{"id":19500,"date":"2022-12-11T21:15:34","date_gmt":"2022-12-11T21:15:34","guid":{"rendered":"http:\/\/johnhealth.blog\/ch\/?p=19500"},"modified":"2022-12-11T21:15:34","modified_gmt":"2022-12-11T21:15:34","slug":"nmn%e5%8f%af%e9%98%b2%e6%b2%bb%e6%96%b0%e5%86%a0%ef%bc%81%e6%b8%85%e8%8f%af%e5%a4%a7%e5%ad%b8%e6%96%bc%e5%85%a8%e7%90%83%e6%ac%8a%e5%a8%81%e9%86%ab%e5%ad%b8%e6%9c%9f%e5%88%8a%e3%80%8a%e6%9f%b3","status":"publish","type":"post","link":"http:\/\/johnhealth.blog\/ch\/?p=19500","title":{"rendered":"NMN\u53ef\u9632\u6cbb\u65b0\u51a0\uff01\u6e05\u83ef\u5927\u5b78\u65bc\u5168\u7403\u6b0a\u5a01\u91ab\u5b78\u671f\u520a\u300a\u67f3\u8449\u5200\u300b\u767c\u8868\u6700\u65b0\u8cc7\u8a0a\uff01"},"content":{"rendered":"<div>\u00a0\u201c\u65b0\u51a0\u80ba\u708e\u662f\u4e00\u79cd\u8870\u8001\u76f8\u5173\u75be\u75c5\u201d \u8fd9\u4e00\u7406\u8bba\uff0c\u6b63\u5728\u9010\u6e10\u6210\u4e3a\u5168\u7403\u5b66\u672f\u754c\u7684\u901a\u8bc6\u3002<\/div>\n<div>\n<p>\u201c\u4e2d\u56fd\u533b\u5b66\u5723\u7ecf\u201c\u300a\u67f3\u53f6\u5200\u300b\uff0c\u5f00\u59cb\u547c\u5401\u533b\u7597\u673a\u6784\u4f7f\u7528\u6297\u8870\u8001\u7269\u8d28\u6cbb\u7597\u65b0\u51a0\u80ba\u708e\u3002<\/p>\n<p>NMN\u7c7b\u7269\u8d28\uff0c\u4f3c\u4e4e\u5c06\u662f\u8fd9\u573a\u6297\u8870\u8001\u7269\u8d28\u201c\u4e34\u5e8a\u7ade\u8d5b\u201d\u4e2d\u7684\u9996\u4e2a\u4f18\u80dc\u8005\u3002<\/p>\n<div><!--more--><br \/>\nNMN\u7c7b\u7269\u8d28\u66fe\u56e0\u5e02\u573a\u6f2b\u5929\u7684\u5938\u5927\u5ba3\u4f20\u4e0e\u4eba\u4f53\u5b9e\u9a8c\u4e34\u5e8a\u6570\u636e\u8f83\u5c11\u800c\u9971\u53d7\u4e89\u8bae\uff0c\u968f\u7740\u7136\u800c\u968f\u7740\u4eba\u4f532\u4e363\u671f\u4e34\u5e8a\uff08NMN\u7c7b\u7269\u8d28\u66fe\u56e0\u5e02\u573a\u6f2b\u5929\u7684\u5938\u5927\u5ba3\u4f20\u4e0e\u4eba\u4f53\u5b9e\u9a8c\u4e34\u5e8a\u6570\u636e\u8f83\u5c11\u800c\u9971\u53d7\u4e89\u8bae\uff0c\u968f\u7740\u7136\u800c\u968f\u7740\u4eba\u4f532\u4e363\u671f\u4e34\u5e8a\uff08\u4eca\u4e95\u771f\u4e00\u90ce\u6f14\u8bb2\u4f1a\u4e28NMN\u4e8c\u671f\u4e34\u5e8a\u8bd5\u9a8c\u6210\u679c\u9762\u4e16\uff01\uff09\u7684\u5b9e\u9a8c\u7ed3\u675f\u5411\u4eba\u4eec\u5c55\u793a\u4e86\u5145\u5206\u7684\u6570\u636e