{"id":19579,"date":"2023-01-22T04:01:24","date_gmt":"2023-01-22T04:01:24","guid":{"rendered":"http:\/\/johnhealth.blog\/ch\/?p=19579"},"modified":"2023-01-22T04:07:45","modified_gmt":"2023-01-22T04:07:45","slug":"%e3%80%90%e7%a7%91%e6%8a%80%e6%96%87%e7%8c%ae%e3%80%91nmn-%e6%8f%90%e9%ab%98%e6%8a%97%e7%99%8c%e5%85%8d%e7%96%ab%e7%bb%86%e8%83%9e%e7%9a%84%e5%8a%9f%e6%95%88","status":"publish","type":"post","link":"http:\/\/johnhealth.blog\/ch\/?p=19579","title":{"rendered":"\u3010\u79d1\u6280\u6587\u732e\u3011NMN \u63d0\u9ad8\u6297\u764c\u514d\u75ab\u7ec6\u80de\u7684\u529f\u6548"},"content":{"rendered":"<p>\u70df\u9170\u80fa\u5355\u6838\u82f7\u9178 \uff08NMN\uff09 \u4ecb\u5165\u7684\u6297\u80bf\u7624 CAR-T \u7ec6\u80de\u663e\u793a\u51fa\u589e\u5f3a\u7684\u5bf9\u6297\u764c\u7ec6\u80de\u548c\u51cf\u5c11\u5c0f\u9f20\u80bf\u7624\u751f\u957f\u7684\u6548\u679c\u3002<\/p>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-image\">\n<div class=\"s-component-content\">\n<div class=\"s-img-wrapper\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-19580\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/01\/975342_242291.webp\" alt=\"\" width=\"740\" height=\"459\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/01\/975342_242291.webp 740w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/01\/975342_242291-300x186.webp 300w\" sizes=\"auto, (max-width: 740px) 100vw, 740px\" \/><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p class=\"author\">\u00a0By\u00a0Brett J. Weiss<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>Published:\u00a012:13 p.m. PST May 17, 2022\u00a0| Updated:\u00a01:42 p.m. PST Sep 26, 2022<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p><em><strong>\u91cd\u5927\u4eae\u70b9<\/strong><\/em><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<ul>\n<li>NMN \u7684\u4ecb\u5165\u53ef\u5c06 CAR-T \u7ec6\u80de\uff08\u6297\u80bf\u7624\u514d\u75ab\u7ec6\u80de\uff09\u589e\u6b96\u589e\u52a0 180 \u500d\uff0c\u540c\u65f6\u5ef6\u957f\u7ec6\u80de\u6740\u6b7b\u764c\u7ec6\u80de\u7684\u80fd\u529b\u3002<\/li>\n<li>\u901a\u8fc7 NMN \u4ecb\u5165\uff0c\u6297\u764c CAR-T \u7ec6\u80de\u663e\u793a\u51fa\u5ef6\u7f13\u8870\u8001\u7684\u8ff9\u8c61\uff0c\u8868\u73b0\u4e3a\u7aef\u7c92\u957f\u5ea6\u53d8\u957f\u548c\u6b7b\u4ea1\u6216\u5782\u6b7b\u7684 CAR-T \u7ec6\u80de\u4e30\u5ea6\u51cf\u5c11\u3002<\/li>\n<li>NMN \u4ecb\u5165\u7684 CAR-T \u7ec6\u80de\u6291\u5236\u80bf\u7624\u751f\u957f\uff0c\u5bf9\u764c\u75c7\u5c0f\u9f20\u5177\u6709\u66f4\u6301\u4e45\u7684\u4f5c\u7528\u3002<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>&nbsp;<\/p>\n<p>\u6211\u4eec\u7684\u514d\u75ab\u7cfb\u7edf\u4e0d\u4ec5\u4f1a\u5bfb\u627e\u5e76\u6d88\u706d\u6765\u81ea\u4f53\u5916\u7684\u5f02\u7269\uff0c\u8fd8\u4f1a\u6d88\u9664\u4f53\u5185\u6709\u95ee\u9898\u7684\u7ec6\u80de\uff0c\u4f8b\u5982\u764c\u7ec6\u80de\u548c\u80bf\u7624\u751f\u957f\u3002 \u7136\u800c\uff0c\u968f\u7740\u5e74\u9f84\u7684\u589e\u957f\uff0c\u6211\u4eec\u7684\u514d\u75ab\u7cfb\u7edf\u6548\u7387\u964d\u4f4e\uff0c\u5185\u90e8\u7ec6\u80de\u9519\u8bef\u53d8\u5f97\u66f4\u5bb9\u6613\u53d1\u751f\uff0c\u4ece\u800c\u5bfc\u81f4\u7f79\u60a3\u764c\u75c7\u7684\u53ef\u80fd\u6027\u589e\u52a0\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<p><!