{"id":19587,"date":"2023-01-23T15:40:45","date_gmt":"2023-01-23T15:40:45","guid":{"rendered":"http:\/\/johnhealth.blog\/ch\/?p=19587"},"modified":"2023-01-23T15:41:00","modified_gmt":"2023-01-23T15:41:00","slug":"nmn%e8%a7%a3%e9%94%81%e8%a7%a3%e9%85%92%e6%8a%a4%e8%82%9d%e6%96%b0%e5%8a%9f%e8%83%bd%ef%bc%8c%e6%88%96%e6%9c%89%e5%8a%a9%e4%ba%8e%e6%94%b9%e5%96%84%e9%85%92%e7%b2%be%e6%80%a7","status":"publish","type":"post","link":"http:\/\/johnhealth.blog\/ch\/?p=19587","title":{"rendered":"NMN\u89e3\u9501\u201c\u89e3\u9152\u62a4\u809d\u201d\u65b0\u529f\u80fd\uff0c\u6216\u6709\u52a9\u4e8e\u6539\u5584\u9152\u7cbe\u6027\u809d\u75c5"},"content":{"rendered":"<section>\n<section>\u529d\u4eba\u6212\u9152\u6709\u591a\u96be\u7b14\u8005\u8fd9\u91cc\u5c31\u4e0d\u7ec6\u8bf4\u4e86\uff0c\u4f46\u9000\u800c\u6c42\u5176\u6b21\uff0c\u54b1\u4eec\u8fd8\u80fd\u5229\u7528\u4e00\u4e9b\u73b0\u4ee3\u79d1\u5b66\u7684\u4ea7\u7269\u7f13\u89e3\u751a\u81f3\u9006\u8f6c\u9152\u7cbe\u5e26\u6765\u7684\u5371\u5bb3\u3002\u4e00\u9879\u7814\u7a76\u89e3\u9501\u4e86NMN\uff08\u03b2-\u70df\u9170\u80fa\u5355\u6838\u82f7\u9178\uff09\u201c\u89e3\u9152\u62a4\u809d\u201c\u7684\u65b0\u529f\u80fd[1]\uff0c\u7b97\u662f\u7ed9\u9876\u7740\u8102\u80aa\u809d\u3001\u764c\u75c7\u3001\u8111\u8870\u8001\u3001\u9ad8\u8840\u538b\u3001\u4e2d\u98ce\u3001\u7cd6\u5c3f\u75c5\u3001\u60c5\u7eea\u969c\u788d\u7b49\u526f\u4f5c\u7528\u7684\u9152\u9b3c\u4eec\u5e26\u6765\u4e86\u4e00\u70b9\u597d\u6d88\u606f\u5427\u2026\u2026<\/section>\n<\/section>\n<section>\n<section><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-19588\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/01\/62549d9b-929e-4f49-8fd3-fb7b6fe51990.jpg\" alt=\"\" width=\"936\" height=\"374\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/01\/62549d9b-929e-4f49-8fd3-fb7b6fe51990.jpg 936w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/01\/62549d9b-929e-4f49-8fd3-fb7b6fe51990-300x120.jpg 300w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/01\/62549d9b-929e-4f49-8fd3-fb7b6fe51990-768x307.jpg 768w\" sizes=\"auto, (max-width: 936px) 100vw, 936px\" \/><\/section>\n<section>\n<section>\n<section>\n<section>\n<section>\n<h3><span style=\"color: #ff0000;\"><strong>01 <\/strong><strong style=\"font-size: 1rem;\">\u4e9a\u6d32\u4eba\u559d\u9152\u66f4\u4f24\u8eab<\/strong><\/span><\/h3>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p><!--more--><\/p>\n<section>\n<section>\u9152\u7cbe\u672c\u8eab\u4e0d\u53ef\u6015\uff0c\u5b83\u5728\u4ee3\u8c22\u8fc7\u7a0b\u4e2d\u4ea7\u751f\u7684<strong>\u4e59\u919b<\/strong>\u624d\u662f\u771f\u6b63\u7684\u7f6a\u9b41\u7978\u9996\u3002\u9152\u7cbe\u7684\u5206\u89e3\u4ee3\u8c22\u4e3b\u8981\u6709\u4e09\u6b65\uff1a&#x1f447;&#x1f447;<\/section>\n<\/section>\n<section>\n<section>\n<section><\/section>\n<section>\n<ul>\n<li>1.