\u652f\u6491\uff0cNMN\u7c7b\u7269\u8d28\u5bf9\u4eba\u4f53\u5065\u5eb7\u7684\u6b63\u9762\u529f\u6548\u5f97\u5230\u9a8c\u8bc1\u3002\uff09\u7684\u5b9e\u9a8c\u7ed3\u675f\u5411\u4eba\u4eec\u5c55\u793a\u4e86\u5145\u5206\u7684\u6570\u636e\u652f\u6491\uff0cNMN\u7c7b\u7269\u8d28\u5bf9\u4eba\u4f53\u5065\u5eb7\u7684\u6b63\u9762\u529f\u6548\u5f97\u5230\u9a8c\u8bc1\u3002\u8fd1\u65e5\uff0c\u5728\u4e2d\u56fd\u4e2d\u79d1\u9662\u56e2\u961f\u8054\u5408\u5317\u4eac\u5927\u5b66\u4e36\u6e05\u534e\u5927\u5b66\u5728\u9876\u7ea7\u671f\u520a\u300aCell Discovery\u300b\u4e0a\u53d1\u8868\u4e86\u4ed6\u4eec\u7684\u4e34\u5e8a\u524d\u7814\u7a76\uff0c\u4ed6\u4eec\u53d1\u73b0\u8865\u5145NMN\u5bf9\u65bc\u65b0\u51a0\u5177\u6709\u7c7b\u4f3cNAD+\u7684\u6548\u679c\uff0c\u5b83\u4e0d\u4ec5\u53ef\u4ee5\u6539\u5584\u611f\u67d3\u65b0\u51a0\u540e\u5f15\u8d77\u7684NAD+\u4ee3\u8c22\uff0c\u8fd8\u80fd\u6539\u5584\u514d\u75ab\u53cd\u5e94\u548c\u7ec6\u80de\u6b7b\u4ea1\u76f8\u5173\u57fa\u56e0\u8868\u8fbe\u7684\u5931\u8c03\uff0c\u6291\u5236\u7ec6\u80de\u6b7b\u4ea1[1]\u3002<\/p>\n<\/div>\n<div><\/div>\n<div>\n<p>&nbsp;<\/p>\n<p><img decoding=\"async\" src=\"https:\/\/img.shoplineapp.com\/media\/image_clips\/62821ff444b59f0027da8d97\/original.png?1652695028\" \/><\/p>\n<p>[2]\u00a0\u00a0Jiang, Y., Deng, Y., Pang, H., Ma, T.,Ye, Q., Chen, Q., &#8230; &amp; Xu, Z. (2022). Treatment of SARS-CoV-2-inducedpneumonia with NAD+ and NMN in two mouse models.\u00a0CellDiscovery,\u00a08(1), 1-17.<\/p>\n<p>\u5728\u5c0f\u9f20\u6a21\u578b\u4e2d\u7528 NAD+ \u6cbb\u7597 SARS-CoV-2 \u8bf1\u5bfc\u7684\u80ba\u708e<\/p>\n<p>\u4e3a\u4e86\u63a2\u7d22 COVID-19 \u7684\u6f5c\u5728\u6cbb\u7597\u9776\u70b9\uff0c\u5b9e\u9a8c\u68c0\u67e5\u4e86\u5c0f\u9f20\u9002\u5e94\u7684 SARS-CoV-2 (MASCp6) \u611f\u67d3\u5c0f\u9f20\u6a21\u578b\u4e2d\u7684\u5931\u8c03\u57fa\u56e0 [2]\u3002\u5b9e\u9a8c\u56e2\u961f\u5728\u611f\u67d3\u5f8c 3.5 \u5929 (dpi) \u5bf9 8 \u4e2a\u6708\u5927\u5c0f\u9f20\u7684 SARS-CoV-2 \u611f\u67d3\u80ba\u90e8\u8fdb\u884c\u4e86\u5168\u7403\u57fa\u56e0\u8868\u8fbe\u5206\u6790\u3002\u5c06\u9ebb\u9189\u7684 6-7 \u5468\u548c 8 \u4e2a\u6708\u5927\u7684\u96cc\u6027 BALB\/c \u5c0f\u9f20\u9f3b\u5185\u7528 