{"id":19846,"date":"2023-03-14T03:57:43","date_gmt":"2023-03-14T03:57:43","guid":{"rendered":"http:\/\/johnhealth.blog\/ch\/?p=19846"},"modified":"2023-03-14T03:57:43","modified_gmt":"2023-03-14T03:57:43","slug":"%e4%b8%b4%e5%ba%8a%e8%af%95%e9%aa%8c%e6%98%be%e7%a4%banmn%e5%af%b9%e4%ba%ba%e4%bd%93%e7%9a%84%e5%ae%89%e5%85%a8%e6%80%a7","status":"publish","type":"post","link":"http:\/\/johnhealth.blog\/ch\/?p=19846","title":{"rendered":"\u4e34\u5e8a\u8bd5\u9a8c\u663e\u793aNMN\u5bf9\u4eba\u4f53\u7684\u5b89\u5168\u6027"},"content":{"rendered":"

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By\u00a0Brett J. Weiss Published:\u00a09:07 am PST Mar 7, 2020\u00a0| Updated:\u00a010:32 am PST Oct 1, 2020<\/p>\n

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  1. Junichiro Irie, Emi Inagaki, Masataka Fujita, Hideaki Nakaya, Masanori Mitsuishi, Shintaro Yamaguchi, Kazuya Yamashita, Shuhei Shigaki, Takashi Ono, Hideo Yukioka, Hideyuki Okano, Yo-ichi Nabeshima, Shin-irchiro Imai, Masato Yasui, Kazuo Tsubota, Hiroshi Itoh. Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men. Endocr J , 2019; DOI: 10.1507\/endocrj. EJ19-0313<\/a>.<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n
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    1. Alessia Grozio, Kathryn F. Fills, Jun Yoshino, Santina Bruzzone, Giovanna Sociali, Kyohei Tokizane, Hanyue Cecilia Lei, Richard Cunningham, You Sasaki, Marie E. Migaud, Shin-ichiro Imai . Slc12a8 is a nicotinamide mononucleotide transporter. Nat Metab, 2019; DOI: 10.1038\/s42255-018-0009-4<\/a>.<\/li>\n
    2. Kazuhiro Hasegawa, Shu Wakino, Petra Simic, Yusuke Sakamaki, Hitoshi Minakuchi, Keiko Fujimura, Kozi Hosoya, Motoaki Komatsu, Yuka Kaneko, Takeshi Kanda, Eiji Kubota, Hirobumi Tokuyama , Koichi Hayashi, Leonard Guarente, Hiroshi Itoh. Renal tubular Sirt1 attenuates diabetic albuminuria by epigenetically suppressing Claudin-1 overexpression in podocytes. Nat Med, 2013; DOI: 10.1038\/nm.3363<\/a>.<\/li>\n
    3. Jonathan B. Lin, Shunsuke Kubota, Norimitsu Ban, Mitsukuni Yoshida, Andrea Santeford, Abdoulaye Sene, Rei Nakamura, Nicole Zapata, Miyuki Kubota, Kazuo Tsubota, Jun Yoshino, Shin-ichiro Imai, Rajendra S. Apte. \u00a0NAMPT-Mediated NAD+\u00a0Biosynthesis Is Essential for Vision in Mice. \u00a0Cell Rep, 2016; DOI:\u00a010.1016\/j.celrep.2016.08.073<\/a>.<\/li>\n
    4. Kathryn F. Mills, Shohei Yoshida, Liana R. Stein, Alessia Grozio, Shunsuke Kubota, Yo Sasaki, Philip Redpath, Marie E. Migaud, Rajendra S. Apte, Koji Uchida, Jun Yoshino. \u00a0Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice. \u00a0Cell Metab, 2016; DOI:\u00a010.1016\/j.cmet.2016.09.013<\/a>.<\/li>\n
