{"id":19582,"date":"2023-01-22T04:06:35","date_gmt":"2023-01-22T04:06:35","guid":{"rendered":"http:\/\/johnhealth.blog\/ch\/?p=19582"},"modified":"2023-01-22T04:06:35","modified_gmt":"2023-01-22T04:06:35","slug":"%e3%80%90%e7%a7%91%e6%8a%80%e6%96%87%e7%8c%ae%e3%80%91nad-%e4%bb%a3%e8%b0%a2%e4%bf%83%e8%bf%9b%e5%af%b9%e6%8a%97%e7%99%8c%e6%b2%bb%e7%96%97%e7%9a%84%e6%95%8f%e6%84%9f%e6%80%a7","status":"publish","type":"post","link":"http:\/\/johnhealth.blog\/ch\/?p=19582","title":{"rendered":"\u3010\u79d1\u6280\u6587\u732e\u3011NAD +\u4ee3\u8c22\u4fc3\u8fdb\u5bf9\u6297\u764c\u6cbb\u7597\u7684\u654f\u611f\u6027"},"content":{"rendered":"

NAD+\u8865\u5145\u5242\u8054\u5408PD-L1\u6297\u4f53\u4e3a\u514d\u75ab\u6cbb\u7597\u8010\u836f\u6027\u80bf\u7624\u63d0\u4f9b\u4e86\u4e00\u79cd\u65b0\u7684\u6cbb\u7597\u7b56\u7565<\/p>\n

NAD +\u4ee3\u8c22\u9a71\u4f7f\u80bf\u7624\u9003\u907f\u514d\u75ab\u53cd\u5e94\uff0c\u4f46\u63d0\u9ad8NAD +\u6c34\u5e73\u53ef\u63d0\u9ad8\u6297\u764c\u6cbb\u7597\u7684\u529f\u6548\u3002<\/span><\/p>\n

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By\u00a0Brett J. Weiss<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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Published:\u00a012:30 p.m. PST Nov 16, 2020\u00a0| Updated:\u00a04:30 p.m. PST Nov 11, 2020<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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NAD +\u662f\u7ec6\u80de\u529f\u80fd\u548c\u5065\u5eb7\u7684\u91cd\u8981\u5206\u5b50\uff0c\u5728\u8425\u517b\u7269\u8d28\u5982\u4f55\u4ea7\u751f\u80fd\u91cf\u4ee5\u53ca\u7ec6\u80de\u5185\u4fe1\u606f\u5982\u4f55\u4f20\u64ad\u7b49\u65b9\u9762\u8d77\u7740\u5173\u952e\u4f5c\u7528\u3002 \u7814\u7a76\u663e\u793a\uff0c\u5728\u4eba\u7c7b\u764c\u75c7\u4e2d\uff0c\u7ec6\u80de\u5185NAD +\u4ea7\u91cf\u589e\u52a0\uff08\u751f\u7269\u5408\u6210\uff09\uff0c\u5728\u764c\u75c7\u7684\u53d1\u751f\u3001\u53d1\u5c55\u548c\u590d\u53d1\u4e2d\u8d77\u5173\u952e\u4f5c\u7528\u3002 \u7136\u800c\uff0cNAD +\u4ee3\u8c22\uff08\u5373\u4ea7\u751f\uff0c\u52a0\u5de5\u548c\u4f7f\u7528NAD +\u7684\u5316\u5b66\u53cd\u5e94\uff09\u5982\u4f55\u901a\u8fc7\u9003\u907f\u673a\u4f53\u7684\u514d\u75ab\u53cd\u5e94\u800c\u5728\u8c03\u8282\u80bf\u7624\u8fdb\u7a0b\u4e2d\u6240\u8d77\u7684\u4f5c\u7528\uff0c\u76ee\u524d\u5c1a\u4e0d\u6e05\u695a\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u6700\u8fd1\uff0c\u6765\u81ea\u4e2d\u56fd\u4e0a\u6d77\u7b2c\u4e8c\u519b\u533b\u5927\u5b66\u7684Wang\u548c\u540c\u4e8b\u5728\u5b66\u672f\u671f\u520a\u300a\u7ec6\u80de\u4ee3\u8c22\u300b\uff08Cell