--more--><\/p>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>&nbsp;<\/p>\n<p>\u4e3a\u4e86\u523a\u6fc0\u514d\u75ab\u7cfb\u7edf\uff0cCAR-T \u7ec6\u80de\u7597\u6cd5\u5df2\u88ab\u7528\u4e8e\u6cbb\u7597\u5176\u4ed6\u7597\u6cd5\u65e0\u6cd5\u6709\u6548\u6cbb\u7597\u7684\u6076\u6027\u80bf\u7624\uff0c\u5c24\u5176\u662f\u8840\u764c\u3002 \u540c\u65f6\uff0c\u8fd9\u79cd\u6cbb\u7597\u9009\u62e9\u53d7\u5230T\u7ec6\u80de\u5b58\u6d3b\u7387\u4f4e\u548c\u7f3a\u4e4f\u6297\u764c\u7ec6\u80de\u6301\u4e45\u7597\u6548\u7684\u9650\u5236\u3002 \u6cbf\u7740\u8fd9\u4e9b\u601d\u8def\uff0c\u7814\u7a76\u4eba\u5458\u4e00\u76f4\u5728\u5bfb\u627e\u65b0\u7684\u65b9\u6cd5\u6765\u63d0\u9ad8 CAR-T \u7ec6\u80de\u7684\u5bff\u547d\u548c\u6301\u4e45\u7684\u6297\u764c\u80fd\u529b\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>&nbsp;<\/p>\n<p>\u5728\u4e00\u4efd\u672a\u7ecf\u540c\u884c\u8bc4\u5ba1\u7684\u9884\u5370\u672c\u8bba\u6587\u4e2d\uff0cZhong\u53ca\u5176\u6765\u81ea\u4e2d\u56fd\u5317\u4eac\u9996\u90fd\u533b\u79d1\u5927\u5b66\u7684\u540c\u4e8b\u8bc1\u660e\uff0c<a href=\"https:\/\/www.researchsquare.com\/article\/rs-1483519\/v1\" target=\"_blank\" rel=\"noopener\" data-type=\"web\">\u7528 100 \u03bcM NMN \u4ecb\u5165 CAR-T \u7ec6\u80de\u53ef\u663e\u8457\u63d0\u9ad8\u5176\u653b\u51fb\u764c\u7ec6\u80de\u7684\u529f\u6548\u548c\u6301\u4e45\u6027<\/a>\u00a0\u3002 \u6b64\u5916\uff0cNMN\u4ecb\u5165\u589e\u5f3a\u4e86\u7ec6\u80de\u8870\u8001\u5ef6\u8fdf\u7684\u8ff9\u8c61\uff0c\u5982\u5ef6\u957f\u7aef\u7c92\u957f\u5ea6\uff0c\u5e76\u51cf\u5c11\u4e86\u6b7b\u4ea1\u6216\u5782\u6b7b\u7684CAR-T\u7ec6\u80de\u7684\u79ef\u7d2f\u3002 \u66f4\u91cd\u8981\u7684\u662f\uff0c\u5f53\u5c06\u7ecf NMN \u4ecb\u5165\u7684 CAR-T \u7ec6\u80de\u6ce8\u5c04\u5230\u5177\u6709\u5b9e\u9a8c\u8bf1\u5bfc\u80bf\u7624\u7684\u5c0f\u9f20\u4f53\u5185\u65f6\uff0c\u80bf\u7624\u5927\u5c0f\u663e\u8457\u7f29\u5c0f\u3002 \u8fd9\u4e9b\u53d1\u73b0\u6307\u51fa\u4e86\u4e00\u6761\u65b0\u9014\u5f84\uff0c\u7814\u7a76\u4eba\u5458<a href=\"https:\/\/www.ihealthtaiwan.com\/blog\/nmn-enhances-cancer-preventing-immune-cell-activation\" target=\"_blank\" rel=\"noopener\" data-type=\"web\">\u53ef\u4ee5\u7528 NMN \u589e\u5f3a CAR-T \u7ec6\u80de\uff0c\u4ee5\u63d0\u9ad8\u5176\u6297\u764c\u80fd\u529b\u548c\u6709\u6548\u6027<\/a>\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>&nbsp;<\/p>\n<h3><strong><span style=\"color: #ff6600;\">NMN \u6cbb\u7597\u589e\u5f3a\u6297\u764c\u80fd\u529b<\/span><\/strong><\/h3>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>&nbsp;<\/p>\n<p>\u4e3a\u4e86\u7814\u7a76NMN\u5bf9\u4eba\u7c7bCAR-T\u7ec6\u80de\u589e\u6b96\u548c\u6297\u764c\u80fd\u529b\u7684\u5f71\u54cd\uff0c\u5728\u57f9\u517b\u7269\u4e2d\u5b58\u5728NALM-6\u7ec6\u80de\u7684\u60c5\u51b5\u4e0b\uff0c\u7528100 \u03bcM NMN\u4ecb\u5165CAR-T\u7ec6\u80de\u3002 NALM-6 \u7ec6\u80de\u662f\u4e00\u79cd\u6a21\u4eff\u8840\u764c\u7ec6\u80de\u72b6\u51b5\u7684\u767d\u8840\u75c5\u7ec6\u80de\u7cfb\u3002 \u7814\u7a76\u56e2\u961f\u53d1\u73b0\uff0c\u5bf9\u4e8e\u7ecf\u8fc7NMN\u4ecb\u5165\u7684\u7ec6\u80de\uff0c\u5728\u57f9\u517b28\u5929\u540e\uff0cCAR-T\u7ec6\u80de\u7684\u6570\u91cf\u662f\u51e0\u4e4e\u6240\u6709\u672a\u7ecf\u8fc7NMN\u4ecb\u5165\u7684CAR-T\u7ec6\u80de\u7684180\u500d\u3002 \u6b64\u5916\uff0c\u5728NMN\u5b58\u5728\u7684\u60c5\u51b5\u4e0b\uff0cCAR-T\u7ec6\u80de\u4fdd\u6301\u5176\u6740\u6b7b\uff08\u88c2\u89e3\uff09\u6076\u6027\u7ec6\u80de\u7684\u80fd\u529b\u6bd4\u672a\u7ecfNMN\u4ecb\u5165\u7684CAR-T\u7ec6\u80de\u66f4\u5353\u8d8a\u3002 \u8fd9\u4e9b\u7ed3\u679c\u4f7f NMN \u589e\u5f3a\u57f9\u517b\u7269\u4e2d CAR-T \u7ec6\u80de\u7684\u589e\u6b96\u548c\u80bf\u7624\u6740\u4f24\u529f\u80fd\u7684\u89c2\u70b9\u53d8\u5f97\u53ef\u4fe1\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-image\">\n<div>\n<div class=\"s-component-content\">\n<div class=\"s-img-wrapper\"><img decoding=\"async\" class=\"crop-default\" title=\"\" src=\"https:\/\/custom-images.strikinglycdn.com\/res\/hrscywv4p\/image\/upload\/c_limit,fl_lossy,h_9000,w_1200,f_auto,q_auto\/3160820\/421593_148992.png\" alt=\"\" data-description=\"\" data-image-link=\"javascript:void(0);\" \/><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p><a href=\"https:\/\/www.researchsquare.com\/article\/rs-1483519\/v1\" target=\"_blank\" rel=\"noopener\" data-type=\"\">(Yu et al., 2022 |<\/a>\u00a0<a href=\"https:\/\/www.researchsquare.com\/article\/rs-1483519\/v1\" target=\"_blank\" rel=\"noopener\" data-type=\"\"><em>Research Square<\/em><\/a><a href=\"https:\/\/www.researchsquare.com\/article\/rs-1483519\/v1\" target=\"_blank\" rel=\"noopener\" data-type=\"\">)<\/a>\u00a0NMN \u4ecb\u5165\u53ef\u663e\u8457\u589e\u5f3a\u6297\u80bf\u7624 CAR-T \u7ec6\u80de\u589e\u6b96\u5e76\u63d0\u9ad8\u764c\u75c7\u653b\u51fb\u80fd\u529b\u3002 \u572828\u5929\u7684\u8fc7\u7a0b\u4e2d\uff0c\u7ecfNMN\u4ecb\u5165\u7684CAR-T\u7ec6\u80de\u589e\u6b96\u6bd4\u672a\u7ecfNMN\u4ecb\u5165\u7684CAR-T\u7ec6\u80de\u591a180\u500d\uff0c\u672a\u7ecfNMN\u4ecb\u5165\u7684CAR-T\u7ec6\u80de\u00a0\u57fa\u672c\u4e0a\u572828\u5929\u540e\u5df2\u7ecf\u6b7b\u4ea1\uff08\u56fe b\uff09\u3002 \u572828\u5929\u7684\u8fc7\u7a0b\u4e2d\uff0cCAR-T\u7ec6\u80de\u7528100 uM NMN\u4ecb\u5165\u56db\u6b21\uff08\u7b2c0\u8f6e\u5230\u7b2c3\u8f6e\uff09\u3002 \u5728\u7b2c\u4e09\u8f6e\uff0828\u5929\uff09\uff0cNMN\u4ecb\u5165\u7684CAR-T\u7ec6\u80de\u6740\u6b7b\uff08\u88c2\u89e3\uff09\u7684NALM-6\u767d\u8840\u75c5\u7ec6\u80de\u767e\u5206\u6bd4\u662f\u672aNMN\u4ecb\u5165\u7684CAR-T\u7ec6\u80de\u6740\u6b7b\u7684\u4e24\u500d\uff08\u56fe f\uff09\u3002 \u8fd9\u4e9b\u53d1\u73b0\u8868\u660e NMN \u589e\u5f3a\u4e86\u57f9\u517b\u7269\u4e2d CAR-T \u7ec6\u80de\u7684\u589e\u6b96\u548c\u6297\u764c\u80fd\u529b\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>\u4e3a\u4e86\u53d1\u73b0 NMN \u662f\u5426\u80fd\u5ef6\u7f13 CAR-T \u7ec6\u80de\u7684\u8870\u8001\uff0cZhong \u53ca\u5176\u540c\u4e8b\u6d4b\u8bd5\u4e86\u7aef\u7c92\u9176\u7684\u6d3b\u6027\uff0c\u8be5\u9176\u53ef\u5ef6\u957f\u67d3\u8272\u4f53\u672b\u7aef\u7684\u7aef\u7c92\u3002 \u7aef\u7c92\u9176\u662f CAR-T \u7ec6\u80de\u590d\u5236\u548c\u6574\u4f53\u529f\u80fd\u7684\u5173\u952e\u56e0\u7d20\uff0c\u5b83\u7684\u4e30\u5ea6\u4f1a\u968f\u7740\u7ec6\u80de\u5206\u88c2\u3001\u8870\u8001\u548c\u75be\u75c5\u800c\u51cf\u5c11\u3002 \u968f\u7740\u7aef\u7c92\u9176\u6d3b\u6027\u7684\u964d\u4f4e\uff0cCAR-T \u7ec6\u80de\u901a\u5e38\u4f1a\u6b7b\u4ea1\u6216\u53d8\u5f97\u8001\u5316\u3001\u65e0\u529f\u80fd\u548c\u4e0d\u589e\u6b96\uff08\u8870\u8001\uff09\uff0c\u5bfc\u81f4 CAR-T \u529f\u80fd\u53d7\u6291\u5236\u548c\u7f3a\u4e4f\u957f\u671f\u6297\u764c\u80fd\u529b\u3002 Zhong \u53ca\u5176\u540c\u4e8b\u53d1\u73b0\uff0c\u7528 NMN \u4ecb\u5165 CAR-T \u7ec6\u80de\u4f1a\u589e\u52a0\u7aef\u7c92\u9176\u6d3b\u6027\uff0c\u800c\u8870\u8001\u7684 CAR-T \u7ec6\u80de\u4e30\u5ea6\u4f1a\u5927\u5e45\u4e0b\u964d\u3002 \u8fd9\u4e00\u53d1\u73b0\u8bc1\u5b9e\uff0cNMN\u901a\u8fc7\u4fc3\u8fdb\u7aef\u7c92\u9176\u6d3b\u6027\u548c\u51cf\u5c11\u57f9\u517b\u4e2d\u8870\u8001\u7684 CAR-T \u7ec6\u80de\u6570\u91cf\u6765\u5ef6\u957f CAR-T \u7ec6\u80de\u7684\u5bff\u547d\u5e76\u5ef6\u957f\u4f5c\u7528\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-image\">\n<div>\n<div class=\"s-component-content\">\n<div class=\"s-img-wrapper\"><img decoding=\"async\" class=\"crop-default\" title=\"\" src=\"https:\/\/custom-images.strikinglycdn.com\/res\/hrscywv4p\/image\/upload\/c_limit,fl_lossy,h_9000,w_1200,f_auto,q_auto\/3160820\/172782_831526.png\" alt=\"\" data-description=\"\" data-image-link=\"javascript:void(0);\" \/><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p><a href=\"https:\/\/www.researchsquare.com\/article\/rs-1483519\/v1\" target=\"_blank\" rel=\"noopener\" data-type=\"\">(Yu et al., 2022 |<\/a>\u00a0<a href=\"https:\/\/www.researchsquare.com\/article\/rs-1483519\/v1\" target=\"_blank\" rel=\"noopener\" data-type=\"\"><em>Research Square<\/em><\/a><a href=\"https:\/\/www.researchsquare.com\/article\/rs-1483519\/v1\" target=\"_blank\" rel=\"noopener\" data-type=\"\">)<\/a>\u00a0NMN \u4ecb\u5165\u663e\u8457\u51cf\u7f13\u4e86 CAR-T \u7ec6\u80de\u4e2d\u67d3\u8272\u4f53\u672b\u7aef\uff08\u7aef\u7c92\uff09\u7684\u78e8\u635f\u5e76\u51cf\u7f13\u4e86\u5b83\u4eec\u7684\u8870\u8001\u3002 CAR-T\u7ec6\u80de\u572828\u5929\u7684\u65f6\u95f4\u5185\u7528100 \u03bcM NMN\u4ecb\u5165\u56db\u8f6e\uff08\u7b2c0\u8f6e\u5230\u7b2c3\u8f6e\uff09\uff0c\u4e0e\u672a\u6709NMN\u4ecb\u5165\u7684CAR-T\u7ec6\u80de\u76f8\u6bd4\uff0c\u6709NMN\u4ecb\u5165\u7684CAR-T\u7ec6\u80de\u51cf\u7f13\u4e86\u7aef\u7c92\u957f\u5ea6\u7684\u9000\u5316\uff08\u56fe c\uff09\u3002 \u4f7f\u7528 NMN \u4ecb\u5165\u540e\uff0c\u57f9\u517b\u4e2d\u8870\u8001\u7684 CAR-T \u7ec6\u80de\uff08\u7528 \u03b2-\u534a\u4e73\u7cd6\u82f7\u9176\u6807\u8bb0\u7684\u84dd\u70b9\uff09\u7684\u6570\u91cf\u5728 28 \u5929\u540e\u7ea6\u4e3a\u672a\u7ecf NMN \u4ecb\u5165\u7684\u7ec6\u80de\u7684\u4e00\u534a\uff08\u56fe d\uff09\u3002 \u8fd9\u4e9b\u53d1\u73b0\u8868\u660e NMN \u4fc3\u8fdb\u4e86 CAR-T \u7ec6\u80de\u7684\u5bff\u547d\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>&nbsp;<\/p>\n<h3><strong>NMN \u4ecb\u5165\u7684 CAR-T \u7ec6\u80de\u6291\u5236\u5c0f\u9f20\u80bf\u7624\u751f\u957f<\/strong><\/h3>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>Zhong \u53ca\u5176\u540c\u4e8b\u63a5\u4e0b\u6765\u8bd5\u56fe\u627e\u51fa\u7ecf NMN \u5904\u7406\u7684 CAR-T \u7ec6\u80de\u5bf9\u5c0f\u9f20\u80bf\u7624\u7684\u5f71\u54cd\u3002 \u9996\u5148\u7ed9\u5c0f\u9f20\u6ce8\u5c04NALM-6\u767d\u8840\u75c5\u7ec6\u80de\u4ee5\u751f\u6210\u5c0f\u9f20\u764c\u75c7\u6a21\u578b\uff0c\u7136\u540e\u518d\u6ce8\u5c04NMN\u4ecb\u5165\u7684CAR-T\u7ec6\u80de\u3002 \u603b\u90e8\u4f4d\u4e8e\u5317\u4eac\u7684\u7814\u7a76\u56e2\u961f\u53d1\u73b0\uff0c\u7528 NMN \u4ecb\u5165\u7684 CAR-T \u7ec6\u80de\u6cbb\u7597\u53ef\u4fc3\u8fdb\u66f4\u6301\u4e45\u7684\u80bf\u7624\u6291\u5236\uff0c\u5982\u80bf\u7624\u4f53\u79ef\u8f83\u5c0f\u6240\u793a\u3002 \u8fd9\u4e9b\u53d1\u73b0\u8fdb\u4e00\u6b65\u652f\u6301 NMN \u589e\u5f3a\u4e86 CAR-T \u7ec6\u80de\u7684\u6297\u764c\u80fd\u529b\uff0c\u6b63\u5982\u8be5\u764c\u75c7\u5c0f\u9f20\u6a21\u578b\u6240\u8bc1\u660e\u7684\u90a3\u6837\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-image\">\n<div>\n<div class=\"s-component-content\">\n<div class=\"s-img-wrapper\"><img decoding=\"async\" class=\"crop-default\" title=\"\" src=\"https:\/\/custom-images.strikinglycdn.com\/res\/hrscywv4p\/image\/upload\/c_limit,fl_lossy,h_9000,w_1200,f_auto,q_auto\/3160820\/646906_288914.png\" alt=\"\" data-description=\"\" data-image-link=\"javascript:void(0);\" \/><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p><a href=\"https:\/\/www.researchsquare.com\/article\/rs-1483519\/v1\" target=\"_blank\" rel=\"noopener\" data-type=\"\">(Yu et al., 2022 |<\/a>\u00a0<a href=\"https:\/\/www.researchsquare.com\/article\/rs-1483519\/v1\" target=\"_blank\" rel=\"noopener\" data-type=\"\"><em>Research Square<\/em><\/a><a href=\"https:\/\/www.researchsquare.com\/article\/rs-1483519\/v1\" target=\"_blank\" rel=\"noopener\" data-type=\"\">)<\/a>\u00a0NMN \u4ecb\u5165\u7684 CAR-T \u7ec6\u80de\u6291\u5236\u5c0f\u9f20\u80bf\u7624\u3002 \u7ed9\u5c0f\u9f20\u6ce8\u5c04\u4eba\u7c7b NALM-6 \u767d\u8840\u75c5\u7ec6\u80de\u4ee5\u4fc3\u8fdb\u80bf\u7624\u751f\u957f\u3002 \u7136\u540e\u5c0f\u9f20\u4e0d\u63a5\u53d7\u4efb\u4f55\u6cbb\u7597 \uff08NT\uff09\u3001\u4e0d\u542b NMN \u7684 CAR-T \u7ec6\u80de \uff08CD19 CAR-T\uff09 \u6216\u7ecf NMN \u4ecb\u5165\u7684 CAR-T \u7ec6\u80de \uff08CD19 CAR-T + NMN\uff09\u3002 \u7ecf\u8fc7 28 \u5929\u7684\u65f6\u95f4\u8fdb\u7a0b\u540e\uff0c\u63a5\u53d7 NMN \u4ecb\u5165\u7684 CD19 CAR-T \u7ec6\u80de\u7684\u5c0f\u9f20\u5177\u6709\u8f83\u4f4e\u7684\u80bf\u7624\u8d1f\u8377\uff0c\u5982\u8f83\u4f4e\u7684\u80bf\u7624\u8f90\u5c04\u6240\u793a\uff08\u56fe b \u548c d\uff09\u3002 NMN\u4ecb\u5165\u7684CD19 CAR-T\u7ec6\u80de\u7684\u4f5c\u7528\u4e5f\u66f4\u6301\u4e45\uff0c\u598228\u5929\u540e\u8f83\u4f4e\u7684\u80bf\u7624\u8d1f\u8377\u6240\u793a\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>&nbsp;<\/p>\n<h3><strong>NMN \u523a\u6fc0\u4e0e\u957f\u5bff\u76f8\u5173\u7684 Sirt1 \u57fa\u56e0<\/strong><\/h3>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>\u4e3a\u4e86\u627e\u51faNMN\u523a\u6fc0\u4e86\u54ea\u4e9b\u57fa\u56e0\uff0cZhong\u53ca\u5176\u540c\u4e8b\u8fdb\u884c\u4e86\u57fa\u56e0\u6d3b\u6027\u5206\u6790\uff0c\u53d1\u73b0NMN\u4fc3\u8fdb\u4e86\u4e0e\u7ec6\u80de\u5bff\u547d\u76f8\u5173\u7684Sirt1\u57fa\u56e0\u7684\u6fc0\u6d3b\u3002 \u5728 NMN \u5904\u7406\u7684 CAR-T \u7ec6\u80de\u4e2d\uff0cSirt1 \u6d3b\u6027\u7684\u589e\u52a0\u4e5f\u4e0e\u7ec6\u80de\u6b7b\u4ea1\u548c\u708e\u75c7\u76f8\u5173\u57fa\u56e0\u7684\u6fc0\u6d3b\u51cf\u5c11\u6709\u5173\u3002 \u7531\u4e8e\u63a8\u6d4bSirt1\u5177\u6709\u6291\u5236\u7ec6\u80de\u6b7b\u4ea1\u76f8\u5173\u57fa\u56e0\u6fc0\u6d3b\u7684\u4f5c\u7528\uff0c\u8fd9\u4e9b\u53d1\u73b0\u4e3aNMN\u4fc3\u8fdbCAR-T\u6297\u80bf\u7624\u529f\u6548\u7684\u7ec6\u80de\u673a\u5236\u63d0\u4f9b\u4e86\u4e00\u4e9b\u7ebf\u7d22\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>\u786e\u5b9aNMN\u523a\u6fc0\u7684\u7cbe\u786e\u7ec6\u80de\u673a\u5236<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-quote-content\">\n<div class=\"quote-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>&nbsp;<\/p>\n<p>\u201c\u5728\u8fd9\u9879\u7814\u7a76\u4e2d\uff0c\u6211\u4eec\u53d1\u73b0 NMN \u53ef\u4ee5\u901a\u8fc7\u4e0a\u8c03\u957f\u5bff\u57fa\u56e0 Sirt1 \u6765\u589e\u52a0\u7ec6\u80de\u518d\u751f\u548c\u7ec6\u80de\u589e\u6b96\uff0c\u8fd9\u8ba9\u6211\u4eec\u5bf9 NMN \u53ef\u4ee5\u63d0\u9ad8 CD19 CAR-T \u7ec6\u80de\u7684\u5bff\u547d\u548c\u6297\u80bf\u7624\u6548\u7387\u5145\u6ee1\u4fe1\u5fc3\uff0c\u201dZhong \u53ca\u5176\u540c\u4e8b\u5728\u4ed6\u4eec\u7684\u8bba\u6587\u4e2d\u8bf4\u9053\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>&nbsp;<\/p>\n<p>\u8be5\u7814\u7a76\u7684\u7ed3\u679c\u7a81\u51fa\u4e86 NMN \u5728 CAR-T \u7ec6\u80de\u4eba\u7c7b\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u4e2d\u7684\u6f5c\u5728\u4e34\u5e8a\u5e94\u7528\u3002 \u968f\u7740NMN\u7684\u5e94\u7528\uff0c\u4eba\u7c7bCAR-T\u7ec6\u80de\u66f4\u6709\u6d3b\u529b\uff0c\u5e76\u4e14\u5177\u6709\u66f4\u597d\u7684\u6740\u4f24\u764c\u7ec6\u80de\u7684\u80fd\u529b\u3002 \u8fd9\u4e9b\u53d1\u73b0\u4e5f\u9002\u7528\u4e8e\u5c0f\u9f20\u764c\u75c7\u6a21\u578b\uff0c\u5176\u4e2d\u6ce8\u5c04\u7ecf NMN \u4ecb\u5165\u7684 CAR-T \u7ec6\u80de\u53ef\u51cf\u5c11\u80bf\u7624\u751f\u957f\uff0c\u8bf4\u660e NMN \u53ef\u80fd\u662f\u589e\u5f3a CAR-T \u7597\u6cd5\u7684\u5173\u952e\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>\u672a\u6765\u7684\u7814\u7a76\u9700\u8981\u9610\u660e NMN \u4fc3\u8fdb CAR-T \u6d3b\u529b\u3001\u5bff\u547d\u548c\u6297\u764c\u80fd\u529b\u7684\u7cbe\u786e\u7ec6\u80de\u673a\u5236\u3002 \u66f4\u8be6\u7ec6\u5730\u4e86\u89e3 NMN \u5bf9\u7ec6\u80de\u7684\u5f71\u54cd\u5c06\u4f7f\u7814\u7a76\u4eba\u5458\u80fd\u591f\u67e5\u660e NMN \u5f71\u54cd\u7684\u5176\u4ed6\u9014\u5f84\u3002 \u8fd9\u6837\u505a\uff0c\u6211\u4eec\u53ef\u80fd\u4f1a\u8fdb\u4e00\u6b65\u4e86\u89e3\u6539\u5584 CAR-T \u7ec6\u80de\u529f\u80fd\u4ee5\u5bf9\u6297\u764c\u75c7\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>\u8fd9\u9879\u7814\u7a76\u6df1\u5165\u4e86\u89e3 NMN \u5982\u4f55\u901a\u8fc7\u6fc0\u6d3b CAR-T \u7ec6\u80de\u6765\u5e2e\u52a9\u6062\u590d\u514d\u75ab\u7cfb\u7edf\u3002 \u7531\u4e8e\u514d\u75ab\u7cfb\u7edf\u4f1a\u968f\u7740\u8870\u8001\u800c\u4e0b\u964d\uff0c\u56e0\u6b64\u00a0<a href=\"http:\/\/johnhealth.blog\/ch\/?p=19582\" target=\"_blank\" rel=\"noopener\" data-type=\"web\">NMN \u6709\u53ef\u80fd\u88ab\u7528\u4f5c\u9884\u9632\u764c\u75c7\u751f\u957f\u7684\u63aa\u65bd<\/a>\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-separator\">\n<div class=\"s-separator-content\">\n<div class=\"separator\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>\u53c2\u8003\u6587\u732e<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>Zhen Yu, Shuai Tong, Can Zhang et al. Nicotinamide mononucleotide