{"id":19406,"date":"2022-11-19T21:29:30","date_gmt":"2022-11-19T21:29:30","guid":{"rendered":"http:\/\/johnhealth.blog\/ch\/?p=19406"},"modified":"2022-11-20T03:55:35","modified_gmt":"2022-11-20T03:55:35","slug":"%e3%80%90%e7%a7%91%e6%8a%80%e6%96%87%e7%8c%ae%e3%80%91%e7%a0%94%e7%a9%b6%e8%a1%a8%e6%98%8e-nmn-%e5%8f%af%e9%98%bb%e6%ad%a2%e5%b0%8f%e9%bc%a0%e8%a1%80%e7%ae%a1%e8%80%81%e5%8c%96","status":"publish","type":"post","link":"http:\/\/johnhealth.blog\/ch\/?p=19406","title":{"rendered":"\u3010\u79d1\u6280\u6587\u732e\u3011\u7814\u7a76\u8868\u660e NMN \u53ef\u963b\u6b62\u5c0f\u9f20\u8840\u7ba1\u8001\u5316"},"content":{"rendered":"

NAD+ \u4e0b\u964d\u4f1a\u50ac\u751f\u5c0f\u9f20\u7684\u5fc3\u8840\u7ba1\u75be\u75c5\uff0c\u8fd9\u53ef\u4ee5\u901a\u8fc7NAD+\u7684\u524d\u4f53 NMN \u6765\u7f13\u89e3<\/p>\n

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By\u00a0Jonathan D. Grinstein, Ph.D.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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Published:\u00a012:17 p.m. PST Jun 22, 2021\u00a0| Updated:\u00a012:04 p.m. PST Sep 29, 2021<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u91cd\u5927\u4eae\u70b9<\/strong><\/em><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u00b7\u7f3a\u4e4f CD38\uff08\u4e00\u79cd\u6d88\u8017 NAD+ \u7684\u9176\uff09\u53ef\u7f13\u89e3\u9ad8\u8840\u538b\u548c\u5fc3\u8840\u7ba1\u75be\u75c5\u76f8\u5173\u7684\u8840\u7ba1\u53d8\u5316\u3002
\n\u00b7\u00a0NMN \u8865\u5145\u5242\u6216 CD38 \u6291\u5236\u901a\u8fc7\u6539\u5584\u8840\u7ba1\u7ec6\u80de\u5468\u671f\u505c\u6ede\uff08\u8870\u8001\uff09\u6765\u6062\u590d\u5fc3\u8840\u7ba1\u529f\u80fd\u3002<\/p>\n

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CD38 \u662f\u964d\u89e3\u70df\u9170\u80fa\u817a\u560c\u5464\u4e8c\u6838\u82f7\u9178 \uff08NAD+\uff09 \u6700\u4e3b\u8981\u7684\u9176\u2014NAD+ \u662f 400 \u591a\u79cd\u5173\u952e\u7ec6\u80de\u6d3b\u52a8\u7684\u8f85\u52a9\u56e0\u5b50\u2014\u8fd9\u4e00\u8fc7\u7a0b\u88ab\u8bc1\u660e\u6709\u52a9\u4e8e\u8870\u8001\u3002 \u56db\u5ddd\u5927\u5b66\u548c\u5357\u660c\u5927\u5b66\u7684\u7814\u7a76\u4eba\u5458\u5728\u4ed6\u4eec\u53d1\u8868\u5728\u5b66\u672f\u671f\u520a\u300a\u4fe1\u53f7\u8f6c\u5bfc\u548c\u9776\u5411\u6cbb\u7597\u300b\uff08Signal Transduction and Targeted Therapy\uff09<\/em>\u4e0a\u7684\u8bba\u6587\u4e2d\u8868\u660e\uff0cCD38 \u548c\u76f8\u5173\u7684\u7ec6\u80de\u5185 NAD+ \u4e0b\u964d\u5bf9\u4e8e\u9a71\u52a8\u4e0e\u5e74\u9f84\u76f8\u5173\u7684\u5fc3\u8840\u7ba1\u75be\u75c5\uff08\u5982\u52a8\u8109\u7ca5\u6837\u786c\u5316\u548c\u9ad8\u8840\u538b\uff09\u7684\u8fc7\u7a0b\u81f3\u5173\u91cd\u8981<\/a>\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u5728\u7f3a\u4e4f CD38 \u6216\u8865\u5145\u4e86 CD38 \u6291\u5236\u5242\u6216 NAD+ \u524d\u4f53\u70df\u9170\u80fa\u5355\u6838\u82f7\u9178 \uff08NMN\uff09<\/a>\u00a0\u7684\u5c0f\u9f20\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u901a\u8fc7\u9650\u5236\u9ad8\u8840\u538b\u548c\u589e\u52a0\u8840\u7ba1\u7ec6\u80de\u8870\u8001\u6765\u963b\u6b62\u5fc3\u8840\u7ba1\u75be\u75c5\u7684\u53d1\u5c55\u2014\u2014\u7ec6\u80de\u65e0\u6cd5\u518d\u590d\u5236\u7684\u6c38\u4e45\u72b6\u6001\u3002 \u6b64\u5916\uff0c\u7814\u7a76\u4eba\u5458\u89c2\u5bdf\u5230\uff0cCD38 \u7f3a\u4e4f\u6216 NAD+ \u8865\u5145\u53ef\u4ee5\u901a\u8fc7\u6291\u5236\u79f0\u4e3a\u7ec6\u80de\u5916\u56ca\u6ce1\u7684\u7ec6\u80de\u4e4b\u95f4\u7684\u4fe1\u53f7\u6709\u6548\u8f7d\u8377\uff0c\u4ece\u800c\u4fc3\u8fdb\u76f8\u90bb\u672a\u53d7\u635f\u7ec6\u80de\u7684\u8870\u8001\uff0c\u4ece\u800c\u663e\u8457\u51cf\u8f7b\u4e86\u8840\u7ba1\u7ec6\u80de\u7684\u8870\u8001\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u7814\u7a76\u4eba\u5458\u6307\u51fa\u201cNAD+\u4fc3\u8fdb\u5242\u548cCD38\u6291\u5236\u5242\u7684\u5e94\u7528\u53ef\u80fd\u662f\u6cbb\u7597\u4e0e\u5e74\u9f84\u6709\u5173\u7684\u75be\u75c5\u7684\u65b0\u7b56\u7565\u201d\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u8870\u8001\u4f1a\u5bfc\u81f4\u5fc3\u8840\u7ba1\u75be\u75c5<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u5fc3\u8840\u7ba1\u75be\u75c5\u7684\u53d1\u75c5\u7387\u968f\u7740\u5e74\u9f84\u7684\u589e\u957f\u800c\u663e\u8457\u589e\u52a0\u3002 \u8870\u8001\u7ec6\u80de\u7684\u79ef\u7d2f\u2014\u4e00\u79cd\u6c38\u4e45\u6027\u7ec6\u80de\u5468\u671f\u505c\u6ede\u72b6\u6001\u2014\u662f\u8870\u8001\u7684\u6807\u5fd7\uff0c\u5e76\u4e14\u5df2\u88ab\u8bc1\u660e\u4e0e\u5fc3\u8840\u7ba1\u75be\u75c5\u7684\u75c5\u7406\u8fdb\u5c55\u6709\u5173\uff0c\u5305\u62ec\u5fc3\u810f\u8870\u7aed\u3001\u52a8\u8109\u7ca5\u6837\u786c\u5316\u75be\u75c5\u548c\u9ad8\u8840\u538b\u3002 \u8840\u7ba1\u5e73\u6ed1\u808c\u7ec6\u80de\uff08VSMCs\uff09\u7684\u8870\u8001\u6709\u52a9\u4e8e\u75c5\u7406\u6027\u8840\u7ba1\u91cd\u5851\u548c\u9ad8\u8840\u538b\u63a7\u5236\u7684\u6076\u5316\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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NAD+\u4e0b\u964d\u5bfc\u81f4\u8840\u7ba1\u7ec6\u80de\u8870\u8001<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u8fd9\u9879\u7814\u7a76\u8868\u660e\uff0c\u57fa\u56e0\u53bb\u9664 CD38 \u6216\u7528\u6291\u5236\u5242\u963b\u65ad CD38 \u53ef\u663e\u8457\u51cf\u8f7b\u5316\u5b66\u8bf1\u5bfc\u7684\u5c0f\u9f20\u8840\u7ba1\u91cd\u5851\uff0c\u8fd9\u662f\u5fc3\u8840\u7ba1\u75be\u75c5\u53d1\u5c55\u7684\u6a21\u578b\u3002 \u5f53\u7814\u7a76\u4eba\u5458\u4ece\u5c0f\u9f20\u4e2d\u57fa\u56e0\u5220\u9664 CD38 \u65f6\uff0c\u8fd9\u4e9b\u52a8\u7269\u5728\u5bfc\u81f4\u5fc3\u8840\u7ba1\u75be\u75c5\u7684\u8fc7\u7a0b\u4e2d\u5f97\u5230\u4e86\u6539\u5584\uff0c\u4f8b\u5982\u9ad8\u8840\u538b\u3001\u8840\u7ba1\u58c1\u539a\u5ea6\u589e\u52a0\uff08\u8868\u660e\u8840\u7ba1\u66f4\u786c\u3001\u529f\u80fd\u66f4\u5dee\uff09\u4ee5\u53ca \u5bf9\u7ef4\u6301\u8840\u7ba1\u5b8c\u6574\u6027\u81f3\u5173\u91cd\u8981\u7684\u86cb\u767d\u8d28\u6c34\u5e73\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u4ed6\u4eec\u7684\u7ed3\u679c\u8fd8\u8868\u660e\uff0cCD38 \u7f3a\u4e4f\u663e\u8457\u51cf\u5f31\u4e86\u5316\u5b66\u8bf1\u5bfc\u7684 DNA \u635f\u4f24\uff0c\u5e76\u51cf\u5c11\u4e86\u8fd9\u4e9b\u5c0f\u9f20\u52a8\u8109\u4e2d VSMC \u4e2d\u8870\u8001\u76f8\u5173\u6807\u5fd7\u7269\u7684\u79ef\u7d2f\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u201c\u5728\u76ee\u524d\u7684\u7814\u7a76\u4e2d\uff0c\u6211\u4eec\u8bc1\u660e CD38 \u4e0d\u4ec5\u6709\u52a9\u4e8e\u9ad8\u8840\u538b\u7684\u8840\u7ba1\u91cd\u5851\uff0c\u800c\u4e14\u8fd8\u5728 VSMC \u8870\u8001\u4e2d\u53d1\u6325\u4e86\u6709\u5bb3\u7684\u4fc3\u8870\u8001\u4f5c\u7528\uff0c\u8fdb\u4e00\u6b65\u8bc1\u5b9e\u4e86 NAD \u4e0b\u964d\u4e0e\u8870\u8001\u7684\u76f8\u5173\u6027\uff0c\u201d\u7814\u7a76\u4eba\u5458\u603b\u7ed3\u9053\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u63d0\u9ad8 NAD+ \u6c34\u5e73\u53ef\u7f13\u89e3\u9ad8\u8840\u538b\u548c\u8840\u7ba1\u91cd\u5851<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u7814\u7a76\u4eba\u5458\u8fd8\u68c0\u67e5\u4e86\u8865\u5145 NAD+ \u662f\u5426\u53ef\u4ee5\u633d\u6551 VSMC \u8870\u8001\u3002 \u5728\u5065\u5eb7\u6761\u4ef6\u4e0b\uff0c\u4e0e\u672a\u7ecf\u4fee\u9970\u7684\u5c0f\u9f20\u76f8\u6bd4\uff0c\u7f3a\u4e4f CD38 \u7684\u5c0f\u9f20\u7684\u6574\u4e2a\u4e3b\u52a8\u8109\u7ec4\u7ec7\u7684\u7ec6\u80de\u5185 NAD+ \u6c34\u5e73\u589e\u52a0\u4e86\u8fd1 50%\u3002 \u6b64\u5916\uff0c\u53e3\u670d NMN \uff08300 mg\/kg\uff09 \u4ee5\u63d0\u9ad8 NAD+ \u6c34\u5e73\u53ef\u7f13\u89e3\u5316\u5b66\u6027\u9ad8\u8840\u538b\u3002 \u5728\u8fd9\u4e9b\u9ad8\u8840\u538b\u5c0f\u9f20\u4e2d\uff0c\u5728\u6ce8\u5c04 NMN\uff08\u8179\u8154\u6ce8\u5c04\uff0c10mg\/kg\/\u5242\u91cf\uff09\u540e\uff0c\u8840\u7ba1\u4ecb\u8d28\u539a\u5ea6\u3001\u4ecb\u8d28\u4e0e\u7ba1\u8154\u6bd4\u548c\u80f6\u539f\u6c89\u79ef\u5206\u522b\u51cf\u5c11\u4e86 26%\u300127% \u548c 30%\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u00a0(Gan et al., 2021 |<\/strong><\/a>\u00a0Signal Transduct Target Ther.