Metabolism\uff09 \u4e2d\u53d1\u8868\u4e86\u4e00\u9879\u7814\u7a76\u6210\u679c\uff0c\u4ed6\u4eec\u4e3a\u7ec6\u80de\u5185NAD +\u5408\u6210\u4fc3\u8fdb\u80bf\u7624\u8fdb\u5c55\u7684\u7ec6\u80de\u673a\u5236\u63d0\u4f9b\u4e86\u8bc1\u636e<\/a>\u3002 \u4ed6\u4eec\u7684\u5b9e\u9a8c\u8868\u660e\uff0c\u8865\u5145NAD +\u7684\u524d\u9a71\u7269NMN\u53ef\u4ee5\u63d0\u9ad8NAD +\u6c34\u5e73\uff0c\u5e76\u63d0\u9ad8\u514d\u75ab\u7597\u6cd5\uff08\u4e00\u79cd\u6709\u52a9\u4e8e\u514d\u75ab\u7cfb\u7edf\u62b5\u6297\u80bf\u7624\u7684\u764c\u75c7\u6cbb\u7597\u65b9\u6cd5\uff09\u5bf9\u6297\u80bf\u7624\u6cbb\u7597\u7684\u6709\u6548\u6027\u3002<\/p>\n

\u5728\u4ed6\u4eec\u7684\u7814\u7a76\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u63d0\u4f9b\u4e86\u6765\u81ea\u5c0f\u9f20\u7684\u5b9e\u9a8c\u8bc1\u636e\uff0c\u8868\u660eNAD +\u751f\u7269\u5408\u6210\u9014\u5f84\u4e2d\u5173\u952e\u9176NAMPT\u7684\u6c34\u5e73\u964d\u4f4e\uff0c\u5bfc\u81f4\u653b\u51fbCD8 + T\u7ec6\u80de\u7684\u767d\u7ec6\u80de\u6d3b\u5316\u589e\u5f3a\u3002 \u8fd9\u4e9bT\u7ec6\u80de\u7684\u6d3b\u5316\u4fc3\u8fdb\u4e86\u5b83\u4eec\u5bf9\u6297\u80bf\u7624\u7684\u529f\u80fd\u3002 NAMPT\u9176\u6c34\u5e73\u7684\u964d\u4f4e\u4f34\u968f\u7740NAD +\u7ec6\u80de\u6c34\u5e73\u7684\u964d\u4f4e\uff0c\u8868\u660eNAD +\u4ee3\u8c22\u63a7\u5236\u7740CD8 + T\u7ec6\u80de\u62b5\u6297\u80bf\u7624\u7684\u529f\u80fd\u3002<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u4ed6\u4eec\u7684\u6570\u636e\u8fd8\u8868\u660e\uff0cNAD +\u4ee3\u8c22\u53ef\u901a\u8fc7\u4fc3\u8fdb\u764c\u7ec6\u80dePD-L1\u4e0a\u7684\u86cb\u767d\u8d28\u6c34\u5e73\u6765\u9a71\u4f7f\u80bf\u7624\u9003\u79bb\u514d\u75ab\u7cfb\u7edf\u3002 \u764c\u7ec6\u80de\u8868\u9762\u4e0a\u7684PD-L1\u901a\u8fc7\u4e0eT\u7ec6\u80de\uff08\u4e00\u79cd\u6dcb\u5df4\u7ec6\u80de\uff0c\u5728\u514d\u75ab\u53cd\u5e94\u4e0a\u626e\u6f14\u91cd\u8981\u89d2\u8272\uff09\u8868\u9762\u4e0a\u79f0\u4e3aPD-1\u7684\u53d7\u4f53\u7ed3\u5408\u800c\u6291\u5236T\u7ec6\u80de\u7684\u529f\u80fd\u3002 \u764c\u7ec6\u80de\u4e0a\u7684PD-L1\u4e0eT\u7ec6\u80de\u4e0a\u7684PD-1\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u5bfc\u81f4T\u7ec6\u80de\u8870\u7aed\uff0c\u8fd9\u4f7fT\u7ec6\u80de\u7ed3\u5408\u8fc7\u591a\u5f02\u7269\u800c\u5931\u53bb\u6740\u6b7b\u764c\u7ec6\u80de\u7684\u80fd\u529b\uff0c\u4ece\u800c\u9003\u907f\u4e86\u5bf9\u764c\u7ec6\u80de\u7684\u514d\u75ab\u53cd\u5e94\u3002 \u7814\u7a76\u5c0f\u7ec4\u968f\u540e\u53d1\u73b0\uff0c\u80bf\u7624\u7ec6\u80de\u4e2d\u66f4\u591a\u7684NAMPT\u4e0e\u764c\u7ec6\u80de\u8868\u9762\u4e0a\u8f83\u9ad8\u6c34\u5e73\u7684PD-L1\u86cb\u767d\u76f8\u5173\uff0c\u5e76\u4e14\u514d\u75ab\u53cd\u5e94\u4e2d\u80bf\u7624\u9003\u9038\u7684\u53ef\u80fd\u6027\u66f4\u9ad8\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\uff08Lv et al.\uff0c 2020 |<\/a>\u00a0Cell Metabolism<\/em><\/a>\uff09<\/a>\u00a0NAD+ \u4ee3\u8c22\u63a7\u5236\u80bf\u7624\u7ec6\u80de\u9003\u907f\u514d\u75ab\u53cd\u5e94\u3002\u00a0<\/strong>\u8f83\u9ad8\u6c34\u5e73\u7684NAMPT\u9176\u4fc3\u8fdbNAD +\u751f\u7269\u5408\u6210\uff0c\u4ece\u800c\u89e6\u53d1\u79f0\u4e3aNAMPT-TET1-p-STAT1-IRF1-PD-L1\u8f74\u7684\u7ec6\u80de\u7ea7\u8054\u53cd\u5e94\uff0c\u4ece\u800c\u4fc3\u8fdb\u764c\u7ec6\u80de\u8868\u9762PD-L1\u86cb\u767d\u7684\u6c34\u5e73\u5347\u9ad8\u3002 \u672c\u8d28\u4e0a\uff0c\u7ec6\u80de\u7ea7\u8054\u53cd\u5e94\u4fc3\u8fdb\u79f0\u4e3aIRF1\u7684\u86cb\u767d\u8d28\u4e0e\u7f16\u7801PD-L1\u7684DNA\u533a\u57df\u7684\u7ed3\u5408\uff0c\u4ece\u800c\u5728\u80bf\u7624\u7ec6\u80de\u8868\u9762\u8bf1\u5bfc\u66f4\u9ad8\u6c34\u5e73\u7684PD-L1\u86cb\u767d\u8d28\u6c34\u5e73\u3002 PD-L1\u4e0eT\u7ec6\u80de\u4e0a\u7684PD-1\u53d7\u4f53\u7ed3\u5408\uff0c\u5bfc\u81f4T\u7ec6\u80de\u8870\u7aed\uff0cT\u7ec6\u80de\u529f\u80fd\u4e27\u5931\uff0c\u968f\u540e\u80bf\u7624\u7ec6\u80de\u9003\u907f\u514d\u75ab\u53cd\u5e94\u3002<\/p>\n

\u6b64\u5916\uff0c\u7814\u7a76\u4eba\u5458\u7684\u7ed3\u679c\u8868\u660e\uff0c\u8865\u5145NMN\u6765\u63d0\u5347\u7ec6\u80de\u4e2dNAD +\u7684\u6c34\u5e73\u53ef\u4ee5\u589e\u5f3a\u57fa\u4e8e\u6291\u5236PD-L1\u529f\u80fd\u4ee5\u589e\u5f3a\u514d\u75ab\u7cfb\u7edf\u4e4b\u7597\u6cd5\u7684\u6548\u679c\u3002 \u8fd9\u662f\u56e0\u4e3a\u8f83\u9ad8\u7684NAMPT\u8868\u8fbe\u6c34\u5e73\u53ef\u4ee5\u9884\u6d4b\u6b64\u7597\u6cd5\u6709\u66f4\u597d\u7684\u7597\u6548\uff0c\u56e0\u4e3a\u662f\u7531\u4e8eNAMPT\u5728\u7ec6\u80de\u4e2dNAD +\u5408\u6210\u4e2d\u7684\u4f5c\u7528\u4fc3\u8fdb\u4e86PD-L1\u5728\u80bf\u7624\u7ec6\u80de\u8868\u9762\u7684\u5448\u9012\uff08\u5728\u514d\u75ab\u53cd\u5e94\u8fc7\u7a0b\u4e2d\uff0c\u5c06\u6297\u539f\u7269\u8d28\u63d0\u5448\u7ed9T\u7ec6\u80de\uff09\u3002 \u5f53\u8be5\u5c0f\u7ec4\u5411\u57f9\u517b\u76bf\u4e2d\u7684\u5c0f\u9f20\u764c\u7ec6\u80de\u8865\u5145NMN\u65f6\uff0c\u4ed6\u4eec\u53d1\u73b0\u8fd9\u79cdNAD +\u8865\u5145\u65b9\u6cd5\u4f7f\u80bf\u7624\u5bf9\u514d\u75ab\u7597\u6cd5\u654f\u611f\u3002 \u79d1\u5b66\u5bb6\u5c06\u8fd9\u79cd\u8865\u5145\u4e86NMN\u7684\u80bf\u7624\u4e0e\u79f0\u4e3aPD-L1\u6297\u4f53\u7684\u514d\u75ab\u7cfb\u7edf\u86cb\u767d\u6210\u5206\u4f5c\u4e3a\u6297\u764c\u7597\u6cd5\u8fdb\u884c\u4e86\u6cbb\u7597\uff0c\u8be5\u7597\u6cd5\u663e\u8457\u6291\u5236\u4e86\u80bf\u7624\u7684\u8fdb\u5c55\u3002<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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(Lv et al., 2020 |<\/a>\u00a0Cell Metabolism<\/em><\/a>)<\/a>\u00a0NMN\u4ecb\u5165\u589e\u5f37\u514d\u75ab\u7642\u6cd5\u5c0d\u6297\u764c\u75c7\u7684\u6548\u679c\u3002<\/strong>NMN\u4ecb\u5165\u986f\u8457\u589e\u5f37\u4e86PD-L1\u6297\u9ad4\uff08\u514d\u75ab\u7cfb\u7d71\u7684\u86cb\u767d\u8cea\u6210\u5206\uff09\u7684\u6297\u764c\u4f5c\u7528\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u9019\u9805\u7814\u7a76\u95e1\u660e\u4e86NAD +\u4ee3\u8b1d\u5728\u8abf\u7bc0\u816b\u7624\u514d\u75ab\u9003\u9038\u4e2d\u7684\u4f5c\u7528\uff0c\u5176\u4e2d\u5347\u9ad8\u7684NAD +\u6c34\u5e73\u4fc3\u9032\u4e86PD-L1\u86cb\u767d\u5728\u816b\u7624\u7d30\u80de\u4e0a\u7684\u5448\u905e\u4ee5\u53ca\u96a8\u5f8c\u7684\u514d\u75ab\u7d30\u80de\u8870\u7aed\u3002 \u800c\u4e14\uff0c\u7d50\u679c\u8868\u660e\uff0c\u900f\u904eNMN\u589e\u52a0NAD +\u6c34\u5e73\u53ef\u4ee5\u589e\u5f37\u816b\u7624\u5c0d\u764c\u75c7\u514d\u75ab\u7642\u6cd5\u7684\u654f\u611f\u6027\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\uff08Lv et al.\uff0c 2020 |<\/a>\u00a0Cell Metabolism<\/em><\/a>\uff09<\/a>\u901a\u8fc7\u8865\u5145 NMN \u589e\u52a0 NAD+ \u6c34\u5e73\u53ef\u63d0\u9ad8\u80bf\u7624\u5bf9\u4e8e\u764c\u75c7\u6cbb\u7597\u7684\u654f\u611f\u6027\u3002\u00a0<\/strong>\u8f83\u4f4e\u6c34\u5e73\u7684NAD +\u5bfc\u81f4\u80bf\u7624\u7ec6\u80de\u4e0a\u5448\u73b0\u8f83\u4f4e\u6c34\u5e73\u7684PD-L1\u86cb\u767d\uff0c\u5e76\u4e14\u5bf9\u514d\u75ab\u7597\u6cd5\u4e0d\u654f\u611f\u3002 \u8865\u5145NAD +\u4f1a\u589e\u52a0\u7ec6\u80de\u4e2dNAD +\u548cPD-L1\u86cb\u767d\u7684\u5b58\u5728\uff0c\u4ece\u800c\u589e\u5f3a\u5bf9\u6297\u514d\u75ab\u7597\u6cd5\u7684\u654f\u611f\u6027\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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Wang\u53ca\u5176\u540c\u4e8b\u5728\u62a5\u544a\u4e2d\u8bf4\uff1a\u201c NAD +\u8865\u5145\u5242\u4e0ePD-L1\u6297\u4f53\u8054\u5408\u63d0\u4f9b\u4e86\u4e00\u79cd\u9488\u5bf9\u80bf\u7624\u4e4b\u514d\u75ab\u6cbb\u7597\u7684\u65b0\u9896\u6cbb\u7597\u7b56\u7565\u3002 \u201d<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u4ed6\u4eec\u4ecd\u7136\u5728\u52a8\u7269\u80bf\u7624\u7ec6\u80de\u4e2d\u8fdb\u884c\u4e86\u8fd9\u9879\u7814\u7a76\uff0c\u800c\u52a8\u7269\u80bf\u7624\u7ec6\u80de\u53ea\u80fd\u90e8\u5206\u6982\u62ec\u4eba\u7c7b\u80bf\u7624\u7684\u75c5\u7406\u751f\u7406\u3002 NAD +\u8865\u5145\u5242\u4e0ePD-L1\u7ed3\u5408\u662f\u5426\u53ef\u4f5c\u4e3a\u6cbb\u7597\u7b56\u7565\uff0c\u9700\u8981\u5728\u4eba\u7c7b\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u8fdb\u884c\u9a8c\u8bc1\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u53c2\u8003\u6587\u732e\uff1a<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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Lv H, Lv G, Chen C, Zong Q, Jiang G, Ye D, Cui X, He Y, Xiang W, Han Q, Tang L, Yang W, Wang H. NAD+ Metabolism Maintains Inducible PD-L1 Expression to Drive Tumor Immune Evasion. Cell Metab. 2020 Nov 9. DOI:\u00a010.1016\/j.cmet.2020.10.021<\/a><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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https:\/\/www.nmn.com\/news\/nad-metabolism-promotes-tumor-development-and-sensitivity-to-anti-cancer-therapy<\/p>\n

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NAD+\u8865\u5145\u5242\u8054\u5408PD-L1\u6297\u4f53\u4e3a\u514d\u75ab\u6cbb\u7597\u8010\u836f\u6027\u80bf\u7624\u63d0\u4f9b\u4e86\u4e00\u79cd\u65b0\u7684\u6cbb\u7597\u7b56\u7565 NAD +\u4ee3\u8c22\u9a71\u4f7f\u80bf\u7624\u9003\u907f\u514d\u75ab\u53cd\u5e94\uff0c\u4f46\u63d0\u9ad8NAD +\u6c34\u5e73\u53ef\u63d0\u9ad8\u6297\u764c\u6cbb\u7597\u7684\u529f\u6548\u3002 By\u00a0Brett J. Weiss Published:\u00a012:30 p.m. PST Nov 16, 2020\u00a0| Updated:\u00a04:30 p.m. PST Nov 11, 2020   NAD +\u662f\u7ec6\u80de\u529f\u80fd\u548c\u5065\u5eb7\u7684\u91cd\u8981\u5206\u5b50\uff0c\u5728\u8425\u517b\u7269\u8d28\u5982\u4f55\u4ea7\u751f\u80fd\u91cf\u4ee5\u53ca\u7ec6\u80de\u5185\u4fe1\u606f\u5982\u4f55\u4f20\u64ad\u7b49\u65b9\u9762\u8d77\u7740\u5173\u952e\u4f5c\u7528\u3002 \u7814\u7a76\u663e\u793a\uff0c\u5728\u4eba\u7c7b\u764c\u75c7\u4e2d\uff0c\u7ec6\u80de\u5185NAD +\u4ea7\u91cf\u589e\u52a0\uff08\u751f\u7269\u5408\u6210\uff09\uff0c\u5728\u764c\u75c7\u7684\u53d1\u751f\u3001\u53d1\u5c55\u548c\u590d\u53d1\u4e2d\u8d77\u5173\u952e\u4f5c\u7528\u3002 \u7136\u800c\uff0cNAD +\u4ee3\u8c22\uff08\u5373\u4ea7\u751f\uff0c\u52a0\u5de5\u548c\u4f7f\u7528NAD +\u7684\u5316\u5b66\u53cd\u5e94\uff09\u5982\u4f55\u901a\u8fc7\u9003\u907f\u673a\u4f53\u7684\u514d\u75ab\u53cd\u5e94\u800c\u5728\u8c03\u8282\u80bf\u7624\u8fdb\u7a0b\u4e2d\u6240\u8d77\u7684\u4f5c\u7528\uff0c\u76ee\u524d\u5c1a\u4e0d\u6e05\u695a\u3002   \u6700\u8fd1\uff0c\u6765\u81ea\u4e2d\u56fd\u4e0a\u6d77\u7b2c\u4e8c\u519b\u533b\u5927\u5b66\u7684Wang\u548c\u540c\u4e8b\u5728\u5b66\u672f\u671f\u520a\u300a\u7ec6\u80de\u4ee3\u8c22\u300b\uff08Cell Metabolism\uff09 \u4e2d\u53d1\u8868\u4e86\u4e00\u9879\u7814\u7a76\u6210\u679c\uff0c\u4ed6\u4eec\u4e3a\u7ec6\u80de\u5185NAD +\u5408\u6210\u4fc3\u8fdb\u80bf\u7624\u8fdb\u5c55\u7684\u7ec6\u80de\u673a\u5236\u63d0\u4f9b\u4e86\u8bc1\u636e\u3002 \u4ed6\u4eec\u7684\u5b9e\u9a8c\u8868\u660e\uff0c\u8865\u5145NAD +\u7684\u524d\u9a71\u7269NMN\u53ef\u4ee5\u63d0\u9ad8NAD +\u6c34\u5e73\uff0c\u5e76\u63d0\u9ad8\u514d\u75ab\u7597\u6cd5\uff08\u4e00\u79cd\u6709\u52a9\u4e8e\u514d\u75ab\u7cfb\u7edf\u62b5\u6297\u80bf\u7624\u7684\u764c\u75c7\u6cbb\u7597\u65b9\u6cd5\uff09\u5bf9\u6297\u80bf\u7624\u6cbb\u7597\u7684\u6709\u6548\u6027\u3002 \u5728\u4ed6\u4eec\u7684\u7814\u7a76\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u63d0\u4f9b\u4e86\u6765\u81ea\u5c0f\u9f20\u7684\u5b9e\u9a8c\u8bc1\u636e\uff0c\u8868\u660eNAD +\u751f\u7269\u5408\u6210\u9014\u5f84\u4e2d\u5173\u952e\u9176NAMPT\u7684\u6c34\u5e73\u964d\u4f4e\uff0c\u5bfc\u81f4\u653b\u51fbCD8 + T\u7ec6\u80de\u7684\u767d\u7ec6\u80de\u6d3b\u5316\u589e\u5f3a\u3002 \u8fd9\u4e9bT\u7ec6\u80de\u7684\u6d3b\u5316\u4fc3\u8fdb\u4e86\u5b83\u4eec\u5bf9\u6297\u80bf\u7624\u7684\u529f\u80fd\u3002 NAMPT\u9176\u6c34\u5e73\u7684\u964d\u4f4e\u4f34\u968f\u7740NAD +\u7ec6\u80de\u6c34\u5e73\u7684\u964d\u4f4e\uff0c\u8868\u660eNAD +\u4ee3\u8c22\u63a7\u5236\u7740CD8 + T\u7ec6\u80de\u62b5\u6297\u80bf\u7624\u7684\u529f\u80fd\u3002<\/p>\n

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