\u9152\u7cbe\uff08\u4e59\u9187\uff09\u5728\u4e59\u9187\u8131\u6c22\u9176\uff08ADH\uff09\u4e0eNAD+\u4f5c\u7528\u4e0b\u8f6c\u5316\u4e3a<strong>\u4e59\u919b<\/strong>\uff1b<\/li>\n<li><span style=\"color: #82868b; font-size: 1rem;\">2.\u4e59\u919b\u5728\u4e59\u919b\u8131\u6c22\u91762\uff08ALDH2\uff09\u4e0eNAD+\u4f5c\u7528\u4e0b\u8f6c\u5316\u4e3a<\/span><strong style=\"color: #82868b; font-size: 1rem;\">\u4e59\u9178<\/strong><span style=\"color: #82868b; font-size: 1rem;\">\uff1b<\/span><\/li>\n<li><span style=\"color: #82868b; font-size: 1rem;\">3.\u4e59\u9178\u8fdb\u5165\u4e09\u7fa7\u9178\u5faa\u73af\uff0c\u8f6c\u5316\u4e3a<\/span><strong style=\"color: #82868b; font-size: 1rem;\">\u4e8c\u6c27\u5316\u78b3\u548c\u6c34<\/strong><span style=\"color: #82868b; font-size: 1rem;\">\u3002<\/span><\/li>\n<\/ul>\n<\/section>\n<\/section>\n<\/section>\n<section>\n<section><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-19589\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/01\/563a9c82-fcbd-4984-bdca-b6d0836b7210.jpg\" alt=\"\" width=\"604\" height=\"540\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/01\/563a9c82-fcbd-4984-bdca-b6d0836b7210.jpg 604w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/01\/563a9c82-fcbd-4984-bdca-b6d0836b7210-300x268.jpg 300w\" sizes=\"auto, (max-width: 604px) 100vw, 604px\" \/><\/section>\n<section><\/section>\n<section>\u4e59\u9187\u80fd\u8ba9\u6211\u4eec\u4ea7\u751f\u9189\u610f\uff0c\u4f46\u6ca1\u4ec0\u4e48\u6bd2\u6027\uff0c\u4e59\u9178\u8bf4\u767d\u4e86\u5c31\u662f\u918b\uff0c\u4e8c\u6c27\u5316\u78b3\u548c\u6c34\u66f4\u4e0d\u7528\u8bf4\u3002\u4f46\u4e59\u919b\uff0c\u5373\u4f7f\u662f\u6ca1\u5b66\u8fc7\u5316\u5b66\u7684\u4eba\uff0c\u4e00\u542c\u8fd9\u4e2a\u201c\u919b\u201d\u5b57\u4e5f\u8981\u5fc3\u91cc\u6253\u9f13\u3002\u79d1\u5b66\u7814\u7a76\u544a\u8bc9\u6211\u4eec\uff0c<strong><span style=\"color: #ff0000;\">\u4e59\u919b\u4e0d\u4ec5\u80fd\u5f15\u8d77DNA\u635f\u4f24\u7a81\u53d8\uff0c\u662f\u660e\u786e\u7684\u81f4\u764c\u7269[2]<\/span><\/strong>\uff0c\u8fd8\u4e0e<strong><span style=\"color: #ff0000;\">\u8111\u8870\u8001\u3001\u514d\u75ab\u8870\u8001\u3001\u9aa8\u6298\u3001\u53f6\u9178\u4ee3\u8c22\u53d8\u5316<\/span><\/strong>\uff08\u5f71\u54cd\u4e0b\u4e00\u4ee3\uff09\u8131\u4e0d\u5f00\u5e72\u7cfb[3]\u3002<\/section>\n<section><\/section>\n<\/section>\n<section>\n<section>\u5f53\u7136\uff0c<strong>\u9152\u7cbe\u4e3b\u8981\u7684\u4ee3\u8c22\u573a\u6240\u662f\u809d\u810f<\/strong>\uff0c\u6240\u4ee5\u559d\u9152\u65f6\u809d\u810f\u9996\u5f53\u5176\u51b2\uff0c\u53d7\u5230\u7684\u5371\u5bb3\u6700\u5927\u3002\u957f\u671f\u996e\u9152\u5bf9\u809d\u810f\u9020\u6210\u7684\u635f\u5bb3\u521d\u671f\u8868\u73b0\u4e3a\u8102\u80aa\u809d\uff0c\u8fdb\u800c\u53ef\u53d1\u5c55\u6210<span