\u6210\u5927\u91cf\u6d3b\u6027\u6c27\uff08ROS\uff09\uff0c\u9020\u6210DNA\u635f\u4f24\uff0c\u800c\u4e3a\u4e86\u8fdb\u884c\u4fee\u590d\uff0c\u7ec6\u80de\u4f1a\u751f\u4ea7\u5927\u91cfDNA\u4fee\u590d\u9176PARP-1\uff0c\u4f7f\u4f53\u5185\u50a8\u91cf\u6709\u9650\u7684NAD+\u88ab\u4e25\u91cd\u635f\u8017\uff0c\u5bfc\u81f4\u7ec6\u80de\u6b7b\u4ea1\uff0c\u52a0\u5267\u708e\u75c7\u3002\u56e0\u6b64\uff0c\u8865\u5145NAD+\u53ef\u80fd\u6210\u4e3a\u4e00\u79cd\u5168\u65b0\u4e14\u53ef\u884c\u7684\u65b0\u51a0\u80ba\u708e\u4ecb\u5165\u624b\u6bb5\u3002<\/p>\n<p>\u800c\u540c\u6837\u57282020\u5e744\u6708\uff0c\u5f53\u65b0\u51a0\u75c5\u6bd2\u521a\u5f00\u59cb\u8513\u5ef6\u4e4b\u9645\uff0c\u7f8e\u56fd\u7231\u8377\u534e\u5927\u5b66\u7684Brenner\u56e2\u961f\u53d1\u8868\u4e86\u4e00\u7bc7\u520a\u767b\u5728\u300aJournal of Biological Chemistry\u300b\u4e0a\u7684\u7814\u7a76\u62a5\u544a\uff0c\u63ed\u793a\u4e86NAD+\u5728\u65b0\u51a0\u75c5\u6bd2\u62b5\u5fa1\u4e2d\u7684\u91cd\u8981\u4f5c\u7528\u3002<\/p>\n<p>\u5f53\u65b0\u51a0\u75c5\u6bd2\u4fb5\u5165\u4eba\u4f53\u65f6\uff0c\u4eba\u4f53\u5148\u5929\u514d\u75ab\u7cfb\u7edf\u4f1a\u542f\u52a8\u4e00\u7cfb\u5217\u9632\u5fa1\u673a\u5236\u6765\u4fdd\u62a4\u81ea\u5df1\uff0c\u5176\u4e2d\u6700\u5173\u952e\u7684\u662f\u5927\u89c4\u6a21\u7684PARPs\u8f6c\u5f55\uff0c\u4ee5\u6291\u5236\u75c5\u6bd2\u7684\u590d\u5236\u80fd\u529b\uff0c\u800c\u8fd9\u4e2a\u8fc7\u7a0b\u9700\u8981\u6d88\u8017\u5927\u91cf\u7684NAD+\u3002<\/p>\n<p>\u56e0\u6b64\uff0cBrenner\u56e2\u961f\u63d0\u51fa\u4e86\u591a\u79cd\u53ef\u884c\u7684\u89e3\u51b3\u7b56\u7565\uff0c\u5176\u4e2d\u8865\u5145\u5916\u6e90\u6027NAD+\u88ab\u8ba4\u4e3a\u662f\u6700\u4e3a\u6709\u6548\u7684\u65b9\u6cd5\uff0c\u540c\u65f6\u4e5f\u662f\u534f\u52a9\u5148\u5929\u514d\u75ab\u7cfb\u7edf\u5bf9\u6297\u65b0\u51a0\u75c5\u6bd2\u7684\u5173\u952e\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-19954\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/03\/\u6df1\u8c08NMN\u7cfb\u5217-\u80ba\u708e2.jpg\" alt=\"\" width=\"940\" height=\"788\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/03\/\u6df1\u8c08NMN\u7cfb\u5217-\u80ba\u708e2.jpg 940w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/03\/\u6df1\u8c08NMN\u7cfb\u5217-\u80ba\u708e2-300x251.jpg 300w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/03\/\u6df1\u8c08NMN\u7cfb\u5217-\u80ba\u708e2-768x644.jpg 768w\" sizes=\"auto, (max-width: 940px) 100vw, 940px\" \/><\/p>\n<p>\u5168\u6587\u8fde\u7ed3\uff1a<a href=\"http:\/\/johnhealth.blog\/ch\/?p=19503\">\u65b0\u51a0\u75c5\u6bd2\u4e0eNMN \uff08\u4ece\u9884\u9632\u5230\u6cbb\u6108\uff09\u5927\u6c47\u603b \u2013 John\u54e5\u8c08\u5065\u5eb7 (johnhealth.blog)<\/a><\/p>\n<p>Coronavirus infection and PARP expression dysregulate the NAD metabolome: An actionable component of innate immunity Heer, Collin D. et al. Journal of Biological Chemistry, Volume 295, Issue 52, 17986 &#8211; 17996<\/p>\n<div class=\"pvc_clear\"><\/div>\n<p id=\"pvc_stats_19953\" class=\"pvc_stats all  \" data-element-id=\"19953\" style=\"\"><i class=\"pvc-stats-icon medium\" aria-hidden=\"true\"><svg aria-hidden=\"true\" focusable=\"false\" data-prefix=\"far\" data-icon=\"chart-bar\" role=\"img\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\" class=\"svg-inline--fa fa-chart-bar fa-w-16 fa-2x\"><path fill=\"currentColor\" d=\"M396.8 352h22.4c6.4 0 12.8-6.4 12.8-12.8V108.