{"id":19924,"date":"2023-03-30T03:49:33","date_gmt":"2023-03-30T03:49:33","guid":{"rendered":"http:\/\/johnhealth.blog\/ch\/?p=19924"},"modified":"2023-03-30T03:50:02","modified_gmt":"2023-03-30T03:50:02","slug":"%e6%ad%90%e6%b4%b2%e6%96%b0%e7%a0%94%e7%a9%b6%ef%bc%9a%e7%94%a8-nmn-%e6%81%a2%e5%be%a9-nad-%e5%8f%af%e6%8c%bd%e6%95%91%e5%85%8d%e7%96%ab%e7%b4%b0%e8%83%9e%e6%8a%97b%e5%9e%8b%e8%82%9d%e7%82%8e","status":"publish","type":"post","link":"http:\/\/johnhealth.blog\/ch\/?p=19924","title":{"rendered":"\u3010\u79d1\u6280\u8fdb\u5c55\u3011\u6b50\u6d32\u65b0\u7814\u7a76\uff1a\u7528 NMN \u6062\u5fa9 NAD+ \u53ef\u633d\u6551\u514d\u75ab\u7d30\u80de\u6297B\u578b\u809d\u708e\u7684\u529f\u80fd"},"content":{"rendered":"<p>\u6b50\u6d32\u65b0\u7814\u7a76\uff1a\u7528 NMN \u6062\u5fa9 NAD+ \u53ef\u633d\u6551\u514d\u75ab\u7d30\u80de\u6297B\u578b\u809d\u708e\u7684\u529f\u80fd<\/p>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-image\">\n<div>\n<div class=\"s-component-content\">\n<div class=\"s-img-wrapper\"><img decoding=\"async\" class=\"crop-default\" title=\"\" src=\"https:\/\/custom-images.strikinglycdn.com\/res\/hrscywv4p\/image\/upload\/c_limit,fl_lossy,h_9000,w_1200,f_auto,q_auto\/3160820\/594993_191020.png\" alt=\"\" data-description=\"\" data-image-link=\"javascript:void(0);\" \/><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p class=\"author\">By Brett J. Weiss<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p class=\"date main-color-g\">Published: 10:01 am PST Mar 28, 2023 | Updated: 6:31 p.m. PST Mar 28, 2023<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p><em><strong>\u91cd\u5927\u4eae\u9ede<\/strong><\/em><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<ul>\n<li>\u7159\u9170\u80fa\u817a\u560c\u5464\u4e8c\u6838\u82f7\u9178 (NAD+) \u7684\u524d\u9ad4 NMN \u53ef\u63d0\u9ad8B\u578b\u809d\u708e\u75c5\u6bd2\u7279\u7570\u6027\u514d\u75ab\u7d30\u80de\uff08CD8 T \u7d30\u80de\uff09\u7684\u6297\u75c5\u6bd2\u6d3b\u6027\u3002<\/li>\n<li>\u529f\u80fd\u53d7\u640d\u7684\u8870\u7aedB\u578b\u809d\u708e\u7279\u7570\u6027 CD8 T \u7d30\u80de\u8868\u73fe\u51fa\u9ad8\u6c34\u5e73\u7684 DNA \u640d\u50b7\u548c DNA \u4fee\u5fa9\u6a5f\u5236\u7684\u7f3a\u9677 \u3002<\/li>\n<li>\u5728\u8017\u76e1\u72c0\u614b\u4e0b\uff0cCD8 T \u514d\u75ab\u7d30\u80de\u986f\u793a\u51fa\u66f4\u9ad8\u7684\u6d88\u8017 NAD+ \u7684 CD38 \u9176\u6c34\u5e73\u548c\u66f4\u4f4e\u7684\u6297\u75c5\u6bd2\u86cb\u767d\u7522\u91cf\u3002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<p><!