style=\"color: #ff0000;\"><strong>\u9152\u7cbe\u6027\u809d\u708e\u3001\u809d\u7ea4\u7ef4\u5316\u3001\u809d\u786c\u5316\u548c\u809d\u764c<\/strong><\/span>\uff1b\u4e25\u91cd\u9157\u9152\u8fd8\u53ef\u80fd\u5bfc\u81f4<strong>\u809d\u8870\u7aed<\/strong>\u3002<img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-19590\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/01\/3a3abf4c-4417-4eab-8ac8-8ab86d1e2f1d.jpg\" alt=\"\" width=\"584\" height=\"535\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/01\/3a3abf4c-4417-4eab-8ac8-8ab86d1e2f1d.jpg 584w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/01\/3a3abf4c-4417-4eab-8ac8-8ab86d1e2f1d-300x275.jpg 300w\" sizes=\"auto, (max-width: 584px) 100vw, 584px\" \/><\/p>\n<\/section>\n<\/section>\n<section>\n<section>ALDH2\u57fa\u56e0\u6b63\u5e38\u7684\u4eba\u80fd\u591f\u53ca\u65f6\u5c06\u4e59\u919b\u5206\u89e3\uff1b\u800c\u5f53ALDH2\u5b58\u5728\u7f3a\u9677\u65f6\uff0c<strong>\u4e59\u919b\u53ea\u80fd\u5728\u809d\u810f\u4e2d\u84c4\u79ef\uff0c\u88ab\u809d\u810f\u4e2d\u7684\u6c27\u5316\u9176P450\u6162\u6162\u6c27\u5316\u4ee3\u8c22<\/strong>\uff0c\u5f15\u8d77\u9762\u90e8\u6f6e\u7ea2\u3001\u5fc3\u8df3\u52a0\u901f\u3001\u5934\u6655\u76ee\u7729\u3001\u6076\u5fc3\u5455\u5410\u7b49\u4e0d\u9002\u3001\u66f4\u5bb9\u6613\u5bf9\u5185\u810f\u5668\u5b98\u9020\u6210\u4f24\u5bb3\uff0c\u9057\u61be\u7684\u662f\uff0c<span style=\"color: #ff0000;\"><strong>\u7ea630%-50%\u7684\u56fd\u4eba\u5c5e\u4e8eALDH2\u57fa\u56e0\u5f02\u5e38\u4eba\u7fa4<\/strong><\/span>\uff0c\u8fd9\u610f\u5473\u7740\u559d\u9152\u5bf9\u6211\u4eec\u800c\u8a00\u66f4\u52a0\u81f4\u547d[4]\u3002<\/section>\n<\/section>\n<section>\n<section>\u5c11\u559d\u4e00\u70b9\u884c\u4e0d\u884c\u5462\uff1f&#x1f633;<\/p>\n<p>18\u5e74\u67f3\u53f6\u5200\u53d1\u8868\u7684\u91cd\u78c5\u7814\u7a76\u544a\u8bc9\u6211\u4eec\uff1a\u9157\u9152\u4e0d\u53ef\u53d6\uff0c\u5c0f\u914c\u4e5f\u4f24\u8eab\u3002\u201c\u9002\u91cf\u996e\u9152\u6709\u76ca\u201c\u7684\u8bf4\u6cd5\u6839\u672c\u4e0d\u5b58\u5728\uff01<strong>\u4e3a\u4e86\u5065\u5eb7\u7740\u60f3\uff0c\u6700\u597d\u4e00\u6ef4\u90fd\u522b\u559d[5]\u3002<\/strong><\/p>\n<\/section>\n<\/section>\n<section>\n<section>\n<section>\n<section>\n<h3><span style=\"color: #ff0000;\"><strong>02 <\/strong><strong style=\"font-size: 