{"id":19426,"date":"2022-11-24T04:06:46","date_gmt":"2022-11-24T04:06:46","guid":{"rendered":"http:\/\/johnhealth.blog\/ch\/?p=19426"},"modified":"2022-11-24T04:07:37","modified_gmt":"2022-11-24T04:07:37","slug":"%e3%80%90%e7%a7%91%e6%8a%80%e6%96%87%e7%8c%ae%e3%80%91%e6%a0%b9%e6%8d%ae%e4%b8%ad%e5%9b%bd%e7%a0%94%e7%a9%b6%ef%bc%8cnmn%e5%8f%af%e6%8a%91%e5%88%b6covid-19%e6%84%9f%e6%9f%93","status":"publish","type":"post","link":"http:\/\/johnhealth.blog\/ch\/?p=19426","title":{"rendered":"\u3010\u79d1\u6280\u6587\u732e\u3011\u6839\u636e\u4e2d\u56fd\u7814\u7a76\uff0cNMN\u53ef\u6291\u5236COVID-19\u611f\u67d3"},"content":{"rendered":"<p>\u4e0e\u5e74\u9f84\u76f8\u5173\u7684 DNA \u635f\u4f24\u4fc3\u8fdb SARS-CoV-2 \u75c5\u6bd2\u8fdb\u5165\u5c0f\u9f20\u80ba\u7ec6\u80de\uff0c\u4f46 NMN \u53ef\u9632\u6b62\u8fd9\u79cd\u611f\u67d3\u3002<\/p>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-image\">\n<div class=\"s-component-content\">\n<div class=\"s-img-wrapper\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-19427\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/11\/694538_78274.webp\" alt=\"\" width=\"745\" height=\"462\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/11\/694538_78274.webp 745w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/11\/694538_78274-300x186.webp 300w\" sizes=\"auto, (max-width: 745px) 100vw, 745px\" \/><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p class=\"author\">By\u00a0Brett J. Weiss<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p class=\"date main-color-g\">Published:\u00a02:42 p.m. PST Nov 3, 2022\u00a0| Updated:\u00a04:19 p.m. PST Nov 8, 2022<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p><em><strong>\u91cd\u5927\u4eae\u70b9<\/strong><\/em><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<ul>\n<li>SARS-CoV-2 \u75c5\u6bd2\u5728\u63a5\u53d7 DNA \u635f\u4f24\u8bf1\u5bfc\u8f90\u5c04\u4ecb\u5165\u7684\u4eba\u7c7b\u80ba\u7ec6\u80de\u4e2d\u7684\u8fdb\u5165\u7387\u66f4\u9ad8\u3002<\/li>\n<li>\u6291\u5236 DNA \u4fee\u590d\u4f1a\u963b\u788d SARS-CoV-2 \u4e3b\u8981\u53d7\u4f53\uff08ACE2 \u53d7\u4f53\uff09\u5728\u7ec6\u80de\u8868\u9762\u7684\u79ef\u7d2f\uff0c\u8fd9\u8868\u660e DNA \u4fee\u590d\u4e0e\u53d7\u4f53\u4ecb\u5bfc\u7684\u75c5\u6bd2\u8fdb\u5165\u4e4b\u95f4\u5b58\u5728\u8054\u7cfb\u3002<\/li>\n<li>NMN \u5df2\u77e5\u6709\u52a9\u4e8e\u4fee\u590d DNA\uff0c\u53ef\u6291\u5236\u5c0f\u9f20\u7ec6\u80de\u8868\u9762 ACE2 \u53d7\u4f53\u7684\u79ef\u7d2f\u4ee5\u53ca SARS-CoV-2 \u75c5\u6bd2\u8f7d\u91cf\u3002<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<p><!