<\/strong><\/em><\/a>\u00a0\uff09<\/strong><\/a>\u00a0NMN \u51cf\u8f7b\u4e86\u5c0f\u9f20\u7684\u9ad8\u8840\u538b\u548c\u8840\u7ba1\u91cd\u5851<\/strong>\u3002 \uff08a\uff09 \u5728\u8f93\u6ce8\u4e00\u79cd\u79f0\u4e3a\u8840\u7ba1\u7d27\u5f20\u7d20 II \uff08Ang II\uff09 \u7684\u9ad8\u8840\u538b\u8bf1\u5bfc\u5316\u5b66\u7269\u8d28\u540e\uff0c\u6bcf 7 \u5929\u5728\u7ed9\u4e88\u6216\u4e0d\u7ed9\u4e88 NMN \u7684\u5c0f\u9f20\u4e2d\u68c0\u6d4b\u5c3e\u52a8\u8109\u8840\u538b\u3002 \uff08b\uff09 \u5728 Ang II \u8f93\u6ce8\u540e 4 \u5468\uff0c\u5728\u6709\u6216\u6ca1\u6709 NMN \u4ecb\u5165\u7684\u5c0f\u9f20\u4e2d\u68c0\u6d4b\u5230\u9888\u52a8\u8109\u7684\u6536\u7f29\u538b\u548c\u8212\u5f20\u538b\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u5728\u7ec6\u80de\u57f9\u517b\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u5c06\u5916\u6e90\u6027 NAD+ \uff08100 \u03bcM\uff09 \u9884\u65bd\u7528\u5230 VSMC \u4e2d\uff0c\u5e76\u68c0\u6d4b Ang II \u8bf1\u5bfc\u7684\u7ec6\u80de\u8870\u8001\u6307\u6807\u3002 \u7ed3\u679c\u8868\u660e\uff0c\u8870\u8001\u7ec6\u80de<\/a>\u7684\u9633\u6027\u9762\u79ef\u51cf\u5c11\u4e8654%\u3002 \u6b64\u5916\uff0c\u5f53\u7814\u7a76\u4eba\u5458\u589e\u52a0 CD38 \u7684\u6c34\u5e73\u65f6\uff0cVSMC \u7684\u8870\u8001\u6c34\u5e73\u663e\u8457\u589e\u52a0\u3002 \u8fd9\u4e9b\u7ed3\u679c\u5f3a\u70c8\u652f\u6301CD38\u53ef\u80fd\u662f\u6297\u8870\u8001\u6cbb\u7597\u7684\u6f5c\u5728\u836f\u7406\u5b66\u9776\u70b9\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u00a0(Gan et al., 2021 |<\/strong><\/a>\u00a0Signal Transduct Target Ther.<\/strong><\/em><\/a>\u00a0\uff09<\/strong><\/a>\u00a0NAD+ \u8865\u5145\u6062\u590d\u4e86\u8840\u7ba1\u5e73\u6ed1\u808c\u7ec6\u80de\u4e2d Ang II \u8bf1\u5bfc\u7684\u7ec6\u80de\u8870\u8001<\/strong>\u3002 \u5728\u7ed9\u4e88 Ang II \u4e4b\u524d\uff0c\u5c06 NAD+ \uff08100 \u03bcM\uff09 \u6dfb\u52a0\u5230\u8840\u7ba1\u5e73\u6ed1\u808c\u7ec6\u80de \uff08VSMC\uff09 \u57f9\u517b\u57fa\u4e2d 4 \u5c0f\u65f6\u3002 \u6240\u6709\u8fd9\u4e9b\u5316\u5408\u7269\u5728\u57f9\u517b\u57fa\u4e2d\u4fdd\u63013\u5929\u3002 \u7136\u540e\u7528\u8870\u8001\u6807\u8bb0\u7269 \uff08SA-\u03b2-gal\uff09 \u5bf9 VSMCs \u8fdb\u884c\u67d3\u8272\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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CD38 \u548c NAD+ \u63a7\u5236\u8bf1\u5bfc\u8870\u8001\u7684\u7ec6\u80de\u95f4\u8d27\u7269\u5bb9\u5668<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u7814\u7a76\u4eba\u5458\u8bc1\u660e\uff0cCD38 \u7f3a\u4e4f\u901a\u8fc7\u6291\u5236\u7ec6\u80de\u5916\u56ca\u6ce1\u7684\u53d1\u751f\u3001\u5206\u6ccc\u548c\u5185\u5316\u6765\u51cf\u5c11 VSMC \u8870\u8001\u2014\u2014\u7ec6\u80de\u5916\u56ca\u6ce1\u662f\u7531\u5305\u88f9\u7ec6\u80de\u7684\u76f8\u540c\u8102\u80aa\u5236\u6210\u7684\u7403\u5f62\u5bb9\u5668\u3002 \u8fd9\u4e9b\u7ed3\u6784\u53ef\u4ee5\u5728\u7ec6\u80de\u548c\u5668\u5b98\u4e4b\u95f4\u4f20\u9012\u5206\u5b50\uff0c\u5305\u62ec\u5728\u8870\u8001\u8fc7\u7a0b\u4e2d\u4fc3\u8fdb\u90bb\u8fd1\u7ec6\u80de\u8870\u8001\u7684\u5206\u5b50\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u5728\u8fd9\u9879\u7814\u7a76\u4e2d\uff0c\u6765\u81ea