1rem;\">NMN\u89e3\u9152\u62a4\u809d\u539f\u7406\u89e3\u6790<\/strong><\/span><\/h3>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section>\n<section>\u6709\u4e9b\u65f6\u5019\uff0c\u4e0d\u662f\u6211\u4eec\u60f3\u9157\u9152\uff0c\u800c\u662f\u559d\u9152\u4e0d\u53ef\u907f\uff0c\u6b64\u65f6\u5e94\u8be5\u600e\u4e48\u529e\u5462\uff1f\u7814\u7a76\u4eba\u5458\u8ba4\u4e3a\uff0c\u5173\u952e\u5728\u4e8e\u63d0\u9ad8NAD+\u542b\u91cf\u3002<\/section>\n<\/section>\n<section>\n<section><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-19591\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/01\/8ae86632-8576-42b2-b610-7aafe53b57b0.jpg\" alt=\"\" width=\"568\" height=\"145\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/01\/8ae86632-8576-42b2-b610-7aafe53b57b0.jpg 568w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/01\/8ae86632-8576-42b2-b610-7aafe53b57b0-300x77.jpg 300w\" sizes=\"auto, (max-width: 568px) 100vw, 568px\" \/><\/section>\n<section>\u6839\u636e\u9152\u7cbe\u4ee3\u8c22\u7684\u76f8\u5173\u5316\u5b66\u53cd\u5e94\uff0c\u4e59\u9187\u4e0e\u4e59\u919b\u7684\u4ee3\u8c22\u5747\u6d89\u53ca\u4e00\u79cd\u4eba\u4f53\u5185\u5173\u952e\u8f85\u9176\uff0c<strong>NAD+<\/strong>\u7684\u53c2\u4e0e\u3002\u5728\u5148\u524d\u7684\u4e0d\u5c11\u7814\u7a76\u4e2d\uff0c\u670d\u7528NMN\u80fd\u591f\u5feb\u901f\u63d0\u9ad8\u809d\u810f\u4e2dNAD+\u542b\u91cf\uff0c\u52a0\u901f\u9152\u7cbe\u7684\u5206\u89e3\u4ee3\u8c22\uff0c\u4ece\u800c\u53d1\u6325\u5feb\u901f\u89e3\u9152\u7684\u4f5c\u7528\u3002<\/section>\n<section><\/section>\n<\/section>\n<section>\u4e0d\u8fc7NMN\u80fd\u505a\u7684\u4e0d\u53ea\u662f\u89e3\u9152\uff0c\u5b83\u5bf9\u809d\u810f\u7684\u4fdd\u62a4\u4f5c\u7528\u662f\u8fd9\u9879\u7814\u7a76\u7684\u91cd\u70b9\u3002\u56e0\u6b64\uff0c\u7814\u7a76\u91c7\u7528\u4e86Lieber-DeCarli\u6162\u6027\u4e59\u9187\u6a21\u578b\uff0c\u8fd9\u4e9b\u6210\u5929\u9157\u9152\u7684\u5c0f\u9f20\u4e0d\u8d1f\u4f17\u671b\u5730\u5728\u516d\u5468\u5185\u60a3\u4e0a\u4e86\u9152\u7cbe\u6027\u809d\u75c5\u3002\u5f53\u7ed9\u8fd9\u4e9b\u5c0f\u9f20\u9694\u5929\u9972\u5582500mg\/kg\u00a0NMN\u540e\uff0c<span style=\"color: #ff6600;\"><strong>\u542b\u91cf\u6062\u590d\u81f3\u5bf9\u7167\u7ec4\u6c34\u5e73\u7684\u4e0d\u4ec5\u662fNAD+\u4e0e\u4e00\u7cfb\u5217\u524d\u4f53\u7269\u8d28\uff0c\u8fd8\u6709TCA\u5faa\u73af\u4ee3\u8c22\u4ea7\u7269\u5982\u4e19\u916e\u9178\u548c2-\u6c27\u620a\u4e8c\u9178<\/strong><\/span>\u3002\u8fd9\u4e9b\u4ee3\u8c22\u4ea7\u7269\u662fTCA\u5faa\u73af\u8fc7\u7a0b\u4e2d\u7684\u5173\u952e\u4e2d\u95f4\u4f53\uff0c\u5b83\u4eec\u7684\u542b\u91cf\u968f\u9152\u7cbe\u800c\u964d\u4f4e\uff0c\u5bfc\u81f4\u6c27\u5316\u5e94\u6fc0\u548c\u8102\u80aa\u53d8\u6027\uff0c\u4ece\u800c\u5f71\u54cd\u809d\u529f\u80fd\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-19592\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/01\/eced28fb-5670-404e-8d9a-90edd864b7a4.jpg\" alt=\"\" width=\"968\" height=\"910\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/01\/eced28fb-5670-404e-8d9a-90edd864b7a4.jpg 