--more--><\/p>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>\u4e0e\u5bfc\u81f4COVID-19\u611f\u67d3\u7684\u75c5\u6bd2SARS-CoV-2\u76f8\u5173\u7684\u4e00\u4e2a\u7279\u6b8a\u73b0\u8c61\u662f\uff0c\u5b83\u5bf9\u8001\u5e74\u4eba\u7684\u5f71\u54cd\u8fdc\u9ad8\u4e8e\u5e74\u8f7b\u4eba\u3002 \u6839\u636e\u75be\u75c5\u63a7\u5236\u4e2d\u5fc3\u7684\u6570\u636e\uff0c<a href=\"https:\/\/www.cdc.gov\/coronavirus\/2019-ncov\/covid-data\/investigations-discovery\/hospitalization-death-by-age.html\" target=\"_blank\" rel=\"noopener\" data-type=\"web\">\u4e0e18-29\u5c81\u7684\u5e74\u8f7b\u4eba\u76f8\u6bd4\uff0c65\u5c81\u4ee5\u4e0a\u7684\u6210\u5e74\u4eba\u7684\u4f4f\u9662\u7387\u9ad8\u51fa5-10\u500d<\/a>\u3002 \u53ef\u80fd\u4f7f\u8001\u5e74\u4eba\u5bb9\u6613\u611f\u67d3COVID-19\u7684\u4e00\u4e2a\u539f\u56e0\u662f<strong><span style=\"color: #ff0000;\">\u8870\u8001\u5bfc\u81f4DNA\u635f\u4f24\u7684\u7d2f\u79ef<\/span><\/strong>\u3002 \u7136\u800c\uff0c\u968f\u7740\u5e74\u9f84\u589e\u957f\u6240\u5e26\u6765\u76f8\u5173\u7684 DNA \u635f\u4f24\u4e0e COVID-19 \u611f\u67d3\u4e4b\u95f4\u7684\u8054\u7cfb\u5c1a\u672a\u786e\u5b9a\u3002<\/p>\n<p><span style=\"font-size: 1rem;\">\u5317\u4eac\u751f\u7269\u6280\u672f\u7814\u7a76\u6240\u7684 Cheng \u548c\u540c\u4e8b\u5728\u5b66\u672f\u671f\u520a\u300a\u8870\u8001\u7ec6\u80de\u300b\uff08Aging Cell\uff09 \u4e0a\u53d1\u8868\u8bba\u6587\uff0c\u4ed6\u4eec\u53d1\u73b0<\/span><a style=\"background-color: #ffffff; font-size: 1rem;\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36254583\/\" target=\"_blank\" rel=\"noopener\" data-type=\"web\">SARS-CoV-2\u75c5\u6bd2\u66f4\u591a\u5730\u8fdb\u5165\u4eba\u7c7b\u80ba\u7ec6\u80de\uff0c\u5e76\u4f34\u6709\u8f90\u5c04\u5f15\u8d77\u7684 DNA \u635f\u4f24<\/a><span style=\"font-size: 1rem;\">\u00a0\u3002 \u6b64\u5916\uff0c\u6291\u5236\u7ec6\u80deDNA \u4fee\u590d\u673a\u5236\u7684 DNA \u635f\u4f24\u53cd\u5e94 \uff08DDR\uff09 \u4f1a\u6291\u5236 SARS-CoV-2 \u7528\u4e8e\u8fdb\u5165\u7ec6\u80de\u7684\u53d7\u4f53\u2014\u2014\u8840\u7ba1\u7d27\u5f20\u7d20\u8f6c\u6362\u9176 2 \uff08ACE2\uff09 \u53d7\u4f53\u7684\u79ef\u7d2f\u3002 \u5728\u996e\u7528\u6c34\u4e2d\u7528 200 mg\/kg\/\u5929\u7684\u70df\u9170\u80fa\u5355\u6838\u82f7\u9178 \uff08NMN\uff09 \u4ecb\u5165\u5c0f\u9f20\u53ef\u4fdd\u7559 DNA\uff0c\u9632\u6b62 ACE2 \u53d7\u4f53\u79ef\u7d2f\uff0c\u5e76\u964d\u4f4e\u611f\u67d3\u540e\u80ba\u90e8\u7684\u75c5\u6bd2\u8f7d\u91cf\u3002 \u8fd9\u4e9b\u53d1\u73b0\u8868\u660e\uff0c\u4e0e\u5e74\u9f84\u76f8\u5173\u7684 DNA \u635f\u4f24\u548c\u7ec6\u80de\u7684 DNA \u4fee\u590d\u673a\u5236\u4f1a\u89e6\u53d1 ACE2 \u53d7\u4f53\u79ef\u7d2f\u548c\u75c5\u6bd2\u611f\u67d3\uff0c\u4f46 NMN \u53ef\u4ee5\u5bf9\u6297\u8fd9\u79cd\u611f\u67d3\u65b9\u5f0f\u3002<\/span><\/p>\n<p><strong><span style=\"font-size: 1rem; color: #ff0000;\">DNA \u635f\u4f24\u8bf1\u5bfc\u75c5\u6bd2\u8fdb\u5165\u4eba\u4f53\u7ec6\u80de<\/span><\/strong><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>&nbsp;<\/p>\n<p>\u4e3a\u4e86\u89e3 