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v230.4c0 6.4 6.4 12.8 12.8 12.8zm-192 0h22.4c6.4 0 12.8-6.4 12.8-12.8V140.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v198.4c0 6.4 6.4 12.8 12.8 12.8zm96 0h22.4c6.4 0 12.8-6.4 12.8-12.8V204.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v134.4c0 6.4 6.4 12.8 12.8 12.8zM496 400H48V80c0-8.84-7.16-16-16-16H16C7.16 64 0 71.16 0 80v336c0 17.67 14.33 32 32 32h464c8.84 0 16-7.16 16-16v-16c0-8.84-7.16-16-16-16zm-387.2-48h22.4c6.4 0 12.8-6.4 12.8-12.8v-70.4c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v70.4c0 6.4 6.4 12.8 12.8 12.8z\" class=\"\"><\/path><\/svg><\/i> <img loading=\"lazy\" decoding=\"async\" width=\"16\" height=\"16\" alt=\"Loading\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/plugins\/page-views-count\/ajax-loader-2x.gif\" border=0 \/><\/p>\n<div class=\"pvc_clear\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u4ece\u4e0a\u4e00\u7bc7\u9884\u5370\u672c\u8bba\u6587\u4e2d\uff0c\u4f0a\u6717\u4f0a\u65af\u6cd5\u7f55\u533b\u79d1\u5927\u5b66\u7684Khanahmd\u56e2\u961f\u53d1\u73b0\u4eba\u4f53\u5185NAD+\u7684\u635f\u8017\u53ef\u80fd\u662f\u65b0\u51a0\u80ba\u708e\u75c7\u72b6\u7684\u6839\u6e90\u3002\u56e0\u4e3a\u65b0\u51a0\u75c5\u6bd2\u611f\u67d3\u4f1a\u4f7f\u80ba\u90e8\u7ec6\u80de\u751f\u6210\u5927\u91cf\u6d3b\u6027\u6c27\uff08ROS\uff09\uff0c\u9020\u6210DNA\u635f\u4f24\uff0c\u800c\u4e3a\u4e86\u8fdb\u884c\u4fee\u590d\uff0c\u7ec6\u80de\u4f1a\u751f\u4ea7\u5927\u91cfDNA\u4fee\u590d\u9176PARP-1\uff0c\u4f7f\u4f53\u5185\u50a8\u91cf\u6709\u9650\u7684NAD+\u88ab\u4e25\u91cd\u635f\u8017\uff0c\u5bfc\u81f4\u7ec6\u80de\u6b7b\u4ea1\uff0c\u52a0\u5267\u708e\u75c7\u3002\u56e0\u6b64\uff0c\u8865\u5145NAD+\u53ef\u80fd\u6210\u4e3a\u4e00\u79cd\u5168\u65b0\u4e14\u53ef\u884c\u7684\u65b0\u51a0\u80ba\u708e\u4ecb\u5165\u624b\u6bb5\u3002 \u800c\u540c\u6837\u57282020\u5e744\u6708\uff0c\u5f53\u65b0\u51a0\u75c5\u6bd2\u521a\u5f00\u59cb\u8513\u5ef6\u4e4b\u9645\uff0c\u7f8e\u56fd\u7231\u8377\u534e\u5927\u5b66\u7684Brenner\u56e2\u961f\u53d1\u8868\u4e86\u4e00\u7bc7\u520a\u767b\u5728\u300aJournal of Biological Chemistry\u300b\u4e0a\u7684\u7814\u7a76\u62a5\u544a\uff0c\u63ed\u793a\u4e86NAD+\u5728\u65b0\u51a0\u75c5\u6bd2\u62b5\u5fa1\u4e2d\u7684\u91cd\u8981\u4f5c\u7528\u3002 \u5f53\u65b0\u51a0\u75c5\u6bd2\u4fb5\u5165\u4eba\u4f53\u65f6\uff0c\u4eba\u4f53\u5148\u5929\u514d\u75ab\u7cfb\u7edf\u4f1a\u542f\u52a8\u4e00\u7cfb\u5217\u9632\u5fa1\u673a\u5236\u6765\u4fdd\u62a4\u81ea\u5df1\uff0c\u5176\u4e2d\u6700\u5173\u952e\u7684\u662f\u5927\u89c4\u6a21\u7684PARPs\u8f6c\u5f55\uff0c\u4ee5\u6291\u5236\u75c5\u6bd2\u7684\u590d\u5236\u80fd\u529b\uff0c\u800c\u8fd9\u4e2a\u8fc7\u7a0b\u9700\u8981\u6d88\u8017\u5927\u91cf\u7684NAD+\u3002 \u56e0\u6b64\uff0cBrenner\u56e2\u961f\u63d0\u51fa\u4e86\u591a\u79cd\u53ef\u884c\u7684\u89e3\u51b3\u7b56\u7565\uff0c\u5176\u4e2d\u8865\u5145\u5916\u6e90\u6027NAD+\u88ab\u8ba4\u4e3a\u662f\u6700\u4e3a\u6709\u6548\u7684\u65b9\u6cd5\uff0c\u540c\u65f6\u4e5f\u662f\u534f\u52a9\u5148\u5929\u514d\u75ab\u7cfb\u7edf\u5bf9\u6297\u65b0\u51a0\u75c5\u6bd2\u7684\u5173\u952e\u3002 \u5168\u6587\u8fde\u7ed3\uff1a\u65b0\u51a0\u75c5\u6bd2\u4e0eNMN \uff08\u4ece\u9884\u9632\u5230\u6cbb\u6108\uff09\u5927\u6c47\u603b \u2013 John\u54e5\u8c08\u5065\u5eb7 (johnhealth.blog) Coronavirus infection and PARP expression dysregulate the NAD metabolome: An actionable component of innate immunity Heer, Collin D. et al. Journal of Biological Chemistry, Volume 295, Issue 52, 17986 &#8211; 17996<\/p>\n<div class=\"pvc_clear\"><\/div>\n<p id=\"pvc_stats_19953\" class=\"pvc_stats all  \" data-element-id=\"19953\" style=\"\"><i class=\"pvc-stats-icon medium\" aria-hidden=\"true\"><svg aria-hidden=\"true\" focusable=\"false\" data-prefix=\"far\" data-icon=\"chart-bar\" role=\"img\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\" class=\"svg-inline--fa fa-chart-bar fa-w-16 fa-2x\"><path fill=\"currentColor\" d=\"M396.8 352h22.4c6.4 0 12.8-6.4 12.8-12.8V108.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v230.4c0 6.4 6.4 12.8 12.8 12.8zm-192 0h22.4c6.4 0 12.8-6.4 12.8-12.8V140.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v198.4c0 6.4 6.4 12.8 12.8 12.8zm96 0h22.4c6.4 0 12.8-6.4 12.8-12.8V204.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v134.4c0 6.4 6.4 12.8 12.8 12.8zM496 400H48V80c0-8.84-7.16-16-16-16H16C7.16 64 0 71.16 0 80v336c0 17.67 14.33 32 32 32h464c8.84 0 16-7.16 16-16v-16c0-8.84-7.16-16-16-16zm-387.2-48h22.4c6.4 0 12.8-6.4 12.8-12.8v-70.4c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v70.4c0 6.4 6.4 12.8 12.8 12.8z\" class=\"\"><\/path><\/svg><\/i> <img loading=\"lazy\" decoding=\"async\" width=\"16\" height=\"16\" alt=\"Loading\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/plugins\/page-views-count\/ajax-loader-2x.gif\" border=0 \/><\/p>\n<div class=\"pvc_clear\"><\/div>\n","protected":false},"author":1,"featured_media":19954,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[191,172],"tags":[728,474],"class_list":["post-19953","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-covid-19","category-nmn-","tag-nmn","tag-474"],"aioseo_notices":[],"_links":{"self":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts\/19953","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=19953"}],"version-history":[{"count":1,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts\/19953\/revisions"}],"predecessor-version":[{"id":19955,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts\/19953\/revisions\/19955"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/media\/19954"}],"wp:attachment":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=19953"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=19953"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=19953"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}