7.2\u00d710 5\u6591\u5757\u5f62\u6210\u5355\u4f4d\uff08PFU\uff09\u7684 SARS-CoV-2 \u5242\u91cf\uff0c\u6bcf\u7ec4\u603b\u4f53\u79ef\u4e3a 40 pL . \u5728\u63a5\u79cd\u75c5\u6bd2\u5f8c\u534a\u5929\u5f00\u59cb\uff0c\u901a\u8fc7\u8179\u819c\u5185\u6ce8\u5c04\u8fde\u7eed\u4e09\u5929\u548c\u6bcf\u5929\u4e00\u6b21\uff0c\u7ed9\u611f\u67d3\u7684\u5c0f\u9f20\u65bd\u7528\u6eb6\u89e3\u5728 0.9% \u76d0\u6c34\u4e2d\u7684 NAD+\u3002<\/p>\n<p><img decoding=\"async\" src=\"https:\/\/img.shoplineapp.com\/media\/image_clips\/6282214cd1666d000f03225c\/original.png?1652695372\" \/><\/p>\n<p>\u56fe\u6ce8\uff1a\u8865\u5145NAD+\u5f8c\u80ba\u90e8\u5404\u9879\u6307\u6807\u7684\u53d8\u5316<\/p>\n<p>c:\u708e\u6027\u7ec6\u80de\u805a\u96c6\u5bc6\u5ea6 d: \u708e\u6027\u7ec6\u80de\u805a\u96c6\u9762\u79efe:\u6c14\u9053\u963b\u585e\u6bd4\u7387 f:\u6c14\u9053\u963b\u585e\u9762\u79ef<\/p>\n<p>\u57fa\u65bcSARS-CoV-2\u548cZIKV\u611f\u67d3\u5bfc\u81f4NAD +\u76f8\u5173\u57fa\u56e0\u5931\u8c03\u4ee5\u53ca\u5c0f\u9f20\u548c\u4eba\u7c7b\u8840\u6e05NAD +\u6c34\u5e73\u964d\u4f4e\u7684\u89c2\u5bdf\u7ed3\u679c\u5b9e\u9a8c\u8c03\u67e5\u4e86NAD +\u8865\u5145\u5242\u662f\u5426\u53ef\u4ee5\u633d\u6551SARS-CoV-2\u8bf1\u5bfc\u7684\u75c5\u7406\u6548\u5e94\u3002\u901a\u8fc7\u66f4\u8be6\u7ec6\u5730\u8868\u5fb5\u4e86\u53d7\u611f\u67d3\u5c0f\u9f20\u80ba\u90e8\u7684\u75c5\u7406\u7279\u5fb5\uff08\u80ba\u708e\uff09\u3002<\/p>\n<p>SARS-CoV-2\u523a\u7a81\u86cb\u767d\u548c\u6838\u8863\u58f3\u86cb\u767d\u6297\u4f53\u7684\u514d\u75ab\u67d3\u8272\u8868\u660e\uff0cSARS-CoV-2\u4e3b\u8981\u611f\u67d3\u6c14\u9053\u4e0a\u76ae\u7ec6\u80de\u548c\u4e00\u4e9b\u80ba\u6ce1\u4e0a\u76ae\u7ec6\u80de\u95ed\u5408\u5230\u6c14\u9053\u3002\u611f\u67d3\u6a21\u5f0f\u7c7b\u4f3c\u65bcSARS-CoV-2\u7684\u53e6\u4e00\u79cd\u5c0f\u9f20\u9002\u5e94\u6a21\u578b\uff0c\u5176\u4e2d\u91cd\u5851\u4e86\u523a\u7a81\u86cb\u767d\u4e2d\u7684\u53d7\u4f53\u7ed3\u5408\u7ed3\u6784\u57df\uff0c\u4ee5\u4fc3\u8fdb\u5176\u4e0e\u5c0f\u9f20ACE2\u7684\u6709\u6548\u7ed3\u5408\u3002\u5b9e\u9a8c\u56e2\u961f\u8bc1\u5b9e\u4e86MASCp6\u611f\u67d3\u7684\u80ba\u90e8\u5b58\u5728\u708e\u75c7\u7ec6\u80de\u6d78\u6da6\uff0c\u80ba\u6ce1\u9694\u819c\u589e\u539a\uff0c\u6813\u585e\uff0c\u4e0a\u76ae\u635f\u4f24\u548c\u7ec6\u80de\u6b7b\u4ea1\uff0c\u7c7b\u4f3c\u65bchACE2\u5c0f\u9f20\u6a21\u578b\u4e2d\u7684\u5f71\u54cd\u3002<\/p>\n<p><img