DNA \u635f\u4f24\u5982\u4f55\u5f71\u54cd SARS-CoV-2 \u8fdb\u5165\u7ec6\u80de\uff0cCheng \u53ca\u5176\u540c\u4e8b\u4f7f\u7528\u66b4\u9732\u4e8e\u7535\u79bb\u8f90\u5c04\u8bf1\u5bfc\u7684\u00a0DNA \u635f\u4f24\u7684\u4eba\u7c7b\u80ba\u7ec6\u80de\u3002 \u5f53\u80ba\u7ec6\u80de\u66b4\u9732\u4e8e\u8f90\u5c04 7 \u5929\u540e\uff0c\u7ec6\u80de\u5438\u6536\u7684\u75c5\u6bd2\u91cf\u662f\u672a\u66b4\u9732\u4e8e\u8f90\u5c04\u7684\u7ec6\u80de\u7684<span style=\"color: #ff0000;\">\u5927\u7ea6\u516d\u500d<\/span>\u3002 \u6b64\u5916\uff0c\u6291\u5236\u7ec6\u80de\u7684 DNA \u4fee\u590d\u53cd\u5e94\u53ef\u663e\u8457\u51cf\u5c11\u75c5\u6bd2\u8fdb\u5165\u7ec6\u80de\u3002 \u8fd9\u4e9b\u53d1\u73b0\u63d0\u4f9b\u7684\u8bc1\u636e\u8868\u660e\uff0c\u4e0e\u8f90\u5c04\u76f8\u5173\u7684DNA\u635f\u4f24\u4f1a\u89e6\u53d1\u66f4\u591aSARS-CoV-2\u75c5\u6bd2\u8fdb\u5165\u7ec6\u80de\uff0c\u4f46\u6291\u5236DDR\u4f1a\u51cf\u5c11\u75c5\u6bd2\u8fdb\u5165\u7ec6\u80de\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-image\">\n<div class=\"s-component-content\">\n<div class=\"s-img-wrapper\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-19428\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/11\/58039_500134.webp\" alt=\"\" width=\"360\" height=\"273\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/11\/58039_500134.webp 360w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/11\/58039_500134-300x228.webp 300w\" sizes=\"auto, (max-width: 360px) 100vw, 360px\" \/><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36254583\/\" target=\"_blank\" rel=\"noopener\" data-type=\"\">\uff08Jin et al.\uff0c 2022 |<\/a>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36254583\/\" target=\"_blank\" rel=\"noopener\" data-type=\"\"><em>Aging Cell<\/em><\/a><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36254583\/\" target=\"_blank\" rel=\"noopener\" data-type=\"\">\uff09<\/a>\u00a0<strong>\u8f90\u5c04\u9020\u6210\u7684 DNA \u635f\u4f24\u4f7f SARS-CoV-2 \u75c5\u6bd2\u8fdb\u5165\u7ec6\u80de\u7684\u75c5\u6bd2\u91cf\u589e\u52a0\u4e86\u516d\u500d\uff0c\u4f46\u6291\u5236 DNA \u635f\u4f24\u53cd\u5e94\u4f1a\u963b\u788d\u75c5\u6bd2\u8fdb\u5165\u7ec6\u80de<\/strong>\u00a0\u3002 \u901a\u8fc7 DNA \u635f\u4f24\u8bf1\u5bfc\u7535\u79bb\u8f90\u5c04 \uff08+IR\uff09\uff0c\u4e0e\u6ca1\u6709\u8f90\u5c04 \uff08-IR\uff09 \u7684\u7ec6\u80de\u76f8\u6bd4\uff0cSARS-CoV-2 \u75c5\u6bd2\u8fdb\u5165\u663e\u8457\u589e\u52a0\u3002 DDR \u6291\u5236\u5206\u5b50\u5496\u5561\u56e0\u3001KU55933 \u548c VE-822 \u53ef\u6291\u5236 SARS-CoV-2 \u75c5\u6bd2\u8fdb\u5165\u80ba\u7ec6\u80de\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>&nbsp;<\/p>\n<p>Cheng \u548c\u540c\u4e8b\u7e7c\u7e8c\u7814\u7a76\u8f3b\u5c04\u5c0d