Ang II \u653b\u51fb\u7684\u5e73\u6ed1\u808c\u7ec6\u80de\u7684\u5c0f\u7ec6\u80de\u5916\u56ca\u6ce1\u52a0\u901f\u4e86\u90bb\u8fd1\u672a\u53d7\u635f\u7ec6\u80de\u7684\u8870\u8001\u3002 \u6b64\u5916\uff0c\u8fd9\u4e9b\u5c0f\u7684\u7ec6\u80de\u5916\u56ca\u6ce1\u5f88\u5bb9\u6613\u88ab\u8870\u8001\u7ec6\u80de\u5185\u5316\uff0c\u52a0\u5267\u4e86\u8fd9\u4e9b\u7ec6\u80de\u7684\u8870\u8001\u8fc7\u7a0b\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u201c\u56e0\u6b64\uff0c\u8fd9\u4e9b\u7ed3\u679c\u4fc3\u8fdb\u4e86\u6211\u4eec\u5bf9\u9ad8\u8840\u538b\u4e2d VSMC \u8870\u8001\u673a\u5236\u7684\u7406\u89e3\uff0c\u5e76\u4e3a\u51cf\u5c11\u8840\u7ba1\u8001\u5316\u7684\u65b0\u6cbb\u7597\u9776\u70b9\u63d0\u4f9b\u4e86\u89c1\u89e3\uff0c\u201d\u4f5c\u8005\u603b\u7ed3\u9053\u3002 \u201c\u6211\u4eec\u7684\u7ed3\u679c\u63d0\u4f9b\u4e86\u5f3a\u6709\u529b\u7684\u8bc1\u636e\uff0c\u8868\u660e CD38 \u6291\u5236\u6216 NAD \u8865\u5145\u5242\u53ef\u80fd\u4f5c\u4e3a\u4e0e\u5e74\u9f84\u76f8\u5173\u75be\u75c5\u7684\u6f5c\u5728\u6cbb\u7597\u7b56\u7565\u3002\u201d<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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Gan L, Liu D, Liu J, Chen E, Chen C, Liu L, Hu H, Guan X, Ma W, Zhang Y, He Y, Liu B, Tang S, Jiang W, Xue J, Xin H.\u00a0CD38 deficiency alleviates Ang II-induced vascular remodeling by inhibiting small extracellular vesicle-mediated vascular smooth muscle cell senescence in mice<\/strong>\u00a0. Signal Transduct Target Ther. 2021 Jun 11; 6(1):223. doi:\u00a010.1038\/s41392-021-00625-0<\/a>. PMID: 34112762.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u6587\u7ae0\u6765\u6e90<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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https:\/\/www.nmn.com\/news\/study-shows-nmn-stops-blood-vessel-aging-in-mice<\/p>\n

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NAD+ \u4e0b\u964d\u4f1a\u50ac\u751f\u5c0f\u9f20\u7684\u5fc3\u8840\u7ba1\u75be\u75c5\uff0c\u8fd9\u53ef\u4ee5\u901a\u8fc7NAD+\u7684\u524d\u4f53 NMN \u6765\u7f13\u89e3 By\u00a0Jonathan D. Grinstein, Ph.D. Published:\u00a012:17 p.m. PST Jun 22, 2021\u00a0| Updated:\u00a012:04 p.m. PST Sep 29, 2021 \u91cd\u5927\u4eae\u70b9 \u00b7\u7f3a\u4e4f CD38\uff08\u4e00\u79cd\u6d88\u8017 NAD+ \u7684\u9176\uff09\u53ef\u7f13\u89e3\u9ad8\u8840\u538b\u548c\u5fc3\u8840\u7ba1\u75be\u75c5\u76f8\u5173\u7684\u8840\u7ba1\u53d8\u5316\u3002 \u00b7\u00a0NMN \u8865\u5145\u5242\u6216 CD38 \u6291\u5236\u901a\u8fc7\u6539\u5584\u8840\u7ba1\u7ec6\u80de\u5468\u671f\u505c\u6ede\uff08\u8870\u8001\uff09\u6765\u6062\u590d\u5fc3\u8840\u7ba1\u529f\u80fd\u3002  <\/p>\n

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