--more--><\/p>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>\u5c0d\u65bc\u5927\u591a\u6578\u611f\u67d3\u8005\u4f86\u8aaa\uff0cB\u578b\u809d\u708e\u901a\u5e38\u6703\u5728\u516d\u500b\u6708\u5167\u6d88\u9000\uff0c\u4f46\u7531\u65bc CD8 T \u7d30\u80de\u8017\u7aed\uff0c\u53ef\u80fd\u6703\u51fa\u73fe\u4e0d\u6703\u6d88\u5931\u7684\u6162\u6027B\u578b\u809d\u708e\u3002 CD8 T \u7d30\u80de\u8017\u7aed\u662f\u7531\u65bc\u9ad8\u6c34\u5e73\u66b4\u9732\u65bc B\u578b\u809d\u708e\u75c5\u6bd2\u7b49\u75c5\u539f\u9ad4\uff0c\u5f15\u767c T \u7d30\u80de DNA \u640d\u50b7\u548c\u529f\u80fd\u5931\u8abf\u7684\u6297\u75c5\u6bd2\u53cd\u61c9\u3002 \u78ba\u5b9a CD8 T \u7d30\u80de\u8017\u7aed\u80cc\u5f8c\u7684\u7d30\u80de\u904e\u7a0b\u6709\u52a9\u65bc\u958b\u767c\u6162\u6027B\u578b\u809d\u708e\u7684\u6cbb\u7642\u65b9\u6cd5\u3002\u4e00\u4e9b\u7814\u7a76\u4eba\u54e1\u6700\u8fd1\u63d0\u51fa\uff0cNAD+ \u8017\u7aed\u662f T \u7d30\u80de\u8017\u7aed\u7684\u57fa\u790e\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>Fisicaro \u53ca\u5176\u4f86\u81ea\u7fa9\u5927\u5229\u5e15\u723e\u99ac\u5927\u5b78\u7684\u540c\u4e8b\u5728\u5b78\u8853\u671f\u520a\u300a\u809d\u81df\u75c5\u5b78\u671f\u520a\u300b(<em>Journal of Hepatology)<\/em>\u4e0a\uff0c\u8b49\u660e<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36893853\/\" target=\"_blank\" rel=\"noopener\" data-type=\"web\">\u7528 NMN \u4ecb\u5165 B\u578b\u809d\u708e\u75c5\u6bd2\u7279\u7570\u6027 CD8 T \u7d30\u80de\u53ef\u63d0\u9ad8\u5176\u6297\u75c5\u6bd2\u86cb\u767d\uff08\u7d30\u80de\u56e0\u5b50\uff09\u7684\u7522\u751f<\/a>\u3002 \u767c\u73fe\u8017\u76e1\u7684B\u578b\u809d\u708e\u7279\u7570\u6027 CD8 T \u7d30\u80de\u5177\u6709\u9ad8\u6c34\u5e73\u7684 DNA \u640d\u50b7\u4ee5\u53ca\u529f\u80fd\u5931\u8abf\u7684 DNA \u4fee\u5fa9\u6a5f\u5236\u3002 \u8a72\u7814\u7a76\u7684\u7d50\u679c\u8868\u660e\uff0cNMN \u548c\/\u6216 CD38 \u6291\u88fd\u5291\u53ef\u7528\u65bc\u6539\u9020\u8017\u76e1\u7684 T \u7d30\u80de\uff0c\u4ee5\u62b5\u79a6\u6162\u6027B\u578b\u809d\u708e\u4ee5\u53ca\u5176\u4ed6\u6f5b\u5728\u7684\u75c5\u6bd2\u611f\u67d3\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>NMN \u6062\u5fa9\u514d\u75ab\u7d30\u80de\u6297\u75c5\u6bd2\u6fc0\u6d3b<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>\u7531\u65bc Fisicaro \u53ca\u5176\u540c\u4e8b\u5047\u8a2d\u7528 NMN \u6062\u5fa9 NAD+ \u6c34\u5e73\u53ef\u4ee5\u4fee\u5fa9\u8017\u76e1\u7684 CD8 T \u7d30\u80de\uff0c\u56e0\u6b64\u4ed6\u5011\u5f9e\u6162\u6027 B\u578b\u809d\u708e\u60a3\u8005\u4e2d\u5206\u96e2\u51fa\u9019\u4e9b\u514d\u75ab\u7d30\u80de\u9032\u884c\u6e2c\u8a66\u3002 \u7528 NMN \u4ecb\u5165\u5f8c\uff0c\u7d30\u80de\u8868\u9054\u4e86\u66f4\u591a\u7684\u6297\u75c5\u6bd2\u7d30\u80de\u56e0\u5b50\uff0c\u7279\u5225\u662f\u7d30\u80de\u56e0\u5b50\u4e7e\u64fe\u7d20\u03b3 (IFN-) \u589e\u52a0\u4e86 2.7 \u500d\uff0c\u8868\u660e