SARS-CoV-2 \u7528\u65bc\u9032\u5165\u7d30\u80de\u7684\u4e3b\u8981\u53d7\u9ad4\u2014\u2014ACE2 \u53d7\u9ad4\u7684\u5f71\u97ff\u3002 \u4f4d\u65bc\u5317\u4eac\u7684\u7814\u7a76\u5c0f\u7d44\u767c\u73fe\uff0c\u66b4\u9732\u65bc\u96fb\u96e2\u8f3b\u5c04\u6703\u4f7f ACE2 \u53d7\u9ad4\u6c34\u5e73\u589e\u52a0\u516d\u500d\uff0c\u4f46\u6703\u6291\u5236 DDR \u53d7\u640d\u7684 ACE2 \u6703\u7a4d\u805a\u3002 \u9019\u4e9b\u7d50\u679c\u8868\u660e\uff0cDNA \u640d\u50b7\u548c DDR \u6703\u5f15\u767c\u7d30\u80de\u8868\u9762 ACE2 \u7684\u6fc0\u589e\uff0c\u9019\u8207\u75c5\u6bd2\u9032\u5165\u7d30\u80de\u7684\u589e\u52a0\u6709\u95dc\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>NMN \u963b\u6b62\u75c5\u6bd2\u9032\u5165\u53d7\u611f\u67d3\u7684\u5c0f\u9f20\u80ba\u7d30\u80de<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>&nbsp;<\/p>\n<p>\u5728 DNA \u4fee\u5fa9\u4e2d\u767c\u63ee\u4f5c\u7528\u7684\u9176\uff0c\u4f8b\u5982\u53bb\u4e59\u9170\u5316\u9176\u548c\u805a\uff08ADP-\u6838\u7cd6\uff09\u805a\u5408\u9176 (PARP)\uff0c\u9700\u8981\u5fc5\u9700\u7684\u7159\u9170\u80fa\u817a\u560c\u5464\u4e8c\u6838\u82f7\u9178 (NAD+) \u5206\u5b50\u624d\u80fd\u767c\u63ee\u4f5c\u7528\u3002 \u51fa\u65bc\u9019\u500b\u539f\u56e0\uff0cCheng \u548c\u4ed6\u7684\u540c\u4e8b\u7528 NAD+ \u4fc3\u9032\u5291 NMN \u88dc\u5145\u4e86\u66b4\u9732\u65bc SARS-CoV-2 \u75c5\u6bd2\u7684\u8001\u5c0f\u9f20\u3002 \u4ed6\u5011\u767c\u73fe NMN \u4ecb\u5165\u8207\u964d\u4f4e DNA \u640d\u50b7\u548c ACE2 \u53d7\u9ad4\u6c34\u5e73\u4ee5\u53ca\u964d\u4f4e\u80ba\u75c5\u6bd2\u8f09\u91cf\u76f8\u95dc\u3002 \u9019\u4e9b\u7d50\u679c\u8868\u660e\uff0c\u81f3\u5c11\u5728\u5c0f\u9f20\u4e2d\uff0cNMN \u53ef\u80fd\u901a\u904e\u7dad\u6301 DNA \u548c\u963b\u65b7 ACE2 \u53d7\u9ad4\u7684\u7a4d\u7d2f\u4f86\u62b5\u79a6 SARS-CoV-2 \u611f\u67d3\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-image\">\n<div class=\"s-component-content\">\n<div class=\"s-img-wrapper\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-19429\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/11\/25917_521665.webp\" alt=\"\" width=\"437\" height=\"253\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/11\/25917_521665.webp 437w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/11\/25917_521665-300x174.webp 300w\" sizes=\"auto, (max-width: 437px) 100vw, 437px\" \/><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36254583\/\" target=\"_blank\" rel=\"noopener\" data-type=\"\">\uff08Jin et al.