enhances the efficacy and persistence of CD19 CAR-T cells via NAD + \u2013Sirt1 axis, 19 April 2022, PREPRINT (Version 1) available at Research Square [https:\/\/doi.org\/10.21203\/rs.3.rs-1483519\/v1]<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>\u6587\u7ae0\u6765\u6e90<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>https:\/\/www.nmn.com\/news\/nmn-increases-cancer-fighting-immune-cells<\/p>\n<p><a href=\"https:\/\/nmnhealth.ihlglobal.com\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-19571\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/01\/SIR.jpg\" alt=\"\" width=\"960\" height=\"540\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/01\/SIR.jpg 960w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/01\/SIR-300x169.jpg 300w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2023\/01\/SIR-768x432.jpg 768w\" sizes=\"auto, (max-width: 960px) 100vw, 960px\" \/><\/a><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"pvc_clear\"><\/div>\n<p id=\"pvc_stats_19579\" class=\"pvc_stats all  \" data-element-id=\"19579\" style=\"\"><i class=\"pvc-stats-icon medium\" aria-hidden=\"true\"><svg aria-hidden=\"true\" focusable=\"false\" data-prefix=\"far\" data-icon=\"chart-bar\" role=\"img\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\" class=\"svg-inline--fa fa-chart-bar fa-w-16 fa-2x\"><path fill=\"currentColor\" d=\"M396.8 352h22.4c6.4 0 12.8-6.4 12.8-12.8V108.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v230.4c0 6.4 6.4 12.8 12.8 12.8zm-192 0h22.4c6.4 0 12.8-6.4 12.8-12.8V140.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v198.4c0 6.4 6.4 12.8 12.8 12.8zm96 0h22.4c6.4 0 12.8-6.4 12.8-12.8V204.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v134.4c0 6.4 6.4 12.8 12.8 12.8zM496 400H48V80c0-8.84-7.16-16-16-16H16C7.16 64 0 71.16 0 80v336c0 17.67 14.33 32 32 32h464c8.84 0 16-7.16 16-16v-16c0-8.84-7.16-16-16-16zm-387.2-48h22.4c6.4 0 12.8-6.4 12.8-12.8v-70.4c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v70.4c0 6.4 6.4 12.8 12.8 12.8z\" class=\"\"><\/path><\/svg><\/i> <img loading=\"lazy\" decoding=\"async\" width=\"16\" height=\"16\" alt=\"Loading\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/plugins\/page-views-count\/ajax-loader-2x.gif\" border=0 \/><\/p>\n<div class=\"pvc_clear\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u70df\u9170\u80fa\u5355\u6838\u82f7\u9178 \uff08NMN\uff09 \u4ecb\u5165\u7684\u6297\u80bf\u7624 CAR-T \u7ec6\u80de\u663e\u793a\u51fa\u589e\u5f3a\u7684\u5bf9\u6297\u764c\u7ec6\u80de\u548c\u51cf\u5c11\u5c0f\u9f20\u80bf\u7624\u751f\u957f\u7684\u6548\u679c\u3002 \u00a0By\u00a0Brett J. Weiss Published:\u00a012:13 p.m. PST May 17, 2022\u00a0| Updated:\u00a01:42 p.m. PST Sep 26, 2022 &nbsp; \u91cd\u5927\u4eae\u70b9 NMN \u7684\u4ecb\u5165\u53ef\u5c06 CAR-T \u7ec6\u80de\uff08\u6297\u80bf\u7624\u514d\u75ab\u7ec6\u80de\uff09\u589e\u6b96\u589e\u52a0 180 \u500d\uff0c\u540c\u65f6\u5ef6\u957f\u7ec6\u80de\u6740\u6b7b\u764c\u7ec6\u80de\u7684\u80fd\u529b\u3002 \u901a\u8fc7 NMN \u4ecb\u5165\uff0c\u6297\u764c CAR-T \u7ec6\u80de\u663e\u793a\u51fa\u5ef6\u7f13\u8870\u8001\u7684\u8ff9\u8c61\uff0c\u8868\u73b0\u4e3a\u7aef\u7c92\u957f\u5ea6\u53d8\u957f\u548c\u6b7b\u4ea1\u6216\u5782\u6b7b\u7684 