NMN \u6062\u5fa9\u4e86 CD8 T \u7d30\u80de\u7684\u6297\u75c5\u6bd2\u7279\u6027\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-image\">\n<div class=\"s-component-content\">\n<div class=\"s-img-wrapper\"><\/div>\n<div><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-19925\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/03\/170098_3153.webp\" alt=\"\" width=\"470\" height=\"286\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/03\/170098_3153.webp 470w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/03\/170098_3153-300x183.webp 300w\" sizes=\"auto, (max-width: 470px) 100vw, 470px\" \/><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36893853\/\" target=\"_blank\" rel=\"noopener\" data-type=\"\">(Montali et al., 2023 | <\/a><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36893853\/\" target=\"_blank\" rel=\"noopener\" data-type=\"\"><em>Journal of Hepatology<\/em><\/a><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36893853\/\" target=\"_blank\" rel=\"noopener\" data-type=\"\">)<\/a> <strong>NMN \u6062\u5fa9\u514d\u75ab\u7d30\u80de\u6297\u75c5\u6bd2\u7d30\u80de\u56e0\u5b50\u7684\u7522\u751f<\/strong>\u3002 \u8207\u55ae\u7368\u4f7f\u7528B\u578b\u809d\u708e\u75c5\u6bd2\u86cb\u767d\uff08\u7070\u8272\u689d\uff09\u76f8\u6bd4\uff0c\u4f7f\u7528 NMN \u548cB\u578b\u809d\u708e\u75c5\u6bd2\u86cb\u767d\uff08\u9ed1\u8272\u689d\uff09\u9032\u884c\u514d\u75ab\u7d30\u80de\u6cbb\u7642\u5f8c\uff0cX \u8ef8\u4e0a\u5217\u51fa\u7684\u7d30\u80de\u56e0\u5b50\u986f\u8457\u589e\u52a0\u3002 Med + Pep= \u5177\u6709\u75c5\u6bd2\u80bd\u523a\u6fc0\u7684\u7d30\u80de\u57f9\u990a\u57fa\uff1b Med + Pep + NMN= \u5177\u6709\u75c5\u6bd2\u80bd\u523a\u6fc0\u548c NMN \u7684\u7d30\u80de\u57f9\u990a\u57fa<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>\u70ba\u4e86\u6aa2\u67e5\u6162\u6027 B\u578b\u809d\u708e\u611f\u67d3\u4e2d\u4f34\u96a8 T \u7d30\u80de\u8870\u7aed\u7684\u7d30\u80de\u640d\u50b7\uff0cFisicaro \u53ca\u5176\u540c\u4e8b\u6bd4\u8f03\u4e86 B\u578b\u809d\u708e\u7279\u7570\u6027 T \u7d30\u80de\u8207\u6d41\u611f (FLU) \u7279\u7570\u6027 T \u7d30\u80de\u7684 DNA \u640d\u50b7\u3002 \u7814\u7a76\u4eba\u54e1\u5728 B\u578b\u809d\u708e\u7279\u7570\u6027 T \u7d30\u80de\u4e2d\u767c\u73fe\u660e\u986f\u66f4\u591a\u7684 DNA \u640d\u50b7\u3002 \u4ed6\u5011\u9084\u767c\u73fe\uff0c\u8207 \u6d41\u611f\u7279\u7570\u6027 T \u7d30\u80de\u76f8\u6bd4\uff0c\u7528 DNA \u640d\u50b7\u8a98\u5c0e\u5206\u5b50\uff08\u4f9d\u6258\u6cca\u82f7\uff09\u4f86\u4ecb\u5165\u7d30\u80de\u6703\u5f15\u767c DNA \u640d\u50b7\u53cd\u61c9\u964d\u4f4e\u7684\u8da8\u52e2\u3002 \u7531\u65bc PARPs \u4ecb\u5c0e\u7684 DNA \u640d\u50b7\u53cd\u61c9\u6703\u9700\u8981 