decoding=\"async\" src=\"https:\/\/img.shoplineapp.com\/media\/image_clips\/628228ba94e6c00012ed3264\/original.png?1652697274\" \/><\/p>\n<p>SARS-CoV-2 \u611f\u67d3\u5bfc\u81f4\u80ba\u4e2d NAD+ \u76f8\u5173\u57fa\u56e0\u7684\u5931\u8c03\u3002<\/p>\n<p>NAD+ \u8865\u5145\u5242\u53ef\u7f13\u89e3\u7531 SARS-CoV-2 \u611f\u67d3\u5f15\u8d77\u7684\u80ba\u708e<\/p>\n<p>\u5728\u4e00\u4e9b\u6c14\u9053\u4e2d\u68c0\u6d4b\u5230\u6813\u585e\uff0c\u6709\u8bb8\u591a\u5de8\u566c\u7ec6\u80de\uff08CD68 +\uff09\u541e\u566c\u611f\u67d3\u7ec6\u80de\u3002\u7528NAD +\uff081mg \/ g \/\u5929ip\u6301\u7eed3\u5929\uff09\u6cbb\u7597SARS-CoV-2\u611f\u67d3\u7684\u5c0f\u9f20\u5f8c\u4e0e\u76d0\u6c34\u7ec4H&amp;E\u67d3\u8272\u68c0\u6d4b\u5230\u7684\u4e25\u91cd\u708e\u75c7\u7ec6\u80de\u6d78\u6da6\u548c\u6c14\u9053\u6813\u585e\u76f8\u6bd4\uff0cNAD+\u6cbb\u7597\u7ec4\u708e\u75c7\u7ec6\u80de\u805a\u96c6\u7684\u6570\u91cf\u548c\u5927\u5c0f\u660e\u663e\u51cf\u5c11\u3002\u6b64\u5916\uff0c\u6cbb\u7597\u5f8c\u6c14\u9053\u6813\u585e\u6bd4\u548c\u76f8\u5bf9\u6813\u585e\u9762\u79ef\u5747\u663e\u7740\u964d\u4f4e\uff08P&lt;0.001\u3002\u7136\u800c\uff0c\u5728\u76d0\u6c34\u548cNAD +\u6cbb\u7597\u7ec4\u4e2d\u68c0\u6d4b\u5230SARS-CoV-2\u5f3a\u5ea6\u548c\u611f\u67d3\u9762\u79ef\u7684\u53ef\u6bd4\u6c34\u5e73\uff0c\u8868\u660eNAD +\u6cbb\u7597\u4e0d\u4f1a\u964d\u4f4e\u611f\u67d3\u901f\u7387\uff0c\u4f46\u7f13\u89e3\u4e86\u5176\u75c7\u72b6\u3002<\/p>\n<p><img decoding=\"async\" src=\"https:\/\/img.shoplineapp.com\/media\/image_clips\/6282232494e6c00024ed58a3\/original.png?1652695844\" \/><\/p>\n<p>\u56fe\u6ce8\uff1a\u5c0f\u9f20\u5b58\u6d3b\u7387\u968f\u611f\u67d3\u65f6\u95f4\u7684\u53d8\u5316\u56fe<\/p>\n<p>\u5728\u57fa\u56e0\u8868\u8fbe\u65b9\u9762\uff0cNMN\u7ec4\u548cNAD+\u7ec4\u4e2d\u7684Cd200r3\u8868\u8fbe\u5747\u663e\u7740\u51cf\u5c11\uff0c\u4f46Cd200r4\u548cApaf1\u7684\u8868\u8fbe\u51cf\u5c11\u4ec5\u5728NMN\u7ec4\u89c2\u5bdf\u5f97\u5230\u3002\u8fd9\u4e9b\u7ed3\u679c\u8868\u660e\uff1a\u8865\u5145NMN\u5177\u