{"id":195,"date":"2022-02-26T16:58:04","date_gmt":"2022-02-26T16:58:04","guid":{"rendered":"http:\/\/choosebiz.me\/?p=195"},"modified":"2023-04-08T03:27:18","modified_gmt":"2023-04-08T03:27:18","slug":"%e7%a0%94%e7%a9%b6%e8%a1%a8%e6%98%8e-nmn-%e5%8f%af%e5%a2%9e%e5%bc%ba%e9%a2%84%e9%98%b2%e7%99%8c%e7%97%87%e7%9a%84%e5%85%8d%e7%96%ab%e7%bb%86%e8%83%9e%e6%bf%80%e6%b4%bb","status":"publish","type":"post","link":"http:\/\/johnhealth.blog\/ch\/?p=195","title":{"rendered":"\u7814\u7a76\u8868\u660e NMN \u53ef\u589e\u5f3a\u9884\u9632\u764c\u75c7\u7684\u514d\u75ab\u7ec6\u80de\u6fc0\u6d3b"},"content":{"rendered":"<p>\u901a\u8fc7\u76ae\u4e0b\u6ce8\u5c04\u6216\u53e3\u670d\u670d\u7528 NMN \u53ef\u4ee5\u6539\u5584\u5c0f\u9f20\u4f53\u5185\u653b\u51fb\u764c\u75c7\u548c\u75c5\u6bd2\u611f\u67d3\u7ec6\u80de\u7684\u514d\u75ab\u7ec6\u80de\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-17489\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/02\/immune.jpg\" alt=\"\" width=\"1114\" height=\"650\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/02\/immune.jpg 1114w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/02\/immune-300x175.jpg 300w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/02\/immune-1024x597.jpg 1024w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/02\/immune-768x448.jpg 768w\" sizes=\"auto, (max-width: 1114px) 100vw, 1114px\" \/><\/p>\n<p>\u91cd\u5927\u4eae\u70b9<\/p>\n<ul>\n<li>\u00a0NMN \u5728\u4e0d\u589e\u52a0\u514d\u75ab\u7ec6\u80de\u6570\u91cf\u7684\u60c5\u51b5\u4e0b\u589e\u52a0\u81ea\u7136\u6740\u624b\u7ec6\u80de\u7834\u574f\u764c\u7ec6\u80de\u7684\u80fd\u529b\uff08\u7ec6\u80de\u6bd2\u6027\uff09\u3002<\/li>\n<li>\u00a0\u8be5\u7814\u7a76\u652f\u6301\u670d\u7528 NMN \u53ef\u80fd\u662f\u6062\u590d\u81ea\u7136\u6740\u624b\u514d\u75ab\u7ec6\u80de\u6fc0\u6d3b\u4ee5\u5728\u8870\u8001\u8fc7\u7a0b\u4e2d\u4fdd\u6301\u7ec4\u7ec7\u5065\u5eb7\u7684\u4e00\u79cd\u65b9\u5f0f\u3002<\/li>\n<\/ul>\n<p><!--more--><\/p>\n<p>\u968f\u7740\u4eba\u7c7b\u5e73\u5747\u5bff\u547d\u7684\u5ef6\u957f\uff0c\u4eba\u4eec\u7684\u5065\u5eb7\u72b6\u51b5\u4e0d\u4f73\u548c\u4e0e\u5e74\u9f84\u6709\u5173\u7684\u75be\u75c5\u7684\u65f6\u95f4\u66f4\u957f\uff0c\u4ece\u800c\u5bfc\u81f4\u91cd\u5927\u7684\u7ecf\u6d4e\u548c\u793e\u4f1a\u6210\u672c\u3002 \u5bfc\u81f4\u5e74\u9f84\u76f8\u5173\u75be\u75c5\u53ca\u5176\u8fdb\u5c55\u7684\u4e00\u4e2a\u91cd\u8981\u56e0\u7d20\u662f\u514d\u75ab\u529f\u80fd\u4e0b\u964d\u3002 \u5177\u4f53\u6765\u8bf4\uff0c\u7ec8\u6b62\u764c\u75c7\u548c\u75c5\u6bd2\u611f\u67d3\u7ec6\u80de\u7684 \u81ea\u7136\u6740\u624b\u7ec6\u80de(\u4ee5\u4e0b\u7b80\u79f0NK \u7ec6\u80de)\u53d8\u5f97\u4e0d\u90a3\u9ebd\u6709\u6548\u3002 \u76ee\u524d\uff0c\u5c1a\u65e0\u8865\u6551\u63aa\u65bd\u53ef\u4ee5\u5728\u8870\u8001\u8fc7\u7a0b\u4e2d\u6062\u590d NK \u7ec6\u80de\u7684\u529f\u80fd\u3002 \u56e0\u6b64\uff0c\u523a\u6fc0 NK \u7ec6\u80de\u6d3b\u5316\u7684\u5316\u5408\u7269\u53ef\u4ee5\u9884\u9632\u4e0e\u5e74\u9f84\u76f8\u5173\u7684\u75be\u75c5\u6216\u51cf\u7f13\u5176\u8fdb\u5c55\u3002<\/p>\n<p>\u65e5\u672c\u987a\u5929\u5802\u5927\u5b66\u7684 Okumura \u53ca\u5176\u540c\u4e8b\u7528<strong><span style=\"color: #ff0000;\">\u70df\u9170\u80fa\u5355\u6838\u82f7\u9178 (NMN) \u6cbb\u7597\u5c0f\u9f20\uff0c\u4ee5\u6062\u590d NK \u7ec6\u80de\u7684\u7ec6\u80de\u6bd2\u6027\u2014\u2014\u7834\u574f\u6545\u969c\u7ec6\u80de\u7684\u80fd\u529b<\/span><\/strong>\u3002 \u53d1\u8868\u5728\u5b66\u672f\u671f\u520a\u300a\u751f\u7269\u533b\u5b66\u7814\u7a76\u300b( Biomedical Research) \u4e0a\uff0c\u5f53\u6ce8\u5c04\u00a0NMN\uff08313\u4e36625 \u6216 1250 mg\/kg\uff09\u6216\u53e3\u670dNMN\uff08625 mg\/kg\uff09\u56db\u5929\u65f6\uff0c\u5c0f\u9f20\u4f53\u5185 NK \u7ec6\u80de\u4ea7\u751f\u523a\u6fc0\u3002 \u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u589e\u5f3a\u7684 NK \u7ec6\u80de\u7684\u7ec6\u80de\u6bd2\u6027\u5e76\u975e\u6765\u81ea\u5b83\u4eec\u589e\u5f3a\u7684\u589e\u6b96\u6216\u66f4\u9ad8\u7684 NK \u7ec6\u80de\u6570\u91cf\uff0c\u800c\u662f\u63d0\u9ad8\u4e86 NK \u7ec6\u80de\u6467\u6bc1\u764c\u7ec6\u80de\u7684\u80fd\u529b\u3002 \u8fd9\u4e9b\u53d1\u73b0\u652f\u6301\u8865\u5145 NMN \u53ef\u4ee5\u901a\u8fc7\u51cf\u5c11\u968f\u7740\u5e74\u9f84\u589e\u957f\u800c\u51cf\u5c11\u764c\u524d\u7ec6\u80de\u548c\u75c5\u6bd2\u611f\u67d3\u7ec6\u80de\u7684\u79ef\u7d2f\uff0c\u4ece\u800c\u63d0\u9ad8 NK \u7ec6\u80de\u514d\u75ab\u529b\u548c\u6574\u4f53\u7ec4\u7ec7\u5065\u5eb7\u3002<\/p>\n<h3><strong>NAD+ \u6c34\u5e73\u548c\u514d\u75ab\u529f\u80fd\u968f\u7740\u5e74\u9f84\u7684\u589e\u957f\u800c\u4e0b\u964d<\/strong><\/h3>\n<p>\u514d\u75ab\u529b\u7684\u5f88\u591a\u65b9\u9762\u90fd\u4f1a\u968f\u7740\u5e74\u9f84\u7684\u589e\u957f\u800c\u4e0b\u964d\uff0cNK\u514d\u75ab\u7ec6\u80de\u529f\u80fd\u4e5f\u4e0d\u4f8b\u5916\u3002 \u968f\u7740\u5e74\u9f84\u7684\u589e\u957f\uff0c\u4e0e\u5e74\u9f84\u76f8\u5173\u7684\u514d\u75ab\u529f\u80fd\u9000\u5316\u4e0e\u4e00\u79cd\u79f0\u4e3a\u70df\u9170\u80fa\u817a\u560c\u5464\u4e8c\u6838\u82f7\u9178 (NAD+) \u7684\u57fa\u672c\u5206\u5b50\u7684\u6c34\u5e73\u6709\u5173\uff0c\u8be5\u5206\u5b50\u4e5f\u968f\u7740\u5e74\u9f84\u7684\u589e\u957f\u800c\u4e0b\u964d\u3002 \u7136\u800c\uff0c\u63d0\u9ad8 NAD+ \u6c34\u5e73\u5df2\u88ab\u8bc1\u660e\u53ef\u4ee5\u6539\u5584\u5c0f\u9f20\u7684\u514d\u75ab\u529f\u80fd\u3002 \u4f8b\u5982\uff0c\u7814\u7a76\u8868\u660e\uff0c\u901a\u8fc7\u6291\u5236 NAD+ \u6d88\u8017\u9176\u6765\u63d0\u9ad8 NAD+ \u6c34\u5e73\u53ef\u4ee5\u63d0\u9ad8\u514d\u75ab\u529b\uff0c\u4ece\u800c\u51cf\u8f7b\u5c0f\u9f20\u7684\u80bf\u7624\u3002<\/p>\n<p>NAD+ \u7684\u76f4\u63a5\u524d\u4f53 NMN \u6709\u52a9\u65bc\u6539\u5584\u4e0e\u5e74\u9f84\u76f8\u5173\u7684\u75be\u75c5\uff0c\u5982\u80f0\u5c9b\u7d20\u4e0d\u654f\u611f\u548c\u4ee3\u8c22\u969c\u788d\uff0c\u5982\u8001\u5e74\u5c0f\u9f20\u7684\u80a5\u80d6\u75c7\u3002 \u6b64\u5916\uff0c\u7531\u65bc\u63d0\u9ad8 NAD+ \u6c34\u5e73\u5df2\u88ab\u8bc1\u660e\u53ef\u4ee5\u5bf9\u6297\u5c0f\u9f20\u7684\u80bf\u7624\uff0c\u56e0\u6b64\u5b83\u4e5f\u53ef\u80fd\u589e\u5f3a\u6297\u80bf\u7624 NK \u7ec6\u80de\u7684\u6d3b\u6027\u3002 \u5398\u6e05 NMN \u662f\u5426\u5728 NK \u7ec6\u80de\u4e2d\u5177\u6709\u8fd9\u4e9b\u514d\u75ab\u6062\u590d\u4f5c\u7528\u5bf9\u65bc\u786e\u5b9a\u5b83\u662f\u5426\u662f\u6211\u4eec\u4e00\u76f4\u5728\u5bfb\u627e\u6062\u590d\u5176\u7ec6\u80de\u6bd2\u6027\u7684\u5316\u5408\u7269\u81f3\u5173\u91cd\u8981\u3002<\/p>\n<div class=\"s-img-wrapper\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-17490\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/02\/693844_826909.webp\" alt=\"\" width=\"759\" height=\"514\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/02\/693844_826909.webp 759w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/02\/693844_826909-300x203.webp 300w\" sizes=\"auto, (max-width: 759px) 100vw, 759px\" \/><\/div>\n<p>(<a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2017.01124\/full\" target=\"_blank\" rel=\"noopener\">Paul &amp; Lal, 2017 |\u00a0Frontiers in Immunology<\/a>)\u00a0\u81ea\u7136\u6740\u624b\u514d\u75ab\u7ec6\u80de (NK\u7ec6\u80de)\u00a0\u9488\u5bf9\u764c\u75c7\u548c\u75c5\u6bd2\u611f\u67d3\u7684\u7ec6\u80de\u7684\u7ec6\u80de\u6bd2\u6027\u53cd\u5e94\u3002\u00a0\u5728\u7b2c\u4e00\u6b65 (A) \u4e2d\uff0cNK \u7ec6\u80de\u8bc6\u522b\u76ee\u6807\u7ec6\u80de\u5e76\u5411\u5176\u805a\u96c6\u3002 \u5728\u7b2c\u4e8c\u6b65 (B) \u4e2d\uff0c\u7ec6\u80de\u91cd\u7ec4\u5176\u5185\u90e8\u7ed3\u6784\u4ee5\u671d\u5411\u76ee\u6807\u7ec6\u80de\u3002 \u7b2c\u4e09\u6b65 (C) \u5305\u62ec NK \u7ec6\u80de\u5bf9\u63a5\u5e76\u9760\u8fd1\u76ee\u6807\u764c\u7ec6\u80de\u3002 \u7b2c\u56db\u6b65\u4e5f\u662f\u6700\u5f8c\u4e00\u6b65 (D) \u9700\u8981 NK \u7ec6\u80de\u7834\u574f\u76ee\u6807\u764c\u7ec6\u80de\uff0c\u4f7f\u5176\u7206\u88c2\u3002<\/p>\n<h3><strong>\u6ce8\u5c04 NMN \u589e\u5f3a\u5c0f\u9f20\u514d\u75ab\u7ec6\u80de\u6d3b\u6027<\/strong><\/h3>\n<p>\u4e3a\u4e86\u5206\u6790 NMN \u5bf9 NK \u7ec6\u80de\u7684\u5f71\u54cd\uff0cTakeda \u548c Okumura \u7ed9\u4e0d\u540c\u5e74\u9f84\u7684\u5c0f\u9f20\u6ce8\u5c04\u4e86 NMN\uff0c\u5e76\u8bc4\u4f30\u4e86 NK \u7ec6\u80de\u7684\u6d3b\u5316\u548c\u7ec6\u80de\u6bd2\u6027\u3002 \u7814\u7a76\u4e8c\u4eba\u7ec4\u5c06\u4e0d\u540c\u5242\u91cf\u7684 1250\u4e36625\u4e36313 \u6216 125 mg\/kg\/\u5929\u7684 NMN \u6ce8\u5c04\u5230 36 \u5468\u5927\u7684\u5c0f\u9f20\u4f53\u5185\u56db\u5929\uff0c\u7136\u5f8c\u4ece\u809d\u810f\u548c\u813e\u810f\u4e2d\u6536\u96c6 NK \u7ec6\u80de\u3002 \u7136\u5f8c\u5c06\u8fd9\u4e9b NK \u7ec6\u80de\u653e\u5165\u88c5\u6709\u4e0d\u540c\u6bd4\u4f8b\u764c\u7ec6\u80de\u7684\u57f9\u517b\u76bf\u4e2d\uff0c\u5e76\u6839\u636e\u88ab\u7834\u574f\u7684\u764c\u7ec6\u80de\u7684\u767e\u5206\u6bd4\u5206\u6790\u7ec6\u80de\u6bd2\u6027\u3002 \u8fd9\u4e9b\u53d1\u73b0\u8868\u660e\uff0c\u6ce8\u5c04 313 mg\/kg \u6216\u66f4\u591a\u7684 NMN \u53ef\u589e\u5f3a\u8870\u8001 NK \u7ec6\u80de\u7834\u574f\u5c0f\u9f20\u529f\u80fd\u5931\u8c03\u7ec6\u80de\u7684\u80fd\u529b\u3002<\/p>\n<div class=\"s-img-wrapper\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-17491\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/02\/470044_43353.webp\" alt=\"\" width=\"521\" height=\"301\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/02\/470044_43353.webp 521w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/02\/470044_43353-300x173.webp 300w\" sizes=\"auto, (max-width: 521px) 100vw, 521px\" \/><\/div>\n<p>(<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34544993\/\" target=\"_blank\" rel=\"noopener\">Takeda &amp; Okumura, 2021 |\u00a0Biomedical Research<\/a>)\u00a0NMN \u6ce8\u5c04\uff08313 mg\/kg\/\u5929\u6216\u66f4\u9ad8\uff09\u663e\u7740\u589e\u5f3a\u4e86 36 \u5468\u9f84\u5c0f\u9f20\u7684 NK \u7ec6\u80de\u6bd2\u6027\u3002\u00a0\u6548\u5e94\/\u9776\u6807\u6bd4\u7387\u4ee3\u8868 NK \u7ec6\u80de\u4e0e\u764c\u7ec6\u80de\u7684\u6bd4\u4f8b\u3002 \u7ec6\u80de\u6bd2\u6027\u767e\u5206\u6bd4\u2014\u2014\u88ab\u5206\u6790\u7684\u764c\u7ec6\u80de\u4e2d\u88ab\u7834\u574f\u7684\u764c\u7ec6\u80de\u7684\u767e\u5206\u6bd4\u2014\u2014\u968f\u4e0d\u540c\u7684\u6548\u5e94\u7269\/\u9776\u6807\u6bd4\u7387\u800c\u53d8\u5316\u3002 10 \u548c 5 \u7684\u6548\u5e94\u7269\/\u9776\u6807\u6bd4\u7387\u8868\u660e NMN \u5728\u809d\u810f\u4e2d\u7684\u7ec6\u80de\u6bd2\u6027\u663e\u7740\u589e\u5f3a\uff0c\u800c 100 \u7684\u6548\u5e94\u7269\/\u9776\u6807\u6bd4\u7387\u5bf9\u65bc NMN \u5728\u813e\u810f\u4e2d\u7684\u529f\u6548\u662f\u6700\u4f73\u7684\u3002 \u5012\u7f6e\u7684\u5b9e\u5fc3\u4e09\u89d2\u5f62\u8868\u793a 125 mg\/kg\/\u5929\u7684\u5242\u91cf\uff0c\u76f4\u7acb\u7684\u548c\u5b9e\u5fc3\u4e09\u89d2\u5f62\u8868\u793a 313 mg\/kg\/\u5929\u7684\u5242\u91cf\uff0c\u5b9e\u5fc3\u65b9\u5757\u8868\u793a 625 mg\/kg\/\u5929\u7684\u5242\u91cf\uff0c\u5b9e\u5fc3\u5706\u5708\u8868\u793a 1250 mg\/kg \/\u5929\u5242\u91cf\u503c\u3002 \u8fd9\u4e9b\u7ed3\u679c\u8868\u660e\uff0cNMN \u6709\u76ca\u7684\u7ec6\u80de\u6bd2\u6027\u4fc3\u8fdb\u76ca\u5904\u5177\u6709\u7ec4\u7ec7\u7279\u5f02\u6027\u4f5c\u7528\uff0c\u53ef\u6839\u636e\u7ec4\u7ec7\u7c7b\u578b\u5728\u4e0d\u540c\u7684\u6548\u5e94\u5b50\/\u9776\u7ec6\u80de\u6bd4\u7387\u4e0b\u8fdb\u884c\u4f18\u5316\u3002<\/p>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"s-component-content s-font-body\">\n<h3><strong>\u53e3\u670d NMN \u7ed9\u836f\u53ef\u6539\u5584\u5c0f\u9f20\u514d\u75ab\u7ec6\u80de\u529f\u80fd<\/strong><\/h3>\n<p>\u4f7f\u7528\u76f8\u540c\u7684\u7ec6\u80de\u6bd2\u6027\u6d4b\u91cf\u65b9\u6cd5\uff0c\u7814\u7a76\u5c0f\u7ec4\u968f\u5f8c\u8bd5\u56fe\u786e\u5b9a\u53e3\u670d NMN \u662f\u5426\u6709\u7c7b\u4f3c\u7684\u597d\u5904\u3002 \u5728\u6b66\u7530\u548c\u5965\u6751\u7528\u65bc\u5206\u6790\u7684 32 \u5468\u9f84\u5c0f\u9f20\u4e2d\uff0c625 mg\/kg \u7684\u53e3\u670d\u8865\u5145 NMN \u663e\u7740\u589e\u5f3a\u4e86 NK \u7ec6\u80de\u7684\u7ec6\u80de\u6bd2\u6027\u3002 \u6ce8\u5c04\u6216\u53e3\u670d NMN \u90fd\u4e0d\u4f1a\u589e\u52a0 NK \u7ec6\u80de\u6570\u91cf\u3002 \u8fd9\u4e00\u7ed3\u679c\u5f3a\u70c8\u652f\u6301\u8865\u5145 NMN \u53ef\u6539\u5584\u5c0f\u9f20\u7684\u6574\u4f53 NK \u7ec6\u80de\u7ec6\u80de\u6bd2\u6027\uff0c\u56e0\u4e3a NK \u7ec6\u80de\u663e\u793a\u51fa\u6539\u5584\u7684\u4e36\u6709\u6548\u7684\u764c\u7ec6\u80de\u7834\u574f\u80fd\u529b\uff0c\u800c\u4e0d\u4f1a\u53d8\u5f97\u66f4\u52a0\u4e30\u5bcc\u3002<\/p>\n<div class=\"s-img-wrapper\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-17492\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/02\/112106_569306.webp\" alt=\"\" width=\"402\" height=\"403\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/02\/112106_569306.webp 402w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/02\/112106_569306-300x300.webp 300w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/02\/112106_569306-150x150.webp 150w\" sizes=\"auto, (max-width: 402px) 100vw, 402px\" \/><\/div>\n<p>(<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34544993\/\" target=\"_blank\" rel=\"noopener\">Takeda &amp; Okumura, 2021 |\u00a0Biomedical Research)<\/a>\u00a0625 mg\/kg\/\u5929\u5242\u91cf\u7684\u53e3\u670d NMN \u8865\u5145\u5242\u53ef\u589e\u5f3a\u813e\u810f\u548c\u809d\u810f\u7684\u7ec6\u80de\u6bd2\u6027\u3002 \u6700\u4f73\u6548\u5e94\u5668\/\u9776\u6807\u6bd4\u7387\u2014\u2014NK \u7ec6\u80de\u4e0e\u764c\u7ec6\u80de\u7684\u6bd4\u4f8b\u2014\u2014\u809d\u810f\u4e3a 5\u4e3610 \u548c 20\uff0c\u813e\u810f\u4e3a 200\u3002 \u5728\u8fd9\u4e9b\u6bd4\u7387\u4e0b\uff0c\u88ab\u7834\u574f\u7684\u764c\u7ec6\u80de\u7684\u767e\u5206\u6bd4\uff0c\u7ec6\u80de\u6bd2\u6027\u767e\u5206\u6bd4\uff0c\u5728 625 mg\/kg\/\u5929\u7684\u5242\u91cf\u4e0b\u663e\u7740\u589e\u52a0\uff08\u56fe\u4e2d\u7684\u5b9e\u5fc3\u65b9\u5757\uff09\u3002 \u8fd9\u4e9b\u53d1\u73b0\u8868\u660e\uff0c\u53e3\u670d\u548c\u6ce8\u5c04 NMN \u53ef\u4ee5\u63d0\u9ad8\u4e24\u79cd\u4e0d\u540c\u54c1\u79cd\u7684\u5c0f\u9f20\u7684 NK \u7ec6\u80de\u6bd2\u6027\u3002<\/p>\n<p>Okumura \u53ca\u5176\u540c\u4e8b\u5728\u4ed6\u4eec\u7684\u5b66\u672f\u8bba\u6587\u4e2d\u8bf4\uff1a\u201c\u6211\u4eec\u5728\u672c\u6587\u4e2d\u8bc1\u660e\uff0c\u8179\u819c\u5185\u6ce8\u5c04\u6216\u53e3\u670d NMN\u53ef\u589e\u5f3a NK \u7ec6\u80de\u7684\u7ec6\u80de\u6bd2\u6027\u3002\u201d<\/p>\n<p>\u7814\u7a76\u7ee7\u7eed\u8868\u660e\uff0c\u5728\u80f0\u5c9b\u7d20\u654f\u611f\u6027\u964d\u4f4e\u4e36\u8dd1\u6b65\u8010\u529b\u548c\u808c\u8089\u529f\u80fd\u8001\u5316\u7b49\u6761\u4ef6\u4e0b\uff0cNMN \u7684\u5065\u5eb7\u76ca\u5904\u4ece\u5c0f\u9f20\u5230\u4eba\u7c7b\u7684\u53ef\u8f6c\u5316\u6027\u662f\u5f88\u9ad8\u7684\u3002 \u56e0\u6b64\uff0c\u5c3d\u7ba1\u8fd9\u4e9b\u7ed3\u679c\u5982\u4f55\u4ee5\u53ca\u662f\u5426\u9002\u7528\u65bc\u4eba\u7c7b\u4ecd\u7136\u60ac\u800c\u672a\u51b3\uff0c\u4f46\u8be5\u7814\u7a76\u4e3a NMN \u901a\u8fc7\u6539\u5584 NK \u7ec6\u80de\u7684\u7ec6\u80de\u6bd2\u6027\u63d0\u9ad8\u8001\u5e74\u4eba\u514d\u75ab\u529b\u7684\u8bf1\u4eba\u524d\u666f\u5e26\u6765\u4e86\u5e0c\u671b\u3002<\/p>\n<p>\u4e00\u4e9b\u7814\u7a76\u5c40\u9650\u6027\u5305\u62ec NMN \u5728 NK \u7ec6\u80de\u4e0e\u764c\u7ec6\u80de\u7684\u4e0d\u540c\u6bd4\u4f8b\u4e0b\u4ee5\u6700\u4f73\u65b9\u5f0f\u589e\u5f3a NK \u7ec6\u80de\u7684\u7ec6\u80de\u6bd2\u6027\uff0c\u4f46\u5e76\u672a\u63a2\u8ba8\u8fd9\u4e00\u53d1\u73b0\u7684\u610f\u4e49\u3002 \u4f8b\u5982\uff0c\u53e3\u670d NK \u7ec6\u80de\u4e0e\u764c\u7ec6\u80de\u7684\u6700\u4f73\u6bd4\u4f8b\u5728\u809d\u810f\u4e2d\u4e3a 10 \u5230 20\uff0c\u800c\u5728\u813e\u4e2d\u4e3a 200\u3002 \u8fd9\u4e00\u53d1\u73b0\u7684\u786e\u5207\u542b\u4e49\u4ecd\u7136\u4e0d\u786e\u5b9a\u3002<\/p>\n<p>\u53e6\u4e00\u4e2a\u9650\u5236\u662f\u7ec6\u80de\u6bd2\u6027\u5206\u6790\u662f\u5728\u5b9e\u9a8c\u5ba4\u57f9\u517b\u76bf\u4e2d\u5b8c\u6210\u7684\uff0c\u5e76\u4e0d\u603b\u662f\u8f6c\u5316\u4e3a\u6d3b\u7ec4\u7ec7\u3002 \u672a\u6765\u7684\u5b9e\u9a8c\u53ef\u4ee5\u5229\u7528\u6d3b\u4f53\u52a8\u7269\u7ec4\u7ec7\u4e2d\u7684\u7ec6\u80de\u6bd2\u6027\u6d4b\u91cf\u6765\u8fdb\u4e00\u6b65\u652f\u6301 NMN \u589e\u5f3a NK \u7ec6\u80de\u7684\u7ec6\u80de\u6bd2\u6027\u3002<\/p>\n<p>\u53c2\u8003\u6587\u732e:<\/p>\n<p>Takeda K, Okumura K. Nicotinamide mononucleotide augments the cytotoxic activity of natural killer cells in young and elderly mice. Biomed Res. 2021;42(5):173-179. doi: 10.2220\/biomedres.42.173. PMID: 34544993.<\/p>\n<p>\u6587\u7ae0\u6765\u6e90:<\/p>\n<p>https:\/\/www.nmn.com\/news\/study-shows-nmn-enhances-cancer-preventing-immune-cell-activation<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"pvc_clear\"><\/div>\n<p id=\"pvc_stats_195\" class=\"pvc_stats all  \" data-element-id=\"195\" style=\"\"><i class=\"pvc-stats-icon medium\" aria-hidden=\"true\"><svg aria-hidden=\"true\" focusable=\"false\" data-prefix=\"far\" data-icon=\"chart-bar\" role=\"img\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\" class=\"svg-inline--fa fa-chart-bar fa-w-16 fa-2x\"><path fill=\"currentColor\" d=\"M396.8 352h22.4c6.4 0 12.8-6.4 12.8-12.8V108.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v230.4c0 6.4 6.4 12.8 12.8 12.8zm-192 0h22.4c6.4 0 12.8-6.4 12.8-12.8V140.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v198.4c0 6.4 6.4 12.8 12.8 12.8zm96 0h22.4c6.4 0 12.8-6.4 12.8-12.8V204.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v134.4c0 6.4 6.4 12.8 12.8 12.8zM496 400H48V80c0-8.84-7.16-16-16-16H16C7.16 64 0 71.16 0 80v336c0 17.67 14.33 32 32 32h464c8.84 0 16-7.16 16-16v-16c0-8.84-7.16-16-16-16zm-387.2-48h22.4c6.4 0 12.8-6.4 12.8-12.8v-70.4c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v70.4c0 6.4 6.4 12.8 12.8 12.8z\" class=\"\"><\/path><\/svg><\/i> <img loading=\"lazy\" decoding=\"async\" width=\"16\" height=\"16\" alt=\"Loading\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/plugins\/page-views-count\/ajax-loader-2x.gif\" border=0 \/><\/p>\n<div class=\"pvc_clear\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u901a\u8fc7\u76ae\u4e0b\u6ce8\u5c04\u6216\u53e3\u670d\u670d\u7528 NMN \u53ef\u4ee5\u6539\u5584\u5c0f\u9f20\u4f53\u5185\u653b\u51fb\u764c\u75c7\u548c\u75c5\u6bd2\u611f\u67d3\u7ec6\u80de\u7684\u514d\u75ab\u7ec6\u80de\u3002 \u91cd\u5927\u4eae\u70b9 \u00a0NMN \u5728\u4e0d\u589e\u52a0\u514d\u75ab\u7ec6\u80de\u6570\u91cf\u7684\u60c5\u51b5\u4e0b\u589e\u52a0\u81ea\u7136\u6740\u624b\u7ec6\u80de\u7834\u574f\u764c\u7ec6\u80de\u7684\u80fd\u529b\uff08\u7ec6\u80de\u6bd2\u6027\uff09\u3002 \u00a0\u8be5\u7814\u7a76\u652f\u6301\u670d\u7528 NMN \u53ef\u80fd\u662f\u6062\u590d\u81ea\u7136\u6740\u624b\u514d\u75ab\u7ec6\u80de\u6fc0\u6d3b\u4ee5\u5728\u8870\u8001\u8fc7\u7a0b\u4e2d\u4fdd\u6301\u7ec4\u7ec7\u5065\u5eb7\u7684\u4e00\u79cd\u65b9\u5f0f\u3002<\/p>\n<div class=\"pvc_clear\"><\/div>\n<p id=\"pvc_stats_195\" class=\"pvc_stats all  \" data-element-id=\"195\" style=\"\"><i class=\"pvc-stats-icon medium\" aria-hidden=\"true\"><svg aria-hidden=\"true\" focusable=\"false\" data-prefix=\"far\" data-icon=\"chart-bar\" role=\"img\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\" class=\"svg-inline--fa fa-chart-bar fa-w-16 fa-2x\"><path fill=\"currentColor\" d=\"M396.8 352h22.4c6.4 0 12.8-6.4 12.8-12.8V108.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v230.4c0 6.4 6.4 12.8 12.8 12.8zm-192 0h22.4c6.4 0 12.8-6.4 12.8-12.8V140.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v198.4c0 6.4 6.4 12.8 12.8 12.8zm96 0h22.4c6.4 0 12.8-6.4 12.8-12.8V204.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v134.4c0 6.4 6.4 12.8 12.8 12.8zM496 400H48V80c0-8.84-7.16-16-16-16H16C7.16 64 0 71.16 0 80v336c0 17.67 14.33 32 32 32h464c8.84 0 16-7.16 16-16v-16c0-8.84-7.16-16-16-16zm-387.2-48h22.4c6.4 0 12.8-6.4 12.8-12.8v-70.4c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v70.4c0 6.4 6.4 12.8 12.8 12.8z\" class=\"\"><\/path><\/svg><\/i> <img loading=\"lazy\" decoding=\"async\" width=\"16\" height=\"16\" alt=\"Loading\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/plugins\/page-views-count\/ajax-loader-2x.gif\" border=0 \/><\/p>\n<div class=\"pvc_clear\"><\/div>\n","protected":false},"author":1,"featured_media":17490,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[172,272],"tags":[171,316,12,278],"class_list":["post-195","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-nmn-","category-272","tag-nmn","tag-316","tag-12","tag-278"],"aioseo_notices":[],"_links":{"self":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts\/195","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=195"}],"version-history":[{"count":4,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts\/195\/revisions"}],"predecessor-version":[{"id":17585,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts\/195\/revisions\/17585"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/media\/17490"}],"wp:attachment":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=195"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=195"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=195"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}