NAD+\uff0c\u56e0\u6b64\u8a72\u6578\u64da\u8868\u660e\uff0cNAD+ \u7f3a\u4e4f\u8207 B\u578b\u809d\u708e\u7279\u7570\u6027 CD8 T \u7d30\u80de\u8870\u7aed\u4e2d\u66f4\u9ad8\u6c34\u5e73\u7684 DNA \u640d\u50b7\u6709\u95dc\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-image\">\n<div class=\"s-component-content\">\n<div class=\"s-img-wrapper\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-19926\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/03\/292043_854878.webp\" alt=\"\" width=\"591\" height=\"296\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/03\/292043_854878.webp 591w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/03\/292043_854878-300x150.webp 300w\" sizes=\"auto, (max-width: 591px) 100vw, 591px\" \/><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36893853\/\" target=\"_blank\" rel=\"noopener\" data-type=\"\">(Montali et al., 2023 | <\/a><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36893853\/\" target=\"_blank\" rel=\"noopener\" data-type=\"\"><em>Journal of Hepatology<\/em><\/a><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36893853\/\" target=\"_blank\" rel=\"noopener\" data-type=\"\">)<\/a> <strong>B\u578b\u809d\u708e\u7279\u7570\u6027 CD8 T \u7d30\u80de\u5177\u6709\u9ad8\u6c34\u5e73\u7684 DNA \u640d\u50b7\u548c\u5c0d DNA \u640d\u50b7\u5206\u5b50\uff08\u4f9d\u6258\u6cca\u82f7\uff09\u7684\u5f31 DNA \u640d\u50b7\u53cd\u61c9\u3002<\/strong> \u5de6\uff09\u8207\u6d41\u611f\u7279\u7570\u6027 CD8 T \u7d30\u80de (FLU HEALTHY) \u76f8\u6bd4\uff0cB\u578b\u809d\u708e\u7279\u7570\u6027\u7d30\u80de (HBV CHRONIC) \u8868\u73fe\u51fa\u66f4\u9ad8\u6c34\u5e73\u7684 DNA \u640d\u50b7\u6a19\u8a18\u7269 (phosphoH2AX)\u3002 \u53f3\u5716\uff09\u8207 \u6d41\u611f\u7279\u7570\u6027\u514d\u75ab\u7d30\u80de\uff08FLU HEALTHY\uff09\u76f8\u6bd4\uff0c\u7528\u65bc\u8a98\u5c0e DNA \u640d\u50b7\u7684\u5206\u5b50\uff08\u4f9d\u6258\u6cca\u82f7\uff09\u5728B\u578b\u809d\u708e\u7279\u7570\u6027\u514d\u75ab\u7d30\u80de\uff08HBV CHRONIC\uff09\u4e2d\u5f15\u8d77 DNA \u640d\u50b7\u53cd\u61c9\u8f03\u4f4e\u7684\u8da8\u52e2\uff0c\u8868\u660e DNA \u4fee\u5fa9\u6240\u9700\u7684 NAD+ \u8f03\u4f4e .<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>\u70ba\u4e86\u9032\u4e00\u6b65\u63a2\u7d22\u7528 NMN \u88dc\u5145 NAD+ \u5982\u4f55\u6539\u5584\u8017\u76e1\u7684 CD8 T \u7d30\u80de\u6297\u75c5\u6bd2\u7d30\u80de\u56e0\u5b50\u7684\u7522\u751f\uff0cFisicaro \u53ca\u5176\u540c\u4e8b\u6e2c\u91cf\u4e86\u6d88\u8017 NAD+ \u7684 CD38 \u9176\u7684\u9ad8\u6c34\u5e73\u8207\u7d30\u80de\u56e0\u5b50\u6c34\u5e73\u7684\u95dc\u4fc2\u3002 \u4ed6\u5011\u6e2c\u91cf\u4e86\u4e00\u7a2e\u4e3b\u8981\u7d30\u80de\u56e0\u5b50\u2014\u2014IFN-\u2014\u2014\u4e26\u767c\u73fe\u9ad8 