CAR-T \u7ec6\u80de\u4e30\u5ea6\u51cf\u5c11\u3002 NMN \u4ecb\u5165\u7684 CAR-T \u7ec6\u80de\u6291\u5236\u80bf\u7624\u751f\u957f\uff0c\u5bf9\u764c\u75c7\u5c0f\u9f20\u5177\u6709\u66f4\u6301\u4e45\u7684\u4f5c\u7528\u3002 &nbsp; \u6211\u4eec\u7684\u514d\u75ab\u7cfb\u7edf\u4e0d\u4ec5\u4f1a\u5bfb\u627e\u5e76\u6d88\u706d\u6765\u81ea\u4f53\u5916\u7684\u5f02\u7269\uff0c\u8fd8\u4f1a\u6d88\u9664\u4f53\u5185\u6709\u95ee\u9898\u7684\u7ec6\u80de\uff0c\u4f8b\u5982\u764c\u7ec6\u80de\u548c\u80bf\u7624\u751f\u957f\u3002 \u7136\u800c\uff0c\u968f\u7740\u5e74\u9f84\u7684\u589e\u957f\uff0c\u6211\u4eec\u7684\u514d\u75ab\u7cfb\u7edf\u6548\u7387\u964d\u4f4e\uff0c\u5185\u90e8\u7ec6\u80de\u9519\u8bef\u53d8\u5f97\u66f4\u5bb9\u6613\u53d1\u751f\uff0c\u4ece\u800c\u5bfc\u81f4\u7f79\u60a3\u764c\u75c7\u7684\u53ef\u80fd\u6027\u589e\u52a0\u3002<\/p>\n<div class=\"pvc_clear\"><\/div>\n<p id=\"pvc_stats_19579\" class=\"pvc_stats all  \" data-element-id=\"19579\" style=\"\"><i class=\"pvc-stats-icon medium\" aria-hidden=\"true\"><svg aria-hidden=\"true\" focusable=\"false\" data-prefix=\"far\" data-icon=\"chart-bar\" role=\"img\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\" class=\"svg-inline--fa fa-chart-bar fa-w-16 fa-2x\"><path fill=\"currentColor\" d=\"M396.8 352h22.4c6.4 0 12.8-6.4 12.8-12.8V108.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v230.4c0 6.4 6.4 12.8 12.8 12.8zm-192 0h22.4c6.4 0 12.8-6.4 12.8-12.8V140.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v198.4c0 6.4 6.4 12.8 12.8 12.8zm96 0h22.4c6.4 0 12.8-6.4 12.8-12.8V204.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v134.4c0 6.4 6.4 12.8 12.8 12.8zM496 400H48V80c0-8.84-7.16-16-16-16H16C7.16 64 0 71.16 0 80v336c0 17.67 14.33 32 32 32h464c8.84 0 16-7.16 16-16v-16c0-8.84-7.16-16-16-16zm-387.2-48h22.4c6.4 0 12.8-6.4 12.8-12.8v-70.4c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v70.4c0 6.4 6.4 12.8 12.8 12.8z\" class=\"\"><\/path><\/svg><\/i> <img loading=\"lazy\" decoding=\"async\" width=\"16\" height=\"16\" alt=\"Loading\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/plugins\/page-views-count\/ajax-loader-2x.gif\" border=0 \/><\/p>\n<div class=\"pvc_clear\"><\/div>\n","protected":false},"author":1,"featured_media":19580,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[409,172,272],"tags":[665,12,54],"class_list":["post-19579","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-nad","category-nmn-","category-272","tag-nmn","tag-12","tag-54"],"aioseo_notices":[],"_links":{"self":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts\/19579","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=19579"}],"version-history":[{"count":2,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts\/19579\/revisions"}],"predecessor-version":[{"id":19585,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts\/19579\/revisions\/19585"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/media\/19580"}],"wp:attachment":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=19579"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=19579"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=19579"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}