    5. Jun Yoshino, Kathryn F. Mills, Myeong Jin Yoon, Shin-ichiro Imai. \u00a0Nicotinamide Mononucleotide, a Key NAD+\u00a0Intermediate, Treats the Pathophysiology of Diet- and Age- Induced Diabetes in Mice. \u00a0Cell Metab, 2011; DOI:\u00a010.1016\/j.cmet.2011.08.014<\/a>.<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n
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      https:\/\/www.nmn.com\/news\/results-of-first-human-study-of-nmn-administration-reveal-no-safety-concerns<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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      \u65e5\u672c\u5e86\u5e94\u4e49\u587e\u5927\u5b66\u533b\u5b66\u9662\u7684\u79d1\u5b66\u5bb6\u53d1\u8868\u4e86\u7b2c\u4e00\u9879\u8bc4\u4f30\u70df\u9170\u80fa\u5355\u6838\u82f7\u9178\uff08NMN\uff09\u5bf9\u4eba\u4f53\u7ed9\u836f\u5b89\u5168\u6027\u7684\u7814\u7a76\uff0c\u663e\u793a\u6ca1\u6709\u4e0d\u5229\u7684\u5065\u5eb7\u95ee\u9898\u3002 By\u00a0Brett J. Weiss Published:\u00a09:07 am PST Mar 7, 2020\u00a0| Updated:\u00a010:32 am PST Oct 1, 2020 \u5168\u7403\u7684\u4eba\u7c7b\u5e73\u5747\u5bff\u547d\u5df2\u7ecf\u589e\u52a0\u8bb8\u591a\uff0c\u5bfc\u81f4\u4e0e\u5e74\u9f84\u6709\u5173\u7684\u75be\u75c5\uff08\u4f8b\u5982\u764c\u75c7\u3001\u5fc3\u8840\u7ba1\u75be\u75c5\u30012\u578b\u7cd6\u5c3f\u75c5\u3001\u9ad8\u8840\u538b\uff08\u9ad8\u8840\u538b\uff09\u548c\u9ec4\u6591\u90e8\u75c5\u53d8\uff09\u7684\u4eba\u6570\u5927\u91cf\u589e\u52a0\u3002 \u5728\u52a8\u7269\u6a21\u578b\u4e2d\uff0c\u70df\u9170\u80fa\u5355\u6838\u82f7\u9178\uff08NMN\uff09\u7684\u4ecb\u5165\u5df2\u663e\u793a\u53ef\u51cf\u8f7b\u4e0e\u8870\u8001\u76f8\u5173\u7684\u529f\u80fd\u969c\u788d\u3002 \u4f46\u662f\uff0c\u5c1a\u672a\u5e7f\u6cdb\u7814\u7a76NMN\u5728\u4eba\u7c7b\u4e2d\u7684\u6709\u6548\u6027\uff0c\u66f4\u4e0d\u7528\u8bf4\u5b89\u5168\u6027\u4e86\u3002 \u56e0\u6b64\uff0c\u65e5\u672c\u5e86\u5e94\u4e49\u587e\u5927\u5b66\u533b\u5b66\u9662\u7684\u7814\u7a76\u4eba\u5458\u8fdb\u884c\u4e86\u4e00\u9879\u4e34\u5e8a\u7814\u7a76\uff0c\u4ee5\u6d4b\u91cfNMN\u5bf9\u4eba\u4f53\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002 Irie\u548c\u540c\u4e8b\u53d1\u73b0\uff0c\u5728\u5065\u5eb7\u7537\u6027\u4e2d\u5355\u6b21\u53e3\u670dNMN\u662f\u5b89\u5168\u6709\u6548\u7684\uff0c\u4e0d\u4f1a\u5f15\u8d77\u4efb\u4f55\u660e\u663e\u7684\u6709\u5bb3\u5f71\u54cd\u3002 \u201c\u5728\u8fd9\u9879\u7814\u7a76\u4e2d\uff0c\u6211\u4eec\u62a5\u544a\u4e86\u5065\u5eb7\u7537\u6027\u4e2d\u5355\u6b21\u53e3\u670dNMN\u7684\u5b89\u5168\u6027\u548cNMN\u4ee3\u8c22\u4ea7\u7269\u7684\u52a8\u529b\u5b66\uff0c\u201d Irie\u53ca\u5176\u540c\u4e8b\u8bf4\u3002<\/p>\n

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