CD38 \u9176\u6c34\u5e73\u8207\u4f4e IFN- \u6c34\u5e73\u76f8\u95dc\u3002 \u9019\u4e9b\u6578\u64da\u63d0\u4f9b\u4e86\u9ad8 CD38 \u9176\u6c34\u5e73\u53ef\u5c0e\u81f4\u6297\u75c5\u6bd2\u7d30\u80de\u56e0\u5b50\u7522\u751f\u964d\u4f4e\u7684\u8b49\u64da\u3002 \u9019\u4e5f\u4f7f\u4f4e NAD+ \u6c34\u5e73\u5728\u6162\u6027 B\u578b\u809d\u708e\u75c5\u7406\u5b78\u4e2d\u767c\u63ee\u91cd\u8981\u4f5c\u7528\u7684\u65b7\u8a00\u8b8a\u5f97\u53ef\u4fe1\uff0c\u56e0\u70ba\u9ad8 CD38 \u6c34\u5e73\u7406\u8ad6\u4e0a\u6703\u964d\u4f4e\u7d30\u80de NAD+\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-image\">\n<div class=\"s-component-content\">\n<div class=\"s-img-wrapper\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-19927\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/03\/257789_4856.webp\" alt=\"\" width=\"391\" height=\"284\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/03\/257789_4856.webp 391w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/03\/257789_4856-300x218.webp 300w\" sizes=\"auto, (max-width: 391px) 100vw, 391px\" \/><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36893853\/\" target=\"_blank\" rel=\"noopener\" data-type=\"\">(Montali et al., 2023 | <\/a><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36893853\/\" target=\"_blank\" rel=\"noopener\" data-type=\"\"><em>Journal of Hepatology<\/em><\/a><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36893853\/\" target=\"_blank\" rel=\"noopener\" data-type=\"\">)<\/a> <strong>\u8f03\u9ad8\u7684\u514d\u75ab\u7d30\u80de CD38 \u9176\u6c34\u5e73\u8207\u8f03\u4f4e\u7684\u6297\u75c5\u6bd2\u7d30\u80de\u56e0\u5b50\u6c34\u5e73\u76f8\u95dc<\/strong>\u3002 CD38 (%CD38hi) \u5347\u9ad8\u7684\u514d\u75ab\u7d30\u80de\u767e\u5206\u6bd4\u8f03\u9ad8\u8207\u8868\u9054\u6297\u75c5\u6bd2\u7d30\u80de\u56e0\u5b50 IFN- (%IFN-+) \u7684\u53ef\u80fd\u6027\u8f03\u4f4e\u6709\u95dc\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-quote-content\">\n<div class=\"quote-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>&nbsp;<\/p>\n<p>Fisicaro \u53ca\u5176\u540c\u4e8b\u8aaa\uff1a\u201c\u6211\u5011\u7684\u6578\u64da\u986f\u793a\uff0c\u5728 [\u6162\u6027B\u578b\u809d\u708e] \u60a3\u8005\u7684 [B\u578b\u809d\u708e\u75c5\u6bd2] \u7279\u7570\u6027 CD8 T \u7d30\u80de\u4e2d\uff0cDNA \u4fee\u5fa9\u6a5f\u5236\u7684\u6fc0\u6d3b\u6709\u9650\uff0cDNA \u640d\u50b7\u589e\u52a0\u3002\u201d \u201c\u9019\u5f37\u70c8\u8868\u660e\u6d88\u8017 NAD \u7684\u9176\uff0c\u5c24\u5176\u662f\u904e\u5ea6\u8868\u9054\u7684 CD38\uff0c\u53ef\u80fd\u5728 NAD \u6d88\u8017\u4e2d\u767c\u63ee\u95dc\u9375\u4f5c\u7528\u3002 \u901a\u904e\u88dc\u5145 