\uff0c 2022 |<\/a>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36254583\/\" target=\"_blank\" rel=\"noopener\" data-type=\"\"><em>Aging Cell<\/em><\/a><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36254583\/\" target=\"_blank\" rel=\"noopener\" data-type=\"\">\uff09<\/a>\u00a0<span style=\"color: #ff6600;\"><strong>NMN \u53ef\u9632\u6b62 DNA \u635f\u4f24\u548c ACE2 \u53d7\u4f53\u79ef\u7d2f\uff0c\u540c\u65f6\u51cf\u5c11 SARS-CoV-2 \u611f\u67d3\u5c0f\u9f20\u7684\u75c5\u6bd2\u8f7d\u91cf<\/strong><\/span>\u00a0\u3002 \u5de6\u56fe\u8bf4\u660eNMN \uff08O-NMN\uff09\u5c06ACE2\u53d7\u4f53\u7684\u79ef\u7d2f\u51cf\u5c11\u4e86\u4e00\u534a\uff0c\u51cf\u5c11\u4e86\u6fc0\u6d3bACE2\u53d7\u4f53\u79ef\u7d2f\u7684\u86cb\u767d\u8d28\uff08c-Jun\uff09\uff0c\u5e76\u51cf\u5c11\u4e86\u53d7\u611f\u67d3\u7684\u8870\u8001\u8001\u9f20\u80ba\u7ec6\u80de\u4e2d\u7684DNA\u635f\u4f24\uff08\u03b3H2AX\uff09\u4e0e\u672a\u7ecf\u4ecb\u5165\u7684\u53d7\u611f\u67d3\u5c0f\u9f20\uff08O-PBS\uff09\u76f8\u6bd4\u3002 \u53f3\u56fe\u663e\u793a\u7528 NMN \u4ecb\u5165\u7684\u5c0f\u9f20\u53ef\u51cf\u8f7b\u80ba\u90e8\u7684\u75c5\u6bd2\u8f7d\u91cf\u3002<\/p>\n<p><span style=\"font-size: 1rem;\">NMN \u53ef\u80fd\u4f1a\u4fdd\u7559 DNA \u5e76\u963b\u788d ACE2 \u53d7\u4f53\u7684\u79ef\u7d2f<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-quote-content\">\n<div class=\"quote-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>&nbsp;<\/p>\n<p>\u201c\u5728\u8fd9\u91cc\uff0c\u6211\u4eec\u53d1\u73b0\u9776\u5411 DNA \u635f\u4f24&#8230;&#8230; \u901a\u8fc7 NMN \u7684\u4ecb\u5165\u800c\u589e\u52a0 DNA \u4fee\u590d\u7684\u80fd\u529b\uff0c\u964d\u4f4e\u4e86 ACE2 \u7684\u8868\u8fbe\uff0c\u201cCheng \u53ca\u5176\u540c\u4e8b\u8bf4\u3002 \u201c\u66f4\u91cd\u8981\u7684\u662f,&#8230;&#8230; NMN \u51cf\u5c11\u4e86\u75c5\u6bd2\u8f7d\u91cf\u3002 \u201d<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>\u603b\u4f53\u800c\u8a00\uff0c\u8fd9\u9879\u7814\u7a76\u8868\u660e\uff0cNMN\u53ef\u80fd\u4f1a\u963b\u6b62ACE2\u53d7\u4f53\u5728\u8001\u5e74\u4eba\u7684\u80ba\u3001\u80be\u548c\u80a0\u9053\u4e2d\u7684\u79ef\u7d2f\uff0c\u4ece\u800c\u9632\u6b62SARS-CoV-2\u75c5\u6bd2\u8fc7\u5ea6\u8fdb\u5165\u7ec6\u80de\u3002 \u4ece\u7406\u8bba\u4e0a\u8bb2\uff0c\u8fd9\u79cd NAD+ \u4fc3\u8fdb\u5668\u53ef\u4ee5\u901a\u8fc7\u523a\u6fc0 Sirtuins \u548c PARP \u6765\u7ef4\u6301 DNA\uff0c\u4ece\u800c\u6291\u5236 DDR \u7684\u6fc0\u6d3b\u5e76\u51cf\u5c11 ACE2 \u53d7\u4f53\u7684\u79ef\u7d2f\uff0c\u4ece\u800c\u9632\u6b62 DNA \u635f\u4f24\u7684\u7d2f\u79ef\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-separator\">\n<div class=\"s-separator-content\">\n<div class=\"separator\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>\u53c2\u8003\u6587\u732e<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>Jin R, Niu C, Wu F, Zhou S, Han T, Zhang Z, Li E, Zhang X, Xu S, Wang J, Tian S, Chen W, Ye Q, Cao C, Cheng L. DNA damage contributes to age-associated differences in SARS-CoV-2 infection. Aging Cell. 2022 Oct 18:e13729. doi: 10.1111\/acel.13729. Epub ahead of print. PMID: 36254583.