6709\u7c7b\u4f3cNAD+\u7684\u6548\u679c\uff0c\u5728\u67d0\u4e9b\u65b9\u9762NMN\u8868\u73b0\u66f4\u597d\uff0c\u4e0d\u4ec5\u53ef\u4ee5\u51cf\u8f7b\u80ba\u90e8\u7684\u708e\u75c7\u635f\u4f24\u4e36\u6291\u5236\u7ec6\u80de\u6b7b\u4ea1\uff0c\u751a\u81f3\u8fd8\u53ef\u4ee5\u51cf\u5c11\u611f\u67d3\u52a8\u7269\u7684\u6b7b\u4ea1\u7387\u3002<\/p>\n<p>NAD+\u8865\u5145\u5242\u6709\u52a9\u65bc\u7ef4\u6301\u75c5\u6bd2\u611f\u67d3\u7ec6\u80de\u4e2d\u4ee3\u8c22\u8fc7\u7a0b\u7684\u5e73\u8861<\/p>\n<p>\u672c\u6b21\u5b9e\u9a8c\u7ed3\u679c\u8868\u660e\uff0c\u8865\u5145 NAD +\u4f1a\u5bfc\u81f4\u611f\u67d3\u533a\u57df\u6709\u9650\uff0c\u4f46\u4e0d\u4f1a\u6291\u5236 SARS-CoV-2\u5728\u4f53\u5185\u7684\u589e\u6b96\u3002\u76f8\u53cd\uff0c\u6211\u4eec\u53d1\u73b0\u00a0NAD +\u53ef\u4ee5\u6709\u6548\u9884\u9632 SARS-CoV-2 \u548c ZIKV \u5206\u522b\u5728\u5c0f\u9f20\u80ba\u548c\u8111\u4e2d\u5f15\u8d77\u7684\u7ec6\u80de\u6b7b\u4ea1\u3002<\/p>\n<p>\u57fa\u65bc\u7c7b\u4f3c\u7684 NAD+\u5931\u8c03\u5728 ZIKV \u548c SARS-CoV-2 \u611f\u67d3\u7684\u5c0f\u9f20\u6a21\u578b\u4e2d\uff0cNAD +\u6cbb\u7597\u7ec6\u80de\u6b7b\u4ea1\u7684\u673a\u5236\u53ef\u80fd\u76f8\u4f3c\u3002\u7531\u4e0a\u8c03\u7684 PARPs \u8bf1\u5bfc\u7684NAD +\u7f3a\u4e4f\u4f1a\u5f71\u54cd\u8bb8\u591a\u76f8\u5173\u4ee3\u8c22\u9014\u5f84\u7684\u529f\u80fd\uff0c\u4f8b\u5982\u6c27\u5316\u78f7\u9178\u5316\u4e36TCA 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src=\"https:\/\/img.shoplineapp.com\/media\/image_clips\/628224dc07ee918905164846\/original.png?1652696284\" \/><\/p>\n<p>\u56fe\u6ce8\uff1a\u8865\u5145NMN\u540e\u4e0eNAD<sup>+<\/sup>\u76f8\u5173\u4ee3\u8c22\u7269\u7684\u53d8\u5316<\/p>\n<p>\u968f\u7740\u5b9e\u9a8c\u6210\u679c\u7684\u51fa\u793a\uff0c\u8be5\u7814\u7a76\u56e2\u961f\u8868\u793a\u5f3a\u70c8\u652f\u6301\u542f\u52a8\u4e00\u9879\u6cbb\u7597 COVID-19 \u60a3\u8005 NAD 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decoding=\"async\" src=\"https:\/\/img.shoplineapp.com\/media\/image_clips\/628225d9c19b4943e2c647f9\/original.png?1652696537\" \/><\/p>\n<p>[4] Dreis, M. (2021, September 30). What Is Heart Failure\uff1f. GoodRx Health. 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