NMN \u91cd\u5efa\u8a31\u591a\u76f8\u4e92\u95dc\u806f\u7684\u7d30\u80de\u5167\u529f\u80fd\u8868\u660e NAD+ \u8017\u7aed\u53ef\u80fd\u662f T \u7d30\u80de\u8017\u7aed\u7684\u91cd\u8981\u6c7a\u5b9a\u56e0\u7d20\u3002\u201d<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>NMN \u53ef\u80fd\u6703\u5728\u591a\u7a2e\u985e\u578b\u7684\u611f\u67d3\u4e2d\u6539\u9020\u514d\u75ab\u7d30\u80de<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>\u8a72\u7814\u7a76\u63d0\u4f9b\u7684\u8b49\u64da\u8868\u660e\uff0cB\u578b\u809d\u708e\u75c5\u6bd2\u6703\u89f8\u767c\u66f4\u9ad8\u7684 CD38 \u9176\u6fc0\u6d3b\uff0c\u5f9e\u800c\u5c0e\u81f4\u66f4\u4f4e\u7684 NAD+ \u6c34\u5e73\u3002 \u7531\u65bc\u50cf PARPs \u9019\u6a23\u7684 DNA \u4fee\u5fa9\u6a5f\u5236\u9700\u8981 NAD+ \u624d\u80fd\u767c\u63ee\u4f5c\u7528\uff0c\u9019\u53ef\u80fd\u6709\u52a9\u65bc\u89e3\u91cb\u70ba\u4ec0\u9ebc\u7cbe\u75b2\u529b\u7aed\u7684B\u578b\u809d\u708e\u75c5\u6bd2\u7279\u7570\u6027 T \u7d30\u80de\u5177\u6709\u66f4\u591a\u7684 DNA \u640d\u50b7\u3002 \u9019\u4e5f\u6709\u52a9\u65bc\u89e3\u91cb\u70ba\u4ec0\u9ebc DNA \u4fee\u5fa9\u6a5f\u5236\u5728\u8017\u76e1\u7684B\u578b\u809d\u708e\u7279\u7570\u6027 CD8 T \u7d30\u80de\u4e2d\u6548\u679c\u4e0d\u4f73\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>\u7528 NAD+ \u524d\u9ad4 NMN \u4f86\u4ecb\u5165 CD8 T \u514d\u75ab\u7d30\u80de\u53ef\u4ee5\u6062\u5fa9\u6297\u75c5\u6bd2\u7d30\u80de\u56e0\u5b50\u7684\u7522\u751f\uff0c\u9019\u8868\u660e NAD+ \u7684\u88dc\u5145\u53ef\u4ee5\u91cd\u5efa\u5b83\u5011\u7684\u529f\u80fd\u3002 NMN \u6539\u9020\u514d\u75ab\u7d30\u80de\u529f\u80fd\u7684\u80fd\u529b\u652f\u6301 NAD+ \u8017\u7aed\u5c0e\u81f4 CD8 T \u7d30\u80de\u8017\u7aed\u548c\u529f\u80fd\u969c\u7919\u3002 \u672a\u4f86\u61c9\u8a72\u7e7c\u7e8c\u63a2\u7d22 NMN \u662f\u5426\u5c0d\u5176\u4ed6\u985e\u578b\u611f\u67d3\u4e2d\u8017\u76e1\u7684 CD8 T \u7d30\u80de\u7522\u751f\u6709\u76ca\u4f5c\u7528\u3002 \u5982\u679c NMN \u53ef\u4ee5\u5728\u5176\u4ed6\u611f\u67d3\u4e2d\u6062\u5fa9\u8017\u76e1\u7684 T \u7d30\u80de\uff0c\u90a3\u9ebc NAD+ \u53ef\u80fd\u4e5f\u6703\u4f7f\u514d\u75ab\u7d30\u80de\u66f4\u5bb9\u6613\u62b5\u6297\u5176\u4ed6\u985e\u578b\u7684\u611f\u67d3\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-separator\">\n<div class=\"s-separator-content\">\n<div class=\"separator\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>\u53c3\u8003\u6587\u737b<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>Montali I, Berti CC, Morselli M, Acerbi G, Barili V, Pedrazzi G, Montanini B, Boni C, Alfieri A, Pesci M, Loglio A, Degasperi E, Borghi M, Perbellini R, Penna A, Laccabue D, Rossi M, Vecchi A, Tiezzi C, Reverberi V, Boarini C, Abbati G, Massari M, Lampertico P, Missale G, Ferrari C, F\u6587\u7ae0icaro P. Deregulated intracellular pathways define novel molecular targets for HBV-specific CD8 T cell reconstitution in chronic hepatitis B. J Hepatol. 