968w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/01\/eced28fb-5670-404e-8d9a-90edd864b7a4-300x282.jpg 300w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/01\/eced28fb-5670-404e-8d9a-90edd864b7a4-768x722.jpg 768w\" sizes=\"auto, (max-width: 968px) 100vw, 968px\" 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srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/01\/4decc1d8-4f8b-4d05-aab1-31f4a45efe5c.jpg 920w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/01\/4decc1d8-4f8b-4d05-aab1-31f4a45efe5c-300x121.jpg 300w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/01\/4decc1d8-4f8b-4d05-aab1-31f4a45efe5c-768x309.jpg 768w\" sizes=\"auto, (max-width: 920px) 100vw, 920px\" 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loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-19594\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/01\/9b1c00c5-c1e6-483b-899a-70b7e2f1e386.jpg\" alt=\"\" width=\"868\" height=\"613\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/01\/9b1c00c5-c1e6-483b-899a-70b7e2f1e386.jpg 868w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/01\/9b1c00c5-c1e6-483b-899a-70b7e2f1e386-300x212.jpg 300w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/01\/9b1c00c5-c1e6-483b-899a-70b7e2f1e386-768x542.jpg 768w\" sizes=\"auto, (max-width: 868px) 100vw, 868px\" 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+\u6c34\u5e73\uff0c\u901a\u8fc7Atf3\u548cErk1 \/ 2\u4fe1\u53f7\u4f20\u5bfc\u963b\u6b62\u4e59\u9187\u8bf1\u5bfc\u7684ALT\u548cAST\u5347\u9ad8\uff0c\u5e76\u6539\u53d825\uff05\u53d7\u4e59\u9187\u4ee3\u8c22\u8c03\u8282\u7684\u57fa\u56e0\u7684\u8868\u8fbe\uff0c\u5bf9\u9152\u7cbe\u6027\u8102\u80aa\u809d\u7684\u6cbb\u7597\u5177\u6709\u91cd\u8981\u610f\u4e49\u3002<\/section>\n<\/section>\n<\/section>\n<section>\n<section>\n<section>\n<section>\n<section>\n<section><strong>\u53c2\u8003\u6587\u732e<\/strong><\/p>\n<\/section>\n<section><\/section>\n<\/section>\n<\/section>\n<section>\n<section>\n<section>\n<section>\n<section>[1] Assiri MA, Ali HR, Marentette JO, Fritz KS. Investigating RNA expression profiles altered by nicotinamide mononucleotide therapy in a chronic model of alcoholic liver disease. Hum Genomics.2019 Dec 10 ;13(1) :65.[2] Garaycoechea JI, Crossan GP, Langevin F. Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells. Nature.2018 01 11 ;553(7687) :171-177.<\/p>\n<p>[3] Joenje H. Metabolism: alcohol, DNA and disease. Nature.2011 Jul 06 ;475(7354) :45-6.<\/p>\n<p>[4] Cederbaum AI. Alcohol metabolism. Clin Liver Dis. 2012;16(4):667\u2013685.<\/p>\n<p>[5] Griswold M, Fullman N, Hawley C, et al. Alcohol use and burden for 195 countries and territories, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. 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