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>\u6587\u7ae0\u6765\u6e90<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>https:\/\/www.nmn.com\/news\/nmn-inhibits-sars-cov-2-infection-according-to-chinese-study<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-19021\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/09\/7sirt.jpg\" alt=\"\" width=\"775\" height=\"960\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/09\/7sirt.jpg 775w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/09\/7sirt-242x300.jpg 242w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/09\/7sirt-768x951.jpg 768w\" sizes=\"auto, (max-width: 775px) 100vw, 775px\" \/><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"pvc_clear\"><\/div>\n<p id=\"pvc_stats_19426\" class=\"pvc_stats all  \" data-element-id=\"19426\" style=\"\"><i class=\"pvc-stats-icon medium\" aria-hidden=\"true\"><svg aria-hidden=\"true\" focusable=\"false\" data-prefix=\"far\" data-icon=\"chart-bar\" role=\"img\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\" class=\"svg-inline--fa fa-chart-bar fa-w-16 fa-2x\"><path fill=\"currentColor\" d=\"M396.8 352h22.4c6.4 0 12.8-6.4 12.8-12.8V108.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v230.4c0 6.4 6.4 12.8 12.8 12.8zm-192 0h22.4c6.4 0 12.8-6.4 12.8-12.8V140.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v198.4c0 6.4 6.4 12.8 12.8 12.8zm96 0h22.4c6.4 0 12.8-6.4 12.8-12.8V204.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v134.4c0 6.4 6.4 12.8 12.8 12.8zM496 400H48V80c0-8.84-7.16-16-16-16H16C7.16 64 0 71.16 0 80v336c0 17.67 14.33 32 32 32h464c8.84 0 16-7.16 16-16v-16c0-8.84-7.16-16-16-16zm-387.2-48h22.4c6.4 0 12.8-6.4 12.8-12.8v-70.4c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v70.4c0 6.4 6.4 12.8 12.8 12.8z\" class=\"\"><\/path><\/svg><\/i> <img loading=\"lazy\" decoding=\"async\" width=\"16\" height=\"16\" alt=\"Loading\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/plugins\/page-views-count\/ajax-loader-2x.gif\" border=0 \/><\/p>\n<div class=\"pvc_clear\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u4e0e\u5e74\u9f84\u76f8\u5173\u7684 DNA \u635f\u4f24\u4fc3\u8fdb SARS-CoV-2 \u75c5\u6bd2\u8fdb\u5165\u5c0f\u9f20\u80ba\u7ec6\u80de\uff0c\u4f46 NMN \u53ef\u9632\u6b62\u8fd9\u79cd\u611f\u67d3\u3002 By\u00a0Brett J. Weiss Published:\u00a02:42 p.m. PST Nov 3, 2022\u00a0| Updated:\u00a04:19 p.m. PST Nov 8, 2022 \u91cd\u5927\u4eae\u70b9 SARS-CoV-2 \u75c5\u6bd2\u5728\u63a5\u53d7 DNA \u635f\u4f24\u8bf1\u5bfc\u8f90\u5c04\u4ecb\u5165\u7684\u4eba\u7c7b\u80ba\u7ec6\u80de\u4e2d\u7684\u8fdb\u5165\u7387\u66f4\u9ad8\u3002 \u6291\u5236 DNA \u4fee\u590d\u4f1a\u963b\u788d SARS-CoV-2 \u4e3b\u8981\u53d7\u4f53\uff08ACE2 \u53d7\u4f53\uff09\u5728\u7ec6\u80de\u8868\u9762\u7684\u79ef\u7d2f\uff0c\u8fd9\u8868\u660e DNA \u4fee\u590d\u4e0e\u53d7\u4f53\u4ecb\u5bfc\u7684\u75c5\u6bd2\u8fdb\u5165\u4e4b\u95f4\u5b58\u5728\u8054\u7cfb\u3002 NMN \u5df2\u77e5\u6709\u52a9\u4e8e\u4fee\u590d DNA\uff0c\u53ef\u6291\u5236\u5c0f\u9f20\u7ec6\u80de\u8868\u9762 ACE2 \u53d7\u4f53\u7684\u79ef\u7d2f\u4ee5\u53ca SARS-CoV-2 \u75c5\u6bd2\u8f7d\u91cf\u3002<\/p>\n<div class=\"pvc_clear\"><\/div>\n<p id=\"pvc_stats_19426\" class=\"pvc_stats all  \" data-element-id=\"19426\" style=\"\"><i class=\"pvc-stats-icon medium\" aria-hidden=\"true\"><svg aria-hidden=\"true\" focusable=\"false\" data-prefix=\"far\" data-icon=\"chart-bar\" role=\"img\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\" class=\"svg-inline--fa fa-chart-bar fa-w-16 fa-2x\"><path fill=\"currentColor\" d=\"M396.8 352h22.4c6.4 0 12.8-6.4 12.8-12.8V108.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v230.4c0 6.4 6.4 12.8 12.8 12.8zm-192 0h22.4c6.4 0 12.8-6.4 12.8-12.8V140.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v198.4c0 6.4 6.4 12.8 12.8 12.8zm96 0h22.4c6.4 0 12.8-6.4 12.8-12.8V204.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v134.4c0 6.4 6.4 12.8 12.8 12.8zM496 400H48V80c0-8.84-7.16-16-16-16H16C7.16 64 0 71.16 0 80v336c0 17.67 14.33 32 32 32h464c8.84 0 16-7.16 16-16v-16c0-8.84-7.16-16-16-16zm-387.2-48h22.4c6.4 0 12.8-6.4 12.8-12.8v-70.4c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v70.4c0 6.4 6.4 12.8 12.8 12.8z\" class=\"\"><\/path><\/svg><\/i> <img loading=\"lazy\" decoding=\"async\" width=\"16\" height=\"16\" alt=\"Loading\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/plugins\/page-views-count\/ajax-loader-2x.gif\" border=0 \/><\/p>\n<div class=\"pvc_clear\"><\/div>\n","protected":false},"author":1,"featured_media":19429,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[172,272],"tags":[295,171],"class_list":["post-19426","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-nmn-","category-272","tag-covid-19","tag-nmn"],"aioseo_notices":[],"_links":{"self":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts\/19426","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=19426"}],"version-history":[{"count":2,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts\/19426\/revisions"}],"predecessor-version":[{"id":19431,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts\/19426\/revisions\/19431"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/media\/19429"}],"wp:attachment":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=19426"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=19426"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=19426"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}