2023 Mar 7:S0168-8278(23)00167-8. doi: 10.1016\/j.jhep.2023.02.035. Epub ahead of print. PMID: 36893853.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>\u6587\u7ae0\u4f86\u6e90<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>https:\/\/www.nmn.com\/news\/new-european-study-restoring-nad-with-nmn-rescues-immune-cell-function-in-hepatitis-b-patients<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"pvc_clear\"><\/div>\n<p id=\"pvc_stats_19924\" class=\"pvc_stats all  \" data-element-id=\"19924\" style=\"\"><i class=\"pvc-stats-icon medium\" aria-hidden=\"true\"><svg aria-hidden=\"true\" focusable=\"false\" data-prefix=\"far\" data-icon=\"chart-bar\" role=\"img\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\" class=\"svg-inline--fa fa-chart-bar fa-w-16 fa-2x\"><path fill=\"currentColor\" d=\"M396.8 352h22.4c6.4 0 12.8-6.4 12.8-12.8V108.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v230.4c0 6.4 6.4 12.8 12.8 12.8zm-192 0h22.4c6.4 0 12.8-6.4 12.8-12.8V140.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v198.4c0 6.4 6.4 12.8 12.8 12.8zm96 0h22.4c6.4 0 12.8-6.4 12.8-12.8V204.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v134.4c0 6.4 6.4 12.8 12.8 12.8zM496 400H48V80c0-8.84-7.16-16-16-16H16C7.16 64 0 71.16 0 80v336c0 17.67 14.33 32 32 32h464c8.84 0 16-7.16 16-16v-16c0-8.84-7.16-16-16-16zm-387.2-48h22.4c6.4 0 12.8-6.4 12.8-12.8v-70.4c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v70.4c0 6.4 6.4 12.8 12.8 12.8z\" class=\"\"><\/path><\/svg><\/i> <img loading=\"lazy\" decoding=\"async\" width=\"16\" height=\"16\" alt=\"Loading\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/plugins\/page-views-count\/ajax-loader-2x.gif\" border=0 \/><\/p>\n<div class=\"pvc_clear\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u6b50\u6d32\u65b0\u7814\u7a76\uff1a\u7528 NMN \u6062\u5fa9 NAD+ \u53ef\u633d\u6551\u514d\u75ab\u7d30\u80de\u6297B\u578b\u809d\u708e\u7684\u529f\u80fd By Brett J. Weiss Published: 10:01 am PST Mar 28, 2023 | Updated: 6:31 p.m. PST Mar 28, 2023 \u91cd\u5927\u4eae\u9ede \u7159\u9170\u80fa\u817a\u560c\u5464\u4e8c\u6838\u82f7\u9178 (NAD+) \u7684\u524d\u9ad4 NMN \u53ef\u63d0\u9ad8B\u578b\u809d\u708e\u75c5\u6bd2\u7279\u7570\u6027\u514d\u75ab\u7d30\u80de\uff08CD8 T \u7d30\u80de\uff09\u7684\u6297\u75c5\u6bd2\u6d3b\u6027\u3002 \u529f\u80fd\u53d7\u640d\u7684\u8870\u7aedB\u578b\u809d\u708e\u7279\u7570\u6027 CD8 T \u7d30\u80de\u8868\u73fe\u51fa\u9ad8\u6c34\u5e73\u7684 DNA \u640d\u50b7\u548c DNA \u4fee\u5fa9\u6a5f\u5236\u7684\u7f3a\u9677 \u3002 \u5728\u8017\u76e1\u72c0\u614b\u4e0b\uff0cCD8 T \u514d\u75ab\u7d30\u80de\u986f\u793a\u51fa\u66f4\u9ad8\u7684\u6d88\u8017 NAD+ \u7684 CD38 \u9176\u6c34\u5e73\u548c\u66f4\u4f4e\u7684\u6297\u75c5\u6bd2\u86cb\u767d\u7522\u91cf\u3002 &nbsp;<\/p>\n<div class=\"pvc_clear\"><\/div>\n<p id=\"pvc_stats_19924\" class=\"pvc_stats all  \" data-element-id=\"19924\" style=\"\"><i class=\"pvc-stats-icon medium\" aria-hidden=\"true\"><svg aria-hidden=\"true\" focusable=\"false\" data-prefix=\"far\" data-icon=\"chart-bar\" role=\"img\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\" class=\"svg-inline--fa fa-chart-bar fa-w-16 fa-2x\"><path fill=\"currentColor\" d=\"M396.8 352h22.4c6.4 0 12.8-6.4 12.8-12.8V108.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v230.4c0 6.4 6.4 12.8 12.8 12.8zm-192 0h22.4c6.4 0 12.8-6.4 12.8-12.8V140.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v198.4c0 6.4 6.4 12.8 12.8 12.8zm96 0h22.4c6.4 0 12.8-6.4 12.8-12.8V204.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v134.4c0 6.4 6.4 12.8 12.8 12.8zM496 400H48V80c0-8.84-7.16-16-16-16H16C7.16 64 0 71.16 0 80v336c0 17.67 14.33 32 32 32h464c8.84 0 16-7.16 16-16v-16c0-8.84-7.16-16-16-16zm-387.2-48h22.4c6.4 0 12.8-6.4 12.8-12.8v-70.4c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v70.4c0 6.4 6.4 12.8 12.8 12.8z\" class=\"\"><\/path><\/svg><\/i> <img loading=\"lazy\" decoding=\"async\" width=\"16\" height=\"16\" alt=\"Loading\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/plugins\/page-views-count\/ajax-loader-2x.gif\" border=0 \/><\/p>\n<div class=\"pvc_clear\"><\/div>\n","protected":false},"author":1,"featured_media":19925,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[172,272],"tags":[737,171,304],"class_list":["post-19924","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-nmn-","category-272","tag-b","tag-nmn","tag-304"],"aioseo_notices":[],"_links":{"self":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts\/19924","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=19924"}],"version-history":[{"count":2,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts\/19924\/revisions"}],"predecessor-version":[{"id":19929,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts\/19924\/revisions\/19929"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/media\/19925"}],"wp:attachment":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=19924"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=19924"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=19924"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}